Published in Mol Pharmacol on March 29, 2012
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking. Cancer Biol Ther (2015) 0.77
Calcium and P-glycoprotein independent synergism between schweinfurthins and verapamil. Cancer Biol Ther (2015) 0.75
3-Deoxyschweinfurthin B Lowers Cholesterol Levels by Decreasing Synthesis and Increasing Export in Cultured Cancer Cell Lines. Lipids (2015) 0.75
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science (1997) 9.53
The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature (1988) 7.98
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov (2008) 7.64
Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene (2006) 6.61
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood (2006) 5.21
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85
Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate. Proc Natl Acad Sci U S A (1996) 2.82
Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity. J Biol Chem (1996) 2.19
ER chaperone functions during normal and stress conditions. J Chem Neuroanat (2004) 2.13
Increased synthesis of secreted proteins induces expression of glucose-regulated proteins in butyrate-treated Chinese hamster ovary cells. J Biol Chem (1989) 2.09
ER export: public transportation by the COPII coach. Curr Opin Cell Biol (2001) 2.02
Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol Pharmacol (2000) 1.63
The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J Biol Chem (2002) 1.54
Cytotoxic geranyl stilbenes from Macaranga schweinfurthii. J Nat Prod (1998) 1.50
Signal transduction pathways that regulate eukaryotic protein synthesis. J Biol Chem (1999) 1.48
Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities. J Med Chem (2002) 1.43
Synthesis of nonracemic 3-deoxyschweinfurthin B. J Org Chem (2005) 1.26
Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis. J Cell Physiol (1992) 1.24
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series. Bioorg Med Chem Lett (2006) 1.21
Caspase-9 regulation: an update. Apoptosis (2004) 1.13
Molecular recognition of taxol by microtubules. Kinetics and thermodynamics of binding of fluorescent taxol derivatives to an exposed site. J Biol Chem (2000) 1.13
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity. Bioorg Med Chem (2005) 1.07
Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure. Bioorg Med Chem (2010) 1.06
Total synthesis of (+)-schweinfurthins B and E. J Org Chem (2009) 1.06
BF3 x Et2O-mediated cascade cyclizations: synthesis of schweinfurthins F and G. J Org Chem (2008) 1.06
Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer Res (2003) 1.05
Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner. Mol Cancer Ther (2010) 1.01
Fluorescent verapamil derivative for monitoring activity of the multidrug transporter. Mol Pharmacol (1991) 0.99
The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem (2006) 0.98
Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage. Mol Pharmacol (2005) 0.97
Synthesis and biological activity of a fluorescent schweinfurthin analogue. Bioorg Med Chem (2009) 0.96
Fluorescent schweinfurthin B and F analogs with anti-proliferative activity. Bioorg Med Chem (2010) 0.94
Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia. J Pharmacol Exp Ther (2009) 0.93
Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. Lipids (2011) 0.86
Role of Smac in cephalostatin-induced cell death. Cell Death Differ (2008) 0.82
Interaction of a fluorescent paclitaxel analogue with tubulin. Biochemistry (1995) 0.81
Quantifying the astrocytoma cell response to candidate pharmaceutical from F-ACTIN image analysis. Conf Proc IEEE Eng Med Biol Soc (2009) 0.76
Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301. J Clin Oncol (2009) 1.75
Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia. Cancer (2004) 1.56
Phase III randomised study of dexamethasone with or without oblimersen sodium for patients with advanced multiple myeloma. Leuk Lymphoma (2009) 1.54
Isoprenoids: remarkable diversity of form and function. Lipids (2004) 1.47
Synthesis of nonracemic 3-deoxyschweinfurthin B. J Org Chem (2005) 1.26
Synthesis and biological activity of isoprenoid bisphosphonates. Bioorg Med Chem (2006) 1.25
Anti-cancer therapy: targeting the mevalonate pathway. Curr Cancer Drug Targets (2006) 1.24
Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase. Biochem Biophys Res Commun (2006) 1.23
Total synthesis of (R,R,R)- and (S,S,S)-schweinfurthin F: differences of bioactivity in the enantiomeric series. Bioorg Med Chem Lett (2006) 1.21
Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells. Anal Biochem (2005) 1.20
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. Bioorg Med Chem (2008) 1.19
Pharmacodynamic effects of high dose lovastatin in subjects with advanced malignancies. Cancer Chemother Pharmacol (2005) 1.12
Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101. J Clin Oncol (2007) 1.11
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Bioorg Med Chem (2007) 1.11
Synthesis and activity of fluorescent isoprenoid pyrophosphate analogues. J Org Chem (2004) 1.11
Consequences of mevalonate depletion. Differential transcriptional, translational, and post-translational up-regulation of Ras, Rap1a, RhoA, AND RhoB. J Biol Chem (2002) 1.10
The intermediate enzymes of isoprenoid metabolism as anticancer targets. Anticancer Agents Med Chem (2009) 1.07
Synthesis and structure-activity studies of schweinfurthin B analogs: Evidence for the importance of a D-ring hydrogen bond donor in expression of differential cytotoxicity. Bioorg Med Chem (2005) 1.07
Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure. Bioorg Med Chem (2010) 1.06
BF3 x Et2O-mediated cascade cyclizations: synthesis of schweinfurthins F and G. J Org Chem (2008) 1.06
Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent. Eur J Pharm Sci (2002) 1.06
