G L Drusano

Author PubWeight™ 139.77‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Pharmacodynamics of levofloxacin: a new paradigm for early clinical trials. JAMA 1998 4.99
2 A controlled trial of early versus late treatment with zidovudine in symptomatic human immunodeficiency virus infection. Results of the Veterans Affairs Cooperative Study. N Engl J Med 1992 3.34
3 Larger vancomycin doses (at least four grams per day) are associated with an increased incidence of nephrotoxicity. Antimicrob Agents Chemother 2008 3.09
4 Daptomycin: a novel agent for Gram-positive infections. Expert Opin Investig Drugs 1999 2.83
5 Pharmacodynamics of fluconazole in a murine model of systemic candidiasis. Antimicrob Agents Chemother 1998 2.59
6 Effect of 2',3'-didehydro-3'-deoxythymidine in an in vitro hollow-fiber pharmacodynamic model system correlates with results of dose-ranging clinical studies. Antimicrob Agents Chemother 1994 2.46
7 Emergence of resistance to imipenem in Pseudomonas aeruginosa. Antimicrob Agents Chemother 1987 2.44
8 Postantibiotic effect of imipenem on Pseudomonas aeruginosa. Antimicrob Agents Chemother 1984 2.43
9 Pharmacodynamics of daptomycin in a murine thigh model of Staphylococcus aureus infection. Antimicrob Agents Chemother 2001 2.24
10 A 24-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS 1996 2.03
11 Multiple-dose pharmacokinetics of imipenem-cilastatin. Antimicrob Agents Chemother 1984 1.98
12 Absolute oral bioavailability of ciprofloxacin. Antimicrob Agents Chemother 1986 1.97
13 Prospective evaluation of the effect of an aminoglycoside dosing regimen on rates of observed nephrotoxicity and ototoxicity. Antimicrob Agents Chemother 1999 1.90
14 Human serum alpha 1 acid glycoprotein reduces uptake, intracellular concentration, and antiviral activity of A-80987, an inhibitor of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother 1996 1.89
15 Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria. Antimicrob Agents Chemother 1999 1.77
16 In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model. Antimicrob Agents Chemother 2011 1.75
17 Levofloxacin population pharmacokinetics and creation of a demographic model for prediction of individual drug clearance in patients with serious community-acquired infection. Antimicrob Agents Chemother 1998 1.73
18 Impact of drug-exposure intensity and duration of therapy on the emergence of Staphylococcus aureus resistance to a quinolone antimicrobial. J Infect Dis 2007 1.70
19 Effective antimicrobial regimens for use in humans for therapy of Bacillus anthracis infections and postexposure prophylaxis. Antimicrob Agents Chemother 2005 1.69
20 The acylampicillins: mezlocillin, piperacillin, and azlocillin. Rev Infect Dis 1984 1.48
21 Multiple-dose pharmacokinetics of ciprofloxacin administered intravenously to normal volunteers. Antimicrob Agents Chemother 1985 1.46
22 Pharmacodynamics of β-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases. Antimicrob Agents Chemother 2011 1.46
23 Fluoroquinolone pharmacodynamics. Clin Infect Dis 2001 1.45
24 Reduction of the in vitro activity of A77003, an inhibitor of human immunodeficiency virus protease, by human serum alpha 1 acid glycoprotein. J Infect Dis 1995 1.43
25 Penetration of meropenem into epithelial lining fluid of patients with ventilator-associated pneumonia. Antimicrob Agents Chemother 2011 1.35
26 Integration of selected pharmacologic and microbiologic properties of three new beta-lactam antibiotics: a hypothesis for rational comparison. Rev Infect Dis 1984 1.33
27 Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers. Antimicrob Agents Chemother 2007 1.33
28 Comparison of the pharmacokinetics of ceftazidime and moxalactam and their microbiological correlates in volunteers. Antimicrob Agents Chemother 1984 1.31
29 An overview of the pharmacology of imipenem/cilastatin. J Antimicrob Chemother 1986 1.31
30 A prospective randomized controlled trial of cefoxitin versus clindamycin-aminoglycoside in mixed anaerobic-aerobic infections. Surg Gynecol Obstet 1982 1.28
31 Pharmacokinetic profile of imipenem/cilastatin in normal volunteers. Am J Med 1985 1.28
32 The combination of meropenem and levofloxacin is synergistic with respect to both Pseudomonas aeruginosa kill rate and resistance suppression. Antimicrob Agents Chemother 2010 1.27
