Published in PLoS One on February 13, 2012
Oxidative stress in malaria. Int J Mol Sci (2012) 1.24
Pharmacologic inhibition of CXCL10 in combination with anti-malarial therapy eliminates mortality associated with murine model of cerebral malaria. PLoS One (2013) 0.94
Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria. PLoS Pathog (2013) 0.93
Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: implications for gene therapy of restenosis. Atherosclerosis (2013) 0.88
Glucocorticosteroids in nano-sterically stabilized liposomes are efficacious for elimination of the acute symptoms of experimental cerebral malaria. PLoS One (2013) 0.84
A new hypothesis on the manifestation of cerebral malaria: the secret is in the liver. Med Hypotheses (2013) 0.81
L-Arginine supplementation in mice enhances NO production in spleen cells and inhibits Plasmodium yoelii transmission in mosquitoes. Parasit Vectors (2015) 0.80
Vascular dysfunction as a target for adjuvant therapy in cerebral malaria. Mem Inst Oswaldo Cruz (2014) 0.79
Uptake and metabolism of arginine impact Plasmodium development in the liver. Sci Rep (2017) 0.75
Toxoplasma gondii upregulates interleukin-12 to prevent Plasmodium berghei-induced experimental cerebral malaria. Infect Immun (2014) 0.75
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial. Lancet (2005) 12.98
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med (2003) 8.95
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial. Lancet (2010) 8.52
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med (2002) 7.59
The murine cerebral malaria phenomenon. Trends Parasitol (2009) 5.62
Erectile dysfunction. N Engl J Med (2000) 4.92
Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. J Exp Med (2007) 3.13
Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur Respir J (1997) 2.79
Oxidation of nitrogen oxides by bound dioxygen in hemoproteins. J Inorg Biochem (1981) 2.77
Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med (1996) 2.75
Cognitive impairment after cerebral malaria in children: a prospective study. Pediatrics (2007) 2.47
Nitrite infusions to prevent delayed cerebral vasospasm in a primate model of subarachnoid hemorrhage. JAMA (2005) 2.47
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med (2006) 2.33
Arginine metabolism: boundaries of our knowledge. J Nutr (2007) 2.33
Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke (2002) 2.24
Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol (2009) 2.24
Cyclic GMP phosphodiesterase-5: target of sildenafil. J Biol Chem (1999) 2.23
Effects of early cerebral malaria on cognitive ability in Senegalese children. J Dev Behav Pediatr (2002) 2.02
Cerebral malaria: why experimental murine models are required to understand the pathogenesis of disease. Parasitology (2009) 1.87
Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. J Infect Dis (2009) 1.86
Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet (2003) 1.86
The functional nitrite reductase activity of the heme-globins. Blood (2008) 1.58
Behavioural and histopathological alterations in mice with cerebral malaria. Neuropathol Appl Neurobiol (2006) 1.57
Endogenous dimethylarginine as an inhibitor of nitric oxide synthesis. J Cardiovasc Pharmacol (1992) 1.51
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. Am J Pathol (2010) 1.51
Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke (2005) 1.46
Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathog (2010) 1.37
Regulation of nitric oxide production in health and disease. Curr Opin Clin Nutr Metab Care (2010) 1.35
Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ Res (2000) 1.33
Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. Curr Opin Infect Dis (2008) 1.27
Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. J Infect Dis (2008) 1.26
Agmatine : metabolic pathway and spectrum of activity in brain. CNS Drugs (2007) 1.25
Murine cerebral malaria: the whole story. Trends Parasitol (2010) 1.24
Neuropathogenesis of human and murine malaria. Trends Parasitol (2010) 1.24
The 'hidden' burden of malaria: cognitive impairment following infection. Malar J (2010) 1.23
Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide (2011) 1.21
Immunological aspects of cerebral lesions in murine malaria. Clin Exp Immunol (1989) 1.16
Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. J Infect Dis (2011) 1.16
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One (2011) 1.15
Nitrate-nitrite-nitric oxide pathway: implications for anesthesiology and intensive care. Anesthesiology (2010) 1.12
Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain. Antimicrob Agents Chemother (2011) 1.06
Murine cerebral malaria: how far from human cerebral malaria? Trends Parasitol (2010) 1.05
Mice lacking melanin-concentrating hormone receptor 1 demonstrate increased heart rate associated with altered autonomic activity. Am J Physiol Regul Integr Comp Physiol (2004) 1.03
