PubRank

R A Glennon

Author PubWeight™ 106.76‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Evidence for 5-HT2 involvement in the mechanism of action of hallucinogenic agents. Life Sci 1984 1.73
2 Cathinone: an investigation of several N-alkyl and methylenedioxy-substituted analogs. Pharmacol Biochem Behav 1997 1.64
3 Lobeline: structure-affinity investigation of nicotinic acetylcholinergic receptor binding. J Med Chem 1999 1.53
4 Abuse-related and abuse-limiting effects of methcathinone and the synthetic "bath salts" cathinone analogs methylenedioxypyrovalerone (MDPV), methylone and mephedrone on intracranial self-stimulation in rats. Psychopharmacology (Berl) 2013 1.46
5 Methcathinone: a new and potent amphetamine-like agent. Pharmacol Biochem Behav 1987 1.41
6 Radioligand binding evidence implicates the brain 5-HT2 receptor as a site of action for LSD and phenylisopropylamine hallucinogens. Psychopharmacology (Berl) 1988 1.31
7 Antinociceptive responses to nicotinic acetylcholine receptor ligands after systemic and intrathecal administration in mice. J Pharmacol Exp Ther 1998 1.22
8 Do functional relationships exist between 5-HT1A and 5-HT2 receptors? Pharmacol Biochem Behav 1990 1.15
9 A highly conserved aspartic acid (Asp-155) anchors the terminal amine moiety of tryptamines and is involved in membrane targeting of the 5-HT(2A) serotonin receptor but does not participate in activation via a "salt-bridge disruption" mechanism. J Pharmacol Exp Ther 2000 1.10
10 Central serotonin receptors as targets for drug research. J Med Chem 1987 1.09
11 5-HT1 and 5-HT2 binding profiles of the serotonergic agents alpha-methylserotonin and 2-methylserotonin. J Med Chem 1990 1.04
12 Autoradiographic characterization of (+-)-1-(2,5-dimethoxy-4-[125I] iodophenyl)-2-aminopropane ([125I]DOI) binding to 5-HT2 and 5-HT1c receptors in rat brain. J Pharmacol Exp Ther 1990 1.03
13 Is a nitrogen atom an important pharmacophoric element in sigma ligand binding? Bioorg Med Chem 2000 1.02
14 Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol 1999 1.02
15 Agonist activity of LSD and lisuride at cloned 5HT2A and 5HT2C receptors. Psychopharmacology (Berl) 1998 0.99
16 Discriminative stimulus effects of S(-)-methcathinone (CAT): a potent stimulant drug of abuse. Psychopharmacology (Berl) 1998 0.99
17 Further evidence for an amphetamine-like mechanism of action of the alkaloid cathinone. Biochem Pharmacol 1986 0.97
18 Withdrawal from chronic treatment with (+/-)-DOI causes super-sensitivity to 5-HT2 receptor-induced head-twitch behaviour in mice. Eur J Pharmacol 1990 0.95
19 Ketanserin analogues: structure-affinity relationships for 5-HT2 and 5-HT1C serotonin receptor binding. J Med Chem 1992 0.95
20 Quantitative structure-activity relationship analysis of the pharmacology of para-substituted methcathinone analogues. Br J Pharmacol 2015 0.94
21 Antagonism of the effects of the hallucinogen DOM and the purported 5-HT agonist quipazine by 5-HT2 antagonists. Eur J Pharmacol 1983 0.92
22 Differential ergoline and ergopeptine binding to 5-hydroxytryptamine2A receptors: ergolines require an aromatic residue at position 340 for high affinity binding. Mol Pharmacol 1995 0.91
23 Phenethylamine hallucinogens in the locus coeruleus: potency of action correlates with rank order of 5-HT2 binding affinity. Eur J Pharmacol 1986 0.91
24 Behavioral evidence for differential adaptation of the serotonergic system after acute and chronic treatment with (+/- )-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) or ketanserin. J Pharmacol Exp Ther 1992 0.91
25 Exploring the relationship between binding modes of 9-(aminomethyl)-9,10-dihydroanthracene and cyproheptadine analogues at the 5-HT2A serotonin receptor. Bioorg Med Chem Lett 2001 0.90
26 5-HT1 and 5-HT2 binding properties of derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane (2,5-DMA). Eur J Pharmacol 1984 0.90
27 Cathinone, cocaine and methamphetamine: similarity of behavioral effects. Pharmacol Biochem Behav 1985 0.90
