Efficacy of early neonatal vitamin A supplementation in reducing mortality during infancy in Ghana, India and Tanzania: study protocol for a randomized controlled trial.

PubWeight™: 1.10‹?› | Rank: Top 10%

🔗 View Article (PMC 3337818)

Published in Trials on February 23, 2012

Authors

NEOVITA Study Author Group1, Rajiv Bahl, Nita Bhandari, Brinda Dube, Karen Edmond, Wafaie Fawzi, Olivier Fontaine, Jasmine Kaur, Betty R Kirkwood, Jose Martines, Honorati Masanja, Sarmila Mazumder, Salum Msham, Sam Newton, Maureen Oleary, Julia Ruben, Caitlin Shannon, Emily Smith, Sunita Taneja, Sachiyo Yoshida

Author Affiliations

1: Department of Maternal Newborn Child and Adolescent Health, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland. bahlr@who.int

Associated clinical trials:

Efficacy of Newborn Vitamin A Supplementation Versus Placebo in Improving Child Survival (NeoVitA Trial) | NCT01138449

Articles citing this

Quality along the continuum: a health facility assessment of intrapartum and postnatal care in Ghana. PLoS One (2013) 2.03

Effect of neonatal vitamin A supplementation on mortality in infants in Tanzania (Neovita): a randomised, double-blind, placebo-controlled trial. Lancet (2014) 1.89

Heterologous ("nonspecific") and sex-differential effects of vaccines: epidemiology, clinical trials, and emerging immunologic mechanisms. Clin Infect Dis (2013) 1.11

Ghana's Ensure Mothers and Babies Regular Access to Care (EMBRACE) program: study protocol for a cluster randomized controlled trial. Trials (2015) 0.97

Interaction between neonatal vitamin A supplementation and timing of measles vaccination: a retrospective analysis of three randomized trials from Guinea-Bissau. Vaccine (2014) 0.83

Competence of health workers in emergency obstetric care: an assessment using clinical vignettes in Brong Ahafo region, Ghana. BMJ Open (2016) 0.78

A double blind randomized controlled trial in neonates to determine the effect of vitamin A supplementation on immune responses: The Gambia protocol. BMC Pediatr (2014) 0.78

Vitamin A supplementation and risk of atopy: long-term follow-up of a randomized trial of vitamin A supplementation at six and nine months of age. BMC Pediatr (2013) 0.76

Heterologous and sex differential effects of administering vitamin A supplementation with vaccines. Trans R Soc Trop Med Hyg (2014) 0.75

Vaccination timing of low-birth-weight infants in rural Ghana: a population-based, prospective cohort study. Bull World Health Organ (2016) 0.75

A cohort study of low birth weight and health outcomes in the first year of life, Ghana. Bull World Health Organ (2017) 0.75

Articles cited by this

A multiple testing procedure for clinical trials. Biometrics (1979) 26.80

Maternal and child undernutrition: global and regional exposures and health consequences. Lancet (2008) 26.44

Better reporting of harms in randomized trials: an extension of the CONSORT statement. Ann Intern Med (2004) 11.47

Subgroup analysis and other (mis)uses of baseline data in clinical trials. Lancet (2000) 9.80

Vitamin A supplementation and child mortality. A meta-analysis. JAMA (1993) 3.09

Effectiveness of an early supplementation scheme of high-dose vitamin A versus standard WHO protocol in Gambian mothers and infants: a randomised controlled trial. Lancet (2007) 3.01

Effect of vitamin A supplementation in women of reproductive age on maternal survival in Ghana (ObaapaVitA): a cluster-randomised, placebo-controlled trial. Lancet (2010) 2.48

Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ (1993) 2.46

Impact of supplementing newborn infants with vitamin A on early infant mortality: community based randomised trial in southern India. BMJ (2003) 2.44

Newborn vitamin A supplementation reduced infant mortality in rural Bangladesh. Pediatrics (2008) 2.32

Effect of postpartum maternal or neonatal vitamin A supplementation on infant mortality among infants born to HIV-negative mothers in Zimbabwe. Am J Clin Nutr (2005) 2.27

