Shizuo Yamada

Author PubWeight™ 119.16‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications. Int J Pharm 2011 1.38
2 Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors. Br J Pharmacol 2005 1.15
3 Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice. Brain Res Mol Brain Res 2005 1.02
4 Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability. J Pharm Sci 2010 0.94
5 Cordycepin (3'-deoxyadenosine) inhibits the growth of B16-BL6 mouse melanoma cells through the stimulation of adenosine A3 receptor followed by glycogen synthase kinase-3beta activation and cyclin D1 suppression. Naunyn Schmiedebergs Arch Pharmacol 2007 0.93
6 Human muscarinic receptor binding characteristics of antimuscarinic agents to treat overactive bladder. J Urol 2006 0.92
7 A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats. Toxicol Sci 2004 0.90
8 Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers. J Clin Pharmacol 2006 0.89
9 Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice. Br J Pharmacol 2005 0.89
10 Activation of muscarinic M-1 cholinoceptors by curcumin to increase contractility in urinary bladder isolated from Wistar rats. Neurosci Lett 2010 0.88
11 Mouse strain differences in immobility and sensitivity to fluvoxamine and desipramine in the forced swimming test: analysis of serotonin and noradrenaline transporter binding. Eur J Pharmacol 2008 0.88
12 Functional analysis of muscarinic acetylcholine receptors using knockout mice. Life Sci 2004 0.88
13 Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan. J Neurochem 2002 0.88
14 VAT-1 is a novel pathogenic factor of progressive benign prostatic hyperplasia. Prostate 2011 0.88
15 Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes. Drug Metab Pharmacokinet 2012 0.87
16 Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans. Drug Metab Dispos 2007 0.87
17 Advantages for transdermal over oral oxybutynin to treat overactive bladder: Muscarinic receptor binding, plasma drug concentration, and salivary secretion. J Pharmacol Exp Ther 2005 0.87
18 Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and Grape seed proanthocyanidins extract in mice. Biol Pharm Bull 2008 0.87
19 Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test. Eur J Pharmacol 2004 0.86
20 Structure-activity relationships of receptor binding of 1,4-dihydropyridine derivatives. Biol Pharm Bull 2008 0.86
21 Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice. Eur J Pharmacol 2005 0.86
22 Coleus forskohlii extract induces hepatic cytochrome P450 enzymes in mice. Food Chem Toxicol 2011 0.85
23 Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats. Life Sci 2005 0.85
24 Effects of continuous administration of paroxetine on ligand binding site and expression of serotonin transporter protein in mouse brain. Brain Res 2005 0.85
25 Isolation and pharmacological characterization of fatty acids from saw palmetto extract. Anal Sci 2009 0.85
26 In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy. J Control Release 2009 0.85
27 Hepatic cytochrome P450 mediates interaction between warfarin and Coleus forskohlii extract in vivo and in vitro. J Pharm Pharmacol 2012 0.84
28 Blood-brain permeability of [3H]-(3-methyl-His2)thyrotropin-releasing hormone (MeTRH) in mice: effects of TRH and its analogues. Drug Metab Pharmacokinet 2003 0.84
29 Pharmacological effects of Hachi-mi-jio-gan extract (Harncare) on the contractile response and on pharmacologically relevant receptors in the rat bladder. Yakugaku Zasshi 2009 0.84
30 Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice. Phytomedicine 2011 0.84
31 Liposomal formulations of glucagon-like peptide-1: improved bioavailability and anti-diabetic effect. Int J Pharm 2009 0.84
32 Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography. Life Sci 2010 0.84
33 Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells. Biol Pharm Bull 2010 0.83
34 Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for the treatment of asthma/COPD. Peptides 2007 0.83
35 Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice. Br J Pharmacol 2009 0.83
36 Natural vanadium-containing Mt. Fuji ground water improves hypo-activity of liver insulin receptor in Goto-Kakisaki rats. Mol Cell Biochem 2004 0.83
37 Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach. Int J Pharm 2010 0.83