28 3,4-Methylenedioxymethamphetamine (MDMA): stereoselective interactions at brain 5-HT1 and 5-HT2 receptors. Psychopharmacology (Berl) 1986 0.90
29 beta-carboline binding to imidazoline receptors. Drug Alcohol Depend 2001 0.90
30 Structure-activity studies on amphetamine analogs using drug discrimination methodology. Pharmacol Biochem Behav 1984 0.89
31 Pharmacological characterization of ear-scratch response in mice as a behavioral model for selective 5-HT2-receptor agonists and evidence for 5-HT1B- and 5-HT2-receptor interactions. Pharmacol Biochem Behav 1990 0.89
32 Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesis. Psychopharmacology (Berl) 1989 0.89
33 Steric parameters, molecular modeling and hydropathic interaction analysis of the pharmacology of para-substituted methcathinone analogues. Br J Pharmacol 2015 0.88
34 Mechanistic investigation of the stimulus properties of 1-(3-trifluoromethylphenyl)piperazine. Pharmacol Biochem Behav 1992 0.87
35 Molecular connectivity analysis of hallucinogenic mescaline analogs. J Pharm Sci 1979 0.87
36 9-(Aminomethyl)-9,10-dihydroanthracene is a novel and unlikely 5-HT2A receptor antagonist. Eur J Pharmacol 1999 0.87
37 Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane. J Med Chem 1982 0.86
38 DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines. Eur J Pharmacol 1983 0.86
39 Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene. Bioorg Med Chem Lett 2001 0.86
40 MDA: a psychoactive agent with dual stimulus effects. Life Sci 1984 0.86
41 Cocaine-stimulus generalization to two new designer drugs: methcathinone and 4-methylaminorex. Pharmacol Biochem Behav 1993 0.85
42 Drug-induced discrimination: a description of the paradigm and a review of its specific application to the study of hallucinogenic agents. Med Res Rev 1983 0.85
43 Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding. J Med Chem 1998 0.84
44 A structure-affinity study of the binding of 4-substituted analogues of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors. J Med Chem 1990 0.84
45 Discriminative stimulus properties of S(-)- and R(+)-cathinone, (+)-cathine and several structural modifications. Pharmacol Biochem Behav 1984 0.84
46 Discriminative stimulus properties of MDA analogs. Biol Psychiatry 1982 0.84
47 Comparison of behavioral effects of cathinone, amphetamine and apomorphine. Pharmacol Biochem Behav 1984 0.83
48 Selectivity of serotonergic drugs for multiple brain serotonin receptors. Role of [3H]-4-bromo-2,5-dimethoxyphenylisopropylamine ([3H]DOB), a 5-HT2 agonist radioligand. Biochem Pharmacol 1987 0.82
49 Structure-activity relationships and mechanism of action of hallucinogenic agents based on drug discrimination and radioligand binding studies. Psychopharmacol Bull 1986 0.82
50 Discriminative stimulus properties of phenylisopropylamine derivatives. Drug Alcohol Depend 1986 0.82
51 Mesoionic xanthine analogues: antagonists of adenosine receptors. J Med Chem 1984 0.82
52 Synthesis and evaluation of phenyl- and benzoylpiperazines as potential serotonergic agents. J Med Chem 1986 0.82
53 Discriminative stimulus properties of the serotonergic agent 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Life Sci 1986 0.82
54 Demethyl analogues of psychoactive methoxyphenalkylamines: synthesis and serotonin receptor affinities. J Med Chem 1980 0.81
55 An examination of isomeric phenylpropanolamines in (-)ephedrine-trained rats. Drug Alcohol Depend 1999 0.81
56 Indolealkylamine and phenalkylamine hallucinogens: a brief overview. Neurosci Biobehav Rev 1982 0.81
57 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem 1986 0.81
58 Discriminative stimulus properties of amphetamine and structurally related phenalkylamines. Med Res Rev 1986 0.81
59 Investigation of hallucinogenic and related beta-carbolines. Drug Alcohol Depend 1998 0.81
60 Mechanistic studies on DOM as a discriminative stimulus. Pharmacol Biochem Behav 1985 0.80
61 Molecular modeling of the interaction of LSD and other hallucinogens with 5-HT2 receptors. NIDA Res Monogr 1994 0.80
