Published in J Biomed Biotechnol on December 13, 2011
Biological characteristics and genetic heterogeneity between carcinoma-associated fibroblasts and their paired normal fibroblasts in human breast cancer. PLoS One (2013) 1.01
Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression. Front Oncol (2014) 0.87
Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer. Breast Cancer Res Treat (2013) 0.87
Integration of molecular profiling and chemical imaging to elucidate fibroblast-microenvironment impact on cancer cell phenotype and endocrine resistance in breast cancer. PLoS One (2014) 0.86
Resolving cancer-stroma interfacial signalling and interventions with micropatterned tumour-stromal assays. Nat Commun (2014) 0.81
Functional tissue units and their primary tissue motifs in multi-scale physiology. J Biomed Semantics (2013) 0.81
Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Biosci Rep (2013) 0.80
Persistent organic pollutants and obesity: are they potential mechanisms for breast cancer promotion? Endocr Relat Cancer (2015) 0.79
Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro. Sci Rep (2016) 0.78
Characteristic Gene Expression Profiles of Human Fibroblasts and Breast Cancer Cells in a Newly Developed Bilateral Coculture System. Biomed Res Int (2015) 0.76
cMET inhibitor crizotinib impairs angiogenesis and reduces tumor burden in the C3(1)-Tag model of basal-like breast cancer. Springerplus (2016) 0.75
Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging. Front Oncol (2017) 0.75
Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes. Cancer Res (2016) 0.75
Screening and analysis of breast cancer genes regulated by the human mammary microenvironment in a humanized mouse model. Oncol Lett (2016) 0.75
Prognostic and functional role of subtype-specific tumor-stroma interaction in breast cancer. Mol Oncol (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell (2006) 27.36
Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med (1986) 17.64
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc Natl Acad Sci U S A (2005) 13.54
Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer (1953) 11.45
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A (2005) 10.85
Stromal gene expression predicts clinical outcome in breast cancer. Nat Med (2008) 10.68
Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer (2004) 9.68
Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41
Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. PLoS Biol (2004) 9.38
CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell (2009) 8.54
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54
Stromal effects on mammary gland development and breast cancer. Science (2002) 5.22
Regulation of in situ to invasive breast carcinoma transition. Cancer Cell (2008) 4.46
The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer (2007) 4.01
Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res (2000) 3.95
The tension mounts: mechanics meets morphogenesis and malignancy. J Mammary Gland Biol Neoplasia (2004) 3.54
Gene expression profiling of the tumor microenvironment during breast cancer progression. Breast Cancer Res (2009) 3.52
EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics (2007) 3.35
Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res (2011) 3.18
Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res (2011) 2.85
Gene expression patterns associated with p53 status in breast cancer. BMC Cancer (2006) 2.61
Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression. Cold Spring Harb Perspect Biol (2011) 2.48
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol (2008) 2.41
An intraductal human-in-mouse transplantation model mimics the subtypes of ductal carcinoma in situ. Breast Cancer Res (2009) 2.37
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases. Carcinogenesis (2004) 2.35
HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat (2009) 2.34
Gap junction-mediated import of microRNA from bone marrow stromal cells can elicit cell cycle quiescence in breast cancer cells. Cancer Res (2011) 2.31
Reconstruction of human mammary tissues in a mouse model. Nat Protoc (2006) 2.03
Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res (2004) 2.01
The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res (2009) 2.00
The fibromatosis signature defines a robust stromal response in breast carcinoma. Lab Invest (2008) 1.85
The dominance of the microenvironment in breast and ovarian cancer. Semin Cancer Biol (2002) 1.73
Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annu Rev Pathol (2008) 1.55
Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT). Breast Cancer Res Treat (2010) 1.54
Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Genome Biol (2007) 1.54
Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts. Br J Cancer (1993) 1.53
Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers. Mol Cancer Res (2010) 1.53
