Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility.
|
Nat Genet
|
2011
|
2.43
|
2
|
Towards the human colorectal cancer microbiome.
|
PLoS One
|
2011
|
2.30
|
3
|
Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.
|
Crit Care Med
|
2009
|
1.93
|
4
|
Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial.
|
Crit Care
|
2012
|
1.76
|
5
|
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
PLoS Genet
|
2011
|
1.68
|
6
|
A functional polymorphism in UGT1A1 related to hyperbilirubinemia is associated with a decreased risk for Crohn's disease.
|
J Crohns Colitis
|
2011
|
1.54
|
7
|
Inflammation-induced hepatotoxicity in humans.
|
Shock
|
2009
|
1.40
|
8
|
Liver manipulation causes hepatocyte injury and precedes systemic inflammation in patients undergoing liver resection.
|
World J Surg
|
2007
|
1.20
|
9
|
Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.
|
Clin J Am Soc Nephrol
|
2006
|
1.17
|
10
|
Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men.
|
PLoS One
|
2011
|
1.10
|
11
|
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer.
|
Mutat Res
|
2005
|
1.01
|
12
|
Small increases in the urinary excretion of glutathione S-transferase A1 and P1 after cardiac surgery are not associated with clinically relevant renal injury.
|
Intensive Care Med
|
2005
|
1.00
|
13
|
High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.
|
Int J Oncol
|
2012
|
0.95
|
14
|
GWAS-uncovered SNPs in PLCE1 and RFT2 genes are not implicated in Dutch esophageal adenocarcinoma and squamous cell carcinoma etiology.
|
Eur J Cancer Prev
|
2013
|
0.95
|
15
|
Expression of glutathione S-transferases (GSTs) in human colon cells and inducibility of GSTM2 by butyrate.
|
Carcinogenesis
|
2003
|
0.94
|
16
|
Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno- or squamous cell carcinoma.
|
World J Gastroenterol
|
2009
|
0.93
|
17
|
COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk.
|
World J Gastroenterol
|
2009
|
0.93
|
18
|
Genetic polymorphisms of smoking-related carcinogen detoxifying enzymes and head and neck cancer susceptibility.
|
Anticancer Res
|
2009
|
0.92
|
19
|
Dipyridamole augments the antiinflammatory response during human endotoxemia.
|
Crit Care
|
2011
|
0.92
|
20
|
Barrett associated MHC and FOXF1 variants also increase esophageal carcinoma risk.
|
Int J Cancer
|
2013
|
0.91
|
21
|
Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population.
|
Oncol Res
|
2010
|
0.90
|
22
|
The gut fermentation product butyrate, a chemopreventive agent, suppresses glutathione S-transferase theta (hGSTT1) and cell growth more in human colon adenoma (LT97) than tumor (HT29) cells.
|
J Cancer Res Clin Oncol
|
2005
|
0.90
|
23
|
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.
|
Int J Cancer
|
2004
|
0.89
|
24
|
Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways.
|
Biochim Biophys Acta
|
2008
|
0.89
|
25
|
Habitual consumption of fruits and vegetables: associations with human rectal glutathione S-transferase.
|
Carcinogenesis
|
2004
|
0.89
|
26
|
Isoniazid and its toxic metabolite hydrazine induce in vitro pyrazinamide toxicity.
|
Int J Antimicrob Agents
|
2008
|
0.88
|
27
|
A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.
|
Cancer Epidemiol Biomarkers Prev
|
2011
|
0.88
|
28
|
The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial.
|
Haematologica
|
2013
|
0.88
|
29
|
Vitamin B12 status and its association with Helicobacter pylori infection in alcohol dependent patients.
|
J Nutr Sci Vitaminol (Tokyo)
|
2004
|
0.87
|
30
|
Chromosomal and methylation alterations in sporadic and familial adenomatous polyposis-related duodenal carcinomas.
|
Mod Pathol
|
2007
|
0.86
|
31
|
No association between genetic polymorphisms in NAD(P)H oxidase p22phox and paraoxonase 1 and colorectal cancer risk.
|
Anticancer Res
|
2005
|
0.86
|
32
|
Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells.
|
Exp Cell Res
|
2012
|
0.86
|
33
|
Short report: Severe Plasmodium falciparum malaria in Cameroon: associated with the glutathione S-transferase M1 null genotype.
|
Am J Trop Med Hyg
|
2006
|
0.86
|
34
|
Genetic polymorphisms in alcohol-metabolizing enzymes and chronic pancreatitis.
|
Alcohol Alcohol
|
2003
|
0.85
|
35
|
Glutathione and glutathione S-transferases A1-1 and P1-1 in seminal plasma may play a role in protecting against oxidative damage to spermatozoa.
|
Fertil Steril
|
2003
|
0.85
|
36
|
Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.
