1
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A trial of combination antimalarial therapies in children from Papua New Guinea.
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N Engl J Med
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2008
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4.77
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2
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Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria.
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Br J Clin Pharmacol
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2004
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3.48
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3
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Piperaquine: a resurgent antimalarial drug.
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Drugs
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2005
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2.80
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4
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Effects of a high-fat meal on the relative oral bioavailability of piperaquine.
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Antimicrob Agents Chemother
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2005
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2.00
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5
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Artemisinin-based combination therapies for uncomplicated malaria.
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Med J Aust
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2005
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1.98
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6
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Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria.
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Br J Clin Pharmacol
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2004
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1.84
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7
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Pharmacokinetics and efficacy of piperaquine and chloroquine in Melanesian children with uncomplicated malaria.
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Antimicrob Agents Chemother
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2007
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1.64
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8
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Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malaria.
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Antimicrob Agents Chemother
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2011
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1.32
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9
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Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection.
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J Chromatogr B Analyt Technol Biomed Life Sci
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2003
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1.30
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10
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Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome.
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Antimicrob Agents Chemother
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2011
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1.24
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11
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Studying drugs in human milk: time to unify the approach.
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J Hum Lact
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2002
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1.22
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12
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Disposition of artesunate and dihydroartemisinin after administration of artesunate suppositories in children from Papua New Guinea with uncomplicated malaria.
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Antimicrob Agents Chemother
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2004
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1.10
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13
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Pharmacokinetics of chloroquine and monodesethylchloroquine in pregnancy.
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Antimicrob Agents Chemother
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2010
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1.08
|
14
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Pharmacokinetic properties of sulfadoxine-pyrimethamine in pregnant women.
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Antimicrob Agents Chemother
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2009
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1.08
|
15
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Pharmacokinetics, pharmacodynamics, and allometric scaling of chloroquine in a murine malaria model.
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Antimicrob Agents Chemother
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2011
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1.06
|
16
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Artesunate suppositories versus intramuscular artemether for treatment of severe malaria in children in Papua New Guinea.
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Antimicrob Agents Chemother
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2006
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1.05
|
17
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In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea.
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Trop Med Int Health
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2010
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1.04
|
18
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Pharmacokinetic properties of azithromycin in pregnancy.
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Antimicrob Agents Chemother
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2009
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0.98
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19
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Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a pharmacokinetic study.
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Antimicrob Agents Chemother
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2012
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0.98
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20
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Pharmacokinetic comparison of two piperaquine-containing artemisinin combination therapies in Papua New Guinean children with uncomplicated malaria.
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Antimicrob Agents Chemother
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2012
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0.98
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21
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Rectal administration of artemisinin derivatives for the treatment of malaria.
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JAMA
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2007
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0.97
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22
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In vitro interactions between piperaquine, dihydroartemisinin, and other conventional and novel antimalarial drugs.
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Antimicrob Agents Chemother
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2006
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0.96
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23
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Pseudoephedrine: effects on milk production in women and estimation of infant exposure via breastmilk.
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Br J Clin Pharmacol
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2003
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0.96
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24
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Transfer of methylamphetamine and amphetamine into breast milk following recreational use of methylamphetamine.
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Br J Clin Pharmacol
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2009
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0.95
|
25
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Safety and therapeutic efficacy of artesunate suppositories for treatment of malaria in children in Papua New Guinea.
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Pediatr Infect Dis J
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2003
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0.94
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26
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Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants.
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Am J Psychiatry
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2003
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0.93
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27
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Dose-effect study of domperidone as a galactagogue in preterm mothers with insufficient milk supply, and its transfer into milk.
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Br J Clin Pharmacol
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2008
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0.93
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28
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Transfer of lamotrigine into breast milk.
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Ann Pharmacother
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2006
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0.93
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29
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Transfer of chloroquine and desethylchloroquine across the placenta and into milk in Melanesian mothers.
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Br J Clin Pharmacol
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2008
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0.91
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30
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A pilot study of newer antidepressant concentrations in cord and maternal serum and possible effects in the neonate.
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Int J Neuropsychopharmacol
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2004
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0.91
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31
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Pharmacokinetics and pharmacodynamics of piperaquine in a murine malaria model.
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Antimicrob Agents Chemother
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2007
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0.90
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32
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Pharmacokinetics of dihydroartemisinin in a murine malaria model.
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Am J Trop Med Hyg
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2008
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0.89
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33
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Protein binding and alpha : beta anomer ratio of dihydroartemisinin in vivo.
