1
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Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation.
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J Biol Chem
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2003
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2.12
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2
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Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.
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Clin Cancer Res
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2004
|
1.83
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3
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Transgenic overexpression of PKCε in the mouse prostate induces preneoplastic lesions.
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Cell Cycle
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2011
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1.74
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4
|
Complexity of VEGF responses in skin carcinogenesis revealed through ex vivo assays based on a VEGF-A null mouse keratinocyte cell line.
|
J Invest Dermatol
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2008
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1.42
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5
|
The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene.
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J Immunol
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2006
|
1.40
|
6
|
Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
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Mol Cell Biol
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2004
|
1.35
|
7
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Transcriptional regulation of estrogen receptor-alpha by p53 in human breast cancer cells.
|
Cancer Res
|
2009
|
1.26
|
8
|
Cdk4 deficiency inhibits skin tumor development but does not affect normal keratinocyte proliferation.
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Am J Pathol
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2002
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1.24
|
9
|
Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression.
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Neoplasia
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2008
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1.24
|
10
|
Interaction between genetic susceptibility and early-life environmental exposure determines tumor-suppressor-gene penetrance.
|
Proc Natl Acad Sci U S A
|
2005
|
1.19
|
11
|
Enhanced malignant tumorigenesis in Cdk4 transgenic mice.
|
Oncogene
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2004
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1.15
|
12
|
Carcinogenic effects of MGP-7 and B[a]P on the hamster cheek pouch.
|
Toxicol Pathol
|
2009
|
1.14
|
13
|
WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.
|
Genes Chromosomes Cancer
|
2007
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1.13
|
14
|
The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001.
|
Mol Carcinog
|
2012
|
1.12
|
15
|
Inactivation of E2f1 enhances tumorigenesis in a Myc transgenic model.
|
Cancer Res
|
2002
|
1.08
|
16
|
A critical role for ras-mediated, epidermal growth factor receptor-dependent angiogenesis in mouse skin carcinogenesis.
|
Cancer Res
|
2002
|
1.08
|
17
|
Tumor formation in mice with conditional inactivation of Brca1 in epithelial tissues.
|
Oncogene
|
2003
|
1.07
|
18
|
ARF differentially modulates apoptosis induced by E2F1 and Myc.
|
Mol Cell Biol
|
2002
|
1.07
|
19
|
Molecular mechanisms of protein kinase C-induced apoptosis in prostate cancer cells.
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J Biochem Mol Biol
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2005
|
1.05
|
20
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Epidermal abnormalities and increased malignancy of skin tumors in human epidermal keratin 8-expressing transgenic mice.
|
FASEB J
|
2004
|
1.03
|
21
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Protein kinase C and prostate carcinogenesis: targeting the cell cycle and apoptotic mechanisms.
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Curr Drug Targets
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2004
|
1.01
|
22
|
Overexpression of cyclin D2 is associated with increased in vivo invasiveness of human squamous carcinoma cells.
|
Mol Carcinog
|
2002
|
0.98
|
23
|
Inhibition of proprotein convertases: approaches to block squamous carcinoma development and progression.
|
Mol Carcinog
|
2007
|
0.97
|
24
|
Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo.
|
Am J Pathol
|
2008
|
0.96
|
25
|
PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
|
Am J Pathol
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2009
|
0.96
|
26
|
Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice.
|
Carcinogenesis
|
2003
|
0.95
|
27
|
Mutation frequencies in murine keratinocytes as a function of carcinogenic status.
|
Mol Carcinog
|
2004
|
0.92
|
28
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Endothelial cell development, vasculogenesis, angiogenesis, and tumor neovascularization: an update.
|
Semin Thromb Hemost
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2004
|
0.90
|
29
|
p21, p27 and p53 in estrogen and antiprogestin-induced tumor regression of experimental mouse mammary ductal carcinomas.
|
Carcinogenesis
|
2002
|
0.90
|
30
|
Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.
|
Am J Pathol
|
2002
|
0.90
|
31
|
Modulation of the angiogenesis response through Ha-ras control, placenta growth factor, and angiopoietin expression in mouse skin carcinogenesis.
|
Mol Carcinog
|
2003
|
0.89
|
32
|
P53 genotype as a determinant of ER expression and tamoxifen response in the MMTV-Wnt-1 model of mammary carcinogenesis.
|
Breast Cancer Res Treat
|
2010
|
0.88
|
33
|
Chronic stress accelerates ultraviolet-induced cutaneous carcinogenesis.
|
J Am Acad Dermatol
|
2004
|
0.87
|
34
|
Two hypomorphic alleles of mouse Ass1 as a new animal model of citrullinemia type I and other hyperammonemic syndromes.
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Am J Pathol
|
2010
|
0.87
|
35
|
Protective role of cathepsin L in mouse skin carcinogenesis.
|
Mol Carcinog
|
2011
|
0.86
|
36
|
CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
|
Am J Pathol
|
2008
|
0.84
|
37
|
SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies.
|
Exp Dermatol
|
2012
|
0.81
|
38
|
Genetic analyses of mouse skin tumor progression susceptibility using SENCAR inbred derived strains.
|
Mol Carcinog
|
2002
|
0.81
|
39
|
Keratinocyte cell lines derived from severe generalized recessive epidermolysis bullosa patients carrying a highly recurrent COL7A1 homozygous mutation: models to assess cell and gene therapies in vitro and in vivo.
|
Exp Dermatol
|
2013
|
0.81
|
40
|
The regenerative potential of fibroblasts in a new diabetes-induced delayed humanised wound healing model.
|
Exp Dermatol
|
2013
|
0.79
|
41
|
Enhanced skin carcinogenesis and lack of thymus hyperplasia in transgenic mice expressing human cyclin D1b (CCND1b).
|
Mol Carcinog
|
2009
|
0.79
|
42
|
Transgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands.
|
Mol Carcinog
|
2011
|
0.79
|
43
|
Developmental stage determines estrogen receptor alpha expression and non-genomic mechanisms that control IGF-1 signaling and mammary proliferation in mice.
|
J Clin Invest
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2011
|
0.78
|
44
|
Application of inter-simple sequence repeat PCR to mouse models: assessment of genetic alterations in carcinogenesis.
|
Genes Chromosomes Cancer
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2002
|
0.78
|
45
|
Multidrug resistance modulators PSC 833 and CsA show differential capacity to induce apoptosis in lymphoid leukemia cell lines independently of their MDR phenotype.
|
Leuk Res
|
2003
|
0.77
|
46
|
Advances in molecular carcinogenesis: current and future use of mouse models to screen and validate molecularly targeted anticancer drugs.
|
Mol Carcinog
|
2004
|
0.77
|
47
|
Simple duplex fecal PCR assay that allows identification of false-negative results in Helicobacter sp.-infected mice.
|
Comp Med
|
2004
|
0.76
|
48
|
Second symposium of novel molecular targets for cancer therapy.
|
Oncologist
|
2002
|
0.75
|
49
|
Tumor initiation by skin Ha-ras-ment.
|
Exp Dermatol
|
2015
|
0.75
|
50
|
Immunohistochemical analysis of mTOR activity in tissues.
|
Methods Mol Biol
|
2012
|
0.75
|
51
|
Differential susceptibility to chemically induced thymic lymphomas in SENCARB and SSIN inbred mice.
|
Mol Carcinog
|
2006
|
0.75
|
52
|
Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar.
|
Environ Mol Mutagen
|
2003
|
0.75
|