PubRank

Ronald A Depinho

Author PubWeight™ 135.96‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005 12.35
2 Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 2006 8.26
3 High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A 2005 6.52
4 Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 2006 5.90
5 A genetic screen for candidate tumor suppressors identifies REST. Cell 2005 5.61
6 The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 2006 5.11
7 Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 2010 5.02
8 High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 2006 5.01
9 Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab 2007 4.74
10 Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron 2007 4.47
11 Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 2010 4.36
12 Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 2010 3.99
13 Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell 2011 3.88
14 Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 2010 3.54
15 Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev 2012 3.44
16 Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 2005 3.15
17 Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res 2006 2.92
18 Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev 2008 2.61
19 Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res 2010 2.57
20 Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A 2005 2.54
21 mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev 2005 2.37
22 Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med 2008 2.06
23 Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 2008 1.96
24 Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med 2009 1.85
25 FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 2010 1.81
26 Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nat Biotechnol 2009 1.76
27 Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 2005 1.73
28 FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab 2010 1.72
29 ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci U S A 2007 1.61
30 Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation. Proc Natl Acad Sci U S A 2008 1.48
31 Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc Natl Acad Sci U S A 2005 1.47
32 Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res 2006 1.42
33 STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev 2012 1.38
34 The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell 2006 1.30
35 Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol Cell Biol 2009 1.24
36 FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest 2012 1.13
37 Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev 2010 1.11
38 Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc Natl Acad Sci U S A 2007 1.07
39 Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis 2005 1.06
40 Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells 2010 1.06
41 Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis 2008 0.99
42 A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol 2008 0.96
43 Prognostic determinants in prostate cancer. Cancer J 2011 0.95
44 IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab 2012 0.95
45 Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biol Psychiatry 2008 0.94
46 Impact papers on aging in 2009. Aging (Albany NY) 2010 0.89
47 ZNF365 promotes stability of fragile sites and telomeres. Cancer Discov 2013 0.83
48 Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia 2013 0.83
49 Cancer drug discovery faces the FACT. Sci Transl Med 2011 0.75