Impact of neonatal vitamin A supplementation on infant morbidity and mortality. J Pediatr (1996) 2.19

Vitamin A supplementation and BCG vaccination at birth in low birthweight neonates: two by two factorial randomised controlled trial. BMJ (2010) 2.18

Randomized controlled safety and efficacy trial of 2 vitamin A supplementation schedules in Tanzanian infants. Am J Clin Nutr (2007) 2.11

Effect of 50,000 IU vitamin A given with BCG vaccine on mortality in infants in Guinea-Bissau: randomised placebo controlled trial. BMJ (2008) 1.91

An educational intervention to promote appropriate complementary feeding practices and physical growth in infants and young children in rural Haryana, India. J Nutr (2004) 1.74

Randomised trial to assess benefits and safety of vitamin A supplementation linked to immunisation in early infancy. WHO/CHD Immunisation-Linked Vitamin A Supplementation Study Group. Lancet (1998) 1.70

Mortality of infants < 6 mo of age supplemented with vitamin A: a randomized, double-masked trial in Nepal. Am J Clin Nutr (1995) 1.63

Neonatal vitamin A supplementation and infant survival. Lancet (2010) 1.59

Neonatal vitamin A supplementation for prevention of mortality and morbidity in infancy: systematic review of randomised controlled trials. BMJ (2009) 1.51

Maternal vitamin A supplementation and immunity to malaria in pregnancy in Ghanaian primigravids. Trop Med Int Health (2005) 1.03

Neonatal vitamin A supplementation and infant survival in Asia. Lancet (2008) 0.98

Seroprotection associated with infant vitamin A supplementation given with vaccines is not related to antibody affinity to Hepatitis B and Haemophilus influenzae type b vaccines. Vaccine (2010) 0.84

Effect of consumption of micronutrient fortified candies on the iron and vitamin A status of children aged 3-6 years in rural Haryana. Indian Pediatr (2007) 0.79

Articles by these authors

A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 50.94

Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 41.47

Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet (2012) 26.95

Common values in assessing health outcomes from disease and injury: disability weights measurement study for the Global Burden of Disease Study 2010. Lancet (2012) 11.32

Reproductive health, and child health and nutrition in India: meeting the challenge. Lancet (2011) 6.19

Typhoid and paratyphoid fever. Lancet (2005) 6.16

UK health performance: findings of the Global Burden of Disease Study 2010. Lancet (2013) 6.11

Delayed breastfeeding initiation increases risk of neonatal mortality. Pediatrics (2006) 6.05

Late postnatal transmission of HIV-1 in breast-fed children: an individual patient data meta-analysis. J Infect Dis (2004) 5.93

Effectiveness and cost of facility-based Integrated Management of Childhood Illness (IMCI) in Tanzania. Lancet (2004) 5.91

Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study. Lancet (2013) 5.85

Effectiveness of an intervention led by lay health counsellors for depressive and anxiety disorders in primary care in Goa, India (MANAS): a cluster randomised controlled trial. Lancet (2010) 5.36

Neonatal mortality levels for 193 countries in 2009 with trends since 1990: a systematic analysis of progress, projections, and priorities. PLoS Med (2011) 5.33

Infant feeding patterns and risks of death and hospitalization in the first half of infancy: multicentre cohort study. Bull World Health Organ (2005) 5.07

Non-communicable diseases in sub-Saharan Africa: what we know now. Int J Epidemiol (2011) 4.74

Improvement of perinatal and newborn care in rural Pakistan through community-based strategies: a cluster-randomised effectiveness trial. Lancet (2011) 4.42

Cause-specific mortality rates in sub-Saharan Africa and Bangladesh. Bull World Health Organ (2006) 4.12

Effect of community-based promotion of exclusive breastfeeding on diarrhoeal illness and growth: a cluster randomised controlled trial. Lancet (2003) 4.11

Implementing community-based perinatal care: results from a pilot study in rural Pakistan. Bull World Health Organ (2008) 3.99

Standards for CHERG reviews of intervention effects on child survival. Int J Epidemiol (2010) 3.90