Mesenchymal stem cells promote mammosphere formation and decrease E-cadherin in normal and malignant breast cells. PLoS One (2010) 1.49
Mammary ECM composition and function are altered by reproductive state. Mol Carcinog (2004) 1.48
Activation of host wound responses in breast cancer microenvironment. Clin Cancer Res (2009) 1.45
Mammary field cancerization: molecular evidence and clinical importance. Breast Cancer Res Treat (2009) 1.40
Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis. PLoS One (2011) 1.37
Microenvironmental influences that drive progression from benign breast disease to invasive breast cancer. J Mammary Gland Biol Neoplasia (2010) 1.32
Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells. Cancer Res (2008) 1.30
CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. Oncol Rep (2009) 1.30
Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts. Int J Cancer (2009) 1.19
Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way. Glia (2010) 1.13
Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelial-mesenchymal transition-like state in breast cancer cells in vitro. J Cell Sci (2010) 1.10
Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer. Neoplasia (2009) 1.10
Markers of fibrosis and epithelial to mesenchymal transition demonstrate field cancerization in histologically normal tissue adjacent to breast tumors. Int J Cancer (2011) 1.09
Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk. Mol Cancer (2010) 1.08
A complex 3D human tissue culture system based on mammary stromal cells and silk scaffolds for modeling breast morphogenesis and function. Biomaterials (2010) 1.07
Lipid partitioning, incomplete fatty acid oxidation, and insulin signal transduction in primary human muscle cells: effects of severe obesity, fatty acid incubation, and fatty acid translocase/CD36 overexpression. J Clin Endocrinol Metab (2010) 1.03
NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration. Br J Cancer (2010) 1.00
Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression. Tumour Biol (2010) 0.99
Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes. Breast Cancer Res (2009) 0.99
Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification. Carcinogenesis (2011) 0.98
Integrating epithelial cancer, aging stroma and cellular senescence. Adv Gerontol (2003) 0.97
Systems-level modeling of cancer-fibroblast interaction. PLoS One (2009) 0.94
Molecular analysis reveals heterogeneity of mouse mammary tumors conditionally mutant for Brca1. Mol Cancer (2008) 0.93
The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo. BMC Med (2010) 0.92
Molecular mechanisms of breast cancer progression: lessons from mouse mammary cancer models and gene expression profiling. Breast Dis (2004) 0.87
Distinctive responsiveness to stromal signaling accompanies histologic grade programming of cancer cells. PLoS One (2011) 0.85
Influence of stromal-epithelial interactions on breast cancer in vitro and in vivo. Breast Cancer Res Treat (2011) 0.80
Estradiol-17 beta stimulates proliferation of uterine epithelial cells cultured with stromal cells but not cultured separately. In Vitro Cell Dev Biol Anim (1994) 0.80
Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells. BMC Cancer (2010) 0.80
Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures. Exp Mol Pathol (2011) 0.80
Estrogen signaling in cancer microenvironment and prediction of response to hormonal therapy. J Steroid Biochem Mol Biol (2008) 0.77
Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA (2006) 24.01
Estrogen-regulated genes predict survival in hormone receptor-positive breast cancers. J Clin Oncol (2006) 4.84
EGFR associated expression profiles vary with breast tumor subtype. BMC Genomics (2007) 3.35
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A (2011) 2.01
Building prognostic models for breast cancer patients using clinical variables and hundreds of gene expression signatures. BMC Med Genomics (2011) 1.67
Interactions with fibroblasts are distinct in Basal-like and luminal breast cancers. Mol Cancer Res (2010) 1.53
CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res (2010) 1.52
Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J Biol Chem (2014) 1.48
Dynamic regulation of CD24 and the invasive, CD44posCD24neg phenotype in breast cancer cell lines. Breast Cancer Res (2009) 1.42
Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One (2012) 1.27
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression. Breast Cancer Res Treat (2011) 1.24
Systematic bias in genomic classification due to contaminating non-neoplastic tissue in breast tumor samples. BMC Med Genomics (2011) 1.17
Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancer. Clin Cancer Res (2012) 1.15
p53 and NF-κB coregulate proinflammatory gene responses in human macrophages. Cancer Res (2014) 1.09
Basal-like breast cancer cells induce phenotypic and genomic changes in macrophages. Mol Cancer Res (2012) 1.08
Accounting for misclassified outcomes in binary regression models using multiple imputation with internal validation data. Am J Epidemiol (2013) 1.06
