Published in PLoS Biol on February 21, 2012
Transcription elongation and tissue-specific somatic CAG instability. PLoS Genet (2012) 1.01
DNA mismatch repair complex MutSβ promotes GAA·TTC repeat expansion in human cells. J Biol Chem (2012) 0.97
Repeat instability during DNA repair: Insights from model systems. Crit Rev Biochem Mol Biol (2015) 0.97
Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. Curr Pharm Des (2013) 0.93
MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells. Nucleic Acids Res (2012) 0.92
Structural insight into the separate roles of inositol tetraphosphate and deacetylase-activating domain in activation of histone deacetylase 3. Protein Sci (2012) 0.88
Histone deacetylase complexes as caretakers of genome stability. Epigenetics (2012) 0.88
Polyglutamine (polyQ) disorders: the chromatin connection. Nucleus (2012) 0.88
DNA triplet repeat expansion and mismatch repair. Annu Rev Biochem (2015) 0.88
Expanded complexity of unstable repeat diseases. Biofactors (2012) 0.87
Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age. Hum Mol Genet (2013) 0.84
Histone deacetylase-3 interacts with ataxin-7 and is altered in a spinocerebellar ataxia type 7 mouse model. Mol Neurodegener (2013) 0.83
NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps. Mol Cell (2014) 0.81
Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors. Pharmaceuticals (Basel) (2014) 0.80
The role of break-induced replication in large-scale expansions of (CAG)n/(CTG)n repeats. Nat Struct Mol Biol (2016) 0.80
GFP-based fluorescence assay for CAG repeat instability in cultured human cells. PLoS One (2014) 0.79
Coupling transcriptional state to large-scale repeat expansions in yeast. Cell Rep (2014) 0.78
The 26S proteasome drives trinucleotide repeat expansions. Nucleic Acids Res (2013) 0.78
Trinucleotide repeat expansions catalyzed by human cell-free extracts. Cell Res (2013) 0.78
Muscle wasting in myotonic dystrophies: a model of premature aging. Front Aging Neurosci (2015) 0.77
Histone Deacetylase 4 (HDAC4) Inhibitors: A Promising Treatment for Huntington's Disease. ACS Med Chem Lett (2013) 0.75
Enzyme inhibitor may offer dual protection against brain disease. PLoS Biol (2012) 0.75
MSH3 Promotes Dynamic Behavior of Trinucleotide Repeat Tracts In Vivo. Genetics (2015) 0.75
Translating HDAC inhibitors in Friedrich's ataxia. Expert Opin Orphan Drugs (2016) 0.75
Statistical Enrichment of Epigenetic States Around Triplet Repeats that Can Undergo Expansions. Front Neurosci (2016) 0.75
MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions. Nucleic Acids Res (2017) 0.75
Selective extraction of polyoma DNA from infected mouse cell cultures. J Mol Biol (1967) 106.91
Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell (1991) 12.27
Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell (2005) 10.68
Trinucleotide repeat disorders. Annu Rev Neurosci (2007) 9.45
The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
Expandable DNA repeats and human disease. Nature (2007) 5.50
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov (2008) 4.43
Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature (1998) 4.43
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia. Nat Chem Biol (2006) 4.25
The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell (2002) 4.23
Isolation and characterization of cDNAs corresponding to an additional member of the human histone deacetylase gene family. J Biol Chem (1997) 4.16
Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin. Mol Cell (2001) 4.06
Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell (2007) 3.86
Histone acetylation regulates the time of replication origin firing. Mol Cell (2002) 3.67
Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A (2000) 3.46
Repeat instability as the basis for human diseases and as a potential target for therapy. Nat Rev Mol Cell Biol (2010) 3.09
OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature (2007) 3.03
HDACs link the DNA damage response, processing of double-strand breaks and autophagy. Nature (2011) 3.01
CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat Genet (2001) 2.93
The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size. Am J Hum Genet (1997) 2.84
Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Nat Genet (1999) 2.77
(CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol (2005) 2.71
Mechanisms of trinucleotide repeat instability during human development. Nat Rev Genet (2010) 2.67
Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression. Mol Cell Biol (2001) 2.64
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins. Hum Mol Genet (2002) 2.48
CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease. Science (2007) 2.45