62 Discriminative stimulus properties of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH DPAT). Pharmacol Biochem Behav 1986 0.80
63 Serotonin receptor binding affinities of tryptamine analogues. J Med Chem 1979 0.80
64 Structure-activity studies on methoxy-substituted phenylisopropylamines using drug discrimination methodology. Pharmacol Biochem Behav 1985 0.80
65 Indolealkylamine analogs share 5-HT2 binding characteristics with phenylalkylamine hallucinogens. Eur J Pharmacol 1988 0.80
66 Serotonin receptor affinity of cathinone and related analogues. J Med Chem 1982 0.80
67 NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors. Brain Res 1990 0.80
68 The effect of MDMA ("Ecstasy") and its optical isomers on schedule-controlled responding in mice. Pharmacol Biochem Behav 1987 0.80
69 Stimulus properties of PMMA: effect of optical isomers and conformational restriction. Pharmacol Biochem Behav 1999 0.79
70 N1-(Benzenesulfonyl)tryptamines as novel 5-HT6 antagonists. Bioorg Med Chem Lett 2000 0.79
71 Discriminative stimulus properties of the hallucinogenic agent DOM. Commun Psychopharmacol 1980 0.79
72 Discriminative stimulus properties of DOM and several molecular modifications. Pharmacol Biochem Behav 1982 0.79
73 Repeated administration of low doses of cocaine enhances the sensitivity of 5-HT2 receptor function. Pharmacol Biochem Behav 1992 0.79
74 Analogues of the 5-HT1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity. J Med Chem 1991 0.79
75 Indolealkylamine and phenalkylamine hallucinogens. Effect of alpha-methyl and N-methyl substituents on behavioral activity. Biochem Pharmacol 1983 0.79
76 Discriminative stimulus properties of alpha-ethyltryptamine optical isomers. Pharmacol Biochem Behav 2001 0.79
77 A comparison of the behavioral properties of (+/-)-, (-)-, and (+)-5-methoxy-alpha-methyltryptamine. Biol Psychiatry 1983 0.79
78 Chain-lengthened and imidazoline analogues of nicotine. Bioorg Med Chem Lett 2000 0.79
79 Serotonin receptor binding affinities of several hallucinogenic phenylalkylamine and N,N-dimethyltryptamine analogues. J Med Chem 1978 0.79
80 TFMPP may produce its stimulus effects via a 5-HT1B mechanism. Pharmacol Biochem Behav 1986 0.79
81 PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA. Pharmacol Biochem Behav 2001 0.78
82 Bufotenine esters. J Med Chem 1979 0.78
83 Drug-induced cues in studying mechanisms of drug action. Neuropharmacology 1979 0.78
84 The 5-HT3 agent N-(3-chlorophenyl)guanidine (MD-354) serves as a discriminative stimulus in rats and displays partial agonist character in a shrew emesis assay. Psychopharmacology (Berl) 2000 0.78
85 Involvement of the serotonergic system in the hypoactive and antinociceptive effects of nicotine in mice. Brain Res Bull 1994 0.78
86 Behavioral properties of psychoactive phenylisopropylamines in rats. Eur J Pharmacol 1981 0.78
87 Discriminative stimulus properties of (-)ephedrine. Pharmacol Biochem Behav 1998 0.78
88 Benzylimidazolines as h5-HT1B/1D serotonin receptor ligands: a structure-affinity investigation. J Med Chem 1998 0.78
89 A three-lever operant procedure differentiates the stimulus effects of R(-)-MDA from S(+)-MDA. J Pharmacol Exp Ther 1996 0.77
90 Benz-fused mesoionic xanthine analogues as inhibitors of cyclic-AMP phosphodiesterase. J Med Chem 1981 0.77
91 Ketanserin analogues: the effect of structural modification on 5-HT2 serotonin receptor binding. J Med Chem 1995 0.77
92 Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities. Psychopharmacology (Berl) 1980 0.77
93 Determination of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine enantiomers in whole blood. J Chromatogr 1989 0.77
94 MDA: an agent that produces stimulus effects similar to those of 3,4-DMA, LSD and cocaine. Eur J Pharmacol 1984 0.77
95 Binding of beta-carbolines at 5-HT(2) serotonin receptors. Bioorg Med Chem Lett 2003 0.77
96 (-)Ephedrine and caffeine mutually potentiate one another's amphetamine-like stimulus effects. Pharmacol Biochem Behav 1998 0.77
97 Behavioral characterization of 2-O-desmethyl and 5-O-desmethyl metabolites of the phenylethylamine hallucinogen DOM. Pharmacol Biochem Behav 2003 0.77
