Published in Int J Mol Sci on March 15, 2012
Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells. Toxicol Sci (2015) 0.85
Heavy Metals and Human Health: Mechanistic Insight into Toxicity and Counter Defense System of Antioxidants. Int J Mol Sci (2015) 0.84
Oxidative stress and replication-independent DNA breakage induced by arsenic in Saccharomyces cerevisiae. PLoS Genet (2013) 0.79
The LABCG2 Transporter from the Protozoan Parasite Leishmania Is Involved in Antimony Resistance. Antimicrob Agents Chemother (2016) 0.77
An alternate pathway of arsenate resistance in E. coli mediated by the glutathione S-transferase GstB. ACS Chem Biol (2015) 0.76
Silver and Nitrate Oppositely Modulate Antimony Susceptibility through Aquaglyceroporin 1 in Leishmania (Viannia) Species. Antimicrob Agents Chemother (2016) 0.75
The diversity of membrane transporters encoded in bacterial arsenic-resistance operons. PeerJ (2015) 0.75
A silicon transporter in rice. Nature (2006) 4.86
Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch (2003) 3.33
Phosphate transport in Arabidopsis: Pht1;1 and Pht1;4 play a major role in phosphate acquisition from both low- and high-phosphate environments. Plant J (2004) 3.28
Transporters of arsenite in rice and their role in arsenic accumulation in rice grain. Proc Natl Acad Sci U S A (2008) 2.85
Transport of metal-binding peptides by HMT1, a fission yeast ABC-type vacuolar membrane protein. J Biol Chem (1995) 2.64
The Arabidopsis major intrinsic protein NIP5;1 is essential for efficient boron uptake and plant development under boron limitation. Plant Cell (2006) 2.52
Fps1p controls the accumulation and release of the compatible solute glycerol in yeast osmoregulation. Mol Microbiol (1999) 2.52
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells. Cancer Res (1994) 2.49
Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Exp Biol Med (Maywood) (2007) 2.18
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci U S A (2002) 2.16
Arsenic accumulation and metabolism in rice (Oryza sativa L.). Environ Sci Technol (2002) 2.07
The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisiae. Mol Microbiol (2001) 2.02
Pathways of As(III) detoxification in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1999) 2.02
Putative GTP-binding protein, Gtr1, associated with the function of the Pho84 inorganic phosphate transporter in Saccharomyces cerevisiae. Mol Cell Biol (1992) 1.82
Plant aquaporins: novel functions and regulation properties. FEBS Lett (2007) 1.79
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin. J Biol Chem (2004) 1.79
Arsenical-based cancer drugs. Cancer Treat Rev (2007) 1.78
Metabolism of arsenic in human liver: the role of membrane transporters. Arch Toxicol (2009) 1.74
Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides. J Biol Chem (2000) 1.73
As(III) and Sb(III) uptake by GlpF and efflux by ArsB in Escherichia coli. J Biol Chem (2004) 1.72
PHOSPHATE TRANSPORTER TRAFFIC FACILITATOR1 is a plant-specific SEC12-related protein that enables the endoplasmic reticulum exit of a high-affinity phosphate transporter in Arabidopsis. Plant Cell (2005) 1.71
The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport. J Biol Chem (1997) 1.70
Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem (2000) 1.70
Arsenic tolerance in Arabidopsis is mediated by two ABCC-type phytochelatin transporters. Proc Natl Acad Sci U S A (2010) 1.70
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite. J Bacteriol (1998) 1.66
Leishmania major LmACR2 is a pentavalent antimony reductase that confers sensitivity to the drug pentostam. J Biol Chem (2004) 1.60
Isolation of three contiguous genes, ACR1, ACR2 and ACR3, involved in resistance to arsenic compounds in the yeast Saccharomyces cerevisiae. Yeast (1997) 1.58
The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. Mol Biol Cell (2006) 1.57
Antimonite is accumulated by the glycerol facilitator GlpF in Escherichia coli. J Bacteriol (1997) 1.57
The P-glycoprotein multidrug transporter. Essays Biochem (2011) 1.56
Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. strain PCC 6803. J Bacteriol (2003) 1.56
Aquaporin water channels in mammals. Clin Exp Nephrol (2008) 1.55
Heavy metal resistance: a new role for P-glycoproteins in Leishmania. J Biol Chem (1991) 1.55
The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J Biol Chem (2000) 1.54
Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1). Evidence that a tri-glutathione conjugate is required. J Biol Chem (2004) 1.52
A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes. BMC Biol (2008) 1.50
The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase. J Biol Chem (2001) 1.48