38 Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain. Life Sci 2007 0.82
39 Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q(10) formulations. Int J Pharm 2008 0.82
40 Development of rapid and simultaneous quantitative method for green tea catechins on the bioanalytical study using UPLC/ESI-MS. Biomed Chromatogr 2012 0.82
41 Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract. Food Chem Toxicol 2004 0.82
42 Establishment and intra-/inter-laboratory validation of a standard protocol of reactive oxygen species assay for chemical photosafety evaluation. J Appl Toxicol 2012 0.82
43 Relationship between development of nephrotoxicity and blood concentration of cyclosporine A in bone-marrow transplanted recipients who received the continuous intravenous infusion. Biol Pharm Bull 2003 0.82
44 In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment. J Pharmacol Exp Ther 2008 0.82
45 Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates. J Pharm Biomed Anal 2008 0.82
46 Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: a monkey PET study with [(11)C](+)3-MPB. Neuroimage 2011 0.81
47 Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability. Eur J Pharm Sci 2009 0.81
48 High-throughput reactive oxygen species (ROS) assay: an enabling technology for screening the phototoxic potential of pharmaceutical substances. J Pharm Biomed Anal 2007 0.81
49 In vivo characterization of muscarinic receptors in peripheral tissues: evaluation of bladder selectivity of anticholinergic agents to treat overactive bladder. Naunyn Schmiedebergs Arch Pharmacol 2007 0.81
50 Inhalable dry-emulsion formulation of cyclosporine A with improved anti-inflammatory effects in experimental asthma/COPD-model rats. Eur J Pharm Biopharm 2011 0.81
51 Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract. Biol Pharm Bull 2009 0.81
52 Investigation of the bioactive conformation of histamine H3 receptor antagonists by the cyclopropylic strain-based conformational restriction strategy. J Med Chem 2010 0.81
53 In vitro and in vivo characterization of new formulations of St. John's Wort extract with improved pharmacokinetics and anti-nociceptive effect. Drug Metab Pharmacokinet 2011 0.81
54 Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications. Naunyn Schmiedebergs Arch Pharmacol 2008 0.80
55 Effects of oral administration of extracts of Hypericum perforatum (St John's wort) on brain serotonin transporter, serotonin uptake and behaviour in mice. J Pharm Pharmacol 2004 0.80
56 A novel mechanism for polychlorinated biphenyl-induced decrease in serum thyroxine level in rats. Drug Metab Dispos 2007 0.80
57 In vivo measurement of 1,4-dihydropyridine receptors in mesenteric arteries of spontaneously hypertensive rats and effect of nifedipine and cilnidipine. Biol Pharm Bull 2002 0.80
58 Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability. Eur J Pharm Biopharm 2009 0.80
59 Onset of clinical effects and plasma concentration of fluvoxamine in Japanese patients. Biol Pharm Bull 2010 0.80
60 Anti-androgenic effects of S-40542, a novel non-steroidal selective androgen receptor modulator (SARM) for the treatment of benign prostatic hyperplasia. Prostate 2012 0.80
61 Ginkgo biloba extract modifies hypoglycemic action of tolbutamide via hepatic cytochrome P450 mediated mechanism in aged rats. Life Sci 2004 0.80
62 Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide attenuate the cigarette smoke extract-induced apoptotic death of rat alveolar L2 cells. Eur J Biochem 2004 0.80
63 In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts. Phytochemistry 2011 0.79
64 Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis. Neurosci Lett 2008 0.79
65 Development of micellar reactive oxygen species assay for photosafety evaluation of poorly water-soluble chemicals. Toxicol In Vitro 2013 0.79
66 Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice. Life Sci 2002 0.79
67 Photosafety assessments on pirfenidone: photochemical, photobiological, and pharmacokinetic characterization. J Photochem Photobiol B 2013 0.79
68 Long-acting analogue of vasoactive intestinal peptide, [R15, 20, 21, L17]-VIP-GRR (IK312532), protects rat alveolar L2 cells from the cytotoxicity of cigarette smoke. Regul Pept 2004 0.79