Neonatal survival: a call for action. Lancet (2005) 3.44

Care-seeking patterns for fatal malaria in Tanzania. Malar J (2004) 3.41

Food store types, availability, and cost of foods in a rural environment. J Am Diet Assoc (2007) 3.35

Population Health Metrics Research Consortium gold standard verbal autopsy validation study: design, implementation, and development of analysis datasets. Popul Health Metr (2011) 3.21

Co-coverage of preventive interventions and implications for child-survival strategies: evidence from national surveys. Lancet (2005) 3.17

Mobile health (mHealth) approaches and lessons for increased performance and retention of community health workers in low- and middle-income countries: a review. J Med Internet Res (2013) 3.04

Different rates of disease progression of HIV type 1 infection in Tanzania based on infecting subtype. Clin Infect Dis (2006) 3.03

Why do women complain of vaginal discharge? A population survey of infectious and pyschosocial risk factors in a South Asian community. Int J Epidemiol (2005) 2.88

How changes in coverage affect equity in maternal and child health interventions in 35 Countdown to 2015 countries: an analysis of national surveys. Lancet (2012) 2.88

Sex differences in antiretroviral treatment outcomes among HIV-infected adults in an urban Tanzanian setting. AIDS (2011) 2.85

Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial. Lancet Infect Dis (2011) 2.79

The WHO Multicentre Growth Reference Study: planning, study design, and methodology. Food Nutr Bull (2004) 2.76

Revising the WHO verbal autopsy instrument to facilitate routine cause-of-death monitoring. Glob Health Action (2013) 2.69

Epidemiology of malaria in the forest-savanna transitional zone of Ghana. Malar J (2009) 2.67

1 year after The Lancet Neonatal Survival Series--was the call for action heard? Lancet (2006) 2.66

Improving antimicrobial use among health workers in first-level facilities: results from the multi-country evaluation of the Integrated Management of Childhood Illness strategy. Bull World Health Organ (2004) 2.61

Gender disadvantage and reproductive health risk factors for common mental disorders in women: a community survey in India. Arch Gen Psychiatry (2006) 2.58

Why are 4 million newborn babies dying each year? Lancet (2004) 2.50

Efficacy and safety of an extended nevirapine regimen in infant children of breastfeeding mothers with HIV-1 infection for prevention of postnatal HIV-1 transmission (HPTN 046): a randomised, double-blind, placebo-controlled trial. Lancet (2011) 2.49

Effect of vitamin A supplementation in women of reproductive age on maternal survival in Ghana (ObaapaVitA): a cluster-randomised, placebo-controlled trial. Lancet (2010) 2.48

Mosquito nets and the poor: can social marketing redress inequities in access? Trop Med Int Health (2004) 2.44

Effect of implementation of Integrated Management of Neonatal and Childhood Illness (IMNCI) programme on neonatal and infant mortality: cluster randomised controlled trial. BMJ (2012) 2.42

Using verbal autopsy to measure causes of death: the comparative performance of existing methods. BMC Med (2014) 2.39

Comparison of Ready-to-Use Therapeutic Food with cereal legume-based khichri among malnourished children. Indian Pediatr (2009) 2.33

Consensus Statement of IAP National Task Force: status report on management of acute diarrhea. Indian Pediatr (2004) 2.32

Prevalence of active convulsive epilepsy in sub-Saharan Africa and associated risk factors: cross-sectional and case-control studies. Lancet Neurol (2013) 2.28

Occupational therapy practice framework: domain & practice, 2nd edition. Am J Occup Ther (2008) 2.26

Randomized trial of mifepristone and buccal or vaginal misoprostol for abortion through 56 days of last menstrual period. Contraception (2005) 2.17

Effectiveness of zinc supplementation plus oral rehydration salts compared with oral rehydration salts alone as a treatment for acute diarrhea in a primary care setting: a cluster randomized trial. Pediatrics (2008) 2.12

Quality along the continuum: a health facility assessment of intrapartum and postnatal care in Ghana. PLoS One (2013) 2.03

Risk factors for common mental disorders in women. Population-based longitudinal study. Br J Psychiatry (2006) 2.01

