Published in J Lipid Res on December 27, 2011
Fluid biomarkers in Alzheimer's disease - current concepts. Mol Neurodegener (2013) 1.44
Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One (2013) 1.36
Plasma and serum lipidomics of healthy white adults shows characteristic profiles by subjects' gender and age. PLoS One (2014) 1.08
Metabolomics and systems pharmacology: why and how to model the human metabolic network for drug discovery. Drug Discov Today (2013) 1.03
Developing novel blood-based biomarkers for Alzheimer's disease. Alzheimers Dement (2014) 0.96
Plasma lipidomics analysis finds long chain cholesteryl esters to be associated with Alzheimer's disease. Transl Psychiatry (2015) 0.96
Metabolic profiling of Alzheimer's disease brains. Sci Rep (2013) 0.94
Alterations in metabolic pathways and networks in Alzheimer's disease. Transl Psychiatry (2013) 0.93
Recent advances in the application of metabolomics to Alzheimer's Disease. Biochim Biophys Acta (2013) 0.92
Implication of intestinal VDR deficiency in inflammatory bowel disease. Biochim Biophys Acta (2012) 0.91
Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics. J Clin Cell Immunol (2013) 0.88
Feasibility of identifying the tobacco-related global metabolome in blood by UPLC-QTOF-MS. J Proteome Res (2013) 0.86
Comparison between Complementary Dietary Treatment of Alzheimer Disease in Iranian Traditional Medicine and Modern Medicine. Iran J Public Health (2013) 0.85
Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement (2016) 0.84
Alzheimer's disease: brain desmosterol levels. J Alzheimers Dis (2013) 0.82
Wide-ranging alterations in the brain fatty acid complement of subjects with late Alzheimer's disease as detected by GC-MS. Am J Transl Res (2016) 0.79
Current status of biomarker research in neurology. EPMA J (2016) 0.79
Circadian Time Structure of Circulating Plasma Lipid Components in Healthy Indians of Different Age Groups. Indian J Clin Biochem (2015) 0.78
Metabolic profiling of a transgenic Caenorhabditis elegans Alzheimer model. Metabolomics (2014) 0.77
Comparative lipidomics of mouse brain exposed to enriched environment. J Lipid Res (2013) 0.77
Redox Proteomic Profiling of Specifically Carbonylated Proteins in the Serum of Triple Transgenic Alzheimer's Disease Mice. Int J Mol Sci (2016) 0.77
Biomarker Discovery and Translation in Metabolomics. Curr Metabolomics (2016) 0.77
Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis. J Biol Chem (2015) 0.77
Metabolomic method: UPLC-q-ToF polar and non-polar metabolites in the healthy rat cerebellum using an in-vial dual extraction. PLoS One (2015) 0.76
Gas chromatography-mass spectrometric method-based urine metabolomic profile of rats with pelvic inflammatory disease. Exp Ther Med (2016) 0.75
Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats. Age (Dordr) (2014) 0.75
Reduced plasma desmosterol-to-cholesterol ratio and longitudinal cognitive decline in Alzheimer's disease. Alzheimers Dement (Amst) (2015) 0.75
Metabolomics and cognition in African American adults in midlife: the atherosclerosis risk in communities study. Transl Psychiatry (2017) 0.75
Phenotype-driven identification of modules in a hierarchical map of multifluid metabolic correlations. NPJ Syst Biol Appl (2017) 0.75
Serum and Liver Tissue Metabonomic Study on Fatty Liver in Rats Induced by High-Fat Diet and Intervention Effects of Traditional Chinese Medicine Qushi Huayu Decoction. Evid Based Complement Alternat Med (2017) 0.75
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (1993) 33.32
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A (1993) 15.04
Protein aggregation and neurodegenerative disease. Nat Med (2004) 9.51
Cerebrospinal fluid and plasma biomarkers in Alzheimer disease. Nat Rev Neurol (2010) 6.55
Shotgun lipidomics: electrospray ionization mass spectrometric analysis and quantitation of cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev (2005) 5.98
The emerging field of lipidomics. Nat Rev Drug Discov (2005) 4.69
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet (2008) 4.66
Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem (1995) 3.19
Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res (2003) 3.18
Receiver-operating characteristic curve analysis in diagnostic, prognostic and predictive biomarker research. J Clin Pathol (2008) 2.77
Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res (2006) 2.44
Proteome-based plasma biomarkers for Alzheimer's disease. Brain (2006) 1.98
Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry. Methods Enzymol (2007) 1.63
CSF biomarker levels in early and late onset Alzheimer's disease. Neurobiol Aging (2008) 1.52
Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J Lipid Res (1987) 1.50
Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy: part II: the early evidence linking hypercholesterolemia to coronary disease in humans. J Lipid Res (2004) 1.45
Biomarkers of primary and evolving damage in traumatic and ischemic brain injury: diagnosis, prognosis, probing mechanisms, and therapeutic decision making. Curr Opin Crit Care (2008) 1.34
