Thomas P Sakmar

Author PubWeight™ 84.22‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Bilateral olfactory sensory input enhances chemotaxis behavior. Nat Neurosci 2007 2.53
2 Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors. J Mol Biol 2008 2.47
3 Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal 2008 2.33
4 Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat Struct Mol Biol 2009 2.32
5 Curvature and hydrophobic forces drive oligomerization and modulate activity of rhodopsin in membranes. Biophys J 2006 2.23
6 Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. J Virol 2003 1.97
7 G protein-coupled receptors self-assemble in dynamics simulations of model bilayers. J Am Chem Soc 2007 1.90
8 Tracking G-protein-coupled receptor activation using genetically encoded infrared probes. Nature 2010 1.79
9 CXCR7/CXCR4 heterodimer constitutively recruits beta-arrestin to enhance cell migration. J Biol Chem 2011 1.78
10 Retinal counterion switch in the photoactivation of the G protein-coupled receptor rhodopsin. Proc Natl Acad Sci U S A 2003 1.77
11 Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles. J Mol Biol 2008 1.64
12 Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol 2006 1.63
13 Recreating a functional ancestral archosaur visual pigment. Mol Biol Evol 2002 1.62
14 Interaction of small molecule inhibitors of HIV-1 entry with CCR5. Virology 2006 1.59
15 FTIR analysis of GPCR activation using azido probes. Nat Chem Biol 2009 1.52
16 Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis. J Biol Chem 2007 1.45
17 Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration. J Gen Physiol 2002 1.36
18 Opsin is a phospholipid flippase. Curr Biol 2011 1.27
19 Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. Proc Natl Acad Sci U S A 2002 1.25
20 The role of Glu181 in the photoactivation of rhodopsin. J Mol Biol 2005 1.25
21 Function of extracellular loop 2 in rhodopsin: glutamic acid 181 modulates stability and absorption wavelength of metarhodopsin II. Biochemistry 2002 1.24
22 Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch. Biochemistry 2002 1.21
23 Sequential tyrosine sulfation of CXCR4 by tyrosylprotein sulfotransferases. Biochemistry 2008 1.20
24 Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers. J Am Chem Soc 2012 1.20
25 Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery. Biochemistry 2008 1.19
26 Small-molecule antagonists of CCR5 and CXCR4: a promising new class of anti-HIV-1 drugs. Curr Pharm Des 2004 1.18
27 G protein beta gamma subunit interaction with the dynein light-chain component Tctex-1 regulates neurite outgrowth. EMBO J 2007 1.18
28 Parietal-eye phototransduction components and their potential evolutionary implications. Science 2006 1.17
29 Toward a framework for sulfoproteomics: Synthesis and characterization of sulfotyrosine-containing peptides. Biopolymers 2008 1.17
30 Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange. Biochemistry 2002 1.16
31 The differential sensitivity of human and rhesus macaque CCR5 to small-molecule inhibitors of human immunodeficiency virus type 1 entry is explained by a single amino acid difference and suggests a mechanism of action for these inhibitors. J Virol 2004 1.16
32 Mapping the ligand-binding site on a G protein-coupled receptor (GPCR) using genetically encoded photocrosslinkers. Biochemistry 2011 1.09
33 Rhodopsin forms a dimer with cytoplasmic helix 8 contacts in native membranes. Biochemistry 2012 1.09
34 Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors. J Virol 2011 1.07
35 Genetically encoded photo-cross-linkers map the binding site of an allosteric drug on a G protein-coupled receptor. ACS Chem Biol 2012 1.04
36 Agonists and partial agonists of rhodopsin: retinal polyene methylation affects receptor activation. Biochemistry 2006 1.00
37 Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins. J Mol Biol 2009 1.00
38 Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells. Proc Natl Acad Sci U S A 2010 0.97
