|
1
|
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
|
Eur Cytokine Netw
|
2006
|
7.19
|
|
2
|
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice.
|
J Clin Invest
|
2008
|
4.22
|
|
3
|
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.
|
J Biol Chem
|
2003
|
3.45
|
|
4
|
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.
|
FASEB J
|
2004
|
2.82
|
|
5
|
Persistent organic pollutant exposure leads to insulin resistance syndrome.
|
Environ Health Perspect
|
2009
|
2.57
|
|
6
|
Overexpression of leptin mRNA in mesenteric adipose tissue in inflammatory bowel diseases.
|
Gastroenterol Clin Biol
|
2003
|
2.26
|
|
7
|
Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes.
|
Diabetes
|
2003
|
2.19
|
|
8
|
Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism.
|
Am J Clin Nutr
|
2005
|
2.11
|
|
9
|
Expression of Mfn2, the Charcot-Marie-Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor alpha and interleukin-6.
|
Diabetes
|
2005
|
1.77
|
|
10
|
Increased hepatic lipogenesis but decreased expression of lipogenic gene in adipose tissue in human obesity.
|
Am J Physiol Endocrinol Metab
|
2002
|
1.77
|
|
11
|
Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study.
|
Am J Clin Nutr
|
2007
|
1.71
|
|
12
|
Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance.
|
Lancet
|
2002
|
1.59
|
|
13
|
Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolism.
|
Am J Clin Nutr
|
2008
|
1.52
|
|
14
|
Clustering biological annotations and gene expression data to identify putatively co-regulated biological processes.
|
J Bioinform Comput Biol
|
2006
|
1.50
|
|
15
|
Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs.
|
Biochem J
|
2006
|
1.44
|
|
16
|
Microarray profiling of human skeletal muscle reveals that insulin regulates approximately 800 genes during a hyperinsulinemic clamp.
|
J Biol Chem
|
2003
|
1.43
|
|
17
|
Suppressor of cytokine signaling 3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients.
|
Diabetes
|
2004
|
1.43
|
|
18
|
Five-week, low-glycemic index diet decreases total fat mass and improves plasma lipid profile in moderately overweight nondiabetic men.
|
Diabetes Care
|
2002
|
1.36
|
|
19
|
Adiponutrin gene is regulated by insulin and glucose in human adipose tissue.
|
Eur J Endocrinol
|
2006
|
1.28
|
|
20
|
Increased adipose tissue expression of Grb14 in several models of insulin resistance.
|
FASEB J
|
2004
|
1.26
|
|
21
|
Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation.
|
J Nutr Biochem
|
2010
|
1.26
|
|
22
|
The microRNA signature in response to insulin reveals its implication in the transcriptional action of insulin in human skeletal muscle and the role of a sterol regulatory element-binding protein-1c/myocyte enhancer factor 2C pathway.
|
Diabetes
|
2009
|
1.25
|
|
23
|
Resveratrol is a class IA phosphoinositide 3-kinase inhibitor.
|
Biochem J
|
2007
|
1.23
|
|
24
|
Alterations of insulin signaling in type 2 diabetes: a review of the current evidence from humans.
|
Biochim Biophys Acta
|
2008
|
1.22
|
|
25
|
Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.
|
Physiol Genomics
|
2008
|
1.21
|
|
26
|
Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic patients.
|
Antivir Ther
|
2004
|
1.14
|
|
27
|
FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction.
|
Diabetes
|
2010
|
1.13
|
|
28
|
A new role for sterol regulatory element binding protein 1 transcription factors in the regulation of muscle mass and muscle cell differentiation.
|
Mol Cell Biol
|
2009
|
1.13
|
|
29
|
Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues.
|
J Lipid Res
|
2005
|
1.12
|
|
30
|
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
|
Diabetes
|
2009
|
1.12
|
|
31
|
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1.
|
Mol Cell Endocrinol
|
2011
|
1.11
|
|
32
|
Regulation of human adipocyte gene expression by thyroid hormone.
|
J Clin Endocrinol Metab
|
2002
|
1.10
|
|
33
|
Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans.
|
Obes Res
|
2004
|
1.07
|
|
34
|
Chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice.
|
PLoS One
|
2011
|
1.07
|
|
35
|
Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines.
