PubRank

Arthur I Cederbaum

Author PubWeight™ 95.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanisms of hepatotoxicity. Toxicol Sci 2002 4.13
2 CYP2E1 and oxidative liver injury by alcohol. Free Radic Biol Med 2007 2.93
3 Alcohol and oxidative liver injury. Hepatology 2006 2.50
4 Alcohol, oxidative stress, and free radical damage. Alcohol Res Health 2003 2.19
5 Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice. Hepatology 2008 1.90
6 Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 2004 1.83
7 Oxidative stress and alcoholic liver disease. Semin Liver Dis 2009 1.81
8 Cytokines in alcoholic liver disease. Arch Toxicol 2012 1.74
9 Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production. J Clin Invest 2004 1.67
10 A high-fat diet leads to the progression of non-alcoholic fatty liver disease in obese rats. FASEB J 2004 1.53
11 Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. Free Radic Biol Med 2010 1.47
12 Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem 2002 1.43
13 Nrf2 is increased by CYP2E1 in rodent liver and HepG2 cells and protects against oxidative stress caused by CYP2E1. Hepatology 2006 1.40
14 Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology 2002 1.40
15 CYP2E1: biochemistry, toxicology, regulation and function in ethanol-induced liver injury. Curr Mol Med 2003 1.38
16 Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase. Hepatology 2003 1.16
17 Lipopolysaccharide-induced liver injury in rats treated with the CYP2E1 inducer pyrazole. Am J Physiol Gastrointest Liver Physiol 2005 1.11
18 Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1. Free Radic Biol Med 2005 1.08
19 Binge ethanol exposure increases liver injury in obese rats. Gastroenterology 2003 1.08
20 Cisplatin-induced hepatotoxicity is enhanced by elevated expression of cytochrome P450 2E1. Toxicol Sci 2005 1.04
21 Overexpression of CYP2E1 in mitochondria sensitizes HepG2 cells to the toxicity caused by depletion of glutathione. J Biol Chem 2005 1.02
22 Role of cytochrome P450 in phospholipase A2- and arachidonic acid-mediated cytotoxicity. Free Radic Biol Med 2005 1.02
23 Oxidative stress mediated toxicity exerted by ethanol-inducible CYP2E1. Toxicol Appl Pharmacol 2005 1.01
24 Enhancement by pyrazole of lipopolysaccharide-induced liver injury in mice: role of cytochrome P450 2E1 and 2A5. Hepatology 2006 1.01
25 Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. Toxicol Sci 2012 1.00
26 Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free Radic Biol Med 2012 0.99
27 Diallyl sulfide induces heme oxygenase-1 through MAPK pathway. Arch Biochem Biophys 2004 0.99
28 Role of the proteasome in ethanol-induced liver pathology. Alcohol Clin Exp Res 2007 0.99
29 Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice. Hepatology 2005 0.98
30 Ethanol induction of CYP2A5: permissive role for CYP2E1. Drug Metab Dispos 2010 0.98
31 Role of p38 MAPK in CYP2E1-dependent arachidonic acid toxicity. J Biol Chem 2002 0.98
32 Mitochondrial alterations in livers of Sod1-/- mice fed alcohol. Free Radic Biol Med 2007 0.97
33 Development and properties of HepG2 cells that constitutively express CYP2E1. Methods Mol Biol 2008 0.96
34 S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter. J Biol Chem 2005 0.96
35 Catalase protects HepG2 cells from apoptosis induced by DNA-damaging agents by accelerating the degradation of p53. J Biol Chem 2002 0.95
36 Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. Redox Biol 2013 0.94
37 Pyrazole induced oxidative liver injury independent of CYP2E1/2A5 induction due to Nrf2 deficiency. Toxicology 2008 0.94
38 Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med 2012 0.94
39 Role of apoptosis in alcoholic liver injury. Alcohol Clin Exp Res 2003 0.94
40 Antioxidant and pro-oxidant effects of a manganese porphyrin complex against CYP2E1-dependent toxicity. Free Radic Biol Med 2002 0.93
41 The effect of CYP2E1-dependent oxidant stress on activity of proteasomes in HepG2 cells. J Pharmacol Exp Ther 2005 0.93
42 Induction of cytochrome P450 2E1 [corrected] promotes liver injury in ob/ob mice. Hepatology 2007 0.93
43 Cycloheximide protects HepG2 cells from serum withdrawal-induced apoptosis by decreasing p53 and phosphorylated p53 levels. J Pharmacol Exp Ther 2006 0.92
44 Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1. Arch Biochem Biophys 2006 0.92
45 Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1. Arch Biochem Biophys 2006 0.91
46 CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. Genes Nutr 2009 0.91
47 Transcription factor Nrf2 protects HepG2 cells against CYP2E1 plus arachidonic acid-dependent toxicity. J Biol Chem 2006 0.91
48 CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert Opin Drug Metab Toxicol 2005 0.91
49 Increased expression of cytochrome P450 2E1 induces heme oxygenase-1 through ERK MAPK pathway. J Biol Chem 2003 0.90
50 Antioxidant properties of S-adenosyl-L-methionine in Fe(2+)-initiated oxidations. Free Radic Biol Med 2004 0.90