Overexpression of glutathione S-transferase II and multidrug resistance transport proteins is associated with acquired tolerance to inorganic arsenic. Mol Pharmacol (2001) 1.48
Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae. Curr Genet (1996) 1.42
Heat shock and arsenite increase expression of the multidrug resistance (MDR1) gene in human renal carcinoma cells. J Biol Chem (1990) 1.37
Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania. Mol Microbiol (2005) 1.35
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev (2009) 1.34
The rice aquaporin Lsi1 mediates uptake of methylated arsenic species. Plant Physiol (2009) 1.32
Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase. J Biol Chem (1992) 1.30
Antimony uptake systems in the protozoan parasite Leishmania and accumulation differences in antimony-resistant parasites. Antimicrob Agents Chemother (2003) 1.29
Regulation of phosphate acquisition in Saccharomyces cerevisiae. Curr Genet (2003) 1.28
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins. Cancer Res (1997) 1.27
Experimental and theoretical characterization of arsenite in water: insights into the coordination environment of As-O. Inorg Chem (2004) 1.27
A vacuolar arsenite transporter necessary for arsenic tolerance in the arsenic hyperaccumulating fern Pteris vittata is missing in flowering plants. Plant Cell (2010) 1.27
Homologues of the human multidrug resistance genes MRP and MDR contribute to heavy metal resistance in the soil nematode Caenorhabditis elegans. EMBO J (1996) 1.27
Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance. Cancer Res (2000) 1.25
Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun (2004) 1.21
The Arabidopsis thaliana aquaglyceroporin AtNIP7;1 is a pathway for arsenite uptake. FEBS Lett (2008) 1.20
Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. Blood (2006) 1.19
A novel arsenate reductase from the arsenic hyperaccumulating fern Pteris vittata. Plant Physiol (2006) 1.19
How Saccharomyces cerevisiae copes with toxic metals and metalloids. FEMS Microbiol Rev (2010) 1.18
Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania major. Mol Biochem Parasitol (2003) 1.17
Arsenic exposure and the induction of human cancers. J Toxicol (2011) 1.16
Novel pathway for arsenic detoxification in the legume symbiont Sinorhizobium meliloti. J Bacteriol (2005) 1.16
NIP1;1, an aquaporin homolog, determines the arsenite sensitivity of Arabidopsis thaliana. J Biol Chem (2008) 1.15
Assessing aquaglyceroporin gene status and expression profile in antimony-susceptible and -resistant clinical isolates of Leishmania donovani from India. J Antimicrob Chemother (2010) 1.14
A CDC25 homologue from rice functions as an arsenate reductase. New Phytol (2007) 1.13
Tonoplast-localized Abc2 transporter mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. J Biol Chem (2010) 1.12
Metalloids: essential, beneficial or toxic? Major intrinsic proteins sort it out. Trends Biochem Sci (2007) 1.12
Identification of positive regulators of the yeast fps1 glycerol channel. PLoS Genet (2009) 1.11
Mammalian multidrug-resistance proteins (MRPs). Essays Biochem (2011) 1.11
The role of the rice aquaporin Lsi1 in arsenite efflux from roots. New Phytol (2010) 1.10
Arsenic pollution sources. Rev Environ Contam Toxicol (2008) 1.10
Methylarsonous acid transport by aquaglyceroporins. Environ Health Perspect (2006) 1.08
Investigating the contribution of the phosphate transport pathway to arsenic accumulation in rice. Plant Physiol (2011) 1.07
The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS J (2007) 1.07
Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p. Mol Biol Cell (2004) 1.06
Arsenic trioxide uptake by hexose permeases in Saccharomyces cerevisiae. J Biol Chem (2004) 1.03
A putative membrane protein, Pho88p, involved in inorganic phosphate transport in Saccharomyces cerevisiae. Mol Gen Genet (1996) 1.02
Properties of arsenite efflux permeases (Acr3) from Alkaliphilus metalliredigens and Corynebacterium glutamicum. J Biol Chem (2009) 1.00
Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem Biophys Res Commun (2006) 0.99
Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. DmHMT-1 and its yeast homolog, SpHMT-1, are not essential for vacuolar phytochelatin sequestration. J Biol Chem (2008) 0.98
New delivery strategies for the old pentavalent antimonial drugs. Expert Opin Drug Deliv (2010) 0.98
Arsenic-glutathione conjugate transport by the human multidrug resistance proteins (MRPs/ABCCs). J Inorg Biochem (2011) 0.97
ABC transporters in Leishmania and their role in drug resistance. Drug Resist Updat (1998) 0.97
Detoxification of multiple heavy metals by a half-molecule ABC transporter, HMT-1, and coelomocytes of Caenorhabditis elegans. PLoS One (2010) 0.96
Arsenic transport by zebrafish aquaglyceroporins. BMC Mol Biol (2009) 0.96
Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice. Proc Natl Acad Sci U S A (2009) 0.95
Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun (2004) 0.95
Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. J Biol Chem (2006) 0.94
Aquaglyceroporins: ancient channels for metalloids. J Biol (2008) 0.93
Multidrug-resistance mdr1a/1b double knockout mice are more sensitive than wild type mice to acute arsenic toxicity, with higher arsenic accumulation in tissues. Toxicology (2002) 0.93
Resistance of human multidrug resistance-associated protein 1-overexpressing lung tumor cells to the anticancer drug arsenic trioxide. Biochem Pharmacol (2001) 0.92
Structural evidence of the similarity of Sb(OH)3 and As(OH)3 with glycerol: implications for their uptake. Chem Res Toxicol (2007) 0.92
Arsenite transport in plants. Cell Mol Life Sci (2009) 0.91
Worms take the 'phyto' out of 'phytochelatins'. Trends Biotechnol (2002) 0.89
Adventitious arsenate reductase activity of the catalytic domain of the human Cdc25B and Cdc25C phosphatases. Biochemistry (2010) 0.88
Expressing ScACR3 in rice enhanced arsenite efflux and reduced arsenic accumulation in rice grains. Plant Cell Physiol (2011) 0.88
Acr3p is a plasma membrane antiporter that catalyzes As(III)/H(+) and Sb(III)/H(+) exchange in Saccharomyces cerevisiae. Biochim Biophys Acta (2011) 0.87
Pentavalent methylated arsenicals are substrates of human AQP9. Biometals (2009) 0.87
Toxicokinetic and genomic analysis of chronic arsenic exposure in multidrug-resistance mdr1a/1b(-/-) double knockout mice. Mol Cell Biochem (2004) 0.87
Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p. Biochem J (2008) 0.87
Members of rice plasma membrane intrinsic proteins subfamily are involved in arsenite permeability and tolerance in plants. Transgenic Res (2012) 0.86
Arsenic transport in prokaryotes and eukaryotic microbes. Adv Exp Med Biol (2010) 0.86
The MAPK Hog1p modulates Fps1p-dependent arsenite uptake and tolerance in yeast. Mol Biol Cell (2006) 1.57
Yeast G1 DNA damage checkpoint regulation by H2A phosphorylation is independent of chromatin remodeling. Proc Natl Acad Sci U S A (2006) 1.32
Arthroscopic treatment of multidirectional shoulder instability with minimum 270 degrees labral repair: minimum 2-year follow-up. Arthroscopy (2008) 0.89
The Swi2-Snf2-like protein Uls1 is involved in replication stress response. Nucleic Acids Res (2011) 0.88
Acr3p is a plasma membrane antiporter that catalyzes As(III)/H(+) and Sb(III)/H(+) exchange in Saccharomyces cerevisiae. Biochim Biophys Acta (2011) 0.87
Characterization of the DNA-binding motif of the arsenic-responsive transcription factor Yap8p. Biochem J (2008) 0.87
Mitogen-activated protein kinase Hog1 mediates adaptation to G1 checkpoint arrest during arsenite and hyperosmotic stress. Eukaryot Cell (2008) 0.83
Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase. Acta Crystallogr D Biol Crystallogr (2011) 0.82
Design, synthesis, and characterization of a highly effective Hog1 inhibitor: a powerful tool for analyzing MAP kinase signaling in yeast. PLoS One (2011) 0.82
The yeast aquaglyceroporin Fps1p is a bidirectional arsenite channel. FEBS Lett (2009) 0.81
Different sensitivities of mutants and chimeric forms of human muscle and liver fructose-1,6-bisphosphatases towards AMP. Biol Chem (2003) 0.81
Arsenical resistance genes in Saccharomyces douglasii and other yeast species undergo rapid evolution involving genomic rearrangements and duplications. FEMS Yeast Res (2004) 0.80
The yeast permease Acr3p is a dual arsenite and antimonite plasma membrane transporter. Biochim Biophys Acta (2010) 0.80
The regulatory inputs controlling pleiotropic drug resistance and hypoxic response in yeast converge at the promoter of the aminocholesterol resistance gene RTA1. FEMS Yeast Res (2011) 0.79
Oxidative stress and replication-independent DNA breakage induced by arsenic in Saccharomyces cerevisiae. PLoS Genet (2013) 0.79
[Efflux-mediated antimicrobial multidrug resistance]. Postepy Hig Med Dosw (Online) (2011) 0.76
A novel phenotype of eight spores asci in deletants of the prion-like Rnq1p in Saccharomyces cerevisiae. Biochem Biophys Res Commun (2005) 0.76
The LSH/HELLS homolog Irc5 contributes to cohesin association with chromatin in yeast. Nucleic Acids Res (2017) 0.75
The genetic characteristics Saccharomyces cerevisiae aci(+) mutants. Cell Mol Biol Lett (2003) 0.75
The YJL185C, YLR376C and YJR129C genes of Saccharomyces cerevisiae are probably involved in regulation of the glyoxylate cycle. Acta Biochim Pol (2006) 0.75
Quaternary ammonium salt N-(dodecyloxycarboxymethyl)-N,N,N-trimethyl ammonium chloride induced alterations in Saccharomyces cerevisiae physiology. J Biosci (2016) 0.75