PubRank

George Thomas

Author PubWeight™ 252.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004 12.36
2 Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008 10.74
3 Hypothalamic mTOR signaling regulates food intake. Science 2006 8.62
4 Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009 7.80
5 Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A 2005 7.21
6 Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003 6.76
7 S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway. Mol Cell Biol 2004 6.00
8 Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab 2006 4.98
9 mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science 2010 4.81
10 First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors. J Clin Oncol 2011 4.53
11 Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene. PLoS Genet 2010 4.29
12 Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 2006 4.24
13 Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 2003 4.20
14 Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation 2004 4.13
15 Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. Cell Metab 2010 4.08
16 A guide to analysis of mouse energy metabolism. Nat Methods 2011 3.82
17 mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med 2007 3.66
18 The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005 3.59
19 A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J Clin Invest 2010 3.47
20 Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance. Proc Natl Acad Sci U S A 2007 3.32
21 Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004 3.20
22 Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med 2015 3.00
23 Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction. Nat Cell Biol 2009 2.97
24 Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab 2008 2.96
25 Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Genes Dev 2002 2.87
26 Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 2004 2.64
27 Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J Cell Biol 2002 2.46
28 Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K. Bioessays 2002 2.37
29 Evaluation of microsatellite instability and immunohistochemistry for the prediction of germ-line MSH2 and MLH1 mutations in hereditary nonpolyposis colon cancer families. Cancer Res 2002 2.33
30 dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol 2002 2.31
31 Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J Cell Biol 2009 2.30
32 Identifying optimal biologic doses of everolimus (RAD001) in patients with cancer based on the modeling of preclinical and clinical pharmacokinetic and pharmacodynamic data. J Clin Oncol 2008 2.01
33 The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett 2006 1.97
34 Diagnosis, treatment, and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus. Neurosurgery 2005 1.87
35 S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade. J Biol Chem 2008 1.87
36 S6K1 plays a critical role in early adipocyte differentiation. Dev Cell 2010 1.74
37 S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am J Physiol Renal Physiol 2009 1.74
38 Signaling control of mRNA translation in cancer pathogenesis. Oncogene 2004 1.71
39 Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 2002 1.66
40 Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. Cancer Res 2013 1.66
41 Genetic background controls tumor development in PTEN-deficient mice. Cancer Res 2006 1.63
42 Tolerance to nitroglycerin-induced preconditioning of the endothelium: a human in vivo study. Am J Physiol Heart Circ Physiol 2009 1.57
43 Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Sci Signal 2009 1.47
44 hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling. Curr Opin Cell Biol 2007 1.45
45 Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors. Mol Cancer Ther 2008 1.44
46 Time course of adenosine-induced pulmonary vein reconnection after isolation: implications for mechanism of dormant conduction. Pacing Clin Electrophysiol 2012 1.44
47 Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint. Genes Dev 2012 1.44
48 Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol Cell Biol 2004 1.43
49 Medical Council of India and the Indian Medical Association: uneasy relations. Indian J Med Ethics 2011 1.42
