1
|
Biological, clinical and population relevance of 95 loci for blood lipids.
|
Nature
|
2010
|
28.21
|
2
|
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
|
Nat Genet
|
2010
|
17.89
|
3
|
Simvastatin with or without ezetimibe in familial hypercholesterolemia.
|
N Engl J Med
|
2008
|
14.01
|
4
|
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
|
Nature
|
2011
|
13.25
|
5
|
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
|
Nat Genet
|
2008
|
12.32
|
6
|
Genome-wide association study of blood pressure and hypertension.
|
Nat Genet
|
2009
|
11.54
|
7
|
High serum uric acid as a novel risk factor for type 2 diabetes.
|
Diabetes Care
|
2007
|
4.69
|
8
|
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|
Nat Genet
|
2012
|
4.37
|
9
|
Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels.
|
Circulation
|
2011
|
3.68
|
10
|
Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial.
|
JAMA
|
2004
|
3.55
|
11
|
Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
|
Diabetes
|
2008
|
3.54
|
12
|
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
|
Nat Genet
|
2011
|
3.40
|
13
|
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
|
PLoS Genet
|
2012
|
3.21
|
14
|
Efficacy of statins in familial hypercholesterolaemia: a long term cohort study.
|
BMJ
|
2008
|
2.62
|
15
|
Evaluation of risk prediction updates from commercial genome-wide scans.
|
Genet Med
|
2009
|
2.30
|
16
|
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies.
|
Diabetes Care
|
2010
|
2.14
|
17
|
Improvement of risk prediction by genomic profiling: reclassification measures versus the area under the receiver operating characteristic curve.
|
Am J Epidemiol
|
2010
|
2.06
|
18
|
Eating fish and risk of type 2 diabetes: A population-based, prospective follow-up study.
|
Diabetes Care
|
2009
|
2.03
|
19
|
Genetic variation, C-reactive protein levels, and incidence of diabetes.
|
Diabetes
|
2007
|
1.86
|
20
|
Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia.
|
Lancet
|
2004
|
1.84
|
21
|
Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
|
Eur Heart J
|
2008
|
1.80
|
22
|
A genome-wide association search for type 2 diabetes genes in African Americans.
|
PLoS One
|
2012
|
1.72
|
23
|
The role of adiposity in cardiometabolic traits: a Mendelian randomization analysis.
|
PLoS Med
|
2013
|
1.70
|
24
|
SIRT1 genetic variation is related to BMI and risk of obesity.
|
Diabetes
|
2009
|
1.44
|
25
|
Prediction of 9-year cardiovascular outcomes by myocardial perfusion imaging in patients with normal exercise electrocardiographic testing.
|
Eur Heart J Cardiovasc Imaging
|
2012
|
1.44
|
26
|
Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations.
|
Circ Cardiovasc Genet
|
2011
|
1.44
|
27
|
Increased aortic stiffness and blood pressure in non-classic Pompe disease.
|
J Inherit Metab Dis
|
2014
|
1.44
|
28
|
The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy.
|
Circ Cardiovasc Genet
|
2010
|
1.41
|
29
|
Carotid intima-media thickness for cardiovascular risk assessment: systematic review and meta-analysis.
|
Atherosclerosis
|
2013
|
1.41
|
30
|
Long-term prognostic value of exercise technetium-99m tetrofosmin myocardial perfusion single-photon emission computed tomography.
|
J Nucl Cardiol
|
2012
|
1.41
|
31
|
Risk of type 2 diabetes attributable to C-reactive protein and other risk factors.
|
Diabetes Care
|
2007
|
1.34
|
32
|
Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy.
|
J Am Coll Cardiol
|
2010
|
1.20
|
33
|
Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study.
|
Eur J Epidemiol
|
2007
|
1.20
|
34
|
A prospective analysis of elevated fasting glucose levels and cognitive function in older people: results from PROSPER and the Rotterdam Study.
|
Diabetes
|
2010
|
1.17
|
35
|
A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research.
|
Curr Diab Rep
|
2011
|
1.16
|
36
|
Two years after molecular diagnosis of familial hypercholesterolemia: majority on cholesterol-lowering treatment but a minority reaches treatment goal.
|
PLoS One
|
2010
|
1.14
|
37
|
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.
|
Diabetes
|
2011
|
1.13
|
38
|
Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.
|
Circ Cardiovasc Genet
|
2011
|
1.11
|
39
|
Differences in characteristics and risk of cardiovascular disease in familial hypercholesterolemia patients with and without tendon xanthomas: a systematic review and meta-analysis.
|
Atherosclerosis
|
2009
|
1.11
|
40
|
Hepatic lipase: a pro- or anti-atherogenic protein?
|
J Lipid Res
|
2002
|
1.11
|
41
|
Value of genetic profiling for the prediction of coronary heart disease.