Cerebral malaria: human versus mouse studies. Trends Parasitol (2010) 1.01
Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol (2007) 1.01
Cerebral malaria: in praise of epistemes. Trends Parasitol (2010) 0.96
Algorithms to predict cerebral malaria in murine models using the SHIRPA protocol. Malar J (2010) 0.95
Arginase inhibition in airways from normal and nitric oxide synthase 2-knockout mice exposed to ovalbumin. Toxicol Appl Pharmacol (2009) 0.93
Pharmacokinetics of L-arginine in adults with moderately severe malaria. Antimicrob Agents Chemother (2008) 0.92
Safety profile of L-arginine infusion in moderately severe falciparum malaria. PLoS One (2008) 0.92
Free radical production by dysfunctional eNOS. Heart (2004) 0.92
Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain. Anat Cell Biol (2010) 0.85
Wild-type phenylalanine hydroxylase activity is enhanced by tetrahydrobiopterin supplementation in vivo: an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency. Mol Genet Metab (2004) 0.84
Pharmacological manipulation of cyclic GMP levels in brain restores learning ability in animal models of hepatic encephalopathy: therapeutic implications. Neuropsychiatr Dis Treat (2006) 0.81
Estradiol, but not dehydroepiandrosterone, decreases parasitemia and increases the incidence of cerebral malaria and the mortality in plasmodium berghei ANKA-infected CBA mice. Neuroimmunomodulation (2006) 0.80
New regulatory, signaling pathways, and sources of nitric oxide. Acta Neurochir Suppl (2011) 0.77
Pharmacokinetics of arginine and aspartic acid administered simultaneously in the rat: I. Plasma kinetics. Eur J Drug Metab Pharmacokinet (1983) 0.77
Pharmacokinetics of arginine and aspartic acid administered simultaneously in the rat: II. Tissue distribution. Eur J Drug Metab Pharmacokinet (1983) 0.76
Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria. Nat Med (2006) 2.33
G protein-coupled receptors sense fluid shear stress in endothelial cells. Proc Natl Acad Sci U S A (2006) 2.21
The shear stress of it all: the cell membrane and mechanochemical transduction. Philos Trans R Soc Lond B Biol Sci (2007) 1.61
Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol Heart Circ Physiol (2004) 1.52
Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. Am J Pathol (2010) 1.51
PECAM-1 mediates NO-dependent dilation of arterioles to high temporal gradients of shear stress. Arterioscler Thromb Vasc Biol (2005) 1.47
Paradoxical hypotension following increased hematocrit and blood viscosity. Am J Physiol Heart Circ Physiol (2005) 1.35
Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. J Infect Dis (2011) 1.16
A novel approach to blood plasma viscosity measurement using fluorescent molecular rotors. Am J Physiol Heart Circ Physiol (2002) 1.15
Microfluidic enhancement of intramedullary pressure increases interstitial fluid flow and inhibits bone loss in hindlimb suspended mice. J Bone Miner Res (2010) 1.14
Immunization of Saimiri sciureus monkeys with a recombinant hybrid protein derived from the Plasmodium falciparum antigen glutamate-rich protein and merozoite surface protein 3 can induce partial protection with Freund and Montanide ISA720 adjuvants. Clin Diagn Lab Immunol (2005) 1.10
Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem (2009) 1.10
Role of endothelial nitric oxide in microvascular oxygen delivery and consumption. Free Radic Biol Med (2005) 1.09
PECAM-1 is a critical mediator of atherosclerosis. Dis Model Mech (2008) 1.09
Murine cerebral malaria: how far from human cerebral malaria? Trends Parasitol (2010) 1.05
Laurdan fluorescence senses mechanical strain in the lipid bilayer membrane. Biochem Biophys Res Commun (2006) 1.04
Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice. J Neuroinflammation (2011) 1.04
Strain-induced fetal type II epithelial cell differentiation is mediated via cAMP-PKA-dependent signaling pathway. Am J Physiol Lung Cell Mol Physiol (2006) 1.04
Rapid activation of Ras by fluid flow is mediated by Galpha(q) and Gbetagamma subunits of heterotrimeric G proteins in human endothelial cells. Arterioscler Thromb Vasc Biol (2003) 1.03
Oxygen delivery and consumption in the microcirculation after extreme hemodilution with perfluorocarbons. Am J Physiol Heart Circ Physiol (2004) 1.02
Temporal gradients in shear stimulate osteoblastic proliferation via ERK1/2 and retinoblastoma protein. Am J Physiol Endocrinol Metab (2002) 0.98
Temporal gradients in shear, but not spatial gradients, stimulate ERK1/2 activation in human endothelial cells. Am J Physiol Heart Circ Physiol (2005) 0.96
Intravital microscopy of the mouse brain microcirculation using a closed cranial window. J Vis Exp (2010) 0.95
Plasmodium berghei resists killing by reactive oxygen species. Infect Immun (2005) 0.95
Shear-induced endothelial cell-cell junction inclination. Am J Physiol Cell Physiol (2010) 0.95