33 Population pharmacokinetics of zidovudine. The Veterans Administration Cooperative Studies Group. Clin Pharmacol Ther 1990 1.25
34 Pharmacodynamic evaluation of extending the administration time of meropenem using a Monte Carlo simulation. Antimicrob Agents Chemother 2005 1.24
35 Dose ranging study and constant infusion evaluation of ciprofloxacin. Antimicrob Agents Chemother 1986 1.23
36 Pharmacokinetic studies of fluconazole in rabbits characterizing doses which achieve peak levels in serum and area under the concentration-time curve values which mimic those of high-dose fluconazole in humans. Antimicrob Agents Chemother 1998 1.23
37 Effect of dose size on bioavailability of ciprofloxacin. Antimicrob Agents Chemother 1987 1.22
38 Antifungal pharmacokinetics and pharmacodynamics: bridging from the bench to bedside. Clin Microbiol Infect 2009 1.22
39 Preclinical evaluation of antiviral activity and toxicity of Abbott A77003, an inhibitor of the human immunodeficiency virus type 1 protease. Antimicrob Agents Chemother 1993 1.21
40 Pharmacokinetics and absolute bioavailability of ribavirin in healthy volunteers as determined by stable-isotope methodology. Antimicrob Agents Chemother 1999 1.21
41 Efficacy of constant infusion of A-77003, an inhibitor of the human immunodeficiency virus type 1 (HIV-1) protease, in limiting acute HIV-1 infection in vitro. Antimicrob Agents Chemother 1995 1.20
42 Imipenem coadministered with cilastatin compared with moxalactam: integration of serum pharmacokinetics and microbiologic activity following single-dose administration to normal volunteers. Antimicrob Agents Chemother 1986 1.18
43 Pharmacokinetics of intravenously administered ciprofloxacin in patients with various degrees of renal function. Antimicrob Agents Chemother 1987 1.17
44 Pharmacodynamics of levofloxacin in a murine pneumonia model of Pseudomonas aeruginosa infection: determination of epithelial lining fluid targets. Antimicrob Agents Chemother 2009 1.16
45 Use of an in vitro pharmacodynamic model to derive a linezolid regimen that optimizes bacterial kill and prevents emergence of resistance in Bacillus anthracis. Antimicrob Agents Chemother 2008 1.14
46 Meropenem pharmacokinetics in the newborn. Antimicrob Agents Chemother 2009 1.10
47 The plasma pharmacokinetics of high dose (1 g) imipenem coadministered with 1 g cilastatin in six normal volunteers. Eur J Clin Microbiol 1984 1.08
48 Identifying exposure targets for treatment of staphylococcal pneumonia with ceftobiprole. Antimicrob Agents Chemother 2009 1.07
49 Efficacies of high-dose fluconazole plus amphotericin B and high-dose fluconazole plus 5-fluorocytosine versus amphotericin B, fluconazole, and 5-fluorocytosine monotherapies in treatment of experimental endocarditis, endophthalmitis, and pyelonephritis due to Candida albicans. Antimicrob Agents Chemother 1999 1.06
50 Identification of optimal renal dosage adjustments for traditional and extended-infusion piperacillin-tazobactam dosing regimens in hospitalized patients. Antimicrob Agents Chemother 2009 1.05
51 Feedback dose alteration significantly affects probability of pathogen eradication in nosocomial pneumonia. Eur Respir J 2009 1.03
52 Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli. Antimicrob Agents Chemother 1981 1.03
53 Synergism of the combinations of imipenem plus ciprofloxacin and imipenem plus amikacin against Pseudomonas aeruginosa and other bacterial pathogens. Antimicrob Agents Chemother 1987 1.03
54 Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates. Antimicrob Agents Chemother 1998 1.03
55 Optimal sampling schedule design for populations of patients. Antimicrob Agents Chemother 2003 1.03
56 Impact of different carbapenems and regimens of administration on resistance emergence for three isogenic Pseudomonas aeruginosa strains with differing mechanisms of resistance. Antimicrob Agents Chemother 2010 1.03
57 In vitro susceptibility of pathogenic Vibrio species to norfloxacin and six other antimicrobial agents. Antimicrob Agents Chemother 1985 1.02
58 Pharmacokinetics and pharmacodynamics: optimal antimicrobial therapy in the intensive care unit. Crit Care Clin 2011 1.02