|
J Biol Chem
|
2004
|
1.07
|
|
36
|
Modified quantitative insulin sensitivity check index is better correlated to hyperinsulinemic glucose clamp than other fasting-based index of insulin sensitivity in different insulin-resistant states.
|
J Clin Endocrinol Metab
|
2003
|
1.03
|
|
37
|
High protein intake reduces intrahepatocellular lipid deposition in humans.
|
Am J Clin Nutr
|
2009
|
1.01
|
|
38
|
Insulin-sensitizing effects on muscle and adipose tissue after dietary fiber intake in men and women with metabolic syndrome.
|
J Clin Endocrinol Metab
|
2012
|
1.01
|
|
39
|
Calcium-sensing receptor autoantibodies are relevant markers of acquired hypoparathyroidism.
|
J Clin Endocrinol Metab
|
2004
|
1.01
|
|
40
|
Eicosapentaenoic acid induces mRNA expression of peroxisome proliferator-activated receptor gamma.
|
Obes Res
|
2002
|
1.01
|
|
41
|
A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction.
|
Diabetologia
|
2013
|
1.00
|
|
42
|
Visceral fat accumulation during lipid overfeeding is related to subcutaneous adipose tissue characteristics in healthy men.
|
J Clin Endocrinol Metab
|
2013
|
0.99
|
|
43
|
Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects.
|
Diabetes Care
|
2013
|
0.99
|
|
44
|
Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans.
|
Am J Physiol Endocrinol Metab
|
2010
|
0.98
|
|
45
|
Oil composition of high-fat diet affects metabolic inflammation differently in connection with endotoxin receptors in mice.
|
Am J Physiol Endocrinol Metab
|
2011
|
0.97
|
|
46
|
Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake.
|
Am J Clin Nutr
|
2010
|
0.97
|
|
47
|
Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women.
|
J Clin Endocrinol Metab
|
2008
|
0.96
|
|
48
|
Glucose-to-insulin ratio rather than sex hormone-binding globulin and adiponectin levels is the best predictor of insulin resistance in nonobese women with polycystic ovary syndrome.
|
J Clin Endocrinol Metab
|
2003
|
0.95
|
|
49
|
Insulin regulation of gene expression and concentrations of white adipose tissue-derived proteins in vivo in healthy men: relation to adiponutrin.
|
J Endocrinol
|
2006
|
0.93
|
|
50
|
Acute hyperglycemia induces a global downregulation of gene expression in adipose tissue and skeletal muscle of healthy subjects.
|
Diabetes
|
2007
|
0.93
|
|
51
|
Phospholipase D regulates myogenic differentiation through the activation of both mTORC1 and mTORC2 complexes.
|
J Biol Chem
|
2011
|
0.93
|
|
52
|
Four-week low-glycemic index breakfast with a modest amount of soluble fibers in type 2 diabetic men.
|
Metabolism
|
2002
|
0.93
|
|
53
|
Effect of beta1- and beta2-adrenergic stimulation on energy expenditure, substrate oxidation, and UCP3 expression in humans.
|
Am J Physiol Endocrinol Metab
|
2003
|
0.93
|
|
54
|
Inhibition of xanthine oxidase reduces hyperglycemia-induced oxidative stress and improves mitochondrial alterations in skeletal muscle of diabetic mice.
|
Am J Physiol Endocrinol Metab
|
2011
|
0.93
|
|
55
|
Grape polyphenols prevent fructose-induced oxidative stress and insulin resistance in first-degree relatives of type 2 diabetic patients.
|
Diabetes Care
|
2012
|
0.92
|
|
56
|
The eicosapentaenoic acid metabolite 15-deoxy-δ(12,14)-prostaglandin J3 increases adiponectin secretion by adipocytes partly via a PPARγ-dependent mechanism.
|
PLoS One
|
2013
|
0.92
|
|
57
|
Genetic association and gene expression analysis identify FGFR1 as a new susceptibility gene for human obesity.
|
J Clin Endocrinol Metab
|
2011
|
0.91
|
|
58
|
Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in the meal: a randomized crossover clinical trial.
|
Am J Clin Nutr
|
2012
|
0.91
|
|
59
|
Determinants of human adipose tissue gene expression: impact of diet, sex, metabolic status, and cis genetic regulation.
|
PLoS Genet
|
2012
|
0.91
|
|
60
|
Reduced PDK4 expression associates with increased insulin sensitivity in postobese patients.