51 Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway. Arch Biochem Biophys 2007 0.89
52 Inhibition of CYP2E1 catalytic activity in vitro by S-adenosyl-L-methionine. Biochem Pharmacol 2005 0.89
53 Heme oxygenase-1 protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Free Radic Biol Med 2004 0.88
54 Opposite action of S-adenosyl methionine and its metabolites on CYP2E1-mediated toxicity in pyrazole-induced rat hepatocytes and HepG2 E47 cells. Am J Physiol Gastrointest Liver Physiol 2005 0.88
55 Increased Sp1-dependent transactivation of the LAMgamma 1 promoter in hepatic stellate cells co-cultured with HepG2 cells overexpressing cytochrome P450 2E1. J Biol Chem 2003 0.88
56 Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice. Toxicol Sci 2006 0.88
57 Role of calcium and calcium-activated proteases in CYP2E1-dependent toxicity in HEPG2 cells. J Biol Chem 2001 0.88
58 Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. Arch Biochem Biophys 2007 0.87
59 Green tea polyphenol epigallocatechin-3-gallate protects HepG2 cells against CYP2E1-dependent toxicity. Free Radic Biol Med 2004 0.87
60 Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. FASEB J 2011 0.87
61 Adenovirus-mediated expression of Cu/Zn- or Mn-superoxide dismutase protects against CYP2E1-dependent toxicity. Hepatology 2003 0.86
62 Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med 2006 0.86
63 Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1. Free Radic Biol Med 2006 0.86
64 S-adenosyl-L-methionine attenuates hepatotoxicity induced by agonistic Jo2 Fas antibody following CYP2E1 induction in mice. J Pharmacol Exp Ther 2005 0.85
65 Role of phosphatidylinositol 3-kinase/AKT as a survival pathway against CYP2E1-dependent toxicity. J Pharmacol Exp Ther 2006 0.84
66 Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo. Free Radic Biol Med 2013 0.84
67 Geldanamycin, an inhibitor of Hsp90, potentiates cytochrome P4502E1-mediated toxicity in HepG2 cells. J Pharmacol Exp Ther 2006 0.84
68 Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria. Hepatology 2002 0.84
69 Role of phospholipase A2 activation and calcium in CYP2E1-dependent toxicity in HepG2 cells. J Biol Chem 2003 0.84
70 Metabolism of a liver-selective nitric oxide-releasing agent, V-PYRRO/NO, by human microsomal cytochromes P450. Nitric Oxide 2006 0.83
71 Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells. Free Radic Biol Med 2011 0.83
72 Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability. Am J Physiol Gastrointest Liver Physiol 2013 0.83
73 Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free Radic Biol Med 2009 0.82
74 Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice. Hepatology 2011 0.82
75 The liver-selective nitric oxide donor O2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (V-PYRRO/NO) protects HepG2 cells against cytochrome P450 2E1-dependent toxicity. Mol Pharmacol 2004 0.81
76 Adenovirus mediated overexpression of CYP2E1 increases sensitivity of HepG2 cells to acetaminophen induced cytotoxicity. Mol Cell Biochem 2004 0.80
77 Synergistic toxicity induced by prolonged glutathione depletion and inhibition of nuclear factor-kappaB signaling in liver cells. Toxicol In Vitro 2007 0.80
78 Toxicity by pyruvate in HepG2 cells depleted of glutathione: role of mitochondria. Free Radic Biol Med 2002 0.80
79 Metallothionein 2A induction by zinc protects HEPG2 cells against CYP2E1-dependent toxicity. Free Radic Biol Med 2003 0.80
80 Ca2+-dependent and independent mitochondrial damage in HepG2 cells that overexpress CYP2E1. Arch Biochem Biophys 2002 0.79
81 CYP2E1 overexpression inhibits microsomal Ca2+-ATPase activity in HepG2 cells. Toxicology 2008 0.79
82 Proteasome inhibition potentiates CYP2E1-mediated toxicity in HepG2 cells. Hepatology 2003 0.79
83 Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice. Free Radic Biol Med 2008 0.79
84 Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol. Alcohol Clin Exp Res 2005 0.79
85 Protein kinase C signaling as a survival pathway against CYP2E1-derived oxidative stress and toxicity in HepG2 cells. J Pharmacol Exp Ther 2004 0.78
86 S-adenosyl-L-methionine decreases the elevated hepatotoxicity induced by Fas agonistic antibody plus acute ethanol pretreatment in mice. Arch Biochem Biophys 2008 0.78
87 S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury. Am J Physiol Gastrointest Liver Physiol 2007 0.78
88 Cytochrome P450 2E1 responsiveness in the promoter of glutamate-cysteine ligase catalytic subunit. Hepatology 2003 0.77
89 Adenovirus-mediated overexpression of catalase in the cytosolic or mitochondrial compartment protects against toxicity caused by glutathione depletion in HepG2 cells expressing CYP2E1. J Pharmacol Exp Ther 2002 0.75
90 Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver. Alcohol 2013 0.75
91 Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters. Pharmacology 2003 0.75