39 Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. J Am Chem Soc 2011 0.96
40 Insider access: pepducin symposium explores a new approach to GPCR modulation. Ann N Y Acad Sci 2009 0.96
41 Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2. J Mol Biol 2006 0.95
42 Coupling of protonation switches during rhodopsin activation. Photochem Photobiol 2007 0.93
43 Resonance Raman analysis of the mechanism of energy storage and chromophore distortion in the primary visual photoproduct. Biochemistry 2004 0.93
44 Escaping the flatlands: new approaches for studying the dynamic assembly and activation of GPCR signaling complexes. Trends Pharmacol Sci 2011 0.90
45 Direct measurement of thermal stability of expressed CCR5 and stabilization by small molecule ligands. Biochemistry 2010 0.89
46 Roles of specific extracellular domains of the glucagon receptor in ligand binding and signaling. Biochemistry 2002 0.89
47 Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors. Chembiochem 2014 0.87
48 Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants. J Virol 2013 0.87
49 Modulating rhodopsin receptor activation by altering the pKa of the retinal Schiff base. J Am Chem Soc 2006 0.87
50 Site-specific in vitro and in vivo incorporation of molecular probes to study G-protein-coupled receptors. Curr Opin Chem Biol 2011 0.86
51 6-s-cis Conformation and polar binding pocket of the retinal chromophore in the photoactivated state of rhodopsin. J Am Chem Soc 2009 0.86
52 Nucleobindin 1 is a calcium-regulated guanine nucleotide dissociation inhibitor of G{alpha}i1. J Biol Chem 2010 0.86
53 Time-resolved photointermediate changes in rhodopsin glutamic acid 181 mutants. Biochemistry 2004 0.85
54 Site-specific epitope tagging of G protein-coupled receptors by bioorthogonal modification of a genetically encoded unnatural amino acid. Biochemistry 2013 0.85
55 Unnatural amino acid mutagenesis of GPCRs using amber codon suppression and bioorthogonal labeling. Methods Enzymol 2013 0.84
56 A novel interaction between atrophin-interacting protein 4 and beta-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain. J Biol Chem 2007 0.84
57 SEIRA spectroscopy on a membrane receptor monolayer using lipoprotein particles as carriers. Biophys J 2010 0.83
58 Probing G protein-coupled receptor-ligand interactions with targeted photoactivatable cross-linkers. Biochemistry 2013 0.83
59 Mapping a ligand binding site using genetically encoded photoactivatable crosslinkers. Methods Enzymol 2013 0.82
60 G protein-coupled receptor modulation with pepducins: moving closer to the clinic. Ann N Y Acad Sci 2011 0.82
61 Proton movement and photointermediate kinetics in rhodopsin mutants. Biochemistry 2006 0.82
62 Structural biology: snapshot of a signalling complex. Nature 2011 0.81
63 Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism. J Am Chem Soc 2013 0.81
64 Homogeneous time-resolved fluorescence assay to probe folded G protein-coupled receptors. Methods Enzymol 2013 0.79
65 Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation. J Mol Biol 2012 0.79
66 Synthetic gene technology: applications to ancestral gene reconstruction and structure-function studies of receptors. Methods Enzymol 2002 0.78
67 Methodology of pulsed photoacoustics and its application to probe photosystems and receptors. Sensors (Basel) 2010 0.78
68 Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acids. Biochemistry 2015 0.77
69 Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers. Biochemistry 2014 0.77
70 Site-specific labeling of genetically encoded azido groups for multicolor, single-molecule fluorescence imaging of GPCRs. Methods Cell Biol 2013 0.77
71 Rhodopsin's active state is frozen like a DEER in the headlights. Proc Natl Acad Sci U S A 2008 0.77
72 Genetically-encoded molecular probes to study G protein-coupled receptors. J Vis Exp 2013 0.76
73 Structural biology: Ion channel in the spotlight. Nature 2012 0.75
74 Quantitative Multi-color Detection Strategies for Bioorthogonally Labeled GPCRs. Methods Mol Biol 2015 0.75