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Br J Clin Pharmacol
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2004
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0.89
|
34
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Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.
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Antimicrob Agents Chemother
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2006
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0.87
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35
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Methylphenidate and breast-feeding.
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Ann Pharmacother
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2006
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0.87
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36
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Determination of olanzapine in plasma by high-performance liquid chromatography using ultraviolet absorbance detection.
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J Chromatogr B Analyt Technol Biomed Life Sci
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2002
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0.86
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37
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Development of a pharmacodynamic model of murine malaria and antimalarial treatment with dihydroartemisinin.
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Int J Parasitol
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2007
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0.86
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38
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Transfer of the antidepressant mirtazapine into breast milk.
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Br J Clin Pharmacol
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2006
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0.85
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39
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Role of P glycoprotein in absorption of novel antimalarial drugs.
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Antimicrob Agents Chemother
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2006
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0.85
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40
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Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N-acetyltransferase and glutathione S-transferase activities.
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Environ Mol Mutagen
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2004
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0.85
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41
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Development of a sublingual/oral formulation of ketamine for use in neuropathic pain: Preliminary findings from a three-way randomized, crossover study.
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Clin Drug Investig
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2009
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0.84
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42
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Population pharmacokinetic modeling of tramadol and its O-desmethyl metabolite in plasma and breast milk.
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Eur J Clin Pharmacol
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2011
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0.84
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43
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Penetration of dihydroartemisinin into cerebrospinal fluid after administration of intravenous artesunate in severe falciparum malaria.
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Antimicrob Agents Chemother
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2003
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0.83
|
44
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Evaluation of a deuterium-labeled internal standard for the measurement of sirolimus by high-throughput HPLC electrospray ionization tandem mass spectrometry.
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Clin Chem
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2008
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0.83
|
45
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Investigation of reproductive toxicity of piperaquine in mice.
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Reprod Toxicol
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2009
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0.83
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46
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Estimation of desvenlafaxine transfer into milk and infant exposure during its use in lactating women with postnatal depression.
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Arch Womens Ment Health
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2010
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0.83
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47
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Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.
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Chem Biol Interact
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2004
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0.82
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48
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Cyclosporin monitoring in Australasia: 2002 update of consensus guidelines.
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Ther Drug Monit
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2002
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0.82
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49
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CYP2D6 and CYP2C19 in Papua New Guinea: High frequency of previously uncharacterized CYP2D6 alleles and heterozygote excess.
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Int J Mol Epidemiol Genet
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2010
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0.82
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50
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Comparison of gentamicin dose estimates derived from manual calculations, the Australian 'Therapeutic Guidelines: Antibiotic' nomogram and the SeBA-GEN and DoseCalc software programs.
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Br J Clin Pharmacol
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2004
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0.82
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51
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The amount of fluvoxamine in milk is unlikely to be a cause of adverse effects in breastfed infants.
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J Hum Lact
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2002
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0.81
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52
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The wellbeing of infants exposed to buprenorphine via breast milk at 4 weeks of age.
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J Hum Lact
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2014
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0.81
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53
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Simultaneous determination of primaquine and carboxyprimaquine in plasma using solid phase extraction and LC-MS assay.
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J Chromatogr B Analyt Technol Biomed Life Sci
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2012
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0.81
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54
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Transfer of escitalopram and its metabolite demethylescitalopram into breastmilk.
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Br J Clin Pharmacol
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2006
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0.80
|
55
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Pharmacokinetic properties of conventional and double-dose sulfadoxine-pyrimethamine given as intermittent preventive treatment in infancy.
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Antimicrob Agents Chemother
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2011
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0.80
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56
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Transfer of parecoxib and its primary active metabolite valdecoxib via transitional breastmilk following intravenous parecoxib use after cesarean delivery: a comparison of naive pooled data analysis and nonlinear mixed-effects modeling.
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Anesth Analg
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2012
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0.80
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57
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Use of duloxetine in pregnancy and lactation.
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Ann Pharmacother
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2009
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0.79
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58
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Measurement of nicotine and cotinine in human milk by high-performance liquid chromatography with ultraviolet absorbance detection.
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J Chromatogr B Analyt Technol Biomed Life Sci
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2003
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0.79
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59
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Piperaquine pharmacodynamics and parasite viability in a murine malaria model.
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Antimicrob Agents Chemother
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2009
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0.79
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60
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Toxicity related to chloroquine treatment of resistant vivax malaria.