50 Recovery of atrioventricular conduction after pacemaker placement following cardiac valvular surgery. J Cardiovasc Electrophysiol 2013 1.42
51 The minister of health, the director of AIIMS and Shah Rukh Khan. Indian J Med Ethics 2008 1.41
52 Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proc Natl Acad Sci U S A 2010 1.39
53 Focal ablation versus single vein isolation for atrial tachycardia originating from a pulmonary vein. Pacing Clin Electrophysiol 2010 1.39
54 Mechanisms, predictors, and trends of electrical failure of Riata leads. Heart Rhythm 2013 1.38
55 Cold active microbial lipases: some hot issues and recent developments. Biotechnol Adv 2008 1.38
56 The Bhopal gas disaster and the poor state of occupational health and safety India. Indian J Med Ethics 2011 1.38
57 5S ribosomal RNA is an essential component of a nascent ribosomal precursor complex that regulates the Hdm2-p53 checkpoint. Cell Rep 2013 1.37
58 Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. Learn Mem 2008 1.35
59 Cerebrospinal fluid shunt placement for pseudotumor cerebri-associated intractable headache: predictors of treatment response and an analysis of long-term outcomes. J Neurosurg 2004 1.26
60 Phytohormones participate in an S6 kinase signal transduction pathway in Arabidopsis. Plant Physiol 2004 1.24
61 mTOR, cancer and transplantation. Am J Transplant 2008 1.24
62 mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Sci Transl Med 2012 1.21
63 Growth control and ribosomopathies. Curr Opin Genet Dev 2013 1.17
64 The role of p53 in ribosomopathies. Semin Hematol 2011 1.17
65 A working group classification of focal prostate atrophy lesions. Am J Surg Pathol 2006 1.13
66 Tubers and tumors: rapamycin therapy for benign and malignant tumors. Curr Opin Cell Biol 2009 1.13
67 Insulin regulation of insulin-like growth factor-binding protein-1 gene expression is dependent on the mammalian target of rapamycin, but independent of ribosomal S6 kinase activity. J Biol Chem 2002 1.12
68 Characterization of complex chromosomal rearrangements by targeted capture and next-generation sequencing. Genome Res 2011 1.10
69 Activation of S6K1 (p70 ribosomal protein S6 kinase 1) requires an initial calcium-dependent priming event involving formation of a high-molecular-mass signalling complex. Biochem J 2003 1.02
70 Loss of tumor suppressor RPL5/RPL11 does not induce cell cycle arrest but impedes proliferation due to reduced ribosome content and translation capacity. Mol Cell Biol 2013 1.00
71 Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. PLoS One 2013 0.99
72 Horizontal biases in rats' use of three-dimensional space. Behav Brain Res 2011 0.98
73 Fat fuels insulin resistance through Toll-like receptors. Nat Med 2006 0.98
74 Mammalian target of rapamycin inhibitors in renal cell carcinoma: current status and future applications. Semin Oncol 2006 0.97
75 Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis. Haematologica 2013 0.94
76 Calpain and reactive oxygen species targets Bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis. PLoS One 2013 0.94
77 The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb. Novartis Found Symp 2004 0.94
78 Cardiac resynchronization therapy in CKD: a systematic review. Clin J Am Soc Nephrol 2013 0.93
79 Isolation, characterization and expression studies of resistance gene candidates (RGCs) from Zingiber spp. Theor Appl Genet 2007 0.92
80 Scapula fractures: interobserver reliability of classification and treatment. J Orthop Trauma 2014 0.92
81 Differential effects of adenosine on pulmonary vein ectopy after pulmonary vein isolation: implications for arrhythmogenesis. Circ Arrhythm Electrophysiol 2012 0.91
82 Institutional ethics committees: critical gaps. Indian J Med Ethics 2011 0.91
83 Sequencing and analysis of a South Asian-Indian personal genome. BMC Genomics 2012 0.91
84 Phospholipase D and mTORC1: nutrients are what bring them together. Sci Signal 2012 0.91
85 Mode of cell death induced by the HSP90 inhibitor 17-AAG (tanespimycin) is dependent on the expression of pro-apoptotic BAX. Oncotarget 2013 0.90
86 Objective assessment of gait in normal-pressure hydrocephalus. Am J Phys Med Rehabil 2008 0.89
87 How 'informed' is informed consent? Findings from a study in South India. Indian J Med Ethics 2012 0.89
