PubRank

Christian Becker

Author PubWeight™ 143.35‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet 2006 5.36
2 Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 2006 5.29
3 Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nat Genet 2012 5.28
4 Correlation between genetic and geographic structure in Europe. Curr Biol 2008 5.02
5 A systematic approach to mapping recessive disease genes in individuals from outbred populations. PLoS Genet 2009 3.06
6 Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement. Am J Hum Genet 2006 2.96
7 Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. Nat Genet 2012 2.92
8 Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med 2007 2.88
9 Mutations in MRAP, encoding a new interacting partner of the ACTH receptor, cause familial glucocorticoid deficiency type 2. Nat Genet 2005 2.83
10 A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet 2007 2.75
11 Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation. Am J Hum Genet 2007 2.74
12 Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia. Am J Hum Genet 2008 2.74
13 Loss of GLIS2 causes nephronophthisis in humans and mice by increased apoptosis and fibrosis. Nat Genet 2007 2.46
14 Haplotypes and SNPs in 13 lipid-relevant genes explain most of the genetic variance in high-density lipoprotein and low-density lipoprotein cholesterol. Hum Mol Genet 2004 2.45
15 Mutations in RDH12 encoding a photoreceptor cell retinol dehydrogenase cause childhood-onset severe retinal dystrophy. Nat Genet 2004 2.40
16 Diagnostic yield of various genetic approaches in patients with unexplained developmental delay or mental retardation. Am J Med Genet A 2006 2.31
17 Familial hemophagocytic lymphohistiocytosis type 5 (FHL-5) is caused by mutations in Munc18-2 and impaired binding to syntaxin 11. Am J Hum Genet 2009 2.29
18 tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat Genet 2008 2.28
19 COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness. J Clin Invest 2011 2.21
20 Mutations of the CEP290 gene encoding a centrosomal protein cause Meckel-Gruber syndrome. Hum Mutat 2008 2.03
21 Demographic history of Oceania inferred from genome-wide data. Curr Biol 2010 1.93
22 Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans. Aging Cell 2008 1.81
23 Volcanic emissions of mercury to the atmosphere: global and regional inventories. Sci Total Environ 2003 1.77
24 Lysozyme M-positive monocytes mediate angiotensin II-induced arterial hypertension and vascular dysfunction. Circulation 2011 1.76
25 Mutations in different components of FGF signaling in LADD syndrome. Nat Genet 2006 1.76
26 TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Am J Hum Genet 2011 1.65
27 Angiotensin II-induced vascular dysfunction depends on interferon-γ-driven immune cell recruitment and mutual activation of monocytes and NK-cells. Arterioscler Thromb Vasc Biol 2013 1.57
28 Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One 2007 1.57
29 Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism. Nat Genet 2009 1.55
30 Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study. J Perinat Med 2006 1.50
31 Genome-wide single-nucleotide polymorphism arrays demonstrate high fidelity of multiple displacement-based whole-genome amplification. Electrophoresis 2005 1.45
32 Human CD25+ regulatory T cells: two subsets defined by the integrins alpha 4 beta 7 or alpha 4 beta 1 confer distinct suppressive properties upon CD4+ T helper cells. Eur J Immunol 2004 1.43
33 Truncating mutation of the DFNB59 gene causes cochlear hearing impairment and central vestibular dysfunction. Hum Mutat 2007 1.38
34 Human CD4+CD25+ regulatory T cells: proteome analysis identifies galectin-10 as a novel marker essential for their anergy and suppressive function. Blood 2007 1.38
35 LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome. Am J Hum Genet 2010 1.37
36 Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1. Am J Hum Genet 2007 1.27
37 A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One 2012 1.26
38 Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia. J Med Genet 2010 1.26