|
Anticancer Res
|
2004
|
0.85
|
37
|
Assessment of oxidative stress in chronic pancreatitis patients.
|
World J Gastroenterol
|
2006
|
0.85
|
38
|
Short-term beneficial effects of methylene blue on kidney damage in septic shock patients.
|
Intensive Care Med
|
2007
|
0.84
|
39
|
Polymorphisms of the glutathione S-transferase P1 gene and head and neck cancer susceptibility.
|
Head Neck
|
2003
|
0.83
|
40
|
EPHX1 polymorphisms do not modify esophageal carcinoma susceptibility in Dutch Caucasians.
|
Oncol Rep
|
2012
|
0.83
|
41
|
Microsomal epoxide hydrolase genotypes and the risk for head and neck cancer.
|
Head Neck
|
2008
|
0.83
|
42
|
Polymorphisms in genes encoding acetylsalicylic acid metabolizing enzymes are unrelated to upper gastrointestinal health in cardiovascular patients on acetylsalicylic acid.
|
Br J Clin Pharmacol
|
2005
|
0.83
|
43
|
Orofacial clefts and spina bifida: N-acetyltransferase phenotype, maternal smoking, and medication use.
|
Teratology
|
2002
|
0.83
|
44
|
Low plasma levels of oxidized low density lipoprotein in preeclampsia.
|
Acta Obstet Gynecol Scand
|
2004
|
0.82
|
45
|
GSTP1-1 in ovarian cyst fluid and disease outcome of patients with ovarian cancer.
|
Cancer Epidemiol Biomarkers Prev
|
2009
|
0.81
|
46
|
N-acetylcysteine restores nitric oxide-mediated effects in the fetoplacental circulation of preeclamptic patients.
|
Am J Obstet Gynecol
|
2004
|
0.81
|
47
|
Glutathione S-transferase Mu null genotype affords protection against alcohol induced chronic pancreatitis.
|
Am J Med Genet A
|
2003
|
0.81
|
48
|
Proteomic inventory of "anchorless" proteins on the colon adenocarcinoma cell surface.
|
Biochim Biophys Acta
|
2006
|
0.81
|
49
|
Prognostic value of free plasma homocysteine levels in patients hospitalized with acute coronary syndrome.
|
Am J Cardiol
|
2008
|
0.81
|
50
|
Ursodeoxycholic acid intervention in patients with familial adenomatous polyposis: a pilot study.
|
Transl Res
|
2007
|
0.81
|
51
|
Functional polymorphisms of UDP-glucuronosyltransferases 1A1, 1A6 and 1A8 are not involved in chronic pancreatitis.
|
Pharmacogenetics
|
2004
|
0.81
|
52
|
Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury.
|
Crit Care
|
2011
|
0.81
|
53
|
High oxygen radical production in patients with sporadic colorectal cancer.
|
Free Radic Biol Med
|
2005
|
0.81
|
54
|
The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease.
|
PLoS One
|
2010
|
0.80
|
55
|
HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone.
|
Hypertens Pregnancy
|
2008
|
0.80
|
56
|
Genetic polymorphism in the conjugating enzyme UGT1A1 and the risk of head and neck cancer.
|
Int J Cancer
|
2010
|
0.80
|
57
|
Maternal antioxidant concentrations after uncomplicated pregnancies.
|
Free Radic Res
|
2005
|
0.79
|
58
|
Genistein protects human mammary epithelial cells from benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide and 4-hydroxy-2-nonenal genotoxicity by modulating the glutathione/glutathione S-transferase system.
|
Carcinogenesis
|
2006
|
0.79
|
59
|
The I,105V polymorphism in glutathione S-transferase P1, parental smoking and the risk for nonsyndromic cleft lip with or without cleft palate.
|
Eur J Hum Genet
|
2008
|
0.79
|
60
|
Effects of oral N-acetylcysteine on plasma homocysteine and whole blood glutathione levels in healthy, non-pregnant women.
|
Clin Chem Lab Med
|
2002
|
0.79
|
61
|
Assessment of plasma aminothiol levels and the association with recurrent atherothrombotic events in patients hospitalized for an acute coronary syndrome: a prospective study.
|
Clin Chem Lab Med
|
2013
|
0.79
|
62
|
Distribution of components of the glutathione detoxification system across the human placenta after uncomplicated vaginal deliveries.
|
Placenta
|
2002
|
0.79
|
63
|
The transient increase of oxidative stress during normal pregnancy is higher and persists after delivery in women with pre-eclampsia.
|
Eur J Obstet Gynecol Reprod Biol
|
2007
|
0.79
|
64
|
No role for glutathione S-transferase genotypes in Caucasian esophageal squamous cell or adenocarcinoma etiology: an European case-control study.
|
BMC Gastroenterol
|
2013
|
0.78
|
65
|
Effect of genetic polymorphisms in UDP-glucuronosyltransferase 1A6 (UGT1A6) on acetylsalicylic acid metabolism in healthy female volunteers.