98 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem 1986 0.77
99 Stimulus effects of phenylpropanolamine optical isomers in (+)amphetamine-trained rats. Pharmacol Biochem Behav 2000 0.77
100 Stereochemistry of the metabolism of MDMA to MDA. Life Sci 1989 0.77
101 Further investigation of the discriminative stimulus properties of MDA. Pharmacol Biochem Behav 1984 0.77
102 A preliminary investigation of mesoionic xanthine analogues as inhibitors of platelet aggregation. Bioorg Med Chem 2000 0.76
103 Binding of nicotine and homoazanicotine analogues at neuronal nicotinic acetylcholinergic (nACh) receptors. Bioorg Med Chem Lett 2003 0.76
104 1-[4-(3-Phenylalkyl)phenyl]-2-aminopropanes as 5-HT(2A) partial agonists. J Med Chem 2000 0.76
105 Inhibition of 5-HT2 receptor-mediated head-twitch response by cocaine via indirect stimulation of adrenergic alpha 2 and serotonergic 5-HT1A receptors. Pharmacol Biochem Behav 1991 0.76
106 The binding of arylguanidines at 5-HT(3) serotonin receptors: a structure-affinity investigation. Bioorg Med Chem Lett 2001 0.76
107 A comparison of the behavioral effects of DOM homologs. Pharmacol Biochem Behav 1982 0.76
108 Behavioral effects of 5-methoxy-N,N-dimethyltryptamine and dose-dependent antagonism by BC-105. Psychopharmacology (Berl) 1983 0.76
109 Approaches to molecular modeling studies and specific application to serotonin ligands and receptors. Pharmacol Biochem Behav 1991 0.76
110 Unique [3H]tryptamine binding sites in rat brain: distribution and pharmacology. Arch Int Pharmacodyn Ther 1984 0.76
111 Further studies on the dose-dependent stimulus properties of 5-methoxy-N,N-dimethyltryptamine. Pharmacol Biochem Behav 1986 0.76
112 Effect of 5-HT2-selective agonists on cat platelet aggregation. Life Sci 1987 0.76
113 Clobenzorex: evidence for amphetamine-like behavioral actions. Pharmacol Biochem Behav 1997 0.76
114 Structure-activity relationships for the binding of arylpiperazines and arylbiguanides at 5-HT3 serotonin receptors. J Med Chem 1996 0.76
115 Synthesis and evaluation of a novel series of N,N-dimethylisotryptamines. J Med Chem 1984 0.76
116 Stereoselective stimulus effects of 3-methylflunitrazepam and pentobarbital. Life Sci 1984 0.76
117 The effect of MDA and MDMA ("Ecstasy") isomers in combination with pirenpirone on operant responding in mice. Pharmacol Biochem Behav 1987 0.76
118 Photoelectron spectra of psychotropic drugs. 6. Relationships between the physical properties and pharmacological actions of amphetamine analogues. J Med Chem 1981 0.75
119 Design and synthesis of propranolol analogues as serotonergic agents. J Med Chem 1989 0.75
120 Serotonin receptor affinities of psychoactive phenalkylamine analogues. J Med Chem 1980 0.75
121 Receptor pharmacology of MDMA and related hallucinogens. Ann N Y Acad Sci 1990 0.75
122 N-methyl derivatives of the 5-HT2 agonist 1-(4-bromo-2,5-dimethoxyphenyl)-2-aminopropane. J Med Chem 1987 0.75
123 Stimulus properties of ring-methyl amphetamine analogs. Pharmacol Biochem Behav 1990 0.75
124 Comparison of behavioral properties of di- and tri-methoxyphenylisopropylamines. Pharmacol Biochem Behav 1982 0.75
125 Hallucinogens as a discriminative stimuli: generalization of DOM to a 5-methoxy-N, N-dimethyltryptamine stimulus. Life Sci 1979 0.75
126 Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5-HT2- versus 5-HT1C-selective antagonist. J Med Chem 1993 0.75
127 1-(2,3-Methylenedioxyphenyl)-2-aminopropane (2,3-MDA): a preliminary investigation. Gen Pharmacol 1984 0.75
128 The electronic and serotonin receptor binding affinity properties of N,N-dimethyltryptamine analogs. Res Commun Chem Pathol Pharmacol 1977 0.75
129 2-(Alkylamino)tetralin derivatives: interaction with 5-HT1A serotonin binding sites. J Med Chem 1989 0.75
130 Mesoionic xanthine analogues: phosphodiesterase inhibitory and hypotensive activity. J Med Chem 1981 0.75
131 Comparative discriminative stimulus effects of 5-methoxy-N,N-dimethyltryptamine and LSD. Life Sci 1982 0.75
132 [3H]DOB: a specific agonist radioligand for 5-HT2 serotonin receptors. Eur J Pharmacol 1985 0.75
