Published in Gastroenterology on January 24, 2012
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology (2011) 2.67
Rapid decline of viral RNA in hepatitis C patients treated with VX-950: a phase Ib, placebo-controlled, randomized study. Gastroenterology (2006) 2.78
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology (2012) 2.39
Antiviral activity of telaprevir (VX-950) and peginterferon alfa-2a in patients with hepatitis C. Hepatology (2007) 2.37
Liver adenomatosis: re-evaluation of aetiology and management. Liver Int (2008) 2.30
Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation. J Hepatol (2003) 2.24
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology (2014) 2.19
Cytokine regulation of pro- and anti-apoptotic genes in rat hepatocytes: NF-kappaB-regulated inhibitor of apoptosis protein 2 (cIAP2) prevents apoptosis. J Hepatol (2002) 1.99
The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract. Hepatology (2011) 1.94
High expression of MDR1, MRP1, and MRP3 in the hepatic progenitor cell compartment and hepatocytes in severe human liver disease. J Pathol (2003) 1.80
Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial. Eur Heart J (2012) 1.79
Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases. J Hepatol (2005) 1.72
Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. Gastroenterology (2003) 1.64
Diagnostic and therapeutic potential of miRNA signatures in patients with hepatocellular carcinoma. J Hepatol (2012) 1.63
High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis. Hepatology (2009) 1.62
Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol (2003) 1.61
Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology (2004) 1.60
Antiviral effect of peginterferon alfa-2b and alfa-2a compared. J Hepatol (2006) 1.42
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology (2004) 1.37
Immunoglobulin coating of faecal bacteria in inflammatory bowel disease. Eur J Gastroenterol Hepatol (2004) 1.32
Adenoviral overexpression of apolipoprotein A-V reduces serum levels of triglycerides and cholesterol in mice. Biochem Biophys Res Commun (2002) 1.32
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology (2002) 1.31
Adenosine triphosphate-binding cassette transporter genes up-regulation in untreated hepatocellular carcinoma is mediated by cellular microRNAs. Hepatology (2012) 1.31
Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study. J Lipid Res (2006) 1.28
Management of giant liver hemangiomas: an update. Expert Rev Gastroenterol Hepatol (2013) 1.25
Alterations of hormonally active fibroblast growth factors after Roux-en-Y gastric bypass surgery. Dig Dis (2011) 1.25
Association between Toll-like receptor 4 and inflammatory bowel disease. Inflamm Bowel Dis (2005) 1.24
Insulin-like growth factor I (IGF-I) replacement therapy increases albumin concentration in liver cirrhosis: results of a pilot randomized controlled clinical trial. J Hepatol (2005) 1.23
Lifestyle intervention for non-alcoholic fatty liver disease: prospective cohort study of its efficacy and factors related to improvement. Arch Dis Child (2011) 1.20
The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance. Am J Physiol Gastrointest Liver Physiol (2010) 1.16
The biliary HCO(3)(-) umbrella: a unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies. Hepatology (2010) 1.16
Drug transport proteins in the liver. Adv Drug Deliv Rev (2003) 1.14
Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor. Gastroenterology (2005) 1.12
Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism. Atherosclerosis (2006) 1.11
Fibroblast growth factor 21 is induced by endoplasmic reticulum stress. Biochimie (2012) 1.10
Hepatitis C testing and treatment among active drug users in Amsterdam: results from the DUTCH-C project. Eur J Gastroenterol Hepatol (2011) 1.00
Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health. J Hepatol (2012) 1.00
Decreased P-glycoprotein (P-gp/MDR1) expression in inflamed human intestinal epithelium is independent of PXR protein levels. Inflamm Bowel Dis (2007) 0.99
Peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated regulation of multidrug resistance 2 (Mdr2) expression and function in mice. Biochem J (2003) 0.99
Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol (2004) 0.96
A progressive familial intrahepatic cholestasis type 2 mutation causes an unstable, temperature-sensitive bile salt export pump. J Hepatol (2004) 0.96
Thyroid hormone regulates the hypotriglyceridemic gene APOA5. J Biol Chem (2005) 0.96
High incidence of type 1 diabetes mellitus during or shortly after treatment with pegylated interferon alpha for chronic hepatitis C virus infection. Liver Int (2007) 0.95
Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C. Eur Radiol (2013) 0.94
Targeting nitric oxide in the gastrointestinal tract. Curr Opin Investig Drugs (2004) 0.92
Baseline hepatitis B surface antigen (HBsAg) as predictor of sustained HBsAg loss in chronic hepatitis B patients treated with pegylated interferon-α2a and adefovir. Antivir Ther (2013) 0.92
Budesonide in previously untreated autoimmune hepatitis. Liver Int (2005) 0.91
Clinical outcome of Crohn's disease according to the Vienna classification: disease location is a useful predictor of disease course. Eur J Gastroenterol Hepatol (2006) 0.91
Opposite effect of oxidative stress on inducible nitric oxide synthase and haem oxygenase-1 expression in intestinal inflammation: anti-inflammatory effect of carbon monoxide. J Pathol (2004) 0.91
Carbon monoxide blocks oxidative stress-induced hepatocyte apoptosis via inhibition of the p54 JNK isoform. Free Radic Biol Med (2007) 0.90
Rapid increase of bile salt secretion is associated with bile duct injury after human liver transplantation. J Hepatol (2004) 0.90
