Published in ACS Chem Biol on June 04, 2012
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Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. Eur J Med Chem (2014) 0.95
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The small molecules AZD0530 and dasatinib inhibit dengue virus RNA replication via Fyn kinase. J Virol (2013) 0.92
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An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin production. Mol Cell Biol (2014) 0.79
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Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophages. J Cell Sci (2014) 0.78
ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells. J Virol (2015) 0.78
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Damage to lens fiber cells causes TRPV4-dependent Src family kinase activation in the epithelium. Exp Eye Res (2015) 0.77
Induction of thermal and mechanical hypersensitivity by parathyroid hormone-related peptide through upregulation of TRPV1 function and trafficking. Pain (2015) 0.77
Increased Src Family Kinase Activity Disrupts Excitatory Synaptic Transmission and Impairs Remote Fear Memory in Forebrain Shp2-Deficient Mice. Mol Neurobiol (2016) 0.77
Development of a chimeric c-Src kinase and HDAC inhibitor. ACS Med Chem Lett (2013) 0.76
PP2 prevents β-adrenergic stimulation of cardiac pacemaker activity. J Cardiovasc Pharmacol (2014) 0.76
Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment Elaboration. ACS Med Chem Lett (2015) 0.76
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The Q510E mutation in Shp2 perturbs heart valve development by increasing cell migration. J Appl Physiol (1985) (2014) 0.76
Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell Chem Biol (2017) 0.76
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase. J Med Chem (2016) 0.75
Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles. Cell Chem Biol (2016) 0.75
The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection. J Cell Sci (2016) 0.75
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Irreversible inhibitors of c-Src kinase that target a nonconserved cysteine. ACS Chem Biol (2012) 0.90
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Development of a chimeric c-Src kinase and HDAC inhibitor. ACS Med Chem Lett (2013) 0.76