|
Pharmacology
|
2009
|
0.78
|
66
|
The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97.
|
Nutr Cancer
|
2012
|
0.78
|
67
|
Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: a Dutch Caucasian case-control study.
|
J Hum Genet
|
2013
|
0.78
|
68
|
Combined effect of genetic polymorphisms in phase I and II biotransformation enzymes on head and neck cancer risk.
|
Head Neck
|
2012
|
0.78
|
69
|
Association of aspirin use with vitamin B12 deficiency (results of the BACH study).
|
Am J Cardiol
|
2004
|
0.78
|
70
|
Umbilical glutathione levels are higher after vaginal birth than after cesarean section.
|
J Perinat Med
|
2003
|
0.78
|
71
|
Allopurinol and 5-aminosalicylic acid influence thiopurine-induced hepatotoxicity in vitro.
|
Cell Biol Toxicol
|
2015
|
0.78
|
72
|
The C50T polymorphism of the cyclooxygenase-1 gene and the risk of thrombotic events during low-dose therapy with acetyl salicylic acid.
|
Thromb Haemost
|
2008
|
0.77
|
73
|
The association between glutathione S-transferase P1 genotype and plasma level in head and neck cancer.
|
Laryngoscope
|
2002
|
0.77
|
74
|
N-Acetylcysteine improves the disturbed thiol redox balance after methionine loading.
|
Clin Sci (Lond)
|
2003
|
0.77
|
75
|
Ursodeoxycholic acid counteracts celecoxib in reduction of duodenal polyps in patients with familial adenomatous polyposis: a multicentre, randomized controlled trial.
|
Orphanet J Rare Dis
|
2013
|
0.77
|
76
|
No evidence for oxidative stress in patients on home parenteral nutrition.
|
Clin Nutr
|
2006
|
0.77
|
77
|
A longitudinal study of antioxidant status during uncomplicated and hypertensive pregnancies.
|
Acta Obstet Gynecol Scand
|
2006
|
0.77
|
78
|
Thiol status and antioxidant capacity in women with a history of severe pre-eclampsia.
|
BJOG
|
2004
|
0.76
|
79
|
Susceptibility to pre-eclampsia is associated with multiple genetic polymorphisms in maternal biotransformation enzymes.
|
Gynecol Obstet Invest
|
2006
|
0.76
|
80
|
Genetic polymorphisms in the tobacco smoke carcinogens detoxifying enzyme UGT1A7 and the risk of head and neck cancer.
|
Head Neck
|
2009
|
0.76
|
81
|
Infliximab exerts no direct hepatotoxic effect on HepG2 cells in vitro.
|
Dig Dis Sci
|
2012
|
0.76
|
82
|
Duodenal mucosal risk markers in patients with familial adenomatous polyposis: effects of celecoxib/ursodeoxycholic acid co-treatment and comparison with patient controls.
|
Orphanet J Rare Dis
|
2013
|
0.76
|
83
|
Disparities of conjugating protective enzyme activities in the colon of patients with adenomas and carcinomas.
|
World J Gastroenterol
|
2013
|
0.76
|
84
|
Loss of extracellular E-cadherin in the normal mucosa of duodenum and colon of patients with familial adenomatous polyposis.
|
Hum Pathol
|
2006
|
0.76
|
85
|
Low detoxification capacity in the ileal pouch mucosa of patients with ulcerative colitis.
|
Inflamm Bowel Dis
|
2006
|
0.76
|
86
|
Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis.
|
Int J Colorectal Dis
|
2011
|
0.75
|
87
|
Glutathione S-transferase phenotypes in relation to genetic variation and fruit and vegetable consumption in an endoscopy-based population.
|
Carcinogenesis
|
2006
|
0.75
|
88
|
N-acetyl-transferase phenotype and risk for preeclampsia.
|
Am J Obstet Gynecol
|
2005
|
0.75
|
89
|
Paraoxonase 1-192Q allele is a risk factor for idiopathic chronic pancreatitis.
|
Mol Diagn
|
2005
|
0.75
|
90
|
Hydrazine-induced liver toxicity is enhanced by glutathione depletion but is not mediated by oxidative stress in HepG2 cells.
|
Int J Antimicrob Agents
|
2009
|
0.75
|
91
|
The Tyr113His polymorphism in exon 3 of the microsomal epoxide hydrolase gene is a risk factor for perinatal mortality.
|
Acta Obstet Gynecol Scand
|
2004
|
0.75
|
92
|
Xanthine oxidase inhibition by allopurinol increases in vitro pyrazinamide-induced hepatotoxicity in HepG2 cells.
|
Drug Chem Toxicol
|
2010
|
0.75
|
93
|
Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage.
|
Drug Metab Lett
|
2009
|
0.75
|