Published in Chem Res Toxicol on April 18, 2012
The CYP2C19*17 variant is not independently associated with clopidogrel response. J Thromb Haemost (2013) 0.94
Cytochrome P450-activated prodrugs. Future Med Chem (2013) 0.82
Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase. PLoS One (2014) 0.82
Morphine interaction with prasugrel: a double-blind, cross-over trial in healthy volunteers. Clin Res Cardiol (2015) 0.80
Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel. Mol Pharmacol (2013) 0.79
JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell (2004) 3.30
Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes. Biochemistry (2003) 1.38
Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding. Biochemistry (2003) 1.34
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis. Mol Cell Biol (2012) 1.28
Metabolic oxidative cleavage of thioesters: evidence for the formation of sulfenic acid intermediates in the bioactivation of the antithrombotic prodrugs ticlopidine and clopidogrel. Chem Res Toxicol (2009) 1.16
Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer. Chem Res Toxicol (2011) 1.06
Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2. Arch Biochem Biophys (2007) 0.96
Unprecedented ipso aromatic nucleophilic substitution upon oxidative decarboxylation of tris(p-carboxyltetrathiaaryl)methyl (TAM) radicals: a new access to diversely substituted TAM radicals. Chem Commun (Camb) (2011) 0.95
Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-. Chem Commun (Camb) (2009) 0.93
N-Aryl N'-hydroxyguanidines, a new class of NO-donors after selective oxidation by nitric oxide synthases: structure-activity relationship. J Med Chem (2002) 0.93
Automatic clustering of docking poses in virtual screening process using self-organizing map. Bioinformatics (2009) 0.92
Inhibitor coordination interactions in the binuclear manganese cluster of arginase. Biochemistry (2004) 0.92
Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid. Arch Biochem Biophys (2003) 0.91
Unusual regioselectivity and active site topology of human cytochrome P450 2J2. Biochemistry (2007) 0.91
Possible role of region 152-156 in the structural duality of a peptide fragment from sheep prion protein. Protein Sci (2004) 0.90
NMR studies for identifying phosphopeptide ligands of the HIV-1 protein Vpu binding to the F-box protein beta-TrCP. Peptides (2005) 0.90
Synthesis and evaluation of new omega-borono-alpha-amino acids as rat liver arginase inhibitors. Bioorg Med Chem (2005) 0.90
Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry (2004) 0.89
Formation and fate of a sulfenic acid intermediate in the metabolic activation of the antithrombotic prodrug prasugrel. Chem Res Toxicol (2010) 0.89
Solution structure of a peptide derived from the oncogenic protein beta-Catenin in its phosphorylated and nonphosphorylated states. Peptides (2005) 0.89
Oxidative decarboxylation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes by peroxidases and related hemeproteins: intermediate formation and characterization of the corresponding cations. Arch Biochem Biophys (2010) 0.88
NMR studies of the phosphorylation motif of the HIV-1 protein Vpu bound to the F-box protein beta-TrCP. Biochemistry (2003) 0.87
Oxidative and reductive metabolism of tris(p-carboxyltetrathiaaryl)methyl radicals by liver microsomes. Chem Res Toxicol (2009) 0.87
Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2. Bioorg Med Chem Lett (2006) 0.87
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450. Arch Biochem Biophys (2003) 0.87
Analogies and surprising differences between recombinant nitric oxide synthase-like proteins from Staphylococcus aureus and Bacillus anthracis in their interactions with l-arginine analogs and iron ligands. J Inorg Biochem (2006) 0.87
Paraoxonase-1 and clopidogrel efficacy. Nat Med (2011) 0.86
STD and TRNOESY NMR studies on the conformation of the oncogenic protein beta-catenin containing the phosphorylated motif DpSGXXpS bound to the beta-TrCP protein. J Biol Chem (2005) 0.85
Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta. J Pharmacol Exp Ther (2002) 0.84
Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols. Angew Chem Int Ed Engl (2009) 0.84
Tryptophan depletion and the kinase GCN2 mediate IFN-γ-induced autophagy. J Immunol (2012) 0.84
A S-adenosylmethionine methyltransferase-like domain within the essential, Fe-S-containing yeast protein Dre2. FEBS J (2012) 0.84
Interaction between the reductase Tah18 and highly conserved Fe-S containing Dre2 C-terminus is essential for yeast viability. Mol Microbiol (2011) 0.84
First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives. Biochem Biophys Res Commun (2005) 0.83
Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases. J Inorg Biochem (2011) 0.83
Reduction of ferric haemoproteins by tetrahydropterins: a kinetic study. Biochem J (2005) 0.83
Toward stable electron paramagnetic resonance oximetry probes: synthesis, characterization, and metabolic evaluation of new ester derivatives of a tris-(para-carboxyltetrathiaaryl)methyl (TAM) radical. Chem Res Toxicol (2013) 0.82
Supramolecular self-assembly of a fluorinated Zn porphyrin. Molecular structure of a two-dimensional network of amine-functionalized, hexacoordinated Zn porphyrins. Chem Commun (Camb) (2002) 0.82
Transfer-NMR and docking studies identify the binding of the peptide derived from activating transcription factor 4 to protein ubiquitin ligase beta-TrCP. Competition STD-NMR with beta-catenin. Biochemistry (2007) 0.81
Post-translational modification of Rhodococcus R312 and Comamonas NI1 nitrile hydratases. J Mass Spectrom (2003) 0.81
Chaperone-assisted expression, purification, and characterization of recombinant nitrile hydratase NI1 from Comamonas testosteroni. Protein Expr Purif (2003) 0.80