|
Obes Res
|
2003
|
0.91
|
|
61
|
Effect of carbohydrate overfeeding on whole body and adipose tissue metabolism in humans.
|
Obes Res
|
2003
|
0.90
|
|
62
|
Increased lipid peroxidation in LDL from type-2 diabetic patients.
|
Lipids
|
2010
|
0.89
|
|
63
|
Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.
|
Diabetes
|
2013
|
0.89
|
|
64
|
Sterol regulatory element-binding protein-1 mediates the effect of insulin on hexokinase II gene expression in human muscle cells.
|
Diabetes
|
2004
|
0.89
|
|
65
|
Expression of adipogenic transcription factors, peroxisome proliferator-activated receptor gamma co-activator 1, IL-6 and CD45 in subcutaneous adipose tissue in lipodystrophy associated with highly active antiretroviral therapy.
|
AIDS
|
2003
|
0.89
|
|
66
|
Jejunal proteins secreted by db/db mice or insulin-resistant humans impair the insulin signaling and determine insulin resistance.
|
PLoS One
|
2013
|
0.88
|
|
67
|
Overfeeding increases postprandial endotoxemia in men: Inflammatory outcome may depend on LPS transporters LBP and sCD14.
|
Mol Nutr Food Res
|
2014
|
0.88
|
|
68
|
Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy.
|
Am J Physiol Endocrinol Metab
|
2004
|
0.87
|
|
69
|
The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-CoA carboxylase-2 expression.
|
Diabetes
|
2002
|
0.87
|
|
70
|
The ubiquitin-proteasome pathway is a new partner for the control of insulin signaling.
|
Curr Opin Clin Nutr Metab Care
|
2004
|
0.87
|
|
71
|
Exosomes participate in the alteration of muscle homeostasis during lipid-induced insulin resistance in mice.
|
Diabetologia
|
2014
|
0.87
|
|
72
|
Regulation of gene expression by glucose.
|
Curr Opin Clin Nutr Metab Care
|
2007
|
0.86
|
|
73
|
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes.
|
J Clin Invest
|
2014
|
0.86
|
|
74
|
The expression of FTO in human adipose tissue is influenced by fat depot, adiposity, and insulin sensitivity.
|
Obesity (Silver Spring)
|
2013
|
0.85
|
|
75
|
Reduction of endoplasmic reticulum stress using chemical chaperones or Grp78 overexpression does not protect muscle cells from palmitate-induced insulin resistance.
|
Biochem Biophys Res Commun
|
2011
|
0.85
|
|
76
|
Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.
|
Cell Commun Signal
|
2013
|
0.85
|
|
77
|
Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations.
|
Am J Clin Nutr
|
2013
|
0.85
|
|
78
|
Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects.
|
Br J Nutr
|
2007
|
0.84
|
|
79
|
Protein acetylation mechanisms in the regulation of insulin and insulin-like growth factor 1 signalling.
|
Mol Cell Endocrinol
|
2012
|
0.84
|
|
80
|
SREBP-1 transcription factors regulate skeletal muscle cell size by controlling protein synthesis through myogenic regulatory factors.
|
PLoS One
|
2012
|
0.84
|
|
81
|
A "futile cycle" induced by thiazolidinediones in human adipose tissue?
|
Nat Med
|
2003
|
0.83
|
|
82
|
Involvement of the peripheral benzodiazepine receptor in the development of rheumatoid arthritis in Mrl/lpr mice.
|
Eur J Pharmacol
|
2002
|
0.83
|
|
83
|
Sigma receptor ligands: applications in inflammation and oncology.
|
Curr Opin Investig Drugs
|
2004
|
0.82
|
|
84
|
Changes in gene expression in skeletal muscle in response to fat overfeeding in lean men.
|
Obesity (Silver Spring)
|
2007
|
0.82
|
|
85
|
High-fat diet action on adiposity, inflammation, and insulin sensitivity depends on the control low-fat diet.
|
Nutr Res
|
2013
|
0.82
|
|
86
|
FTO contributes to hepatic metabolism regulation through regulation of leptin action and STAT3 signalling in liver.
|
Cell Commun Signal
|
2014
|
0.82
|
|
87
|
Differential dose effect of fish oil on inflammation and adipose tissue gene expression in chronic kidney disease patients.