59 Comparative pharmacokinetics and pharmacodynamic target attainment of ertapenem in normal-weight, obese, and extremely obese adults. Antimicrob Agents Chemother 2006 1.01
60 Interaction between fluconazole and amphotericin B in mice with systemic infection due to fluconazole-susceptible or -resistant strains of Candida albicans. Antimicrob Agents Chemother 1999 1.01
61 Impact of dosing schedule upon suppression of a retrovirus in a murine model of AIDS encephalopathy. Antimicrob Agents Chemother 1994 1.00
62 Multiple-dose ciprofloxacin dose ranging and kinetics. Clin Pharmacol Ther 1985 1.00
63 Population pharmacokinetics of extended-infusion piperacillin-tazobactam in hospitalized patients with nosocomial infections. Antimicrob Agents Chemother 2012 1.00
64 Pharmacokinetic evaluation of two dosage regimens of clindamycin phosphate. Antimicrob Agents Chemother 1989 1.00
65 Cefoxitin falsely elevates creatinine levels. JAMA 1982 1.00
66 Flow cytometric determination of ganciclovir susceptibilities of human cytomegalovirus clinical isolates. J Clin Microbiol 1998 1.00
67 Comparative pharmacokinetics of moxalactam, cefoperazone, and cefotaxime in normal volunteers. Rev Infect Dis 1983 1.00
68 Bactericidal activity of ceftazidime in serum compared with that of ticarcillin combined with amikacin. Antimicrob Agents Chemother 1984 0.99
69 An overview of the pharmacology of intravenously administered ciprofloxacin. Am J Med 1987 0.97
70 Potential of imipenem as single-agent empiric antibiotic therapy of febrile neutropenic patients with cancer. Am J Med 1985 0.96
71 Use of pharmacokinetic/pharmacodynamic systems analyses to inform dose selection of tedizolid phosphate. Clin Infect Dis 2014 0.96
72 Prospective use of optimal sampling theory: steady-state ciprofloxacin pharmacokinetics in critically ill trauma patients. Clin Pharmacol Ther 1989 0.94
73 Impact of meropenem in combination with tobramycin in a murine model of Pseudomonas aeruginosa pneumonia. Antimicrob Agents Chemother 2013 0.93
74 A double beta-lactam combination versus an aminoglycoside-containing regimen as empiric antibiotic therapy for febrile granulocytopenic cancer patients. Am J Med 1986 0.93
75 Relevance of plasma protein binding to antiviral activity and clinical efficacy of inhibitors of human immunodeficiency virus protease. J Infect Dis 1996 0.93
76 Effect of coadministration of moxifloxacin and rifampin on Mycobacterium tuberculosis in a murine aerosol infection model. Antimicrob Agents Chemother 2012 0.93
77 Efficacy of ciprofloxacin in the treatment of chronic typhoid carriers. J Infect Dis 1988 0.91
78 Long-term follow-up of symptomatic HIV-infected patients originally randomized to early versus later zidovudine treatment; report of a Veterans Affairs Cooperative Study. VA Cooperative Study Group on AIDS Treatment. J Acquir Immune Defic Syndr Hum Retrovirol 1996 0.90
79 Pharmacodynamics of ceftazidime and meropenem in cerebrospinal fluid: results of population pharmacokinetic modelling and Monte Carlo simulation. J Antimicrob Chemother 2007 0.90
80 Emergence of resistance to carbapenem antibiotics in Pseudomonas aeruginosa. J Antimicrob Chemother 1989 0.89
81 Effect of saturable clearance during high-dose mezlocillin therapy. Antimicrob Agents Chemother 1984 0.89
82 Susceptibilities of human cytomegalovirus clinical isolates to BAY38-4766, BAY43-9695, and ganciclovir. Antimicrob Agents Chemother 2001 0.89
83 Population pharmacokinetic comparison and pharmacodynamic breakpoints of ceftazidime in cystic fibrosis patients and healthy volunteers. Antimicrob Agents Chemother 2010 0.88
84 Modeling of the change in CD4 lymphocyte counts in patients before and after administration of the human immunodeficiency virus protease inhibitor indinavir. Antimicrob Agents Chemother 1997 0.88
85 Use of an in vitro pharmacodynamic model to derive a moxifloxacin regimen that optimizes kill of Yersinia pestis and prevents emergence of resistance. Antimicrob Agents Chemother 2010 0.88
86 Improved micromethod for mezlocillin quantitation in serum and urine by high-pressure liquid chromatography. Antimicrob Agents Chemother 1984 0.88
87 Natural history of Yersinia pestis pneumonia in aerosol-challenged BALB/c mice. Antimicrob Agents Chemother 2013 0.88
88 Cefoxitin-resistant facultative or aerobic gram-negative bacilli in infections associated with the gastrointestinal tract. Ann Intern Med 1981 0.88