A new derivative detected in accelerated ageing of artesunate-amodiaquine fixed dose combination tablets. J Pharm Biomed Anal (2013) 0.80
STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody. FEBS Lett (2006) 0.80
Allosteric tuning of the intra-cavity binding properties of a calix[6]arene through external binding to a ZnII center coordinated to amino side chains. Chemistry (2007) 0.80
Differential effects of alkyl- and arylguanidines on the stability and reactivity of inducible NOS heme-dioxygen complexes. Biochemistry (2006) 0.80
A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis. Arch Biochem Biophys (2011) 0.80
Structure of the complex between phosphorylated substrates and the SCF beta-TrCP ubiquitin ligase receptor: a combined NMR, molecular modeling, and docking approach. J Chem Inf Model (2008) 0.79
Air-stable, electron-deficient Fe(II) catalytic porphyrins. Characterization and molecular structures of rare high spin Fe(II) hexacoordinated porphyrins. Inorg Chem (2002) 0.79
Very general formation of tetrahydropterin cation radicals during reaction of iron porphyrins with tetrahydropterins: model for the corresponding NO-synthase reaction. Chem Commun (Camb) (2003) 0.79
Phosphorylation-dependent structure of ATF4 peptides derived from a human ATF4 protein, a member of the family of transcription factors. Peptides (2007) 0.79
Sulfaphenazole derivatives as tools for comparing cytochrome P450 2C5 and human cytochromes P450 2Cs: identification of a new high affinity substrate common to those enzymes. Biochemistry (2003) 0.79
Reactions of amino acids, peptides, and proteins with oxidized metabolites of tris(p-carboxyltetrathiaaryl)methyl radical EPR probes. Chem Res Toxicol (2014) 0.79
Two modes of binding of N-hydroxyguanidines to NO synthases: first evidence for the formation of iron-N-hydroxyguanidine complexes and key role of tetrahydrobiopterin in determining the binding mode. Biochemistry (2003) 0.78
Structural studies on 24P-IkappaBalpha peptide derived from a human IkappaB-alpha protein related to the inhibition of the activity of the transcription factor NF-kappaB. Biochemistry (2007) 0.78
Deciphering the activation sequence of ferrociphenol anticancer drug candidates. Chemistry (2012) 0.78
First combined in vivo X-ray tomography and high-resolution molecular electron paramagnetic resonance (EPR) imaging of the mouse knee joint taking into account the disappearance kinetics of the EPR probe. Mol Imaging (2012) 0.78
Metabolic activation of the antitumor drug 5-(Aziridin-1-yl)-2,4-dinitrobenzamide (CB1954) by NO synthases. Chem Res Toxicol (2008) 0.77
Coordination chemistry of iron(III)-porphyrin-antibody complexes. Eur J Biochem (2002) 0.77
Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO. FEBS J (2005) 0.77
Urinary metabolic fingerprint of acute intermittent porphyria analyzed by (1)H NMR spectroscopy. Anal Chem (2014) 0.77
Importance of valine 567 in substrate recognition and oxidation by neuronal nitric oxide synthase. J Inorg Biochem (2004) 0.77
Inhibitory effects of a series of 7-substituted-indazoles toward nitric oxide synthases: particular potency of 1H-indazole-7-carbonitrile. Bioorg Med Chem (2008) 0.77
Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents. Eur J Pharmacol (2005) 0.77
Epitope mapping of the phosphorylation motif of the HIV-1 protein Vpu bound to the selective monoclonal antibody using TRNOESY and STD NMR spectroscopy. Biochemistry (2004) 0.77
Mechanism of the aromatic hydroxylation of thiophene by acid-catalyzed peracid oxidation. J Org Chem (2002) 0.77
The first water-soluble copper(I) calix[6]arene complex presenting a hydrophobic ligand binding pocket: a remarkable model for active sites in metalloenzymes. Angew Chem Int Ed Engl (2002) 0.77
Thiolactone sulfoxides as new reactive metabolites acting as bis-electrophiles: implication in clopidogrel and prasugrel bioactivation. Chem Res Toxicol (2013) 0.77
Novel RANK antagonists for the treatment of bone-resorptive disease: theoretical predictions and experimental validation. J Bone Miner Res (2014) 0.76
First non-alpha-amino acid guanidines acting as efficient NO precursors upon oxidation by NO-synthase II or activated mouse macrophages. Biochemistry (2002) 0.76
Reactivity of the heme-dioxygen complex of the inducible nitric oxide synthase in the presence of alternative substrates. FEBS J (2006) 0.76
Synthesis and glycosidase inhibitory activity of new hexa-substituted C8-glycomimetics. Beilstein J Org Chem (2005) 0.75
Contact-based ligand-clustering approach for the identification of active compounds in virtual screening. Adv Appl Bioinform Chem (2012) 0.75
Comparison of wild type neuronal nitric oxide synthase and its Tyr588Phe mutant towards various L-arginine analogues. J Inorg Biochem (2010) 0.75
Metabolic stability of superoxide and hydroxyl radical adducts of a cyclic nitrone toward rat liver microsomes and cytosol: A stopped-flow ESR spectroscopy study. Free Radic Biol Med (2010) 0.75
Antibiotic resistance peptides: interaction of peptides conferring macrolide and ketolide resistance with Staphylococcus aureus ribosomes: conformation of bound peptides as determined by transferred NOE experiments. Biochemistry (2002) 0.75
Microperoxidase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxide. Eur J Biochem (2003) 0.75
Interaction of anions with rat liver arginase: specific inhibitory effects of fluoride. J Inorg Biochem (2002) 0.75
Fixing the conformations of diamineplatinum(II)-GpG chelates: NMR and CD signatures of individual rotamers. J Biol Inorg Chem (2006) 0.75
Ecdysteroids from the medicinal fern Microsorum scolopendria (Burm. f.). Phytochem Anal (2007) 0.75