133 Stimulus properties of benzodiazepines: correlations with binding affinities, therapeutic potency, and structure activity relationships (SAR). Psychopharmacology (Berl) 1987 0.75
134 Investigation of the affinities of two new beta-carbolines for rat brain imidazoline(2) receptors. Ann N Y Acad Sci 2003 0.75
135 Imidazoline-modified benzylimidazolines as h5-HT(1D/1B) serotonergic ligands. Bioorg Med Chem 2001 0.75
136 1-[2-methoxy-5-(3-phenylpropyl)]-2-aminopropane unexpectedly shows 5-HT(2A) serotonin receptor affinity and antagonist character. J Med Chem 2001 0.75
137 Discriminative stimulus properties of the serotonin agonist 1-(3-trifluoromethylphenyl)piperazine (TFMPP). Life Sci 1984 0.75
138 Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts. Life Sci 1982 0.75
139 Mesoionic purinone analogs. 7. In vitro antibacterial activity of mesoionic 1,3,4-thiadiazolo(3,2-a)pyrimidine-5,7-diones. J Med Chem 1974 0.75
140 Zacopride and its optical isomers produce stereoselective antagonism of a 2-methylserotonin discriminative stimulus. Eur J Pharmacol 1992 0.75
141 2-(1-Naphthyloxy)ethylamines with enhanced affinity for human 5-HT1D beta (h5-HT1B) serotonin receptors. J Med Chem 1997 0.75
142 Synthesis and evaluation of novel alkylpiperazines as potential dopamine antagonists. J Med Chem 1981 0.75
143 Mesoionic purinone analogs. IV. Synthesis and in vitro antibacterial properties of mesoionic thiazolo(3,2-a)pyrimidin-5,7-diones and mesoionic 1,3,4-thiadizolo(3,2-a)pyrimidin-5,7-diones. J Pharm Sci 1973 0.75
144 Homoazanicotine: a structure-affinity study for nicotinic acetylcholine (nACh) receptor binding. J Med Chem 2002 0.75
145 Mesoionic purinone analogues as inhibitors of cyclic-AMP phosphodiesterase: a comparison of several ring systems. J Med Chem 1981 0.75
146 Effects of pyrazolopyridines and a triazolopyridazine on the pentobarbital discriminative stimulus. Psychopharmacology (Berl) 1987 0.75
147 A quantum chemical investigation of the pi-electronic structure of the hallucinogenic N,N-dimethyltryptamines. Res Commun Chem Pathol Pharmacol 1974 0.75
148 Cocaine--stimulus generalization to MDA optical isomers: a reevaluation. Pharmacol Biochem Behav 1997 0.75
149 Identification of metabolites of 3,4-methylenedioxymethamphetamine in rats. Drug Alcohol Depend 1990 0.75
150 Structure-activity relationships for hallucinogenic N,N-dialkyltryptamines: photoelectron spectra and serotonin receptor affinities of methylthio and methylenedioxy derivatives. J Med Chem 1982 0.75
151 Psychotomimetic phenalkylamines as serotonin agonists: an SAR analysis. Life Sci 1978 0.75
152 Preliminary studies of mesoionic 3-(substituted-aryl)-psi-oxatriazoles as potential antihypertensive agents. J Med Chem 1982 0.75
153 Serotonin receptor interactions of harmaline and several related beta-carbolines. Life Sci 1981 0.75
154 Studies on several 7-substituted N,N-dimethyltryptamines. J Med Chem 1980 0.75
155 The effect of chirality on serotonin receptor affinity. Life Sci 1979 0.75
156 Recent advances in central 5-hydroxytryptamine receptor agonists and antagonists. Prog Drug Res 1986 0.75
157 Potencies of diazepam metabolites in rats trained to discriminate diazepam. Life Sci 1986 0.75
158 Progress with several models for the study of the SAR of hallucinogenic agents. NIDA Res Monogr 1978 0.75
159 7,N,N-Trimethyltryptamine: a selective inhibitor of synaptosomal serotonin uptake. Res Commun Chem Pathol Pharmacol 1978 0.75
160 2,3-dihydro and carbocyclic analogues of tryptamines: interaction with serotonin receptors. J Med Chem 1982 0.75
161 DOM and related 2,5-dimethoxy-4-alkylphenylisopropylamines: behavioral and serotonin receptor properties. Pharmacol Biochem Behav 1981 0.75
162 Speculations on the mechanism of action of hallucinogenic indolealkylamines. Neurosci Biobehav Rev 1981 0.75
163 Similarity between (+)-amphetamine and amfonelic acid. Pharmacol Biochem Behav 1984 0.75
164 Mesoionic xanthine analogs as inhibitors of cyclic AMP phosphodiesterase. J Pharm Sci 1978 0.75