Published in Nat Commun on February 21, 2012
Essential nontranslational functions of tRNA synthetases. Nat Chem Biol (2013) 1.72
Human tRNA synthetase catalytic nulls with diverse functions. Science (2014) 1.70
Aminoacyl-tRNA synthetases in medicine and disease. EMBO Mol Med (2013) 1.67
Applications of hydrogen/deuterium exchange MS from 2012 to 2014. Anal Chem (2014) 1.16
Oxidative stress diverts tRNA synthetase to nucleus for protection against DNA damage. Mol Cell (2014) 0.99
Genome-scale identification and characterization of moonlighting proteins. Biol Direct (2014) 0.92
Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing. Structure (2012) 0.91
Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases. J Biol Chem (2013) 0.87
Regulation of angiogenesis by aminoacyl-tRNA synthetases. Int J Mol Sci (2014) 0.86
tRNA synthetase counteracts c-Myc to develop functional vasculature. Elife (2014) 0.84
Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway. Arterioscler Thromb Vasc Biol (2016) 0.83
Neddylation requires glycyl-tRNA synthetase to protect activated E2. Nat Struct Mol Biol (2016) 0.82
Uncovering of a short internal peptide activates a tRNA synthetase procytokine. J Biol Chem (2012) 0.81
Crystal structure of human Seryl-tRNA synthetase and Ser-SA complex reveals a molecular lever specific to higher eukaryotes. Structure (2013) 0.80
Architecture and metamorphosis. Top Curr Chem (2014) 0.78
Wars2 is a determinant of angiogenesis. Nat Commun (2016) 0.77
Mixing and matching mitochondrial aminoacyl synthetases and their tRNAs: a new way to treat respiratory chain disorders? EMBO Mol Med (2014) 0.77
The crystal structure of human GlnRS provides basis for the development of neurological disorders. Nucleic Acids Res (2016) 0.77
Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase? J Biomark (2014) 0.76
SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis. Nucleic Acids Res (2015) 0.76
Structural disorder in expanding the functionome of aminoacyl-tRNA synthetases. Chem Biol (2013) 0.76
Competitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis. Nucleic Acids Res (2016) 0.75
Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. Nucleic Acids Res (2016) 0.75
Studying nuclear functions of aminoacyl tRNA synthetases. Methods (2016) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
Solvent content of protein crystals. J Mol Biol (1968) 106.07
Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: identification of a class of bipartite nuclear targeting sequence. Cell (1991) 9.96
Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A (2004) 5.54
Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process. Microbiol Mol Biol Rev (2000) 5.44
Nuclear localization signals (NLS). Crit Rev Eukaryot Gene Expr (1993) 3.05
Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases. Annu Rev Biochem (1993) 2.79
A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Proc Natl Acad Sci U S A (2002) 2.58
Aminoacyl tRNA synthetases and their connections to disease. Proc Natl Acad Sci U S A (2008) 2.41
WHEP domains direct noncanonical function of glutamyl-Prolyl tRNA synthetase in translational control of gene expression. Mol Cell (2008) 2.34
High-performance mass spectrometry: Fourier transform ion cyclotron resonance at 14.5 Tesla. Anal Chem (2008) 2.23
New functions of aminoacyl-tRNA synthetases beyond translation. Nat Rev Mol Cell Biol (2010) 2.22
Fast reversed-phase liquid chromatography to reduce back exchange and increase throughput in H/D exchange monitored by FT-ICR mass spectrometry. J Am Soc Mass Spectrom (2008) 1.43
VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. J Biol Chem (2004) 1.38
Human recombinant [C22A] FK506-binding protein amide hydrogen exchange rates from mass spectrometry match and extend those from NMR. Protein Sci (1997) 1.36
LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Mol Cell (2009) 1.35
Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom (2010) 1.28
Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. Circ Res (2009) 1.23
Functional expansion of human tRNA synthetases achieved by structural inventions. FEBS Lett (2010) 1.19
Noncanonical activity of seryl-tRNA synthetase is involved in vascular development. Circ Res (2009) 1.13
A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities. Anal Biochem (2007) 1.12
Application of micro-electrospray liquid chromatography techniques to FT-ICR MS to enable high-sensitivity biological analysis. J Am Soc Mass Spectrom (1998) 1.07
Simultaneous reduction and digestion of proteins with disulfide bonds for hydrogen/deuterium exchange monitored by mass spectrometry. Anal Chem (2010) 0.97
Crystallographic and mutational studies of seryl-tRNA synthetase from the archaeon Pyrococcus horikoshii. RNA Biol (2008) 0.95
Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex. Proc Natl Acad Sci U S A (2011) 0.91
Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells. Mol Cell Biol (2008) 0.89