69 Physicochemical and pharmacological characterization of alpha-tocopherol-loaded nano-emulsion system. Int J Pharm 2010 0.79
70 Improvement by phytotherapeutic agent of detrusor overactivity, down-regulation of pharmacological receptors and urinary cytokines in rats with cyclophosphamide induced cystitis. J Urol 2012 0.79
71 Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats. Eur J Pharm Sci 2009 0.79
72 In vivo demonstration of muscarinic receptor binding activity of N-desethyl-oxybutynin, active metabolite of oxybutynin. Life Sci 2005 0.79
73 Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects. Eur J Clin Pharmacol 2009 0.78
74 Dietary Coleus forskohlii extract generates dose-related hepatotoxicity in mice. J Appl Toxicol 2012 0.78
75 Comparative assessment of empirical and physiological approaches on predicting human clearances. J Pharm Sci 2010 0.78
76 Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats. Br J Pharmacol 2003 0.78
77 Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifenacin in mice. Biol Pharm Bull 2006 0.78
78 Modulation of phenotype of human prostatic stromal cells by transforming growth factor-betas. Prostate 2004 0.78
79 Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R(15, 20, 21), L(17), A(24,25), des-N(28)]-VIP-GRR) in experimental asthma/COPD model rats. Int J Pharm 2011 0.78
80 Alpha-helical structure in the C-terminus of vasoactive intestinal peptide: functional and structural consequences. Eur J Pharmacol 2004 0.78
81 Cyclopropane-based conformational restriction of GABA by a stereochemical diversity-oriented strategy: identification of an efficient lead for potent inhibitors of GABA transports. Bioorg Med Chem 2013 0.78
82 The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: bladder selectivity based on in vivo drug-receptor binding characteristics of antimuscarinic agents for treatment of overactive bladder. J Pharmacol Sci 2010 0.78
83 Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol 2004 0.78
84 Benzbromarone pharmacokinetics and pharmacodynamics in different cytochrome P450 2C9 genotypes. Drug Metab Pharmacokinet 2010 0.78
85 Inhalable powder formulation of pirfenidone with reduced phototoxic risk for treatment of pulmonary fibrosis. Pharm Res 2013 0.78
86 Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation. Peptides 2012 0.78
87 Relationship between prostatic alpha(1)-adrenoceptor binding and reduction in intraurethral pressure following continuous infusion of KMD-3213 in rats. Pharmacology 2002 0.78
88 Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate. Ann Clin Biochem 2002 0.78
89 Combined use of in vitro phototoxic assessments and cassette dosing pharmacokinetic study for phototoxicity characterization of fluoroquinolones. AAPS J 2011 0.78
90 Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats. Drug Metab Pharmacokinet 2013 0.78
91 Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS. Drug Metab Pharmacokinet 2011 0.78
92 Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats. Eur J Pharm Sci 2010 0.78
93 High-throughput screening strategy for photogenotoxic potential of pharmaceutical substances using fluorescent intercalating dye. J Pharm Biomed Anal 2010 0.78
94 Pharmacokinetic and pharmacodynamic analysis of acetylcholinesterase inhibition by distigmine bromide in rats. Drug Metab Pharmacokinet 2010 0.78
95 Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: anti-inflammatory effect in experimental asthmatic rats. Peptides 2009 0.78
96 Polychlorinated biphenyl-mediated decrease in serum thyroxine level in rodents. Drug Metab Dispos 2009 0.78
97 Brain neurotransmitter receptor-binding characteristics in rats after oral administration of haloperidol, risperidone and olanzapine. Life Sci 2007 0.78
98 Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. Urology 2010 0.78
99 Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development. Curr Drug Saf 2009 0.78
100 Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. J Pharmacol Sci 2009 0.78
101 Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery. Int J Pharm 2009 0.77
102 Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis. Peptides 2010 0.77
103 Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase. Drug Metab Dispos 2005 0.77