89 Steady-state serum pharmacokinetics of novobiocin and rifampin alone and in combination. Antimicrob Agents Chemother 1986 0.88
90 Population differences in ganciclovir clearance as determined by nonlinear mixed-effects modelling. Antimicrob Agents Chemother 1995 0.87
91 Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin. J Antimicrob Chemother 1985 0.86
92 Relationships between renal function and disposition of oral ciprofloxacin. Antimicrob Agents Chemother 1988 0.86
93 Impact of different factors on the probability of clinical response in tigecycline-treated patients with intra-abdominal infections. Antimicrob Agents Chemother 2009 0.86
94 Bactericidal activity of ciprofloxacin compared with that of cefotaxime in normal volunteers. Antimicrob Agents Chemother 1987 0.86
95 The triple combination indinavir-zidovudine-lamivudine is highly synergistic. Antimicrob Agents Chemother 2000 0.85
96 Moxalactam and piperacillin: a study of in vitro characteristics and pharmacokinetics in cancer patients. Infection 1985 0.84
97 Soluble tumor necrosis factor-alpha receptor type II (sTNF alpha RII) correlates with human immunodeficiency virus (HIV) RNA copy number in HIV-infected patients. J Infect Dis 1996 0.84
98 Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration. Exp Eye Res 1996 0.84
99 Dosing adjustment of 10 antimicrobials for patients with renal impairment. Ann Pharmacother 1995 0.84
100 Pharmacokinetics of ceftazidime, alone or in combination with piperacillin or tobramycin, in the sera of cancer patients. Antimicrob Agents Chemother 1985 0.82
101 How does a patient maximally benefit from anti-infective chemotherapy? Clin Infect Dis 2004 0.82
102 How many steps along the path is too far? Clin Infect Dis 2010 0.81
103 Future trends in antimicrobial chemotherapy: expert opinion on the 43rd ICAAC. J Chemother 2004 0.80
104 Use of human renal proximal tubule cell cultures for studying foscarnet-induced nephrotoxicity in vitro. Antimicrob Agents Chemother 1993 0.80
105 Effect of renal function on the bioavailability of ciprofloxacin. Antimicrob Agents Chemother 1990 0.79
106 Serum bactericidal test in volunteers--a review. Eur J Clin Microbiol 1986 0.78
107 Safety and tolerability of multiple doses of imipenem/cilastatin. Clin Pharmacol Ther 1985 0.78
108 Nonparametric expectation maximization population modeling of ganciclovir. J Clin Pharmacol 1996 0.77
109 Saving lives with optimal antimicrobial chemotherapy. Clin Infect Dis 2012 0.77
110 Comparison of the probability of target attainment between ceftriaxone and cefepime in the cerebrospinal fluid and serum against Streptococcus pneumoniae. Diagn Microbiol Infect Dis 2007 0.76
111 Determination of meropenem penetration into the lung from Sparse data. Antimicrob Agents Chemother 2011 0.75
112 Double-blind, prospective, multicenter trial comparing ceftazidime with moxalactam in the treatment of serious gram-negative infections. Antimicrob Agents Chemother 1986 0.75
113 Hollow-fiber pharmacodynamic studies and mathematical modeling to predict the efficacy of amoxicillin for anthrax postexposure prophylaxis in pregnant women and children. Antimicrob Agents Chemother 2013 0.75
114 Measurement of amikacin in serum by a latex agglutination inhibition test. J Clin Microbiol 1985 0.75
115 Acute thrombocytopenia secondary to the administration of the peptidomimetic HIV protease inhibitor MK-639(L735524) AIDS 1996 0.75
116 False elevation in serum creatinine levels. JAMA 1984 0.75
117 The serum bactericidal activity of latamoxef (moxalactam), cefoperazone and cefotaxime. J Antimicrob Chemother 1984 0.75
118 Lack of interference with creatinine assays by four cephalosporin-like antibiotics. Am J Clin Pathol 1984 0.75
119 Pseudomonas meningitis therapy recommendation questioned. Pediatrics 1989 0.75
120 Use of nonlinear, mixed-effects modeling for population analysis of ofloxacin: effects of age on oral drug pharmacokinetics. Pharmacotherapy 1992 0.75
121 Ciprofloxacin pharmacokinetics in critically ill trauma patients. Am J Med 1989 0.75
122 Serum inhibitory and bactericidal activity against methicillin-resistant Staphylococcus aureus in volunteers receiving novobiocin and rifampin alone and in combination. Diagn Microbiol Infect Dis 1994 0.75