The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes.

PubWeight™: 3.66‹?› | Rank: Top 1%

🔗 View Article (PMID 2266943)

Published in Mol Gen Genet on December 01, 1990

Authors

S Dutka-Malen1, C Molinas, M Arthur, P Courvalin

Author Affiliations

1: Unité des Agents Antibactériens, Centre National de la Recherche Scientifique, Unité Associée 271, Institut Pasteur, Paris, France.

Articles citing this

Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J Clin Microbiol (1995) 12.98

Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol (1993) 6.96

Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother (1993) 6.28

Characterization of glycopeptide-resistant enterococci from U.S. hospitals. Antimicrob Agents Chemother (1993) 5.96

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol (1992) 4.99

Vancomycin resistance gene vanC is specific to Enterococcus gallinarum. Antimicrob Agents Chemother (1992) 3.63

Vancomycin-resistant enterococci from nosocomial, community, and animal sources in the United States. Antimicrob Agents Chemother (1996) 3.48

Current perspectives on glycopeptide resistance. Clin Microbiol Rev (1995) 2.99

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. J Bacteriol (1996) 2.87

Analysis of genes encoding D-alanine-D-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. Antimicrob Agents Chemother (1994) 2.65

Multiplex PCR detection of vanA, vanB, vanC-1, and vanC-2/3 genes in enterococci. J Clin Microbiol (1997) 2.61

A gene conferring resistance to vancomycin but not teicoplanin in isolates of Enterococcus faecalis and Enterococcus faecium demonstrates homology with vanB, vanA, and vanC genes of enterococci. Antimicrob Agents Chemother (1993) 2.56

Genetic diversity among Enterococcus faecalis. PLoS One (2007) 2.32

Inducible carboxypeptidase activity in vancomycin-resistant enterococci. Antimicrob Agents Chemother (1992) 2.30

Use of primers selective for vancomycin resistance genes to determine van genotype in enterococci and to study gene organization in VanA isolates. Antimicrob Agents Chemother (1995) 2.11

Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob Agents Chemother (1994) 2.01

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrob Agents Chemother (1992) 1.99

Application of DNA probes for rRNA and vanA genes to investigation of a nosocomial cluster of vancomycin-resistant enterococci. J Clin Microbiol (1993) 1.95

Emergence of high-level resistance to glycopeptides in Enterococcus gallinarum and Enterococcus casseliflavus. Antimicrob Agents Chemother (1994) 1.89

Knockout of the two ldh genes has a major impact on peptidoglycan precursor synthesis in Lactobacillus plantarum. J Bacteriol (1996) 1.81

Identification of clinically relevant viridans group streptococci to the species level by PCR. J Clin Microbiol (1997) 1.77

Clinical and epidemiological significance of enterococci intrinsically resistant to vancomycin (possessing the vanC genotype) J Clin Microbiol (1997) 1.63

Inducible and constitutive expression of vanC-1-encoded resistance to vancomycin in Enterococcus gallinarum. Antimicrob Agents Chemother (1995) 1.61

Analysis of peptidoglycan precursors in vancomycin-resistant enterococci. Antimicrob Agents Chemother (1992) 1.50

Specificity of induction of glycopeptide resistance genes in Enterococcus faecalis. Antimicrob Agents Chemother (1996) 1.41

A vancomycin-inducible lacZ reporter system in Bacillus subtilis: induction by antibiotics that inhibit cell wall synthesis and by lysozyme. J Bacteriol (1996) 1.40

D-Ala-D-Ala ligases from glycopeptide antibiotic-producing organisms are highly homologous to the enterococcal vancomycin-resistance ligases VanA and VanB. Proc Natl Acad Sci U S A (1997) 1.38

Random amplified polymorphic DNA typing versus pulsed-field gel electrophoresis for epidemiological typing of vancomycin-resistant enterococci. J Clin Microbiol (1996) 1.35

Vancomycin resistance in Enterococcus gallinarum. Antimicrob Agents Chemother (1992) 1.32

Emergence and dissemination of a highly vancomycin-resistant vanA strain of Enterococcus faecium at a large teaching hospital. J Clin Microbiol (1997) 1.25

Effects of amino acids on expression of enterococcal vancomycin resistance. Antimicrob Agents Chemother (1992) 1.21

Multiple antibiotic resistance gene transfer from animal to human enterococci in the digestive tract of gnotobiotic mice. Antimicrob Agents Chemother (2003) 1.20