88 Diagnosis, treatment, and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus. Neurosurgery 2008 0.89
89 Quick guide: target of rapamycin. Curr Biol 2002 0.88
90 Drosophila ribosomal protein mutants control tissue growth non-autonomously via effects on the prothoracic gland and ecdysone. PLoS Genet 2011 0.87
91 Gassing up with hydrogen. Sci Am 2007 0.87
92 Research and innovation in the development of everolimus for oncology. Expert Opin Drug Discov 2011 0.86
93 Differential expression of S6K2 dictates tissue-specific requirement for S6K1 in mediating aberrant mTORC1 signaling and tumorigenesis. Cancer Res 2011 0.86
94 Limitations of dormant conduction as a predictor of atrial fibrillation recurrence and pulmonary vein reconnection after catheter ablation. Pacing Clin Electrophysiol 2015 0.85
95 Response to "non-Doppler two-dimensional strain imaging by echocardiography-from technical considerations to clinical applications". J Am Soc Echocardiogr 2007 0.85
96 Serum triglycerides and risk for death in Stage 3 and Stage 4 chronic kidney disease. Nephrol Dial Transplant 2012 0.85
97 Adenosine-induced pulmonary vein ectopy as a predictor of recurrent atrial fibrillation after pulmonary vein isolation. Circ Arrhythm Electrophysiol 2013 0.85
98 3-Acylamino-azetidin-2-one as a novel class of cysteine proteases inhibitors. Bioorg Med Chem Lett 2003 0.84
99 Effective public-private partnership in healthcare: Apollo as a cautionary tale. Indian J Med Ethics 2010 0.84
100 Influence of shunt surgery on healthcare expenditures of elderly fee-for-service Medicare beneficiaries with hydrocephalus. J Neurosurg 2007 0.84
101 Reappraisal of cardiac magnetic resonance imaging in idiopathic outflow tract arrhythmias. J Cardiovasc Electrophysiol 2014 0.84
102 Differentiating pacemaker-mediated tachycardia from tachycardia due to atrial tracking: utility of V-A-A-V versus V-A-V response after postventricular atrial refractory period extension. Heart Rhythm 2011 0.83
103 Prospects for discriminating Zingiberaceae species in India using DNA barcodes. J Integr Plant Biol 2014 0.83
104 Use of Rt-PCR in detecting disseminated cancer cells after incisional biopsy among oral squamous cell carcinoma patients. J Cancer Res Ther 2007 0.83
105 Metabolic control by S6 kinases depends on dietary lipids. PLoS One 2012 0.82
106 Role of the tripartite motif protein 27 in cancer development. J Natl Cancer Inst 2012 0.82
107 Cancer biology: The director's cut. Nature 2012 0.81
108 The nuclear receptor DHR3 modulates dS6 kinase-dependent growth in Drosophila. PLoS Genet 2010 0.81
109 Adenosine-induced atrial fibrillation: insights into mechanism. Circ Arrhythm Electrophysiol 2013 0.81
110 Prior CSF shunting increases the risk of endoscopic third ventriculostomy failure in the treatment of obstructive hydrocephalus in adults. Neurol Res 2007 0.81
111 S6K1 controls pancreatic β cell size independently of intrauterine growth restriction. J Clin Invest 2015 0.81
112 Extrapyramidal signs in normal pressure hydrocephalus: an objective assessment. Cerebrospinal Fluid Res 2007 0.80
113 The role of the mTOR pathway in regulating food intake. Curr Opin Drug Discov Devel 2010 0.80
114 Biopsychosocial impact of the voice in relation to the psychological features in female student teachers. J Psychosom Res 2009 0.80
115 Mechanism-specific effects of adenosine on ventricular tachycardia. J Cardiovasc Electrophysiol 2014 0.78
116 Defence transcriptome profiling of Zingiber zerumbet (L.) Smith by mRNA differential display. J Biosci 2008 0.78
117 Gifts to doctors, scientific information and the credibility gap in the Medical Council of India. Indian J Med Ethics 2010 0.78
118 Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones. Bioorg Med Chem Lett 2008 0.78
119 The background biopsychosocial status of teachers with voice problems. J Psychosom Res 2008 0.77
120 Engineering sugarcane cultivars with bovine pancreatic trypsin inhibitor (aprotinin) gene for protection against top borer (Scirpophaga excerptalis Walker). Plant Cell Rep 2008 0.77
121 A matter of energy stress: p38β meets mTORC1. Cell Res 2011 0.77
122 Kidney pathology: current classification of renal cell carcinoma. Curr Urol Rep 2002 0.77