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Ann Pharmacother
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2003
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0.79
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61
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Pharmacokinetics and pharmacodynamics of methadone enantiomers in hospice patients with cancer pain.
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Ther Drug Monit
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2006
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0.79
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62
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The selective pulmonary vasodilatory effect of inhaled DETA/NO, a novel nitric oxide donor, in ARDS-a pilot human trial.
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J Crit Care
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2004
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0.79
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63
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Transfer of reboxetine into breastmilk, its plasma concentrations and lack of adverse effects in the breastfed infant.
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Eur J Clin Pharmacol
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2006
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0.78
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64
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Investigation of target plasma concentration-effect relationships for olanzapine in schizophrenia.
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Ther Drug Monit
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2003
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0.78
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65
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Disposition and clinical outcome after intraperitoneal meperidine and ropivacaine administration during laparoscopic surgery.
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Anesth Analg
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2008
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0.78
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66
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Buprenorphine exposure in infants of opioid-dependent mothers at birth.
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Aust N Z J Obstet Gynaecol
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2012
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0.78
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67
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Two aerosolized nitric oxide adducts as selective pulmonary vasodilators for acute pulmonary hypertension.
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Chest
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2003
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0.77
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68
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The safety of aerosolized diethylenetriamine nitric oxide adduct after single-dose administration to anesthetized piglets and multiple-dose administration to conscious rats.
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Toxicol Appl Pharmacol
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2003
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0.77
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69
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Population PK modelling and simulation based on fluoxetine and norfluoxetine concentrations in milk: a milk concentration-based prediction model.
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Br J Clin Pharmacol
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2014
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0.77
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70
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Gabapentin and breastfeeding: a case report.
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J Hum Lact
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2006
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0.77
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71
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Optimizing the hydrolysis of codeine and morphine glucuronides in urine.
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Ther Drug Monit
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2002
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0.77
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72
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Olanzapine excretion in human breast milk: estimation of infant exposure.
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Int J Neuropsychopharmacol
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2002
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0.77
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73
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Development of a population pharmacokinetic model for parecoxib and its active metabolite valdecoxib after parenteral parecoxib administration in children.
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Anesthesiology
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2012
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0.77
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74
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Toxicology and pharmacokinetics of piperaquine in mice.
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Toxicology
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2008
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0.76
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75
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Duloxetine transfer across the placenta during pregnancy and into milk during lactation.
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Arch Womens Ment Health
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2011
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0.76
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76
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Inhaled diazeniumdiolates (NONOates) as selective pulmonary vasodilators.
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Expert Opin Investig Drugs
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2002
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0.76
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77
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Quetiapine and breast feeding.
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Ann Pharmacother
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2007
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0.76
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78
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Tramadol withdrawal in a neonate: only one of the clinical presentations to be anticipated...
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Eur J Clin Pharmacol
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2009
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0.75
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79
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Transfer of naltrexone and its metabolite 6,beta-naltrexol into human milk.
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J Hum Lact
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2004
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0.75
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80
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Prediction of milk/plasma concentration ratio of drugs.
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Ann Pharmacother
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2004
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0.75
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81
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Diethylenetriamine nitric oxide adduct relaxes precontracted mouse tracheal smooth muscle.
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Clin Exp Pharmacol Physiol
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2003
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0.75
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82
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Estimation of rac-amisulpride transfer into milk and of infant dose via milk during its use in a lactating woman with bipolar disorder and schizophrenia.
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Breastfeed Med
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2010
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0.75
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83
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Transfer of metyrapone and its metabolite, rac-metyrapol, into breast milk.
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J Hum Lact
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2009
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0.75
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84
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Effective clearance of Ara-U the major metabolite of cytosine arabinoside (Ara-C) by hemodialysis in a patient with lymphoma and end-stage renal failure.
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Cancer Chemother Pharmacol
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2010
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0.75
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85
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The ratio of polymorphonuclear leucocytes (PMN) to non-PMN cells--a novel method of assessing acute lung inflammation.
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Exp Toxicol Pathol
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2002
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0.75
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86
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Blood concentrations of enflurane before, during, and after hypothermic cardiopulmonary bypass.
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J Cardiothorac Vasc Anesth
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2006
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0.75
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87
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Therapeutic drug monitoring for busulfan in plasma during conditioning chemotherapy for autologous stem cell transplantation in relapsed primary cerebral lymphoma.
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Ther Drug Monit
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2010
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0.75
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