39 SNP array-based homozygosity mapping reveals MCPH1 deletion in family with autosomal recessive mental retardation and mild microcephaly. Hum Genet 2005 1.25
40 Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal effector T cells via the cytokine TGF-β. Immunity 2013 1.23
41 Faulty initiation of proteoglycan synthesis causes cardiac and joint defects. Am J Hum Genet 2011 1.20
42 Assessing the enrichment performance in targeted resequencing experiments. Hum Mutat 2012 1.20
43 Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in the MPL gene. Br J Haematol 2008 1.20
44 Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy. J Clin Invest 2010 1.20
45 CD74-NRG1 fusions in lung adenocarcinoma. Cancer Discov 2014 1.19
46 Association of the 867Asp variant of the human anion exchanger 3 gene with common subtypes of idiopathic generalized epilepsy. Epilepsy Res 2002 1.17
47 Mutations in SPINT2 cause a syndromic form of congenital sodium diarrhea. Am J Hum Genet 2009 1.15
48 Molecular karyotyping in patients with mental retardation using 100K single-nucleotide polymorphism arrays. J Med Genet 2007 1.15
49 Targeting of antigens to activated dendritic cells in vivo cures metastatic melanoma in mice. Cancer Res 2005 1.14
50 Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome. Eur J Hum Genet 2010 1.14
51 Genome-wide linkage analysis of malaria infection intensity and mild disease. PLoS Genet 2007 1.13
52 Generation of mature fat pads in vitro and in vivo utilizing 3-D long-term culture of 3T3-L1 preadipocytes. Exp Cell Res 2004 1.12
53 Genome-wide SNP-based linkage scan identifies a locus on 8q24 for an age-related hearing impairment trait. Am J Hum Genet 2008 1.07
54 Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia. PLoS One 2013 1.06
55 Identification of novel mutations in X-linked retinitis pigmentosa families and implications for diagnostic testing. Mol Vis 2008 1.05
56 miR-155 inhibition sensitizes CD4+ Th cells for TREG mediated suppression. PLoS One 2009 1.04
57 Measuring immunoglobulin g antibodies to tetanus toxin, diphtheria toxin, and pertussis toxin with single-antigen enzyme-linked immunosorbent assays and a bead-based multiplex assay. Clin Vaccine Immunol 2008 1.03
58 The non-small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome. Am J Respir Crit Care Med 2015 1.02
59 Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. PLoS One 2013 1.01
60 Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data. Genome Biol 2015 1.01
61 Cyclic AMP underpins suppression by regulatory T cells. Eur J Immunol 2012 0.98
62 Refinement of the MYP3 locus on human chromosome 12 in a German family with Mendelian autosomal dominant high-grade myopia by SNP array mapping. Int J Mol Med 2008 0.98
63 Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2. Gastroenterology 2008 0.97
64 Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene cause autosomal recessive nonsyndromic hearing loss. Hum Mutat 2006 0.97
65 Interferon-α suppresses cAMP to disarm human regulatory T cells. Cancer Res 2013 0.93
66 A novel mutation in the Espin gene causes autosomal recessive nonsyndromic hearing loss but no apparent vestibular dysfunction in a Moroccan family. Am J Med Genet A 2008 0.92
67 Increased regulatory T-cell frequencies in patients with advanced melanoma correlate with a generally impaired T-cell responsiveness and are restored after dendritic cell-based vaccination. Exp Dermatol 2010 0.91
68 Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells. Blood 2013 0.91
69 Tumor vascularity: evaluation in a murine model with contrast-enhanced color Doppler US effect of angiogenesis inhibitors. Radiology 2002 0.90
70 CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Res Cardiol 2013 0.90
71 Dendritic cells: sentinels of immunity and tolerance. Int J Hematol 2005 0.88
72 Repression of cyclic adenosine monophosphate upregulation disarms and expands human regulatory T cells. J Immunol 2011 0.88
73 New universal primers facilitate Pyrosequencing. Electrophoresis 2006 0.87
74 Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis. PLoS One 2013 0.85
75 Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates. Biochem Pharmacol 2007 0.84