104 Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. Int J Pharm 2012 0.77
105 Misinterpretation of the effect of amlodipine on cytosolic calcium concentration with fura-2 fluorospectrometry. Naunyn Schmiedebergs Arch Pharmacol 2008 0.77
106 Overview of green tea interaction with cardiovascular drugs. Curr Pharm Des 2015 0.77
107 Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity. Pharm Res 2011 0.77
108 In vitro/in vivo phototoxic risk assessments of griseofulvin based on photobiochemical and pharmacokinetic behaviors. Eur J Pharm Sci 2009 0.77
109 Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder. J Urol 2007 0.77
110 [Effects of various ginkgo biloba extracts and proanthocyanidin on hepatic cytochrome P450 activity in rats]. Shokuhin Eiseigaku Zasshi 2004 0.77
111 Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice. Eur J Pharmacol 2009 0.77
112 Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects. Eur J Pharm Sci 2013 0.77
113 Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity. J Urol 2005 0.77
114 A possible mechanism for 2,2',4,4',5,5'-hexachlorobiphenyl-mediated decrease in serum thyroxine level in mice. Toxicol Appl Pharmacol 2011 0.77
115 New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy. Expert Opin Drug Deliv 2009 0.77
116 A novel method using confocal laser scanning microscopy for sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells. J Pharm Pharmacol 2011 0.77
117 Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes. Xenobiotica 2014 0.77
118 Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6beta-glucuronide in rats. Life Sci 2007 0.77
119 Comparative studies on physicochemical stability of cyclosporine A-loaded amorphous solid dispersions. Int J Pharm 2012 0.77
120 Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats. Eur J Pharm Sci 2011 0.77
121 High-throughput screening system for identifying phototoxic potential of drug candidates based on derivatives of reactive oxygen metabolites. Pharm Res 2010 0.77
122 Effects of cigarette smoking and cytochrome P450 2D6 genotype on fluvoxamine concentration in plasma of Japanese patients. Biol Pharm Bull 2010 0.77
123 Development of PACAP38 analogue with improved stability: physicochemical and in vitro/in vivo pharmacological characterization. J Mol Neurosci 2010 0.77
124 Muscarinic Receptor Binding in Rat Bladder Urothelium and Detrusor Muscle by Intravesical Solifenacin. Biol Pharm Bull 2016 0.77
125 St. John's wort promotes adipocyte differentiation and modulates NF-κB activation in 3T3-L1 cells. Biol Pharm Bull 2014 0.76
126 Development of meloxicam salts with improved dissolution and pharmacokinetic behaviors in rats with impaired gastric motility. Pharm Res 2012 0.76
127 In vivo identification and characterization of binding sites for selective serotonin reuptake inhibitors in mouse brain. Life Sci 2004 0.76
128 Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay. J Pharm Sci 2009 0.76
129 4-Hydroxy-2,2',3,4',5,5',6-heptachlorobiphenyl-mediated decrease in serum thyroxine level in mice occurs through increase in accumulation of thyroxine in the liver. Drug Metab Dispos 2009 0.76
130 Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors. Eur J Pharm Sci 2012 0.76
131 In vitro/in vivo characterization of nanocrystalline formulation of tranilast with improved dissolution and hepatoprotective properties. Eur J Pharm Biopharm 2013 0.76
132 Development of dry powder inhalation system of novel vasoactive intestinal peptide (VIP) analogue for pulmonary administration. Life Sci 2006 0.76
133 Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tract. Urology 2007 0.76
134 Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases. J Pharm Sci 2011 0.76
135 Pharmacokinetics and pharmacodynamics of low doses of midazolam administered intravenously and orally to healthy volunteers. Clin Exp Pharmacol Physiol 2009 0.76
136 Chemical synthesis and formulation design of a PEGylated vasoactive intestinal peptide derivative with improved metabolic stability. Eur J Pharm Sci 2013 0.76
137 Stereochemical diversity-oriented conformational restriction strategy. Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure. J Med Chem 2006 0.76