|
Am Heart J
|
2009
|
1.10
|
42
|
Liver X receptor activation restores memory in aged AD mice without reducing amyloid.
|
Neurobiol Aging
|
2009
|
1.06
|
43
|
Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism.
|
Diabetes
|
2009
|
1.05
|
44
|
Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population.
|
Circulation
|
2002
|
1.03
|
45
|
Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies.
|
Eur J Hum Genet
|
2008
|
1.02
|
46
|
Cascade Screening for Familial Hypercholesterolemia (FH).
|
PLoS Curr
|
2011
|
0.98
|
47
|
High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants.
|
Atherosclerosis
|
2007
|
0.98
|
48
|
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.
|
Free Radic Biol Med
|
2009
|
0.97
|
49
|
Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia.
|
Am J Cardiol
|
2008
|
0.97
|
50
|
Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine.
|
Diabetes Care
|
2012
|
0.95
|
51
|
Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study.
|
BMC Med
|
2008
|
0.95
|
52
|
Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis.
|
Hum Genet
|
2003
|
0.93
|
53
|
Molecular imaging of inflammation and intraplaque vasa vasorum: a step forward to identification of vulnerable plaques?
|
J Nucl Cardiol
|
2010
|
0.93
|
54
|
Outcome and complications after implantable cardioverter defibrillator therapy in hypertrophic cardiomyopathy: systematic review and meta-analysis.
|
Circ Heart Fail
|
2012
|
0.92
|
55
|
Far-wall pseudoenhancement during contrast-enhanced ultrasound of the carotid arteries: clinical description and in vitro reproduction.
|
Ultrasound Med Biol
|
2012
|
0.91
|
56
|
Family history and cardiovascular risk in familial hypercholesterolemia: data in more than 1000 children.
|
Circulation
|
2003
|
0.89
|
57
|
Glycemic index and glycemic load and their association with C-reactive protein and incident type 2 diabetes.
|
J Nutr Metab
|
2011
|
0.88
|
58
|
Current status and future developments of contrast-enhanced ultrasound of carotid atherosclerosis.
|
J Vasc Surg
|
2012
|
0.87
|
59
|
Usefulness of contrast-enhanced ultrasound for detection of carotid plaque ulceration in patients with symptomatic carotid atherosclerosis.
|
Am J Cardiol
|
2013
|
0.86
|
60
|
15-Year outcome after normal exercise ⁹⁹mTc-sestamibi myocardial perfusion imaging: what is the duration of low risk after a normal scan?
|
J Nucl Cardiol
|
2012
|
0.85
|
61
|
Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance.
|
Eur J Hum Genet
|
2007
|
0.85
|
62
|
Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large.
|
Exp Gerontol
|
2007
|
0.85
|
63
|
Meat consumption and its association with C-reactive protein and incident type 2 diabetes: the Rotterdam Study.
|
Diabetes Care
|
2012
|
0.84
|
64
|
Two common haplotypes of the glucocorticoid receptor gene are associated with increased susceptibility to cardiovascular disease in men with familial hypercholesterolemia.
|
J Clin Endocrinol Metab
|
2008
|
0.84
|
65
|
Interactions between dietary vitamin E intake and SIRT1 genetic variation influence body mass index.
|
Am J Clin Nutr
|
2010
|
0.84
|
66
|
ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia.
|
Atherosclerosis
|
2008
|
0.84
|
67
|
Assessment of subclinical atherosclerosis using contrast-enhanced ultrasound.
|
Eur Heart J Cardiovasc Imaging
|
2012
|
0.84
|
68
|
Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels.
|
J Clin Endocrinol Metab
|
2007
|
0.84
|
69
|
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia.
|
Atherosclerosis
|
2008
|
0.83
|
70
|
The risk of tendon xanthomas in familial hypercholesterolaemia is influenced by variation in genes of the reverse cholesterol transport pathway and the low-density lipoprotein oxidation pathway.
|
Eur Heart J
|
2009
|
0.83
|
71
|
Impact of an alerting clinical decision support system for glucose control on protocol compliance and glycemic control in the intensive cardiac care unit.
|
Diabetes Technol Ther
|
2011
|
0.82
|
72
|
Diagnostic value of post-heparin lipase testing in detecting common genetic variants in the LPL and LIPC genes.
|
Eur J Hum Genet
|
2009
|
0.82
|
73
|
Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial.
|
Circulation
|
2005
|
0.82
|
74
|
Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension.
|
Am J Hypertens
|
2012
|
0.82
|
75
|
A functional polymorphism in the glucocorticoid receptor gene and its relation to cardiovascular disease risk in familial hypercholesterolemia.
|
J Clin Endocrinol Metab
|
2006
|
0.82
|
76
|
Assessment of subclinical atherosclerosis and intraplaque neovascularization using quantitative contrast-enhanced ultrasound in patients with familial hypercholesterolemia.