76 Development of a spray congealing process for the preparation of insulin-loaded lipid microparticles and characterization thereof. Eur J Pharm Biopharm 2006 0.84
77 Induction of strong and persistent MelanA/MART-1-specific immune responses by adjuvant dendritic cell-based vaccination of stage II melanoma patients. Int J Cancer 2006 0.83
78 Immune regulation by dendritic cells and T cells--basic science, diagnostic, and clinical application. Clin Lab 2011 0.82
79 Failure to replicate an allelic association between an exon 8 polymorphism of the human alpha(1A) calcium channel gene and common syndromes of idiopathic generalized epilepsy. Epilepsy Res 2002 0.82
80 Next generation sequencing of the Ago2 interacting transcriptome identified chemokine family members as novel targets of neuronal microRNAs in hepatic stellate cells. J Hepatol 2012 0.81
81 Association of the HLA region with multiple sclerosis as confirmed by a genome screen using >10,000 SNPs on DNA chips. J Mol Med (Berl) 2005 0.80
82 CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease. J Allergy Clin Immunol 2011 0.80
83 An evaluation of the genetic-matched pair study design using genome-wide SNP data from the European population. Eur J Hum Genet 2009 0.80
84 Treatment of human pancreatic cancer in mice with angiogenic inhibitors. World J Surg 2003 0.80
85 Assembly of a transmembrane b-type cytochrome is mainly driven by transmembrane helix interactions. Biochim Biophys Acta 2006 0.80
86 Honey bee odorant-binding protein 14: effects on thermal stability upon odorant binding revealed by FT-IR spectroscopy and CD measurements. Eur Biophys J 2013 0.80
87 A paradigm shift in mechanical biofilm management? Subgingival air polishing: a new way to improve mechanical biofilm management in the dental practice. Quintessence Int 2013 0.79
88 Skeletal dysplasia in a consanguineous clan from the island of Nias/Indonesia is caused by a novel mutation in B3GAT3. Hum Genet 2015 0.79
89 Large scale preparation of human MHC class II+ integrin beta(1)+ Tregs. J Immunol Methods 2010 0.78
90 Toward operative in vivo fluorescence imaging of the c-Met proto-oncogene for personalization of therapy in ovarian cancer. Cancer 2014 0.78
91 Clinal distribution of human genomic diversity across the Netherlands despite archaeological evidence for genetic discontinuities in Dutch population history. Investig Genet 2013 0.78
92 Gene locus ambiguity in posterior urethral valves/prune-belly syndrome. Pediatr Nephrol 2005 0.78
93 Application of genomewide SNP arrays for detection of simulated susceptibility loci. Hum Mutat 2005 0.77
94 Should health insurers target prevention of cardiovascular disease? A cost-effectiveness analysis of an individualised programme in Germany based on routine data. BMC Health Serv Res 2014 0.76
95 Candidate gene analysis of the human metabotropic glutamate receptor type 4 (GRM4) in patients with juvenile myoclonic epilepsy. Am J Med Genet B Neuropsychiatr Genet 2003 0.76
96 SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH. J Mol Biol 2011 0.76
97 Polypeptoid-block-polypeptide copolymers: synthesis, characterization, and application of amphiphilic block Copolypept(o)ides in drug formulations and miniemulsion techniques. Biomacromolecules 2014 0.76
98 Direct binding assay for the detection of type IV allosteric inhibitors of Abl. J Am Chem Soc 2012 0.75
99 Genome-wide linkage analysis is a powerful prenatal diagnostic tool in families with unknown genetic defects. Eur J Hum Genet 2012 0.75
100 GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples. J Chromatogr B Analyt Technol Biomed Life Sci 2009 0.75
101 Interaction of N-(2-hydroxypropyl)methacrylamide based homo, random and block copolymers with primary immune cells. J Biomed Nanotechnol 2014 0.75
102 No evidence for a role of thyroid autoimmunity in the pathogenesis of cervical artery dissection. Cerebrovasc Dis 2009 0.75
103 Chemical synthesis approaches to the engineering of ion channels. Protein Pept Lett 2005 0.75
104 A systematic comparison of two new releases of exome sequencing products: the aim of use determines the choice of product. Biol Chem 2016 0.75