Drug binding and resistance mechanism of KIT tyrosine kinase revealed by hydrogen/deuterium exchange FTICR mass spectrometry. Protein Sci (2010) 0.88
Mammalian aminoacyl-tRNA synthetases: cell signaling functions of the protein translation machinery. Vascul Pharmacol (2009) 0.86
The proximal region of a noncatalytic eukaryotic seryl-tRNA synthetase extension is required for protein stability in vitro and in vivo. Arch Biochem Biophys (2007) 0.82
Specific induction of Z-DNA conformation by a nuclear localization signal peptide of lupin glutaminyl tRNA synthetase. Mol Biol Rep (2000) 0.80
Human epicardial adipose tissue is a source of inflammatory mediators. Circulation (2003) 6.31
Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. Lancet (2013) 6.10
Identification of 315 genes essential for early zebrafish development. Proc Natl Acad Sci U S A (2004) 5.54
Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet (2008) 3.62
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development. Nat Med (2008) 3.33
Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell (2008) 3.15
Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell (2008) 3.04
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Analysis of the human endogenous coregulator complexome. Cell (2011) 2.97
Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Anal Chem (2006) 2.89
KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patients. Proc Natl Acad Sci U S A (2009) 2.84
The first 100 consecutive, robot-assisted, intracorporeal ileal conduits: evolution of technique and 90-day outcomes. Eur Urol (2012) 2.76
Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2. Immunity (2013) 2.74
The role of electron capture dissociation in biomolecular analysis. Mass Spectrom Rev (2005) 2.42
Key interactions in HIV-1 maturation identified by hydrogen-deuterium exchange. Nat Struct Mol Biol (2004) 2.34
Identification of novel interactions in HIV-1 capsid protein assembly by high-resolution mass spectrometry. J Mol Biol (2003) 2.32
High-performance mass spectrometry: Fourier transform ion cyclotron resonance at 14.5 Tesla. Anal Chem (2008) 2.23
New functions of aminoacyl-tRNA synthetases beyond translation. Nat Rev Mol Cell Biol (2010) 2.22
Inactivation of specific β cell transcription factors in type 2 diabetes. J Clin Invest (2013) 2.18
miR-24 regulates apoptosis by targeting the open reading frame (ORF) region of FAF1 in cancer cells. PLoS One (2010) 2.15
MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A (2007) 2.13
MafA and MafB regulate genes critical to beta-cells in a unique temporal manner. Diabetes (2010) 2.01
Dysregulated expression of T cell immunoglobulin and mucin domain 3 is associated with the disease severity and the outcome of patients with spontaneous intracerebral hemorrhage. Clin Biochem (2013) 1.99
The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest (2007) 1.98
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol (2010) 1.98
[[Zn2(HPO4)4][Co(dien)2]].H3O: a zinc phosphate with multidirectional intersecting helical channels. Angew Chem Int Ed Engl (2003) 1.98
Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect. Proc Natl Acad Sci U S A (2007) 1.91
Lack of ABCG2 expression and side population properties in human pluripotent stem cells. Stem Cells (2009) 1.76
Combined electron capture and infrared multiphoton dissociation for multistage MS/MS in a Fourier transform ion cyclotron resonance mass spectrometer. Anal Chem (2003) 1.75
Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus. Protein Cell (2010) 1.74
The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription. J Biol Chem (2005) 1.73
Exact masses and chemical formulas of individual Suwannee River fulvic acids from ultrahigh resolution electrospray ionization Fourier transform ion cyclotron resonance mass spectra. Anal Chem (2003) 1.65
A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome. J Am Soc Mass Spectrom (2009) 1.65
Diabetes-induced oxidative stress and low-grade inflammation in porcine coronary arteries. Circulation (2003) 1.65
Insulin gene transcription is mediated by interactions between the p300 coactivator and PDX-1, BETA2, and E47. Mol Cell Biol (2002) 1.61
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
Characterization of amino acid side chain losses in electron capture dissociation. J Am Soc Mass Spectrom (2002) 1.56
Lysine 63-linked polyubiquitination of TAK1 at lysine 158 is required for tumor necrosis factor alpha- and interleukin-1beta-induced IKK/NF-kappaB and JNK/AP-1 activation. J Biol Chem (2009) 1.56
Hierarchical nanostructured conducting polymer hydrogel with high electrochemical activity. Proc Natl Acad Sci U S A (2012) 1.54
Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes (2004) 1.54
Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis. Chem Soc Rev (2012) 1.53
Understanding avoidance, refusal, and abandonment of chemotherapy before and after cystectomy for bladder cancer. Urology (2013) 1.52
Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation fourier transform-ion cyclotron resonance mass spectrometry. J Biol Chem (2005) 1.50
Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells. PLoS One (2010) 1.48
Construction of a hybrid quadrupole/Fourier transform ion cyclotron resonance mass spectrometer for versatile MS/MS above 10 kDa. J Am Soc Mass Spectrom (2004) 1.46
Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase. Proc Natl Acad Sci U S A (2007) 1.46
Fast reversed-phase liquid chromatography to reduce back exchange and increase throughput in H/D exchange monitored by FT-ICR mass spectrometry. J Am Soc Mass Spectrom (2008) 1.43
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J Biol Chem (2009) 1.43
Synergistic attenuation of vesicular stomatitis virus by combination of specific G gene truncations and N gene translocations. J Virol (2006) 1.42
Rx-Cre, a tool for inactivation of gene expression in the developing retina. Genesis (2006) 1.40
An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science (2013) 1.39
Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: implications for IgA nephropathy. Anal Bioanal Chem (2007) 1.37
Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chin Med (2006) 1.37
Alanyl-tRNA synthetase crystal structure and design for acceptor-stem recognition. Mol Cell (2004) 1.34
Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan. Protein Cell (2013) 1.33
The C-Ala domain brings together editing and aminoacylation functions on one tRNA. Science (2009) 1.33
Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma. Nature (2009) 1.28
Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom (2010) 1.28
Inhibition of connective tissue growth factor by siRNA prevents liver fibrosis in rats. J Gene Med (2006) 1.27
Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol (2011) 1.25
Charcot-Marie-Tooth-linked mutant GARS is toxic to peripheral neurons independent of wild-type GARS levels. PLoS Genet (2011) 1.25
Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet (2010) 1.24
Diagnosis of airway-invasive pulmonary aspergillosis by tree-in-bud sign in an immunocompetent patient: case report and literature review. J Mycol Med (2013) 1.23
Improved ion extraction from a linear octopole ion trap: SIMION analysis and experimental demonstration. J Am Soc Mass Spectrom (2002) 1.22
Hopping transport through defect-induced localized states in molybdenum disulphide. Nat Commun (2013) 1.22
Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature. Arterioscler Thromb Vasc Biol (2008) 1.21
Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis. Proc Natl Acad Sci U S A (2012) 1.21
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy. Proc Natl Acad Sci U S A (2009) 1.21
Petroleum crude oil characterization by IMS-MS and FTICR MS. Anal Chem (2009) 1.21
Diverse origin of intimal cells: smooth muscle cells, myofibroblasts, fibroblasts, and beyond? Circ Res (2002) 1.19
Functional expansion of human tRNA synthetases achieved by structural inventions. FEBS Lett (2010) 1.19
Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism. Cell Rep (2013) 1.19
Electron capture dissociation and infrared multiphoton dissociation of oligodeoxynucleotide dications. J Am Soc Mass Spectrom (2003) 1.18
The role of matrix metalloproteinase 2 on the survival of patients with non-small cell lung cancer: a systematic review with meta-analysis. Cancer Invest (2010) 1.18
Structural switch of lysyl-tRNA synthetase between translation and transcription. Mol Cell (2012) 1.17
Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation. J Biol Chem (2008) 1.17
Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites. J Biol Chem (2005) 1.17
Electrodeposition of hierarchical ZnO nanorod-nanosheet structures and their applications in dye-sensitized solar cells. ACS Appl Mater Interfaces (2011) 1.16
Highly sensitive glucose sensor based on pt nanoparticle/polyaniline hydrogel heterostructures. ACS Nano (2013) 1.15
Preparation and characterization of flexible asymmetric supercapacitors based on transition-metal-oxide nanowire/single-walled carbon nanotube hybrid thin-film electrodes. ACS Nano (2010) 1.15
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Nat Chem Biol (2012) 1.15
Dispersed disease-causing neomorphic mutations on a single protein promote the same localized conformational opening. Proc Natl Acad Sci U S A (2011) 1.14
Improving the quality of randomized controlled trials in Chinese herbal medicine, part IV: applying a revised CONSORT checklist to measure reporting quality. Zhong Xi Yi Jie He Xue Bao (2006) 1.14
Predictive value of ERCC1 and XPD polymorphism in patients with advanced non-small cell lung cancer receiving platinum-based chemotherapy: a systematic review and meta-analysis. Med Oncol (2010) 1.14
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality. Nat Struct Mol Biol (2009) 1.13