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease. Brain Res Rev (2009) 1.25
Analytical strategies in lipidomics and applications in disease biomarker discovery. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.24
Key regulatory oxysterols in liver: analysis as delta4-3-ketone derivatives by HPLC and response to physiological perturbations. J Lipid Res (2001) 1.15
Combination of serum markers related to several mechanisms in Alzheimer's disease. Neurobiol Aging (2003) 1.07
Sterols in blood of normal and Smith-Lemli-Opitz subjects. J Lipid Res (2001) 1.01
Profiling of human stratum corneum ceramides by means of normal phase LC/APCI-MS. Anal Bioanal Chem (2005) 1.00
Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS. J Lipid Res (2004) 0.99
Quantitative measurement of different ceramide species from crude cellular extracts by normal-phase high-performance liquid chromatography coupled to atmospheric pressure ionization mass spectrometry. Rapid Commun Mass Spectrom (2004) 0.97
High sensitive analysis of rat serum bile acids by liquid chromatography/electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal (2005) 0.93
Quantitative profiling of polar cationic metabolites in human cerebrospinal fluid by reversed-phase nanoliquid chromatography/mass spectrometry. Anal Chem (2009) 0.92
Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. Neurobiol Aging (2005) 0.92
Quantitative and wide-ranging profiling of phospholipids in human plasma by two-dimensional liquid chromatography/mass spectrometry. Anal Chem (2010) 0.92
Determination of some hydroxycholesterols in human serum samples. J Chromatogr (1987) 0.91
Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM). J Chromatogr B Analyt Technol Biomed Life Sci (2006) 0.90
Alterations of cholesterol precursor levels in Alzheimer's disease. Biochim Biophys Acta (2010) 0.88
Determination of cholesterol oxides in processed food using high-performance liquid chromatography-mass spectrometry with atmospheric pressure chemical ionisation. J Chromatogr A (2000) 0.88
Biomarkers for Alzheimer's disease. Expert Rev Mol Diagn (2007) 0.88
Simultaneous measurement of cholesterol 7 alpha-hydroxylase activity by reverse-phase high-performance liquid chromatography using both endogenous and exogenous [4-14C]cholesterol as substrate. Anal Biochem (1989) 0.87
New technologies personalize diagnostics and therapeutics. Curr Atheroscler Rep (2010) 0.84
Total serum cholesterol by isotope dilution/mass spectrometry: a candidate definitive method. Clin Chem (1980) 0.82
Sterol synthesis. A timely look at the capabilities of conventional and silver ion high performance liquid chromatography for the separation of C27 sterols related to cholesterol biosynthesis. J Lipid Res (1997) 0.82
Practical metabolomics in drug discovery. Expert Opin Drug Discov (2010) 0.81
HPLC separation and determination of 12 cholesterol oxidation products in fish: comparative study of RI, UV, and APCI-MS detectors. J Agric Food Chem (2006) 0.77
Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein. Mol Cell Proteomics (2005) 10.67
MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16
Identification of membrane-type receptor for bile acids (M-BAR). Biochem Biophys Res Commun (2002) 3.41
Microduplication and triplication of 22q11.2: a highly variable syndrome. Am J Hum Genet (2005) 2.05
Large-scale analysis of the human ubiquitin-related proteome. Proteomics (2005) 2.00
Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and dissection with intracranial and other arterial aneurysms. Circ Res (2011) 1.93
Quantitative mouse brain proteomics using culture-derived isotope tags as internal standards. Nat Biotechnol (2005) 1.76
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles. J Cell Biol (2003) 1.65
Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. J Biol Chem (2005) 1.64
Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration. J Biol Chem (2003) 1.55
Efficient in-gel digestion procedure using 5-cyclohexyl-1-pentyl-beta-D-maltoside as an additive for gel-based membrane proteomics. Rapid Commun Mass Spectrom (2004) 1.27
Circulating miRNA biomarkers for Alzheimer's disease. PLoS One (2013) 1.22
A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. J Immunol (2006) 1.21
Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation. J Cell Biol (2009) 1.19
Developments for a growing Japanese patient population: facilitating new technologies for future health care. J Proteomics (2010) 1.15
Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models. Cancer Sci (2014) 1.13
Evaluation of comprehensive multidimensional separations using reversed-phase, reversed-phase liquid chromatography/mass spectrometry for shotgun proteomics. J Proteome Res (2008) 1.08
Identification of activity-regulated proteins in the postsynaptic density fraction. Genes Cells (2002) 1.02