Motility-, autocorrelation-, and polarization-sensitive optical coherence tomography discriminates cells and gold nanorods within 3D tissue cultures. Opt Lett (2013) 1.03
Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer. Cancer Epidemiol Biomarkers Prev (2012) 1.03
Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Res (2012) 1.03
Gene expression profiles of breast biopsies from healthy women identify a group with claudin-low features. BMC Med Genomics (2011) 1.02
Down-regulation of sfrp1 in a mammary epithelial cell line promotes the development of a cd44high/cd24low population which is invasive and resistant to anoikis. Cancer Cell Int (2009) 0.99
DNA methylation profiling in the Carolina Breast Cancer Study defines cancer subclasses differing in clinicopathologic characteristics and survival. Breast Cancer Res (2014) 0.98
Role of HGF in epithelial-stromal cell interactions during progression from benign breast disease to ductal carcinoma in situ. Breast Cancer Res (2013) 0.98
Mammographic density and breast cancer risk in White and African American Women. Breast Cancer Res Treat (2012) 0.96
Obesity, body fat distribution, and risk of breast cancer subtypes in African American women participating in the AMBER Consortium. Breast Cancer Res Treat (2015) 0.95
Common genetic variation in GATA-binding protein 3 and differential susceptibility to breast cancer by estrogen receptor alpha tumor status. Cancer Epidemiol Biomarkers Prev (2007) 0.94
Proceedings of the second international molecular pathological epidemiology (MPE) meeting. Cancer Causes Control (2015) 0.94
Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal. J Clin Invest (2014) 0.94
Endothelial-like properties of claudin-low breast cancer cells promote tumor vascular permeability and metastasis. Clin Exp Metastasis (2013) 0.91
Longitudinal study of mammary epithelial and fibroblast co-cultures using optical coherence tomography reveals morphological hallmarks of pre-malignancy. PLoS One (2012) 0.91
Expression of exogenous human telomerase in cultures of endometrial stromal cells does not alter their hormone responsiveness. Biol Reprod (2005) 0.91
Body size across the life course and risk of premenopausal and postmenopausal breast cancer in Black women, the Carolina Breast Cancer Study, 1993-2001. Cancer Causes Control (2014) 0.91
Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo. Breast Cancer Res (2012) 0.89
Racial variation in adjuvant chemotherapy initiation among breast cancer patients receiving oncotype DX testing. Breast Cancer Res Treat (2015) 0.89
Serum estradiol levels associated with specific gene expression patterns in normal breast tissue and in breast carcinomas. BMC Cancer (2011) 0.88
Pubertal high fat diet: effects on mammary cancer development. Breast Cancer Res (2013) 0.87
Role of HGF in obesity-associated tumorigenesis: C3(1)-TAg mice as a model for human basal-like breast cancer. Breast Cancer Res Treat (2013) 0.87
Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats. Chem Biol Interact (2002) 0.85
Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status. Breast Cancer Res (2014) 0.84
A case-control analysis of oral contraceptive use and breast cancer subtypes in the African American Breast Cancer Epidemiology and Risk Consortium. Breast Cancer Res (2015) 0.82
Body mass index associated with genome-wide methylation in breast tissue. Breast Cancer Res Treat (2015) 0.81
Race-associated biological differences among Luminal A breast tumors. Breast Cancer Res Treat (2015) 0.81
Association between mammographic density and basal-like and luminal A breast cancer subtypes. Breast Cancer Res (2013) 0.81
Microarrays and epidemiology: ensuring the impact and accessibility of research findings. Cancer Epidemiol Biomarkers Prev (2009) 0.80
Healthy worker survivor bias in the Colorado Plateau uranium miners cohort. Am J Epidemiol (2015) 0.78
Temporal trends in the inflammatory cytokine profile of human breastmilk. Breastfeed Med (2014) 0.78
Dermcidin expression is associated with disease progression and survival among breast cancer patients. Breast Cancer Res Treat (2014) 0.76
African American women's perspectives on breast cancer: implications for communicating risk of basal-like breast cancer. J Health Care Poor Underserved (2013) 0.76
Single-nucleotide polymorphisms in DNA bypass polymerase genes and association with breast cancer and breast cancer subtypes among African Americans and Whites. Breast Cancer Res Treat (2014) 0.75
Associations of Premenopausal Hysterectomy and Oophorectomy With Breast Cancer Among Black and White Women: The Carolina Breast Cancer Study, 1993-2001. Am J Epidemiol (2016) 0.75
Reducing Racial Disparities in Breast Cancer Care: The Role of 'Big Data'. Oncology (Williston Park) (2017) 0.75
Formation and removal of pentachlorophenol-derived protein adducts in rodent liver under acute, multiple, and chronic dosing regimens. Toxicol Sci (2003) 0.75