138 Demonstration of muscarinic and nicotinic receptor binding activities of distigmine to treat detrusor underactivity. Biol Pharm Bull 2010 0.76
139 Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability. Int J Pharm 2013 0.76
140 Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms. Drug Metab Pharmacokinet 2006 0.76
141 Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther 2011 0.76
142 Respirable dry powder formulation of bleomycin for developing a pulmonary fibrosis animal model. J Pharm Sci 2012 0.76
143 Pharmacological effects and lung-binding characteristics of a novel VIP analogue, [R15, 20, 21, L17]-VIP-GRR (IK312532). Regul Pept 2004 0.76
144 Muscarinic receptors and their mRNAs in type 2 Goto-Kakizaki diabetic rat prostate. Prostate 2010 0.76
145 Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability. Drug Metab Pharmacokinet 2012 0.76
146 Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability. J Pharm Sci 2011 0.75
147 Novel homodimer model of the β-adrenergic receptor in complex with free fatty acids and cholesterol: first-principles calculation studies. Bioinformation 2012 0.75
148 Beneficial effects of Gosha-jinki-gan and green tea extract in rats with chemical cystitis. J Pharmacol Sci 2013 0.75
149 Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction. Neurosci Lett 2007 0.75
150 Pharmacological effects of saw palmetto extract in the lower urinary tract. Acta Pharmacol Sin 2009 0.75
151 Editorial comment to suppression of bladder overactivity and oxidative stress by the phytotherapeutic agent, Eviprostat, in a rat model of atherosclerosis-induced chronic bladder ischemia. Int J Urol 2012 0.75
152 Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression. FEBS J 2008 0.75
153 A possible mechanism for the decrease in serum thyroxine level by a 2,3,7,8-tetrachlorodibenzo-p-dioxin-like polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl in mice. Drug Metab Dispos 2010 0.75
154 Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard. Urology 2011 0.75
155 Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. Int J Pharm 2012 0.75
156 Stable dry powder inhaler formulation of tranilast attenuated antigen-evoked airway inflammation in rats. Eur J Pharm Biopharm 2010 0.75
157 In vitro phototoxicity of dihydropyridine derivatives: a photochemical and photobiological study. Eur J Pharm Sci 2007 0.75
158 A possible mechanism for 2,3',4,4',5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level in mice. Biol Pharm Bull 2013 0.75
159 Involvement of the 5-HT(1A) receptor in the anti-immobility effects of fluvoxamine in the forced swimming test and mouse strain differences in 5-HT(1A) receptor binding. Eur J Pharmacol 2009 0.75
160 Is hyperuricemia a risk factor for arteriosclerosis? Uric acid and arteriosclerosis in apolipoprotein e-deficient mice. Biol Pharm Bull 2014 0.75
161 Bladder endothelin-1 receptor binding of bosentan and ambrisentan. J Pharmacol Sci 2013 0.75
162 [In vivo analysis of drug-receptor binding characteristics]. Nihon Yakurigaku Zasshi 2009 0.75
163 Synthesis of 1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents: cyclopropane-based conformationally restricted analogs of haloperidol. Bioorg Med Chem 2008 0.75
164 Development of (-)-epigallocatechin-3-gallate (EGCG)-loaded enteric microparticles with intestinal mucoadhesive property. Int J Pharm 2011 0.75
165 A possible mechanism for the decrease in serum thyroxine level by phenobarbital in rodents. Toxicol Appl Pharmacol 2010 0.75
166 Up-regulation of nicotinic and muscarinic receptor mRNA in rat bladder by repeated administration of nicotine in relation to the pharmacokinetics. Life Sci 2011 0.75
167 Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats. J Pharm Pharmacol 2011 0.75
168 Cyclopropane-based stereochemical diversity-oriented conformational restriction strategy: histamine H3 and/or H4 receptor ligands with the 2,3-methanobutane backbone. Org Biomol Chem 2011 0.75
169 Studies on the transport of thyrotropin-releasing hormone (TRH) analogues in Caco-2 cell monolayers. J Pharm Pharmacol 2003 0.75
170 5th International Symposium on receptor mechanisms, signal transduction and drug effects. Naunyn Schmiedebergs Arch Pharmacol 2008 0.75
171 Different effects of morphine and morphine-6beta-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats. Neurosci Lett 2007 0.75