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proc Natl Acad Sci U S A (2008) 2.37
Trinucleotide expansion in haploid germ cells by gap repair. Nat Genet (2001) 2.21
Trinucleotide repeats in neurogenetic disorders. Annu Rev Neurosci (1996) 2.17
The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae. Mol Cell Biol (2004) 2.10
Histone deacetylase inhibitors as therapeutics for polyglutamine disorders. Nat Rev Neurosci (2006) 2.07
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev (2008) 2.01
CTG repeat instability and size variation timing in DNA repair-deficient mice. EMBO J (2003) 1.96
Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum. Hum Mol Genet (2003) 1.92
Orientation-dependent and sequence-specific expansions of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1998) 1.90
Dynamic changes in histone acetylation regulate origins of DNA replication. Nat Struct Mol Biol (2010) 1.82
Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev (2009) 1.78
CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination. PLoS Genet (2008) 1.72
Pms2 is a genetic enhancer of trinucleotide CAG.CTG repeat somatic mosaicism: implications for the mechanism of triplet repeat expansion. Hum Mol Genet (2004) 1.71
Chemical probes identify a role for histone deacetylase 3 in Friedreich's ataxia gene silencing. Chem Biol (2009) 1.70
Single sperm analysis of the trinucleotide repeats in the Huntington's disease gene: quantification of the mutation frequency spectrum. Hum Mol Genet (1995) 1.67
Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain. Hum Mol Genet (2007) 1.57
Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats. Mol Cell Biol (2004) 1.32
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Hum Mol Genet (2008) 1.28
Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1. Hum Mol Genet (2011) 1.12
Cis-elements governing trinucleotide repeat instability in Saccharomyces cerevisiae. Genetics (2001) 1.09
Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae. Genetics (2009) 1.01
Expansions of CAG.CTG repeats in immortalized human astrocytes. Hum Mol Genet (2007) 0.96
Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats. Mol Cell Biol (2004) 1.32
Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption. Nucleic Acids Res (2009) 1.21
Mrc1, Tof1 and Csm3 inhibit CAG.CTG repeat instability by at least two mechanisms. DNA Repair (Amst) (2008) 1.14
Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae. Mol Cell Biol (2006) 1.05
Expansions of CAG.CTG repeats in immortalized human astrocytes. Hum Mol Genet (2007) 0.96
Mechanistic features of CAG*CTG repeat contractions in cultured cells revealed by a novel genetic assay. Nucleic Acids Res (2005) 0.93
Srs2 helicase of Saccharomyces cerevisiae selectively unwinds triplet repeat DNA. J Biol Chem (2005) 0.92
Identification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiae. Genetics (2002) 0.92
MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells. Nucleic Acids Res (2012) 0.92
New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion. PLoS Genet (2011) 0.90
Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res (2008) 0.90
Histone deacetylase complexes as caretakers of genome stability. Epigenetics (2012) 0.88
DNA elements important for CAG*CTG repeat thresholds in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.86
Examining the potential role of DNA polymerases eta and zeta in triplet repeat instability in yeast. DNA Repair (Amst) (2002) 0.85
CAG*CTG repeat instability in cultured human astrocytes. Nucleic Acids Res (2006) 0.85
Rev1 enhances CAG.CTG repeat stability in Saccharomyces cerevisiae. DNA Repair (Amst) (2006) 0.85
Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae. PLoS One (2008) 0.85
Genetic assays for triplet repeat instability in yeast. Methods Mol Biol (2004) 0.83
DNA polymerase delta, RFC and PCNA are required for repair synthesis of large looped heteroduplexes in Saccharomyces cerevisiae. Nucleic Acids Res (2004) 0.81
The bacterial secondary metabolite 2,4-diacetylphloroglucinol impairs mitochondrial function and affects calcium homeostasis in Neurospora crassa. Fungal Genet Biol (2013) 0.80
Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae. Nucleic Acids Res (2008) 0.79
Trinucleotide repeat expansions catalyzed by human cell-free extracts. Cell Res (2013) 0.78
The 26S proteasome drives trinucleotide repeat expansions. Nucleic Acids Res (2013) 0.78
Solid phase 4'-phosphopantetheinylation: fungal thiolation domains are targets for chemoenzymatic modification. Bioconjug Chem (2009) 0.78
RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility. Cell Rep (2016) 0.75