PubRank

Brian F O'Dowd

Author PubWeight™ 52.81‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 G-protein-coupled receptor oligomerization and its potential for drug discovery. Nat Rev Drug Discov 2002 3.19
2 D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 2006 2.48
3 Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. J Biol Chem 2004 2.32
4 Calcium signaling cascade links dopamine D1-D2 receptor heteromer to striatal BDNF production and neuronal growth. Proc Natl Acad Sci U S A 2009 1.67
5 Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem 2003 1.57
6 Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A 2003 1.33
7 The dopamine D1-D2 receptor heteromer localizes in dynorphin/enkephalin neurons: increased high affinity state following amphetamine and in schizophrenia. J Biol Chem 2010 1.33
8 A role for the distal carboxyl tails in generating the novel pharmacology and G protein activation profile of mu and delta opioid receptor hetero-oligomers. J Biol Chem 2005 1.20
9 The dopamine d1-d2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in Basal Ganglia. Front Neuroanat 2011 1.19
10 Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers. Mol Pharmacol 2009 1.19
11 Modification of the terminal residue of apelin-13 antagonizes its hypotensive action. Endocrinology 2004 1.17
12 Neuronal Gq/11-coupled dopamine receptors: an uncharted role for dopamine. Trends Pharmacol Sci 2007 1.16
13 Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry 2007 1.16
14 Oligomerization of opioid receptors: generation of novel signaling units. Curr Opin Pharmacol 2002 1.14
15 D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4. Biochemistry 2003 1.13
16 A novel dopamine receptor signaling unit in brain: heterooligomers of D1 and D2 dopamine receptors. ScientificWorldJournal 2007 1.13
17 Unravelling the roles of the apelin system: prospective therapeutic applications in heart failure and obesity. Trends Pharmacol Sci 2006 1.13
18 Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms. Curr Opin Pharmacol 2009 1.11
19 Insights into the role of dopamine receptor systems in learning and memory. Rev Neurosci 2007 1.10
20 Deletion of dopamine D1 and D3 receptors differentially affects spontaneous behaviour and cocaine-induced locomotor activity, reward and CREB phosphorylation. Eur J Neurosci 2005 1.09
21 Novel human G-protein-coupled receptors. Biochem Biophys Res Commun 2003 1.08
22 Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol 2007 1.07
23 Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance. Mol Brain 2011 1.06
24 Homo- and hetero-oligomerization of G protein-coupled receptors. Life Sci 2003 1.05
25 Distinct residues in the carboxyl tail mediate agonist-induced desensitization and internalization of the human dopamine D1 receptor. J Biol Chem 2001 0.97
26 Attenuation of sucrose reinforcement in dopamine D1 receptor deficient mice. Eur J Neurosci 2003 0.97
27 Heteromeric dopamine receptor signaling complexes: emerging neurobiology and disease relevance. Neuropsychopharmacology 2013 0.96
28 The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. Biochem Biophys Res Commun 2010 0.96
29 Minireview: Diversity and complexity of signaling through peptidergic G protein-coupled receptors. Endocrinology 2004 0.94
30 Desensitization of the dopamine D1 and D2 receptor hetero-oligomer mediated calcium signal by agonist occupancy of either receptor. Mol Pharmacol 2007 0.94
31 Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2. J Biol Chem 2010 0.93
32 Dopamine D1-D2 receptor heteromer in dual phenotype GABA/glutamate-coexpressing striatal medium spiny neurons: regulation of BDNF, GAD67 and VGLUT1/2. PLoS One 2012 0.92
33 Dopamine receptor homooligomers and heterooligomers in schizophrenia. CNS Neurosci Ther 2010 0.89
34 Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells. Eur J Pharmacol 2007 0.88
35 Non-amine-based dopamine transporter (reuptake) inhibitors retain properties of amine-based progenitors. Eur J Pharmacol 2003 0.84
36 A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol 2012 0.84
37 A G protein-coupled receptor for estrogen: the end of the search? Mol Interv 2005 0.81
38 A cysteinyl leukotriene 2 receptor variant is associated with atopy in the population of Tristan da Cunha. Pharmacogenetics 2003 0.81
39 Discovery of a null mutation in a human trace amine receptor gene. Genomics 2003 0.80
40 The role of palmitoylation in directing dopamine D1 receptor internalization through selective endocytic routes. Biochem Biophys Res Commun 2011 0.80
41 Dopamine D₁-D₂ receptor heteromer regulates signaling cascades involved in addiction: potential relevance to adolescent drug susceptibility. Dev Neurosci 2014 0.80
42 Striatal development involves a switch in gene expression networks, followed by a myelination event: implications for neuropsychiatric disease. Synapse 2012 0.78
43 Blockade of G protein-coupled receptors and the dopamine transporter by a transmembrane domain peptide: novel strategy for functional inhibition of membrane proteins in vivo. J Pharmacol Exp Ther 2003 0.78
44 Continued discovery of ligands for G protein-coupled receptors. Life Sci 2003 0.78
45 Restoration of amphetamine-induced locomotor sensitization in dopamine D1 receptor-deficient mice. Psychopharmacology (Berl) 2009 0.77
46 Enhanced brain-derived neurotrophic factor signaling in the nucleus accumbens of juvenile rats. Dev Neurosci 2013 0.76
47 Family 1 G protein-coupled receptor function in the CNS. Insights from gene knockout mice. Brain Res Brain Res Rev 2003 0.75
48 Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets. Expert Opin Ther Targets 2002 0.75
49 Postnatal maternal deprivation and pubertal stress have additive effects on dopamine D2 receptor and CaMKII beta expression in the striatum. Int J Dev Neurosci 2013 0.75