PubRank

A Thomas Look

Author PubWeight™ 253.33‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004 18.84
2 Acute lymphoblastic leukaemia. Lancet 2008 8.54
3 Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature 2008 6.80
4 NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A 2006 6.80
5 Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002 6.64
6 Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 2007 5.65
7 A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature 2009 5.55
8 Chromosome 1p and 11q deletions and outcome in neuroblastoma. N Engl J Med 2005 4.92
9 FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 2007 4.59
10 tp53 mutant zebrafish develop malignant peripheral nerve sheath tumors. Proc Natl Acad Sci U S A 2005 4.15
11 Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 2006 3.89
12 Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005 3.73
13 BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 2005 3.68
14 The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia. Blood 2005 3.48
15 Resolution of inflammation by retrograde chemotaxis of neutrophils in transgenic zebrafish. J Leukoc Biol 2006 3.21
16 Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 2008 3.15
17 Myc-induced T cell leukemia in transgenic zebrafish. Science 2003 3.15
18 The use of zebrafish to understand immunity. Immunity 2004 3.09
19 Activating Notch1 mutations in mouse models of T-ALL. Blood 2005 3.08
20 High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood 2009 3.02
21 Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish. Dev Cell 2005 2.89
22 Molecular genetics of acute lymphoblastic leukemia. J Clin Oncol 2005 2.74
23 Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. Blood 2004 2.60
24 Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res 2007 2.56
25 The requirement for cyclin D function in tumor maintenance. Cancer Cell 2012 2.49
26 Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2002 2.48
27 Effects of lethal irradiation in zebrafish and rescue by hematopoietic cell transplantation. Blood 2004 2.46
28 Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood 2003 2.35
29 Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo. J Exp Med 2009 2.26
30 Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med 2006 2.23
31 Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A 2005 2.07
32 Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol 2007 2.02
33 The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev 2008 1.93
34 T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell 2010 1.85
35 In vivo tracking of T cell development, ablation, and engraftment in transgenic zebrafish. Proc Natl Acad Sci U S A 2004 1.85
36 TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia. Cancer Discov 2013 1.81
37 Prognostic importance of TLX1 (HOX11) oncogene expression in adults with T-cell acute lymphoblastic leukaemia. Lancet 2004 1.79
38 Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. Dev Biol 2006 1.75
39 Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study. J Clin Oncol 2005 1.74
40 Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther 2009 1.73
41 Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays. PLoS One 2007 1.72
42 PIDD death-domain phosphorylation by ATM controls prodeath versus prosurvival PIDDosome signaling. Mol Cell 2012 1.71
43 Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nat Med 2012 1.69
44 Activated ALK collaborates with MYCN in neuroblastoma pathogenesis. Cancer Cell 2012 1.66
45 L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood 2012 1.61
46 Live imaging of chronic inflammation caused by mutation of zebrafish Hai1. J Cell Sci 2007 1.59
47 Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development 2011 1.54
48 Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res 2009 1.54
49 Gene expression profiling in T-cell acute lymphoblastic leukemia. Semin Hematol 2003 1.54
50 The pu.1 promoter drives myeloid gene expression in zebrafish. Blood 2004 1.49
51 Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation. Blood 2007 1.48
52 Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. Br J Haematol 2007 1.47
53 Outcome after reduced chemotherapy for intermediate-risk neuroblastoma. N Engl J Med 2010 1.47
54 The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med 2005 1.46
55 The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood 2011 1.45
56 Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia. Cancer Cell 2012 1.43
57 CHK1 inhibition as a strategy for targeting Fanconi Anemia (FA) DNA repair pathway deficient tumors. Mol Cancer 2009 1.42
58 Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood 2010 1.40
59 Biallelic transcriptional activation of oncogenic transcription factors in T-cell acute lymphoblastic leukemia. Blood 2003 1.38
60 Knockdown of zebrafish Fancd2 causes developmental abnormalities via p53-dependent apoptosis. Dev Cell 2003 1.38
61 Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med 2007 1.37
62 ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. J Exp Med 2010 1.36
63 Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem 2012 1.33
64 Notch signaling: switching an oncogene to a tumor suppressor. Blood 2014 1.32
65 Hematopoietic gene expression profile in zebrafish kidney marrow. Proc Natl Acad Sci U S A 2004 1.31
66 Inactivation of ribosomal protein L22 promotes transformation by induction of the stemness factor, Lin28B. Blood 2012 1.29
67 Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. J Exp Med 2011 1.27
68 Suppression of apoptosis by bcl-2 overexpression in lymphoid cells of transgenic zebrafish. Blood 2004 1.26
69 NOTCH and PI3K-AKT pathways intertwined. Cancer Cell 2007 1.26
70 SNP array analysis in hematologic malignancies: avoiding false discoveries. Blood 2010 1.26
71 Deletion of proapoptotic Puma selectively protects hematopoietic stem and progenitor cells against high-dose radiation. Blood 2010 1.24
72 c-Myc inhibition prevents leukemia initiation in mice and impairs the growth of relapsed and induction failure pediatric T-ALL cells. Blood 2014 1.23
73 Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell 2010 1.22
74 Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL. J Exp Med 2011 1.21
75 Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish. Blood 2010 1.20
76 Targeted expression of human MYCN selectively causes pancreatic neuroendocrine tumors in transgenic zebrafish. Cancer Res 2004 1.19