Specificity of immobilized metal affinity-based IMAC/C18 tip enrichment of phosphopeptides for protein phosphorylation analysis. Anal Chem (2005) 1.00
Quantitative proteomics using mass spectrometry. Curr Opin Chem Biol (2003) 0.96
Phosphorylation of lysophosphatidylcholine acyltransferase 2 at Ser34 enhances platelet-activating factor production in endotoxin-stimulated macrophages. J Biol Chem (2010) 0.96
Truncations of amphiphysin I by calpain inhibit vesicle endocytosis during neural hyperexcitation. EMBO J (2007) 0.95
Enhancement of the efficiency of phosphoproteomic identification by removing phosphates after phosphopeptide enrichment. J Proteome Res (2007) 0.95
Multiplexed two-dimensional liquid chromatography for MALDI and nanoelectrospray ionization mass spectrometry in proteomics. J Proteome Res (2006) 0.94
Chemical proteomics for drug discovery based on compound-immobilized affinity chromatography. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.93
Mass++: A Visualization and Analysis Tool for Mass Spectrometry. J Proteome Res (2014) 0.93
Quantitative profiling of polar cationic metabolites in human cerebrospinal fluid by reversed-phase nanoliquid chromatography/mass spectrometry. Anal Chem (2009) 0.92
Quantitative and wide-ranging profiling of phospholipids in human plasma by two-dimensional liquid chromatography/mass spectrometry. Anal Chem (2010) 0.92
Quantitative proteomics of mouse brain and specific protein-interaction studies using stable isotope labeling. Methods Mol Biol (2007) 0.89
Stabilization of actin bundles by a dynamin 1/cortactin ring complex is necessary for growth cone filopodia. J Neurosci (2013) 0.89
Pseudo internal standard approach for label-free quantitative proteomics. Anal Chem (2007) 0.89
Polar anionic metabolome analysis by nano-LC/MS with a metal chelating agent. Anal Chem (2009) 0.89
An integrated comprehensive workbench for inferring genetic networks: voyagene. J Bioinform Comput Biol (2004) 0.86
Quantitative phosphorus metabolomics using nanoflow liquid chromatography-tandem mass spectrometry and culture-derived comprehensive global internal standards. Anal Chem (2009) 0.86
Application of microarray-based comparative genomic hybridization in prenatal and postnatal settings: three case reports. Genet Res Int (2011) 0.84
Cardiac features of a novel autosomal recessive dilated cardiomyopathic syndrome due to defective importation of mitochondrial protein. Cardiol Young (2007) 0.83
Highly robust stainless steel tips as microelectrospray emitters. Rapid Commun Mass Spectrom (2002) 0.83
Practical metabolomics in drug discovery. Expert Opin Drug Discov (2010) 0.81
Optimization of in-gel protein digestion system in combination with thin-gel separation and negative staining in 96-well plate format. Rapid Commun Mass Spectrom (2003) 0.81
Ethylenediaminetetraacetic acid increases identification rate of phosphoproteomics in real biological samples. J Proteome Res (2010) 0.80
Improving completeness of ascertainment and quality of information for pregnancies through linkage of administrative and clinical data records. Ann Epidemiol (2013) 0.80
Estimation and optimization of the peak capacity of one-dimensional gradient high performance liquid chromatography using a long monolithic silica capillary column. J Chromatogr A (2012) 0.80
A system for LogD screening of 96-well plates using a water-plug aspiration/injection method combined with high-performance liquid chromatography-mass spectrometry. Anal Chem (2007) 0.79
Quantitative proteomics using mass spectrometry. Drug Discov Today (2004) 0.79
Major Cdk5-dependent phosphorylation sites of amphiphysin 1 are implicated in the regulation of the membrane binding and endocytosis. J Neurochem (2007) 0.79
A case report of monozygotic twins with Smith-Magenis syndrome. J Dev Behav Pediatr (2008) 0.78
Prediction of relaxin-3-induced downstream pathway resulting in anxiolytic-like behaviors in rats based on a microarray and peptidome analysis. J Recept Signal Transduct Res (2013) 0.78
Mass spectrometry-based quantitative proteomics. Biotechnol Genet Eng Rev (2007) 0.77
High-speed solubility screening assay using ultra-performance liquid chromatography/mass spectrometry in drug discovery. J Chromatogr A (2008) 0.77
Comparative lipidomics of mouse brain exposed to enriched environment. J Lipid Res (2013) 0.77
Impact of observed versus hypothesized service utilization on the incremental cost of first trimester screening and prenatal diagnosis for trisomy 21 in a Canadian province. Prenat Diagn (2013) 0.76
Proteomic analysis for neuronal vacuolation induced by MK-801 in rat retrosplenial cortex. J Toxicol Sci (2011) 0.76
Seizure-mediated accumulation of the beta subunit of Ca2+/calmodulin-dependent protein kinase II in nuclei of mouse brain cells. Neurosci Lett (2002) 0.75
In vivo isotopic labeling of proteins for quantitative proteomics. CSH Protoc (2007) 0.75
[Pioneering chemical space in drug discovery research: application of transcriptomic and quantitative proteomic analyses]. Tanpakushitsu Kakusan Koso (2005) 0.75