172 Muscarinic receptor binding of the novel radioligand, [3h]imidafenacin in the human bladder and parotid gland. J Pharmacol Sci 2013 0.75
173 Three-dimensional structural diversity-oriented peptidomimetics based on the cyclopropylic strain. Org Lett 2013 0.75
174 Effects of quinidine on antinociception and pharmacokinetics of morphine in rats. J Pharm Pharmacol 2009 0.75
175 A simple method to evaluate reactivity of acylglucuronides optimized for early stage drug discovery. Biol Pharm Bull 2013 0.75
176 Photosafety screening of phenothiazine derivatives with combined use of photochemical and cassette-dosing pharmacokinetic data. Toxicol Sci 2013 0.75
177 Non-animal photosafety assessment approaches for cosmetics based on the photochemical and photobiochemical properties. Toxicol In Vitro 2013 0.75
178 Effects of repeated morphine treatment on the antinociceptive effects, intestinal absorption, and efflux from intestinal epithelial cells of morphine. Biol Pharm Bull 2009 0.75
179 Comparative study on 2,2',4,5,5'-pentachlorobiphenyl-mediated decrease in serum thyroxine level between C57BL/6 and its transthyretin-deficient mice. Toxicol Appl Pharmacol 2012 0.75
180 Highly sensitive measurement of P-glycoprotein-mediated transport activity in Caco-2 cells. Biol Pharm Bull 2010 0.75
181 The 5-HT2 receptor antagonist reduces immobility of mice treated with the atypical antidepressant mianserin in the forced swimming test. Biol Pharm Bull 2002 0.75
182 Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020. Biol Pharm Bull 2014 0.75
183 Development of an albuminous reactive oxygen species assay for photosafety evaluation under experimental biomimetic conditions. J Appl Toxicol 2013 0.75
184 In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: a novel 5-HT4 partial agonist. J Pharm Sci 2008 0.75
185 Enhancement by grapefruit juice of morphine antinociception. Biol Pharm Bull 2008 0.75
186 Synthesis and structural and pharmacological properties of cyclopropane-based conformationally restricted analogs of 4-methylhistamine as histamine H3/H4 receptor ligands. Bioorg Med Chem 2009 0.75
187 Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy. J Pharm Pharmacol 2010 0.75
188 Effects of ursodeoxycholic acid on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam in healthy volunteers. Naunyn Schmiedebergs Arch Pharmacol 2007 0.75
189 Microenvironmental pH-modification to improve dissolution behavior and oral absorption for drugs with pH-dependent solubility. Expert Opin Drug Deliv 2014 0.75
190 The decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice: no correlation with formation of methylsulfonyl metabolites. Drug Metab Dispos 2005 0.75
191 Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate. J Pharmacol Sci 2011 0.75
192 Fesoterodine, its active metabolite, and tolterodine bind selectively to muscarinic receptors in human bladder mucosa and detrusor muscle. Urology 2013 0.75
193 Cyclopropane-based conformational restriction of histamine. (1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclopropane, a highly selective agonist for the histamine H3 receptor, having a cis-cyclopropane structure. J Med Chem 2003 0.75
194 New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions. Drug Metab Pharmacokinet 2013 0.75
195 Development of cyclosporine A-loaded dry-emulsion formulation using highly purified glycerol monooleate for safe inhalation therapy. Int J Pharm 2013 0.75
196 Exploratory and regulatory assessments on photosafety of new drug entities. Curr Drug Saf 2012 0.75
197 Structure-activity relationship of synthetic truncated analogues of vasoactive intestinal peptide (VIP): an enhancement in the activity by a substitution with arginine. Life Sci 2004 0.75
198 3,3',4,4'-Tetrachlorobiphenyl-mediated decrease of serum thyroxine level in C57BL/6 and DBA/2 mice occurs mainly through enhanced accumulation of thyroxine in the liver. Biol Pharm Bull 2013 0.75
199 Characterization of the carrier-mediated transport of ketoprofen, a nonsteroidal anti-inflammatory drug, in rabbit corneal epithelium cells. J Pharm Pharmacol 2012 0.75
200 In vitro photobiochemical characterization of sulfobutylether-β-cyclodextrin formulation of bufexamac. J Pharm Biomed Anal 2011 0.75