Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile.

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Published in Sci Transl Med on April 04, 2012

Authors

Jeffrey Hrkach1, Daniel Von Hoff, Mir Mukkaram Ali, Elizaveta Andrianova, Jason Auer, Tarikh Campbell, David De Witt, Michael Figa, Maria Figueiredo, Allen Horhota, Susan Low, Kevin McDonnell, Erick Peeke, Beadle Retnarajan, Abhimanyu Sabnis, Edward Schnipper, Jeffrey J Song, Young Ho Song, Jason Summa, Douglas Tompsett, Greg Troiano, Tina Van Geen Hoven, Jim Wright, Patricia LoRusso, Philip W Kantoff, Neil H Bander, Christopher Sweeney, Omid C Farokhzad, Robert Langer, Stephen Zale

Author Affiliations

1: BIND Biosciences Inc., Cambridge, MA 02139, USA.

Associated clinical trials:

A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension), Administered to Patients With Metastatic Castration-Resistant Prostate Cancer | NCT01812746

A Phase 2 Study to Determine the Safety and Efficacy of BIND-014 (Docetaxel Nanoparticles for Injectable Suspension) as Second-line Therapy to Patients With Non-Small Cell Lung Cancer | NCT01792479

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