Induction signals for vancomycin resistance encoded by the vanA gene cluster in Enterococcus faecium. Antimicrob Agents Chemother (1996) 1.20

Constitutively vancomycin-resistant Enterococcus faecium resistant to synergistic beta-lactam combinations. Antimicrob Agents Chemother (1993) 1.18

Antibiotic resistance patterns of enterococci and occurrence of vancomycin-resistant enterococci in raw minced beef and pork in Germany. Appl Environ Microbiol (1998) 1.17

Inducible and constitutive expression of resistance to glycopeptides and vancomycin dependence in glycopeptide-resistant Enterococcus avium. Antimicrob Agents Chemother (1995) 1.14

Vancomycin-resistant Enterococcus spp. isolated from wastewater and chicken feces in the United States. Appl Environ Microbiol (2001) 1.02

Survey of antibiotic resistance among enterococci in North Rhine-Westphalia, Germany. J Clin Microbiol (1999) 0.86

Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales. Antimicrob Agents Chemother (2014) 0.85

DdlN from vancomycin-producing Amycolatopsis orientalis C329.2 is a VanA homologue with D-alanyl-D-lactate ligase activity. J Bacteriol (1998) 0.85

Evaluation of a PCR assay to detect enterococcusfaecalis in blood and determine glycopeptides resistance genes: van a and van B. Iran J Med Sci (2012) 0.82

Vancomycin-resistant Enterococcus faecium strains isolated from community wastewater from a semiclosed agri-food system in Texas. Antimicrob Agents Chemother (2005) 0.79

Emergence of vanA gene among vancomycin-resistant enterococci in a tertiary care hospital of North - East India. Indian J Med Res (2016) 0.78

A deletion polymorphism in the human alpha-2-macroglobulin (A2M) gene. Nucleic Acids Res (1991) 0.76

A locked nucleic acid (LNA)-based real-time PCR assay for the rapid detection of multiple bacterial antibiotic resistance genes directly from positive blood culture. PLoS One (2015) 0.75

New nucleotide sequence data on the EMBL File Server. Nucleic Acids Res (1991) 0.75

Articles by these authors

Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N Engl J Med (1988) 16.74

Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J Clin Microbiol (1995) 12.98

Resolution of recent evolutionary divergence among Escherichia coli from related lineages: the application of pulsed field electrophoresis to molecular epidemiology. J Infect Dis (1990) 8.33

Nucleotide sequence of the Streptococcus faecalis plasmid gene encoding the 3'5"-aminoglycoside phosphotransferase type III. Gene (1983) 8.32

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants. Antimicrob Agents Chemother (1999) 7.94

Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification. Antimicrob Agents Chemother (1991) 7.18

Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol (1993) 6.96

Genetics and mechanisms of glycopeptide resistance in enterococci. Antimicrob Agents Chemother (1993) 6.28

Transferable resistance to third-generation cephalosporins in clinical isolates of Klebsiella pneumoniae: identification of CTX-1, a novel beta-lactamase. J Antimicrob Chemother (1987) 6.27

Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA. Biochemistry (1991) 5.90

Transferable vancomycin and teicoplanin resistance in Enterococcus faecium. Antimicrob Agents Chemother (1989) 5.31

Multidrug resistance in Yersinia pestis mediated by a transferable plasmid. N Engl J Med (1997) 5.23

The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol (1992) 4.99

Nucleotide sequence analysis of the gene specifying the bifunctional 6'-aminoglycoside acetyltransferase 2"-aminoglycoside phosphotransferase enzyme in Streptococcus faecalis and identification and cloning of gene regions specifying the two activities. J Bacteriol (1986) 4.74

Transposable multiple antibiotic resistance in Streptococcus pneumoniae. Mol Gen Genet (1986) 4.49

Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545. Nucleic Acids Res (1986) 4.47

Development of "oligotyping" for characterization and molecular epidemiology of TEM beta-lactamases in members of the family Enterobacteriaceae. Antimicrob Agents Chemother (1990) 4.45

In vivo transfer of genetic information between gram-positive and gram-negative bacteria. EMBO J (1985) 4.24

Contribution of mutations in gyrA and parC genes to fluoroquinolone resistance of mutants of Streptococcus pneumoniae obtained in vivo and in vitro. Antimicrob Agents Chemother (1996) 3.95

Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity. Biochemistry (1991) 3.76

Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545. Nucleic Acids Res (1990) 3.74

Sequence of the vanC gene of Enterococcus gallinarum BM4174 encoding a D-alanine:D-alanine ligase-related protein necessary for vancomycin resistance. Gene (1992) 3.68

Estrogens and endometrial cancer in a retirement community. N Engl J Med (1976) 3.64

Vancomycin resistance gene vanC is specific to Enterococcus gallinarum. Antimicrob Agents Chemother (1992) 3.63

Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454. Antimicrob Agents Chemother (2001) 3.56

Plasmid-mediated resistance to aminocyclitol antibiotics in group D streptococci. J Bacteriol (1980) 3.55

Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae. Antimicrob Agents Chemother (1997) 3.50

Plasmid-mediated resistance to third-generation cephalosporins caused by point mutations in TEM-type penicillinase genes. Rev Infect Dis (1988) 3.49

Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. J Bacteriol (1988) 3.43

Glycopeptide resistance in enterococci. Trends Microbiol (1996) 3.42

Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in gram-positive bacteria. Antimicrob Agents Chemother (1990) 3.33

Molecular characterization of two proteins involved in the excision of the conjugative transposon Tn1545: homologies with other site-specific recombinases. EMBO J (1989) 3.26

Direct sequencing of the amplified structural gene and promoter for the extended-broad-spectrum beta-lactamase TEM-9 (RHH-1) of Klebsiella pneumoniae. Plasmid (1990) 3.19

Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America. Antimicrob Agents Chemother (2000) 3.00

Shuttle vectors containing a multiple cloning site and a lacZ alpha gene for conjugal transfer of DNA from Escherichia coli to gram-positive bacteria. Gene (1991) 3.00

The vanB gene of vancomycin-resistant Enterococcus faecalis V583 is structurally related to genes encoding D-Ala:D-Ala ligases and glycopeptide-resistance proteins VanA and VanC. Gene (1993) 2.99

Structural relationship between the genes encoding 3'-aminoglycoside phosphotransferases in Campylobacter and in gram-positive cocci. Ann Inst Pasteur Microbiol (1986) 2.92

Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria. Antimicrob Agents Chemother (1991) 2.91

Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine. Mol Microbiol (1994) 2.90

Nomenclature for new tetracycline resistance determinants. Antimicrob Agents Chemother (1999) 2.89

Regulation of VanB-type vancomycin resistance gene expression by the VanS(B)-VanR (B) two-component regulatory system in Enterococcus faecalis V583. J Bacteriol (1996) 2.87

Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci. Mol Microbiol (1996) 2.84

Distribution of erythromycin esterase and rRNA methylase genes in members of the family Enterobacteriaceae highly resistant to erythromycin. Antimicrob Agents Chemother (1987) 2.80

Sequence of the vanB and ddl genes encoding D-alanine:D-lactate and D-alanine:D-alanine ligases in vancomycin-resistant Enterococcus faecalis V583. Gene (1994) 2.76

Endoscopic biliary endoprosthesis in the palliation of malignant obstruction of the distal common bile duct: a randomized trial. Br J Surg (1988) 2.74

Sequence of the genes blaT-1B and blaT-2. Gene (1991) 2.72

Worldwide disseminated armA aminoglycoside resistance methylase gene is borne by composite transposon Tn1548. Antimicrob Agents Chemother (2005) 2.71

Characterization of the plasmid genes blaT-4 and blaT-5 which encode the broad-spectrum beta-lactamases TEM-4 and TEM-5 in enterobacteriaceae. Gene (1989) 2.69

Tn1545: a conjugative shuttle transposon. Mol Gen Genet (1987) 2.65

Analysis of genes encoding D-alanine-D-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. Antimicrob Agents Chemother (1994) 2.65

Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus. Antimicrob Agents Chemother (1998) 2.58

Conjugative plasmid transfer from Enterococcus faecalis to Escherichia coli. J Bacteriol (1988) 2.58

A pair of mobilizable shuttle vectors conferring resistance to spectinomycin for molecular cloning in Escherichia coli and in gram-positive bacteria. Nucleic Acids Res (1990) 2.57

Identification of the satA gene encoding a streptogramin A acetyltransferase in Enterococcus faecium BM4145. Antimicrob Agents Chemother (1993) 2.56

Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis. Emerg Infect Dis (2001) 2.50

VanD-type glycopeptide-resistant Enterococcus faecium BM4339. Antimicrob Agents Chemother (1997) 2.50

Detection of erythromycin resistance by the polymerase chain reaction using primers in conserved regions of erm rRNA methylase genes. Antimicrob Agents Chemother (1990) 2.49

The vanB gene confers various levels of self-transferable resistance to vancomycin in enterococci. J Infect Dis (1993) 2.49

Activity of the new fluoroquinolone trovafloxacin (CP-99,219) against DNA gyrase and topoisomerase IV mutants of Streptococcus pneumoniae selected in vitro. Antimicrob Agents Chemother (1996) 2.48

Nomenclature for tetracycline resistance determinants. Antimicrob Agents Chemother (1989) 2.46

An integrative vector exploiting the transposition properties of Tn1545 for insertional mutagenesis and cloning of genes from gram-positive bacteria. Gene (1991) 2.42

TEM beta-lactamase mutants hydrolysing third-generation cephalosporins. A kinetic and molecular modelling analysis. J Mol Biol (1994) 2.35

Effects of combinations of beta-lactams, daptomycin, gentamicin, and glycopeptides against glycopeptide-resistant enterococci. Antimicrob Agents Chemother (1991) 2.31

Updated sequence information for TEM beta-lactamase genes. Antimicrob Agents Chemother (1999) 2.31

Functional gene transfer from intracellular bacteria to mammalian cells. Nat Biotechnol (1998) 2.30

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases. Gene (1991) 2.28

Mechanisms of antibiotic resistance in Campylobacter species. Antimicrob Agents Chemother (1988) 2.26

Susceptibility of Campylobacter pyloridis to 20 antimicrobial agents. Antimicrob Agents Chemother (1986) 2.26

Molecular characterization of integrons in Acinetobacter baumannii: description of a hybrid class 2 integron. Antimicrob Agents Chemother (2000) 2.25

Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin. Antimicrob Agents Chemother (1977) 2.22

Mutation in 23S rRNA responsible for resistance to 16-membered macrolides and streptogramins in Streptococcus pneumoniae. Antimicrob Agents Chemother (2001) 2.22

Translocation of sequences encoding antibiotic resistance from the chromosome to a receptor plasmid in Salmonella ordonez. Mol Gen Genet (1981) 2.22

Resistance to glycopeptides in enterococci. Clin Infect Dis (1997) 2.21

Characterization of the chromosomal aac(6')-Ii gene specific for Enterococcus faecium. Antimicrob Agents Chemother (1993) 2.19

The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction. J Bacteriol (1997) 2.19

A case-control study of menopausal estrogen therapy and breast cancer. JAMA (1980) 2.15

Comparability of antimicrobial susceptibility test results from 22 European countries and Israel: an external quality assurance exercise of the European Antimicrobial Resistance Surveillance System (EARSS) in collaboration with the United Kingdom National External Quality Assurance Scheme (UK NEQAS). J Antimicrob Chemother (2002) 2.14

Menopausal estrogen therapy and hip fractures. Ann Intern Med (1981) 2.13

Will avilamycin convert ziracine into zerocine? Emerg Infect Dis (2000) 2.10

Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarum BM4174. Biochem J (1994) 2.10

The vanZ gene of Tn1546 from Enterococcus faecium BM4147 confers resistance to teicoplanin. Gene (1995) 2.09

Characterization of transposon Tn1549, conferring VanB-type resistance in Enterococcus spp. Microbiology (2000) 2.08

Origin and evolution of genes specifying resistance to macrolide, lincosamide and streptogramin antibiotics: data and hypotheses. J Antimicrob Chemother (1987) 2.06

Characterization of Tn1547, a composite transposon flanked by the IS16 and IS256-like elements, that confers vancomycin resistance in Enterococcus faecalis BM4281. Gene (1996) 2.03

Contribution of VanY D,D-carboxypeptidase to glycopeptide resistance in Enterococcus faecalis by hydrolysis of peptidoglycan precursors. Antimicrob Agents Chemother (1994) 2.01

Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci. Antimicrob Agents Chemother (1992) 1.99

TEM-4, a new plasmid-mediated beta-lactamase that hydrolyzes broad-spectrum cephalosporins in a clinical isolate of Escherichia coli. Antimicrob Agents Chemother (1989) 1.98