Published in Am J Physiol Lung Cell Mol Physiol on January 27, 2012
Acidosis prevents and alkalosis augments endothelium-dependent contractions in mouse arteries. Pflugers Arch (2013) 0.88
Proteasome inhibitor PS-341 attenuates flow-induced pulmonary arterial hypertension. Clin Exp Med (2013) 0.77
Pulmonary arterial hypertension. N Engl J Med (2004) 6.69
The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension. N Engl J Med (1992) 6.40
Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest (2005) 4.74
Pulmonary arterial hypertension: baseline characteristics from the REVEAL Registry. Chest (2009) 4.08
Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol (2009) 3.64
Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J (2001) 3.20
Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation (2005) 2.98
Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am J Respir Crit Care Med (2003) 2.90
A novel murine model of severe pulmonary arterial hypertension. Am J Respir Crit Care Med (2011) 2.89
Endothelial dysfunction in pulmonary hypertension. Circulation (2004) 2.82
Interleukin-6 overexpression induces pulmonary hypertension. Circ Res (2008) 2.64
Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: a randomized controlled clinical trial. J Am Coll Cardiol (2010) 2.55
Formation of plexiform lesions in experimental severe pulmonary arterial hypertension. Circulation (2010) 2.43
Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest (2005) 2.32
Transplantation of autologous endothelial progenitor cells may be beneficial in patients with idiopathic pulmonary arterial hypertension: a pilot randomized controlled trial. J Am Coll Cardiol (2007) 2.23
Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. Circ Res (2007) 2.19
Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res (2000) 2.14
Plexiform-like lesions and increased tissue factor expression in a rat model of severe pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol (2007) 2.08
Pulmonary arterial remodeling induced by a Th2 immune response. J Exp Med (2008) 2.08
Nitric oxide. A novel signal transduction mechanism for transcellular communication. Hypertension (1990) 2.04
Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors. J Biol Chem (2007) 1.99
Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol (2006) 1.93
Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J Clin Invest (1991) 1.91
Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol (2004) 1.90
Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol (2009) 1.81
Notch3 signaling promotes the development of pulmonary arterial hypertension. Nat Med (2009) 1.77
Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. Eur Respir J (2005) 1.71
Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am J Physiol Heart Circ Physiol (2006) 1.65
Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation (2003) 1.63
Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J Clin Invest (1999) 1.59
Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler Thromb Vasc Biol (2003) 1.49
NO: the primary EDRF. J Mol Cell Cardiol (1999) 1.46
Inhaled nitric oxide versus aerosolized iloprost for the treatment of pulmonary hypertension with left heart disease. Crit Care Med (2009) 1.46
Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Am J Respir Crit Care Med (2007) 1.42
S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy. Am J Pathol (2004) 1.42
Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Br J Pharmacol (2005) 1.24
Pulmonary hemodynamics modify the rat pulmonary artery response to injury. A neointimal model of pulmonary hypertension. Am J Pathol (1997) 1.22
Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats. Circ Res (2007) 1.18
Prostacyclin receptor-dependent modulation of pulmonary vascular remodeling. Am J Respir Crit Care Med (2001) 1.16
Altered pulmonary vasoreactivity in the chronically hypoxic lung. Physiol Res (2000) 1.14
Endothelin-1 and serotonin are involved in activation of RhoA/Rho kinase signaling in the chronically hypoxic hypertensive rat pulmonary circulation. J Cardiovasc Pharmacol (2007) 1.13
Therapeutic hypercapnia prevents chronic hypoxia-induced pulmonary hypertension in the newborn rat. Am J Physiol Lung Cell Mol Physiol (2006) 1.11
Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats. Am J Physiol Renal Physiol (2005) 1.09
Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation? J Pharmacol Exp Ther (1988) 1.09
Development of occlusive neointimal lesions in distal pulmonary arteries of endothelin B receptor-deficient rats: a new model of severe pulmonary arterial hypertension. Circulation (2005) 1.04
Chronic metabolic acidosis in azotemic rats on a high-phosphate diet halts the progression of renal disease. Kidney Int (2000) 1.03
Amiloride analogs inhibit chronic hypoxic pulmonary hypertension. Am J Respir Crit Care Med (1998) 0.99
Exaggerated hypoxic pulmonary hypertension in endothelin B receptor-deficient rats. Am J Physiol Lung Cell Mol Physiol (2002) 0.97
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One (2009) 0.96
Pulmonary hypertension in COPD: a review and consideration of the role of arterial vasodilators. COPD (2009) 0.95