Phospholipid-bound molecular rotors: synthesis and characterization. Bioorg Med Chem (2002) 0.93
Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria. PLoS Pathog (2013) 0.93
Rapid changes in shear stress induce dissociation of a G alpha(q/11)-platelet endothelial cell adhesion molecule-1 complex. J Physiol (2009) 0.92
Strain rate mechanotransduction in aligned human vascular smooth muscle cells. Ann Biomed Eng (2003) 0.92
Antibody response profiles induced by Plasmodium falciparum glutamate-rich protein in naturally exposed individuals from a Brazilian area endemic for malaria. Am J Trop Med Hyg (2005) 0.92
S-nitrosoglutathione prevents experimental cerebral malaria. J Neuroimmune Pharmacol (2012) 0.91
Regulation of G protein-coupled receptor activities by the platelet-endothelial cell adhesion molecule, PECAM-1. Biochemistry (2008) 0.91
Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Am J Physiol Cell Physiol (2012) 0.91
Skeletal adaptation to intramedullary pressure-induced interstitial fluid flow is enhanced in mice subjected to targeted osteocyte ablation. PLoS One (2012) 0.89
Effects of amyloid beta-peptides on the lysis tension of lipid bilayer vesicles containing oxysterols. Biophys J (2008) 0.86
Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells. Am J Physiol Cell Physiol (2009) 0.86
Cell- rather than antibody-mediated immunity leads to the development of profound thrombocytopenia during experimental Plasmodium berghei malaria. J Immunol (2005) 0.85
Strain and strain rate activation of G proteins in human endothelial cells. Biochem Biophys Res Commun (2002) 0.84
Evidence for the role of G-proteins in flow stimulation of dinoflagellate bioluminescence. Am J Physiol Regul Integr Comp Physiol (2007) 0.83
Anti-inflammatory properties of micropatterned titanium coatings. J Biomed Mater Res A (2006) 0.83
Slow and continuous delivery of a low dose of nimodipine improves survival and electrocardiogram parameters in rescue therapy of mice with experimental cerebral malaria. Malar J (2013) 0.83
Quantification of Lacunar-Canalicular Interstitial Fluid Flow Through Computational Modeling of Fluorescence Recovery After Photobleaching. Cell Mol Bioeng (2010) 0.83
Amodiaquine analogues containing NO-donor substructures: synthesis and their preliminary evaluation as potential tools in the treatment of cerebral malaria. Eur J Med Chem (2011) 0.82
Extracellular signal-regulated kinase activation and endothelin-1 production in human endothelial cells exposed to vibration. J Physiol (2004) 0.82
Rescue of a primary myelofibrosis model by retinoid-antagonist therapy. Proc Natl Acad Sci U S A (2013) 0.81
NO and CO binding profiles of hemoglobin vesicles as artificial oxygen carriers. Biochim Biophys Acta (2008) 0.81
A lactate dehydrogenase ELISA-based assay for the in vitro determination of Plasmodium berghei sensitivity to anti-malarial drugs. Malar J (2012) 0.81
Estradiol, but not dehydroepiandrosterone, decreases parasitemia and increases the incidence of cerebral malaria and the mortality in plasmodium berghei ANKA-infected CBA mice. Neuroimmunomodulation (2006) 0.80
Maturation enhances fluid shear-induced activation of eNOS in perfused ovine carotid arteries. Am J Physiol Heart Circ Physiol (2005) 0.80
Cell membrane fluidity changes and membrane undulations observed using a laser scattering technique. Ann Biomed Eng (2004) 0.80
A chronic scheme of cranial window preparation to study pial vascular reactivity in murine cerebral malaria. Microcirculation (2013) 0.80
Computerized methods for X-ray-based small bone densitometry. Comput Methods Programs Biomed (2004) 0.80
Stretch activation of GTP-binding proteins in C2C12 myoblasts. Exp Cell Res (2004) 0.79
Transdermal glyceryl trinitrate as an effective adjunctive treatment with artemether for late-stage experimental cerebral malaria. Antimicrob Agents Chemother (2013) 0.79
Reactive oxygen species inhibited by titanium oxide coatings. J Biomed Mater Res A (2003) 0.79
Heparan sulfates mediate the interaction between platelet endothelial cell adhesion molecule-1 (PECAM-1) and the Gαq/11 subunits of heterotrimeric G proteins. J Biol Chem (2014) 0.79
Bone cell responses to fluid flow. Methods Mol Med (2003) 0.78
CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways. Malar J (2015) 0.78
Titanate biomaterials with enhanced antiinflammatory properties. J Biomed Mater Res A (2007) 0.77
Distinctive subcellular Akt-1 responses to shear stress in endothelial cells. J Cell Biochem (2014) 0.77
Hemoglobin serves to protect Plasmodium parasites from nitric oxide and reactive oxygen species. J Investig Med (2005) 0.76
Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity. Biochem Biophys Res Commun (2013) 0.76
The use of dinoflagellate bioluminescence to characterize cell stimulation in bioreactors. Biotechnol Bioeng (2003) 0.75