Total synthesis of (+)-schweinfurthins B and E. J Org Chem (2009) 1.06
Isoprenoids influence expression of Ras and Ras-related proteins. Biochemistry (2002) 1.04
Synthesis and biological evaluation of a series of aromatic bisphosphonates. Bioorg Med Chem (2010) 1.03
Isoprenoid biosynthetic pathway inhibition disrupts monoclonal protein secretion and induces the unfolded protein response pathway in multiple myeloma cells. Leuk Res (2010) 1.03
Exploration of cascade cyclizations terminated by tandem aromatic substitution: total synthesis of (+)-schweinfurthin A. J Org Chem (2011) 1.02
Is there a future for prenyltransferase inhibitors in cancer therapy? Curr Opin Pharmacol (2012) 1.01
Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner. Mol Cancer Ther (2010) 1.01
Triazole-based inhibitors of geranylgeranyltransferase II. Bioorg Med Chem Lett (2012) 1.01
Prodrugs of phosphonates and phosphates: crossing the membrane barrier. Top Curr Chem (2015) 1.00
Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents. Pharm Biol (2009) 0.99
Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. Virol J (2009) 0.97
Regulation of fatty acid synthesis by farnesyl pyrophosphate. J Biol Chem (2005) 0.97
Bisphosphonates induce autophagy by depleting geranylgeranyl diphosphate. J Pharmacol Exp Ther (2011) 0.97
Synthesis and biological activity of a fluorescent schweinfurthin analogue. Bioorg Med Chem (2009) 0.96
Fluorescent schweinfurthin B and F analogs with anti-proliferative activity. Bioorg Med Chem (2010) 0.94
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction. Phytochemistry (2008) 0.92
Quantitative determination of farnesyl and geranylgeranyl diphosphate levels in mammalian tissue. Anal Biochem (2008) 0.92
Isoprenoid metabolism as a therapeutic target in gram-negative pathogens. Curr Top Med Chem (2010) 0.91
Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with inhibition of other isoprenoid biosynthetic enzymes. J Pharmacol Exp Ther (2007) 0.90
Synthesis and reactivity of alkyl-1,1,1-trisphosphonate esters. J Org Chem (2011) 0.90
A tandem cascade cyclization-electrophilic aromatic substitution: application in the total synthesis of (+)-angelichalcone. J Am Chem Soc (2009) 0.89
Geranylgeranyl pyrophosphate stimulates PPARγ expression and adipogenesis through the inhibition of osteoblast differentiation. Bone (2011) 0.89
Geranylgeranyl diphosphate depletion inhibits breast cancer cell migration. Invest New Drugs (2010) 0.88
Biologically active biotin derivatives of schweinfurthin F. Bioorg Med Chem Lett (2010) 0.88
Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia. Leuk Res (2008) 0.88
Erythropoietin stimulates cancer cell migration and activates RhoA protein through a mitogen-activated protein kinase/extracellular signal-regulated kinase-dependent mechanism. J Pharmacol Exp Ther (2007) 0.88
Tripeptide probes for tripeptidyl protease I production via gene transfer. J Med Chem (2003) 0.87
Lovastatin specifically prevents focal ischemic ventricular tachycardia due to triggered activity. Heart Rhythm (2007) 0.87
Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells. Leuk Res (2009) 0.87
Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation. Endocrinology (2011) 0.86
Synthesis of farnesol isomers via a modified Wittig procedure. Org Lett (2005) 0.86
Temperature effects on stereocontrol in the Horner-Wadsworth-Emmons condensation of alpha-phosphono lactones. J Org Chem (2007) 0.86
Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. Lipids (2011) 0.86
Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. Lipids (2003) 0.86
Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo. Leuk Res (2005) 0.86
Direct conversion of benzylic and allylic alcohols to phosphonates. J Org Chem (2011) 0.85
A phase I trial of perillyl alcohol administered four times daily for 14 days out of 28 days. Cancer Chemother Pharmacol (2004) 0.84
A concise synthesis of pawhuskin A. J Nat Prod (2008) 0.84
Alpha-phosphono lactone analogues of farnesyl pyrophosphate: an asymmetric synthesis via ring-closing metathesis. J Org Chem (2002) 0.84
Stereoselective synthesis of the 5'-hydroxy-5'-phosphonate derivatives of cytidine and cytosine arabinoside. J Org Chem (2002) 0.84
Isoprenoid pyrophosphate analogues regulate expression of Ras-related proteins. Biochemistry (2003) 0.83
Lovastatin suppresses erythropoietin receptor surface expression through dual inhibition of glycosylation and geranylgeranylation. Biochem Pharmacol (2007) 0.83
Synthesis of indole analogues of the natural schweinfurthins. J Org Chem (2013) 0.82
Cytokine-induced phosphoinositide 3-kinase activity promotes Cdk2 activation in factor-dependent hematopoietic cells. Exp Cell Res (2004) 0.82
Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor coypus) by gas chromatography-mass spectrometry and gas chromatography-infrared spectrometry. J Chromatogr A (2007) 0.82
Synthesis of fluorescently tagged isoprenoid bisphosphonates that inhibit protein geranylgeranylation. Bioorg Med Chem (2007) 0.82
The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation. J Cell Biochem (2011) 0.81
Relevance of the C-5 position to schweinfurthin induced cytotoxicity. Bioorg Med Chem (2011) 0.81
Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. Lipids (2002) 0.81
Monoterpene regulation of Ras and Ras-related protein expression. J Lipid Res (2003) 0.80
First total synthesis of (+)-Vedelianin, a potent antiproliferative agent. Tetrahedron Lett (2011) 0.79
A cascade cyclization approach to schweinfurthin B. Org Lett (2002) 0.79
Synthesis of a carbon analogue of N-acetylmannosamine via acetolysis on a relatively stable ozonide. J Org Chem (2002) 0.79
Alpha-phosphono lactone analogues of cytidine and cytosine arabinoside diphosphates: synthesis via ring closing metathesis. J Org Chem (2003) 0.79