Endothelin B receptor deficiency potentiates ET-1 and hypoxic pulmonary vasoconstriction. Am J Physiol Lung Cell Mol Physiol (2001) 0.94
Vascular smooth muscle cell phenotypes in primary pulmonary hypertension. Eur Respir J (2001) 0.94
Decreased left ventricular function, myocarditis, and coronary arteriolar medial thickening following monocrotaline administration in adult rats. J Appl Physiol (1985) (2007) 0.94
Chronic hypercapnia inhibits hypoxic pulmonary vascular remodeling. Am J Physiol Heart Circ Physiol (2000) 0.93
Rodent models of PAH: are we there yet? Am J Physiol Lung Cell Mol Physiol (2007) 0.93
Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and rats--species differences and technical considerations. Cell Physiol Biochem (2011) 0.92
The status of pulmonary arterial hypertension in 2008. Circulation (2008) 0.92
The role of Na+/H+ exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol (1996) 0.91
Use of sildenafil to facilitate weaning from inhaled nitric oxide in children with pulmonary hypertension following surgery for congenital heart disease. J Intensive Care Med (2008) 0.91
Key role of the RhoA/Rho kinase system in pulmonary hypertension. Pulm Pharmacol Ther (2010) 0.91
Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther (2009) 0.91
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med (2004) 0.89
Vascular hyperresponsiveness in perfused lungs from monocrotaline-treated rats. Am J Physiol (1986) 0.88
Serotonin transporter protein in pulmonary hypertensive rats treated with atorvastatin. Am J Physiol Lung Cell Mol Physiol (2007) 0.88
Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Am J Physiol Lung Cell Mol Physiol (2007) 0.88
Contribution of Na+/H+ exchange to pH regulation in pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol (1991) 0.86
Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol (2005) 0.85
The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells. J Cell Biochem (2008) 0.85
Metabolic acidosis in rats increases intestinal NHE2 and NHE3 expression and function. Am J Physiol Gastrointest Liver Physiol (2002) 0.84
Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. Am J Physiol Heart Circ Physiol (2010) 0.84
The influence of sex hormones on pulmonary vascular reactivity: possible vasodilator therapies for the treatment of pulmonary hypertension. Curr Vasc Pharmacol (2006) 0.84
Combined use of PDE5 inhibitors and nitrates in the treatment of pulmonary arterial hypertension in patients with heart failure. J Card Fail (2008) 0.84
Mechanistic imbalance of pulmonary vasomotor control in progressive lung injury. Surgery (1996) 0.81
Time-dependent phenotypic and contractile changes of pulmonary artery in chronic hypoxia-induced pulmonary hypertension. J Pharmacol Sci (2009) 0.80
Heme oxygenase-1 does not mediate the effects of extracellular acidosis on vascular smooth muscle cell proliferation, migration, and susceptibility to apoptosis. J Vasc Res (2011) 0.78
Na+/H+ exchange in pulmonary artery smooth muscle from spontaneously hypertensive and Wistar-Kyoto rats. Am J Physiol (1995) 0.77
Sex hormones and vascular protection in pulmonary arterial hypertension. J Cardiovasc Pharmacol (2010) 0.77
Effects of the endothelin ET(A) receptor antagonist, TA-0201, on pulmonary arteries isolated from hypoxic rats. Eur J Pharmacol (1999) 0.77
Effect of metabolic acidosis on the insulin-like growth factor-I system and cathepsins B and L gene expression in the kidney. J Lab Clin Med (2000) 0.76
Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol (2007) 3.19
Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol (2009) 3.05
Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med (2009) 2.83
Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation (2012) 2.70
Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol (2004) 2.58
Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation (2002) 1.78
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol (2004) 1.71
Mechanical ventilation guided by electrical impedance tomography in experimental acute lung injury. Crit Care Med (2013) 1.68
The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol (2006) 1.59
Positional therapy for obstructive sleep apnea patients: A 6-month follow-up study. Laryngoscope (2006) 1.53
Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol (2005) 1.52
Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR. Am J Physiol Regul Integr Comp Physiol (2003) 1.51
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2012) 1.39
Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension. Circulation (2011) 1.34
Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J (2004) 1.31
Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease. Biochem Pharmacol (2012) 1.25
Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. Pulm Circ (2012) 1.23
Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells (2011) 1.18
The vascular endothelin system in hypertension--recent patents and discoveries. Recent Pat Cardiovasc Drug Discov (2006) 1.16
Sex difference in cardiovascular risk: role of pulse pressure amplification. J Am Coll Cardiol (2012) 1.15
Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. J Vasc Surg (2007) 1.11
Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol (2008) 1.11
Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction. J Vasc Surg (2004) 1.09
Gender differences in the regulation of vascular tone. Clin Exp Pharmacol Physiol (2003) 1.08
Cellular mediators of renal vascular dysfunction in hypertension. Am J Physiol Regul Integr Comp Physiol (2009) 1.08
Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion. Hypertension (2003) 1.06
Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol (2010) 1.05
Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation (2008) 1.05
Sex steroids and vascular responses in hypertension and aging. Gend Med (2008) 1.04
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. EXS (2012) 1.03
Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg (2008) 1.02
Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia. Cardiovasc Hematol Agents Med Chem (2010) 1.02
Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Curr Med Chem (2009) 1.01
Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways. Hypertension (2002) 1.01
Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. Am J Physiol Heart Circ Physiol (2009) 1.00
Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol (2002) 0.99
Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats. Hypertension (2003) 0.99
Hypoxia regulates bone morphogenetic protein signaling through C-terminal-binding protein 1. Circ Res (2006) 0.97
Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacol Rev (2012) 0.97
Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg (2010) 0.97
Pathophysiology of essential hypertension: role of the pump, the vessel, and the kidney. Semin Nephrol (2002) 0.96
Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One (2009) 0.96
Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol (2008) 0.96
Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat. Cell Physiol Biochem (2010) 0.95
Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther (2013) 0.95
MSC microvesicles for the treatment of lung disease: a new paradigm for cell-free therapy. Antioxid Redox Signal (2014) 0.95
REM-related obstructive sleep apnea: the effect of body position. J Clin Sleep Med (2010) 0.95
Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C. Hypertension (2004) 0.94
Perinatal stress, brain inflammation and risk of autism-review and proposal. BMC Pediatr (2012) 0.94
Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol (2011) 0.94
Matrix metalloproteinases in venous tissue remodeling and varicose vein formation. Curr Vasc Pharmacol (2008) 0.93
Nkx2-5 suppresses the proliferation of atrial myocytes and conduction system. Circ Res (2014) 0.93
Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2012) 0.92
Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates. J Perinatol (2005) 0.92
Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease. Curr Drug Metab (2010) 0.92
Does the severity of obstructive sleep apnea predict patients requiring high continuous positive airway pressure? Laryngoscope (2006) 0.92
Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther (2009) 0.91
Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat. J Cardiovasc Pharmacol (2013) 0.91
Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease. Expert Rev Cardiovasc Ther (2007) 0.90
Cheyne-Stokes respiration during sleep: a possible effect of body position. Med Sci Monit (2002) 0.90
Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet. Hypertension (2002) 0.88
Neurovascular mechanisms of hypertension in pregnancy. Curr Neurovasc Res (2006) 0.88
TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol (2002) 0.88
[The significance of body posture on breathing abnormalities during sleep: data analysis of 2077 obstructive sleep apnea patients]. Harefuah (2009) 0.88
Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets (2013) 0.87
Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy. Cardiovasc Hematol Disord Drug Targets (2010) 0.87
MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res (2008) 0.87
Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension (2004) 0.86
Severe obstructive sleep apnea: sleepy versus nonsleepy patients. Laryngoscope (2010) 0.86
Decreased endothelium-dependent NO-cGMP vascular relaxation and hypertension in growth-restricted rats on a high-salt diet. Hypertension (2004) 0.86
Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg (2010) 0.86
Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials (2012) 0.85
Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol (2005) 0.85
Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov (2008) 0.85
Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. Am J Respir Crit Care Med (2013) 0.85
Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. Am J Physiol Heart Circ Physiol (2002) 0.85
The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells. J Cell Biochem (2008) 0.85
Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med (2013) 0.84
Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest (2012) 0.84
Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab (2012) 0.84