123 Liver transplantation in India. Natl Med J India 2007 0.77
124 Apoptosis in pluripotent stem cells: RPL11 strikes again. Cell Cycle 2012 0.77
125 Different strategies of cadmium detoxification in the submerged macrophyte Ceratophyllum demersum L. Metallomics 2013 0.76
126 Daily low-dose folic acid supplementation does not prevent nitroglycerin-induced nitric oxide synthase dysfunction and tolerance: a human in vivo study. Can J Cardiol 2010 0.76
127 Phosphatase 2A puts the brakes on mTORC1 nutrient signaling. Cell Metab 2010 0.76
128 A molecular case report: functional assay of tyrosine kinase inhibitors in cells from a patient's primary renal cell carcinoma. Cancer Biol Ther 2012 0.76
129 Molecular characterization of ZzR1 resistance gene from Zingiber zerumbet with potential for imparting Pythium aphanidermatum resistance in ginger. Gene 2012 0.76
130 Skin entrance radiation dose in an interventional radiology procedure. Health Phys 2006 0.75
131 Method for differentiating left superior pulmonary vein exit conduction from pseudo-exit conduction. Pacing Clin Electrophysiol 2013 0.75
132 No dependable alternative to MCQs. Indian J Med Ethics 2012 0.75
133 Bending the path to TOR. Nat Cell Biol 2010 0.75
134 Transformation and analysis of tobacco plant var Petit havana with T-urf13 gene under anther-specific TA29 promoter. 3 Biotech 2011 0.75
135 Biocompatibility and cytotoxic evaluation of drug-loaded biodegradable guided tissue regeneration membranes. J Indian Soc Periodontol 2012 0.75
136 Shortage of doctors in rural areas. Natl Med J India 2013 0.75
137 Unusual presentation of a giant glomus tumor. Indian J Otolaryngol Head Neck Surg 2003 0.75
138 Screening for pre-clinical hypertrophic cardiomyopathy by tissue Doppler imaging. Indian Heart J 2006 0.75
139 Expanding the role of statins in postoperative atrial fibrillation. Heart Rhythm 2011 0.75
140 Tissue Doppler echocardiography: a need for review. Indian Heart J 2003 0.75
141 Effect of 4-Aminopyridine on Action Potential Parameters in Isolated Dog Purkinje Fibers. Arch Drug Inf 2010 0.75
142 Soluble CD14 and endotoxin levels in hemodialysis patients: a tale of 2 molecules. Am J Kidney Dis 2009 0.75
143 Comparative genome analysis of Solanum lycopersicum and Solanum tuberosum. Bioinformation 2013 0.75
144 Is extreme flexion of the knee after total knee replacement a prerequisite for patient satisfaction? Int Orthop 2008 0.75
145 Final report on tobacco risks from a case-control study. Indian Heart J 2002 0.75
146 Publication and citation ethics. Natl Med J India 2006 0.75
147 Characteristics, treatment, and outcomes of periprocedural cerebrovascular accidents during electrophysiologic procedures. J Interv Card Electrophysiol 2012 0.75
148 Religion and intergroup conflict: findings from the Global Group Relations Project. Psychol Sci 2013 0.75
149 Asia's organ farms. Indian J Med Ethics 2008 0.75
150 Budget 2008 and health care: less of the same? Indian J Med Ethics 2008 0.75
151 The Thorat Committee report and the good doctor. Indian J Med Ethics 2008 0.75
152 Classification and nomenclature for coronary artery disease. Int J Cardiol 2003 0.75
153 Carry on debate (doctor). Natl Med J India 2006 0.75
154 Government-funded anti-retroviral therapy for HIV/AIDS: new ethical challenges. Indian J Med Ethics 2005 0.75
155 Occurrence of trypsin-like protease in cardamom (Elettaria cardamomum Maton). Indian J Biochem Biophys 2005 0.75
156 Open letter to Ulf Wiinberg, Chief Executive of Lundbeck Pharmaceuticals. Lancet 2011 0.75
157 A novel criterion for conduction block after catheter ablation of right atrial tachycardia after mitral valve surgery. Circ Arrhythm Electrophysiol 2012 0.75
158 Conundrum of sudden cardiac death: making sense of missense. Circ Arrhythm Electrophysiol 2013 0.75
159 Classification of transmitral Doppler patterns. Indian Heart J 2005 0.75
160 Effects of Cd & Ni toxicity to Ceratophyllum demersum under environmentally relevant conditions in soft & hard water including a German lake. Aquat Toxicol 2013 0.75
161 816 A Unique Neurocognitive Profile Differentiates Idiopathic Normal-pressure Hydrocephalus from Neurodegenerative Dementia: A Novel Guide for Shunt Surgery. Neurosurgery 2005 0.75