77 In vivo interstitial migration of primitive macrophages mediated by JNK-matrix metalloproteinase 13 signaling in response to acute injury. J Immunol 2008 1.19
78 Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. J Clin Invest 2014 1.17
79 Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia. Blood 2006 1.17
80 Absence of biallelic TCRgamma deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia. J Clin Oncol 2010 1.14
81 The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia. J Exp Med 2013 1.14
82 Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia. Blood 2009 1.11
83 IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL. Blood 2003 1.10
84 Outcomes of children with intermediate-risk neuroblastoma after treatment stratified by MYCN status and tumor cell ploidy. J Clin Oncol 2005 1.08
85 Zebrafish as a powerful vertebrate model system for in vivo studies of cell death. Semin Cancer Biol 2006 1.08
86 Evolutionary conservation of zebrafish linkage group 14 with frequently deleted regions of human chromosome 5 in myeloid malignancies. Proc Natl Acad Sci U S A 2002 1.08
87 Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. Blood 2008 1.07
88 Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Hum Mol Genet 2010 1.04
89 Zebrafish sperm cryopreservation with N,N-dimethylacetamide. Biotechniques 2003 1.04
90 Aberrant AKT activation drives well-differentiated liposarcoma. Proc Natl Acad Sci U S A 2011 1.00
91 Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer 2009 1.00
92 The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development 2009 1.00
93 Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors. Haematologica 2013 0.99
94 Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis. Cancer Res 2009 0.99
95 A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes Dev 2007 0.98
96 Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol 2009 0.97
97 Zebrafish as a model for myelopoiesis during embryogenesis. Exp Hematol 2005 0.97
98 Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: a report from the Children's Oncology Group. J Clin Oncol 2008 0.97
99 Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group. Cancer 2013 0.96
100 Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Dev Dyn 2009 0.96
101 Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML. Blood 2011 0.95
102 NUP98-HOXA9-transgenic zebrafish develop a myeloproliferative neoplasm and provide new insight into mechanisms of myeloid leukaemogenesis. Br J Haematol 2011 0.95
103 Identification of structural aberrations in cancer by SNP array analysis. Genome Biol 2007 0.94
104 Zebrafish as a model for the study of human cancer. Methods Cell Biol 2011 0.93
105 Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee. Pediatr Blood Cancer 2012 0.91
106 Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19). Blood 2010 0.91
107 Dominant-interfering C/EBPalpha stimulates primitive erythropoiesis in zebrafish. Exp Hematol 2007 0.90
108 Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53. PLoS Genet 2012 0.90
109 Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem Biol 2013 0.89
110 p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis. Dev Cell 2011 0.89
111 cpsf1 is required for definitive HSC survival in zebrafish. Blood 2011 0.89
112 Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein. Blood 2003 0.89
113 TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors. Blood 2005 0.88
114 Zebrafish as a model organism for blood diseases. Br J Haematol 2003 0.88
115 Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Dis Model Mech 2012 0.88
116 NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches. PLoS One 2012 0.87
117 SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. Genes Chromosomes Cancer 2008 0.87
118 The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell 2016 0.87
119 Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer 2009 0.87
120 State of the Art and Future Needs in Cytogenetic/Molecular Genetics/Arrays in childhood lymphoma: summary report of workshop at the First International Symposium on childhood and adolescent non-Hodgkin lymphoma, April 9, 2003, New York City, NY. Pediatr Blood Cancer 2005 0.86
121 Cardiac and vascular functions of the zebrafish orthologues of the type I neurofibromatosis gene NFI. Proc Natl Acad Sci U S A 2009 0.86
122 Targeting transcription factors in acute leukemia in children. Curr Drug Targets 2007 0.86
123 Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group. Pediatr Dev Pathol 2014 0.86
124 Turning on a dimer: new insights into MLL chimeras. Cancer Cell 2003 0.85
125 MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy. Elife 2013 0.85
126 Up-regulation of survivin by the E2A-HLF chimera is indispensable for the survival of t(17;19)-positive leukemia cells. J Biol Chem 2009 0.85
127 Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study. Clin Cancer Res 2006 0.84
128 Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis. Cell Stem Cell 2012 0.83
129 A leukemogenic twist for GATA1. Nat Genet 2002 0.83
130 Development of the peripheral sympathetic nervous system in zebrafish. Methods Cell Biol 2004 0.83
131 CD34+ cell selection is required to assess HOXA9 expression levels in patients with myelodysplastic syndrome. Br J Haematol 2005 0.82
132 Studying peripheral sympathetic nervous system development and neuroblastoma in zebrafish. Methods Cell Biol 2010 0.79
133 Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. Br J Haematol 2014 0.78
134 Fishing for cancer models. Nat Biotechnol 2006 0.77
135 Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. Br J Haematol 2014 0.77
136 Zebrafish sperm cryopreservation. Methods Cell Biol 2004 0.77
137 DNA microarrays in the diagnosis and management of acute lymphoblastic leukemia. Int J Hematol 2004 0.76
138 mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues. Br J Haematol 2010 0.76
139 Discovery of a secreted tumor suppressor provides a promising therapeutic strategy for follicular lymphoma. Cancer Cell 2011 0.75
140 Investigator profile. An interview with A. Thomas Look, M.D. Interview by Vicki Glaser. Zebrafish 2005 0.75
141 Lessons from transgenic zebrafish expressing the green fluorescent protein (GFP) in the myeloid lineage. Methods Cell Biol 2004 0.75
142 Small molecules thwart crash and burn. Nat Chem Biol 2005 0.75
143 Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun 2017 0.75
144 No evidence for the presence of an imprinted neuroblastoma suppressor gene within chromosome sub-band 1p36.3. Cancer Res 2002 0.75