Published in J Vis Exp on March 25, 2012
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Systematic discovery of Xist RNA binding proteins. Cell (2015) 2.26
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun (2014) 1.84
DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions. Nature (2015) 1.60
A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure. Hum Mol Genet (2013) 1.19
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Association of the Long Non-coding RNA Steroid Receptor RNA Activator (SRA) with TrxG and PRC2 Complexes. PLoS Genet (2015) 0.82
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New insights into the expression and functions of the Kaposi's sarcoma-associated herpesvirus long noncoding PAN RNA. Virus Res (2015) 0.78
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The roles and regulation of Polycomb complexes in neural development. Cell Tissue Res (2014) 0.77
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The 7SK snRNP associates with the little elongation complex to promote snRNA gene expression. EMBO J (2017) 0.75
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Emerging roles for long noncoding RNAs in skeletal biology and disease. Connect Tissue Res (2016) 0.75
Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. Cell Discov (2017) 0.75
Sedentary lifestyle related exosomal release of Hotair from gluteal-femoral fat promotes intestinal cell proliferation. Sci Rep (2017) 0.75
Arabidopsis small nucleolar RNA monitors the efficient pre-rRNA processing during ribosome biogenesis. Proc Natl Acad Sci U S A (2016) 0.75
The interplay of post-translational modification and gene therapy. Drug Des Devel Ther (2016) 0.75
An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR. RNA (2016) 0.75
A long non-coding RNA interacts with Gfra1 and maintains survival of mouse spermatogonial stem cells. Cell Death Dis (2016) 0.75
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Expression of the Antisense-to-Latency Transcript Long Noncoding RNA in Kaposi's Sarcoma-Associated Herpesvirus. J Virol (2016) 0.75
LncFunNet: an integrated computational framework for identification of functional long noncoding RNAs in mouse skeletal muscle cells. Nucleic Acids Res (2017) 0.75
The Long Non-Coding RNA MEG3 is an Epigenetic Determinant of Oncogenic Signaling in Functional Pancreatic Neuroendocrine Tumor Cells. Mol Cell Biol (2017) 0.75
LncRNA GAS5 inhibits microglial M2 polarization and exacerbates demyelination. EMBO Rep (2017) 0.75
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55
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Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science (2008) 13.79
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression. Nature (2011) 11.59
Imaging individual mRNA molecules using multiple singly labeled probes. Nat Methods (2008) 10.40
Kcnq1ot1 antisense noncoding RNA mediates lineage-specific transcriptional silencing through chromatin-level regulation. Mol Cell (2008) 9.76
The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin. Science (2008) 8.45
Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell (2010) 6.88
Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell (2011) 6.83
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RNA as a flexible scaffold for proteins: yeast telomerase and beyond. Cold Spring Harb Symp Quant Biol (2006) 1.65
Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell (2007) 30.22
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature (2010) 23.55
Long noncoding RNA as modular scaffold of histone modification complexes. Science (2010) 15.23
Genome regulation by long noncoding RNAs. Annu Rev Biochem (2012) 11.70
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Molecular mechanisms of long noncoding RNAs. Mol Cell (2011) 11.44
Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell (2008) 7.69
Long noncoding RNAs and human disease. Trends Cell Biol (2011) 7.59
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position. Nat Methods (2013) 7.06
Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. Mol Cell (2011) 6.83
A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell (2009) 6.09
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature (2008) 6.02
Long noncoding RNAs: cellular address codes in development and disease. Cell (2013) 6.01
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet (2011) 5.62
Anatomic demarcation by positional variation in fibroblast gene expression programs. PLoS Genet (2006) 4.75
Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell (2009) 4.43
Deletional tolerance mediated by extrathymic Aire-expressing cells. Science (2008) 4.10
Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A (2003) 3.98
Genetic regulators of large-scale transcriptional signatures in cancer. Nat Genet (2006) 3.96
Genome-wide views of chromatin structure. Annu Rev Biochem (2009) 3.89
Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A (2009) 3.87
Genome-wide analysis of KAP1 binding suggests autoregulation of KRAB-ZNFs. PLoS Genet (2007) 3.75
The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-γ locus. Cell (2013) 3.40
Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res (2011) 3.38
Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3. Genes Dev (2008) 3.32
Decoding global gene expression programs in liver cancer by noninvasive imaging. Nat Biotechnol (2007) 3.17
Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev (2007) 3.16
Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature (2012) 3.08
Genome-wide measurement of RNA folding energies. Mol Cell (2012) 2.85
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A (2006) 2.72
Genomewide view of gene silencing by small interfering RNAs. Proc Natl Acad Sci U S A (2003) 2.56
Long noncoding RNA in genome regulation: prospects and mechanisms. RNA Biol (2010) 2.53
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Cell Stem Cell (2011) 2.49
Understanding the transcriptome through RNA structure. Nat Rev Genet (2011) 2.46
Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock. Cell (2012) 2.15
Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers. Genome Biol (2012) 2.12
Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev (2012) 2.12
RNA SHAPE analysis in living cells. Nat Chem Biol (2012) 2.02
Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila. Mol Cell (2013) 1.99
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Mol Cell (2009) 1.95
Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell (2013) 1.92
Targeted disruption of Hotair leads to homeotic transformation and gene derepression. Cell Rep (2013) 1.89
A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev (2008) 1.85
Systematic functional characterization of cis-regulatory motifs in human core promoters. Genome Res (2008) 1.83
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell (2009) 1.82
RNA templating the epigenome: long noncoding RNAs as molecular scaffolds. Epigenetics (2011) 1.75
Predicting a local recurrence after breast-conserving therapy by gene expression profiling. Breast Cancer Res (2006) 1.69
A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics. Elife (2013) 1.63
The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev (2010) 1.62
A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity. J Invest Dermatol (2009) 1.60
Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survival. J Clin Invest (2011) 1.60
MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species. Cancer Res (2006) 1.57
ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide. Curr Protoc Mol Biol (2015) 1.44
Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression. Cancer Cell (2009) 1.43
Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. J Clin Invest (2008) 1.43
Reversal of aging by NFkappaB blockade. Cell Cycle (2007) 1.36
Regeneration, repair and remembering identity: the three Rs of Hox gene expression. Trends Cell Biol (2009) 1.35
Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma. PLoS One (2012) 1.33
SeqFold: genome-scale reconstruction of RNA secondary structure integrating high-throughput sequencing data. Genome Res (2012) 1.30
Revealing targeted therapy for human cancer by gene module maps. Cancer Res (2008) 1.29
High frequency of false-positive hepatitis C virus enzyme-linked immunosorbent assay in Rakai, Uganda. Clin Infect Dis (2013) 1.26
Uncovering the role of genomic "dark matter" in human disease. J Clin Invest (2012) 1.26
Use of laser capture microdissection to map hepatitis C virus-positive hepatocytes in human liver. Gastroenterology (2013) 1.23
A transcriptional program mediating entry into cellular quiescence. PLoS Genet (2007) 1.23
A systems biology approach to anatomic diversity of skin. J Invest Dermatol (2008) 1.23
Molecular framework for response to imatinib mesylate in systemic sclerosis. Arthritis Rheum (2009) 1.22
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J Am Chem Soc (2015) 1.21
Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency. Elife (2014) 1.16
Structural organization of the inactive X chromosome in the mouse. Nature (2016) 1.15
Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks. PLoS Genet (2011) 1.13
Transcriptome sequencing in Sezary syndrome identifies Sezary cell and mycosis fungoides-associated lncRNAs and novel transcripts. Blood (2012) 1.10
Systematic reconstruction of RNA functional motifs with high-throughput microfluidics. Nat Methods (2012) 1.09
The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression. Cancer Discov (2012) 1.06
Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes. PLoS One (2008) 1.06
Genome-wide mapping of RNA structure using nuclease digestion and high-throughput sequencing. Nat Protoc (2013) 1.05
HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression. Cancer Res (2013) 1.05
HOTAIR: Flight of noncoding RNAs in cancer metastasis. Cell Cycle (2010) 1.03
G1 arrest and differentiation can occur independently of Rb family function. J Cell Biol (2010) 1.02
Stemness, cancer and cancer stem cells. Cell Cycle (2008) 1.02
Active chromatin and noncoding RNAs: an intimate relationship. Curr Opin Genet Dev (2011) 1.02
Detection of microbial translocation in HIV and SIV infection using the Limulus amebocyte lysate assay is masked by serum and plasma. PLoS One (2012) 1.01
CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression. Cancer Res (2008) 1.01
Learning more from microarrays: insights from modules and networks. J Invest Dermatol (2005) 1.00
Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA. J Am Chem Soc (2013) 0.99
Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding. EMBO Rep (2011) 0.96
Gene regulation: Long RNAs wire up cancer growth. Nature (2013) 0.94
Combining biological gene expression signatures in predicting outcome in breast cancer: An alternative to supervised classification. Eur J Cancer (2008) 0.93
Augmenting endogenous Wnt signaling improves skin wound healing. PLoS One (2013) 0.92
HOXA3 modulates injury-induced mobilization and recruitment of bone marrow-derived cells. Stem Cells (2009) 0.90
Laser captured hepatocytes show association of butyrylcholinesterase gene loss and fibrosis progression in hepatitis C-infected drug users. Hepatology (2012) 0.89
High throughput automated chromatin immunoprecipitation as a platform for drug screening and antibody validation. Lab Chip (2012) 0.88
RNA structural analysis by evolving SHAPE chemistry. Wiley Interdiscip Rev RNA (2014) 0.88
Identification of proteins binding coding and non-coding human RNAs using protein microarrays. BMC Genomics (2012) 0.88
From description to causality: mechanisms of gene expression signatures in cancer. Cell Cycle (2006) 0.87
Cytotopic localization by long noncoding RNAs. Curr Opin Cell Biol (2012) 0.86
A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev (2012) 0.81
Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study. J Invest Dermatol (2012) 0.81
Correction to "Structure and Thermodynamics of N(6)-Methyladenosine in RNA: A Spring-Loaded Base Modification". J Am Chem Soc (2015) 0.80
In situ dissection of RNA functional subunits by domain-specific chromatin isolation by RNA purification (dChIRP). Methods Mol Biol (2015) 0.79