|
Atherosclerosis
|
2013
|
0.82
|
77
|
Utility of contrast-enhanced ultrasound for the assessment of the carotid artery wall in patients with Takayasu or giant cell arteritis.
|
Eur Heart J Cardiovasc Imaging
|
2013
|
0.82
|
78
|
Effect of carotid plaque screening using contrast-enhanced ultrasound on cardiovascular risk stratification.
|
Am J Cardiol
|
2012
|
0.81
|
79
|
Gene-load score of the renin-angiotensin-aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia.
|
Eur Heart J
|
2008
|
0.81
|
80
|
Carotid plaque burden as a measure of subclinical coronary artery disease in patients with heterozygous familial hypercholesterolemia.
|
Am J Cardiol
|
2013
|
0.81
|
81
|
Daily red wine consumption improves vascular function by a soluble guanylyl cyclase-dependent pathway.
|
Am J Hypertens
|
2010
|
0.81
|
82
|
Carotid atherosclerosis progression in familial hypercholesterolemia patients: a pooled analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE studies.
|
Circ Cardiovasc Imaging
|
2010
|
0.81
|
83
|
Failing beta-cell adaptation in South Asian families with a high risk of type 2 diabetes.
|
Acta Diabetol
|
2014
|
0.80
|
84
|
The Prevention Of WEight Regain in diabetes type 2 (POWER) study: the effectiveness of adding a combined psychological intervention to a very low calorie diet, design and pilot data of a randomized controlled trial.
|
BMC Public Health
|
2012
|
0.80
|
85
|
Mortality risk of untreated myosin-binding protein C-related hypertrophic cardiomyopathy: insight into the natural history.
|
J Am Coll Cardiol
|
2011
|
0.80
|
86
|
A frequent variant in the ABCA1 gene is associated with increased coronary heart disease risk and a better response to statin treatment in familial hypercholesterolemia patients.
|
Eur Heart J
|
2010
|
0.79
|
87
|
Genetic factors are relevant and independent determinants of antihypertensive drug effects in a multiracial population.
|
Am J Hypertens
|
2009
|
0.79
|
88
|
Arterial stiffness and hypertension in a large population of untreated individuals: the Rotterdam Study.
|
J Hypertens
|
2014
|
0.79
|
89
|
Red wine extract protects against oxidative-stress-induced endothelial senescence.
|
Clin Sci (Lond)
|
2012
|
0.79
|
90
|
Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk.
|
Semin Vasc Med
|
2004
|
0.79
|
91
|
Plasma phospholipid transfer protein activity is decreased in type 2 diabetes during treatment with atorvastatin: a role for apolipoprotein E?
|
Diabetes
|
2006
|
0.79
|
92
|
Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia.
|
Eur Heart J
|
2008
|
0.79
|
93
|
Low-density lipoprotein receptor mutations generate synthetic genome-wide associations.
|
Eur J Hum Genet
|
2012
|
0.78
|
94
|
Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality.
|
Atherosclerosis
|
2011
|
0.78
|
95
|
Genetic polymorphisms in the DRD2, DRD3, and SLC6A3 gene in elderly patients with delirium.
|
Am J Med Genet B Neuropsychiatr Genet
|
2010
|
0.78
|
96
|
Mortality of inherited arrhythmia syndromes: insight into their natural history.
|
Circ Cardiovasc Genet
|
2012
|
0.78
|
97
|
The Diabetes Pearl: Diabetes biobanking in The Netherlands.
|
BMC Public Health
|
2012
|
0.77
|
98
|
The apolipoprotein epsilon4 allele confers additional risk in children with familial hypercholesterolemia.
|
Pediatr Res
|
2003
|
0.76
|
99
|
Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study.
|
Atherosclerosis
|
2004
|
0.76
|
100
|
Effect of low-density lipoprotein cholesterol on angiotensin II sensitivity: a randomized trial with fluvastatin.
|
Hypertension
|
2006
|
0.76
|
101
|
Patients with chronic gastrointestinal ischemia have a higher cardiovascular disease risk and mortality.
|
Atherosclerosis
|
2012
|
0.76
|
102
|
Nitrite- and nitroxyl-induced relaxation in porcine coronary (micro-) arteries: underlying mechanisms and role as endothelium-derived hyperpolarizing factor(s).
|
Pharmacol Res
|
2012
|
0.76
|
103
|
Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation: executive summary.
|
J Atheroscler Thromb
|
2014
|
0.76
|
104
|
5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia.
|
Atherosclerosis
|
2009
|
0.75
|
105
|
[Another indicator of correlation between cholesterol and type 2 diabetes mellitus].
|
Ned Tijdschr Geneeskd
|
2015
|
0.75
|
106
|
[Diabetologist 2.0; patients perform diabetic tests using a multilingual robot].
|
Ned Tijdschr Geneeskd
|
2014
|
0.75
|