Setting research priorities to reduce almost one million deaths from birth asphyxia by 2015. PLoS Med (2011) 2.01

IL-17A-producing neutrophil-regulatory Tn lymphocytes. Immunol Res (2006) 2.00

Research priorities to reduce global mortality from newborn infections by 2015. Pediatr Infect Dis J (2009) 1.99

Zinc with oral rehydration therapy reduces stool output and duration of diarrhea in hospitalized children: a randomized controlled trial. J Pediatr Gastroenterol Nutr (2004) 1.98

HIV-1 epidemic among female bar and hotel workers in northern Tanzania: risk factors and opportunities for prevention. J Acquir Immune Defic Syndr (2002) 1.96

A phase III clinical trial of antibiotics to reduce chorioamnionitis-related perinatal HIV-1 transmission. AIDS (2006) 1.96

Detection of bacterial pathogens in Mongolia meningitis surveillance with a new real-time PCR assay to detect Haemophilus influenzae. Int J Med Microbiol (2011) 1.94

Zinc and low osmolarity oral rehydration salts for diarrhoea: a renewed call to action. Bull World Health Organ (2009) 1.93

Re: Meta-analysis of 200 or 600 mg mifepristone in association with two prostaglandins for termination of early pregnancy. Contraception (2009) 1.92

Effect of early infant feeding practices on infection-specific neonatal mortality: an investigation of the causal links with observational data from rural Ghana. Am J Clin Nutr (2007) 1.82

Effectiveness and efficacy of zinc for the treatment of acute diarrhea in young children. Pediatrics (2002) 1.81

Impact of free delivery care on health facility delivery and insurance coverage in Ghana's Brong Ahafo Region. PLoS One (2012) 1.79

Time to initiation of breastfeeding and neonatal mortality and morbidity: a systematic review. BMC Public Health (2013) 1.75

An educational intervention to promote appropriate complementary feeding practices and physical growth in infants and young children in rural Haryana, India. J Nutr (2004) 1.74

Scaling up diarrhea prevention and treatment interventions: a Lives Saved Tool analysis. PLoS Med (2011) 1.72

Patterns of age-specific mortality in children in endemic areas of sub-Saharan Africa. Am J Trop Med Hyg (2007) 1.70

Why are 4 million newborn babies dying every year? Lancet (2004) 1.69

Effect of geographical access to health facilities on child mortality in rural Ethiopia: a community based cross sectional study. PLoS One (2012) 1.68

Timing of breastfeeding initiation and exclusivity of breastfeeding during the first month of life: effects on neonatal mortality and morbidity--a systematic review and meta-analysis. Matern Child Health J (2015) 1.64

Nutritional status and mortality among HIV-infected patients receiving antiretroviral therapy in Tanzania. J Infect Dis (2011) 1.63

Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. J Cell Biochem (2005) 1.62

Lay health worker led intervention for depressive and anxiety disorders in India: impact on clinical and disability outcomes over 12 months. Br J Psychiatry (2011) 1.61

Maternal and perinatal health research priorities beyond 2015: an international survey and prioritization exercise. Reprod Health (2014) 1.61

Neonatal vitamin A supplementation and infant survival. Lancet (2010) 1.59

Setting research priorities to reduce global mortality from preterm birth and low birth weight by 2015. J Glob Health (2012) 1.58

A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr (2010) 1.58

Aetiology and clinical presentation of pneumonia in hospitalized and outpatient children in Northeast Brazil and risk factors for severity. J Health Popul Nutr (2005) 1.58

Scientific rationale for a change in the composition of oral rehydration solution. JAMA (2004) 1.57

Conclusions of the Joint WHO/UNICEF/IAEA/IZiNCG Interagency Meeting on Zinc Status Indicators. Food Nutr Bull (2007) 1.55

Improving quality of care for maternal and newborn health: prospective pilot study of the WHO safe childbirth checklist program. PLoS One (2012) 1.55

Limited progress in increasing coverage of neonatal and child-health interventions in Africa and Asia. J Health Popul Nutr (2009) 1.55