Comparison of interobserver agreement of magnetic resonance elastography with histopathological staging of liver fibrosis. Abdom Imaging (2014) 0.89
Epidemiology and clinical characteristics of autoimmune hepatitis in the Netherlands. Scand J Gastroenterol (2014) 0.88
Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8. Hepatology (2005) 0.88
Accuracy of prediction scores and novel biomarkers for predicting nonalcoholic fatty liver disease in obese children. Obesity (Silver Spring) (2013) 0.88
Liver fibrosis in type I Gaucher disease: magnetic resonance imaging, transient elastography and parameters of iron storage. PLoS One (2013) 0.88
Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport. Hepatology (2007) 0.87
Inflammatory markers neopterin and alanine aminotransferase in HCV patients treated with HCV NS3.4A protease inhibitor telaprevir (VX-950) and/or peginterferon alfa-2a. Scand J Gastroenterol (2008) 0.87
Monocyte-derived dendritic cells from chronic HCV patients are not infected but show an immature phenotype and aberrant cytokine profile. Liver Int (2007) 0.87
Progressive familial intrahepatic cholestasis type 1. Semin Liver Dis (2010) 0.87
A novel sequence variant in APOA5 gene found in patients with severe hypertriglyceridemia. Atherosclerosis (2006) 0.87
Using mass media and the Internet as tools to diagnose hepatitis C infections in the general population. Am J Prev Med (2011) 0.86
Low retinol levels differentially modulate bile salt-induced expression of human and mouse hepatic bile salt transporters. Hepatology (2009) 0.86
US cannot be used to predict the presence or severity of hepatic steatosis in severely obese adolescents. Radiology (2011) 0.86
PDGF-receptor beta-targeted adenovirus redirects gene transfer from hepatocytes to activated stellate cells. Mol Pharm (2008) 0.85
Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1. Hepatology (2010) 0.85
Stereoselective transport of hydrophilic quaternary drugs by human MDR1 and rat Mdr1b P-glycoproteins. Br J Pharmacol (2002) 0.84
Absence of association between the multidrug resistance (MDR1) gene and inflammatory bowel disease. Scand J Gastroenterol (2006) 0.83
Calorie restriction and Roux-en-Y gastric bypass have opposing effects on circulating FGF21 in morbidly obese subjects. Clin Endocrinol (Oxf) (2014) 0.83
The Long-Term Impact of Autoimmune Pancreatitis on Pancreatic Function, Quality of Life, and Life Expectancy. Pancreas (2015) 0.83
Hepatocellular carcinoma in cirrhotic versus noncirrhotic livers: results from a large cohort in the Netherlands. Eur J Gastroenterol Hepatol (2016) 0.82
Mdr P-glycoproteins are not essential for biliary excretion of the hydrophobic heme precursor protoporphyrin in a griseofulvin-induced mouse model of erythropoietic protoporphyria. Hepatology (2002) 0.81
The gut-liver axis. Curr Opin Clin Nutr Metab Care (2013) 0.81
Efficient lowering of triglyceride levels in mice by human apoAV protein variants associated with hypertriglyceridemia. Biochem Biophys Res Commun (2008) 0.81
Comparable efficacy of low- versus high-dose induction corticosteroid treatment in autoimmune pancreatitis. Pancreas (2014) 0.80
Prometheus' little helper, a novel role for fibroblast growth factor 15 in compensatory liver growth. J Hepatol (2013) 0.80
Up-regulation and cytoprotective role of epithelial multidrug resistance-associated protein 1 in inflammatory bowel disease. J Biol Chem (2008) 0.80
Prevention and reversal of hepatic steatosis with a high-protein diet in mice. Biochim Biophys Acta (2013) 0.80
Apolipoprotein A5 deficiency aggravates high-fat diet-induced obesity due to impaired central regulation of food intake. FASEB J (2013) 0.80
Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders. J Pediatr Gastroenterol Nutr (2016) 0.79
Detection of hepatitis B virus covalently closed circular DNA in paraffin-embedded and cryo-preserved liver biopsies of chronic hepatitis B patients. Eur J Gastroenterol Hepatol (2010) 0.79
Pharmacological activation of the bile acid nuclear farnesoid X receptor is feasible in patients with quiescent Crohn's colitis. PLoS One (2012) 0.79
Hepatocellular carcinoma in noncirrhotic livers is associated with steatosis rather than steatohepatitis: potential implications for pathogenesis. Eur J Gastroenterol Hepatol (2016) 0.78
Hepatic steatosis in morbidly obese patients undergoing gastric bypass surgery: assessment with open-system 1H-MR spectroscopy. AJR Am J Roentgenol (2011) 0.78
Synthesis and evaluation of a fluorine-18 labeled antisense oligonucleotide as a potential PET tracer for iNOS mRNA expression. Nucl Med Biol (2004) 0.78
Transient elevation of serum bile salts after partial hepatectomy is due to metabolic overload and not to cholestasis. J Hepatol (2011) 0.78
Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions. Mol Pharmacol (2003) 0.78
Safety and antiviral activity of JTK-652: a novel HCV infection inhibitor. Antivir Ther (2010) 0.77
Bile salts predict liver regeneration in rabbit model of portal vein embolization. J Surg Res (2012) 0.77
Can plasma bile salt, triglycerides, and apoA-V levels predict liver regeneration? World J Surg (2012) 0.76
Characterization and treatment of persistent hepatocellular secretory failure. Liver Int (2014) 0.76
FXR, intestinal FiXeR of hepatocellular carcinoma? Hepatology (2014) 0.76
ApoE2-associated hypertriglyceridemia is ameliorated by increased levels of apoA-V but unaffected by apoC-III deficiency. J Lipid Res (2008) 0.76
How sweet it is to activate FXR. Hepatology (2014) 0.75
Yin Yang 1 and farnesoid X receptor: a balancing act in non-alcoholic fatty liver disease? Gut (2013) 0.75
A comparative study of diagnostic scoring systems for autoimmune pancreatitis. Pancreas (2014) 0.75