|
Nutrition
|
2013
|
0.82
|
|
88
|
SR31747A: a peripheral sigma ligand with potent antitumor activities.
|
Anticancer Drugs
|
2004
|
0.82
|
|
89
|
Decreased uncoupling protein expression and intramyocytic triglyceride depletion in formerly obese subjects.
|
Obes Res
|
2003
|
0.81
|
|
90
|
Regulation of hepatic mitochondrial metabolism in response to a high fat diet: a longitudinal study in rats.
|
J Physiol Biochem
|
2012
|
0.81
|
|
91
|
Metallothionein 2a gene expression is increased in subcutaneous adipose tissue of type 2 diabetic patients.
|
Mol Genet Metab
|
2012
|
0.81
|
|
92
|
Dietary DHA: time course of tissue uptake and effects on cytokine secretion in mice.
|
Br J Nutr
|
2010
|
0.80
|
|
93
|
Low-dose food contaminants trigger sex-specific, hepatic metabolic changes in the progeny of obese mice.
|
FASEB J
|
2013
|
0.80
|
|
94
|
Short-term activation of peroxysome proliferator-activated receptor beta/delta increases fatty acid oxidation but does not restore insulin action in muscle cells from type 2 diabetic patients.
|
J Mol Med (Berl)
|
2006
|
0.80
|
|
95
|
[Relationship between obesity, inflammation and insulin resistance: new concepts].
|
C R Biol
|
2006
|
0.79
|
|
96
|
Leptin pulsatility in formerly obese women.
|
FASEB J
|
2005
|
0.79
|
|
97
|
C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients.
|
Metabolism
|
2002
|
0.79
|
|
98
|
Rapid down-regulation of mitochondrial fat metabolism in human muscle after training cessation is dissociated from changes in insulin sensitivity.
|
FEBS Lett
|
2009
|
0.79
|
|
99
|
Decreased muscle acetyl-coenzyme A carboxylase 2 mRNA and insulin resistance in formerly obese subjects.
|
Obes Res
|
2003
|
0.78
|
|
100
|
Metabolic impacts of high dietary exposure to persistent organic pollutants in mice.
|
Toxicol Lett
|
2012
|
0.78
|
|
101
|
Gene network analysis leads to functional validation of pathways linked to cancer cell growth and survival.
|
Biotechnol J
|
2012
|
0.77
|
|
102
|
Gender differences in transcriptional signature of developing rat testes and ovaries following embryonic exposure to 2,3,7,8-TCDD.
|
PLoS One
|
2012
|
0.77
|
|
103
|
Transcriptome profiling in response to adiponectin in human cancer-derived cells.
|
Physiol Genomics
|
2010
|
0.77
|
|
104
|
Effects of docosahexaenoic acid on some megakaryocytic cell gene expression of some enzymes controlling prostanoid synthesis.
|
Biochem Biophys Res Commun
|
2008
|
0.77
|
|
105
|
Peripheral benzodiazepine receptor mapping in rat kidney. Effects of angiotensin II-induced hypertension.
|
J Am Soc Nephrol
|
2002
|
0.77
|
|
106
|
Triglyceridemia and peroxisome proliferator-activated receptor-alpha expression are not connected in fenofibrate-treated pregnant rats.
|
Mol Cell Biochem
|
2005
|
0.76
|
|
107
|
Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.
|
J Biol Chem
|
2012
|
0.76
|
|
108
|
Fenofibrate reduces adiposity in pregnant and virgin rats but through different mechanisms.
|
BMB Rep
|
2009
|
0.75
|
|
109
|
Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site.
|
Biochem Cell Biol
|
2013
|
0.75
|
|
110
|
From French to Mediterranean diet: importance of the omega-6/omega-3 fatty acids ratio.
|
World Rev Nutr Diet
|
2011
|
0.75
|
|
111
|
Expression and regulation by insulin of low-density lipoprotein receptor-related protein mRNA in human skeletal muscle.
|
Biochim Biophys Acta
|
2002
|
0.75
|
|
112
|
Transcriptomic classification of antitumor agents: application to the analysis of the antitumoral effect of SR31747A.
|
Gene Expr
|
2003
|
0.75
|
|
113
|
Changes in fat mass influence SREBP-1c and UCP-2 gene expression in formerly obese subjects.
|
Obes Res
|
2005
|
0.75
|