Membrane progesterone receptors: evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3489003)

Published in Neuroendocrinology on September 14, 2012

Authors

Peter Thomas1, Yefei Pang

Author Affiliations

1: The University of Texas at Austin Marine Science Institute, Port Aransas, TX 78373, USA. peter.thomas@utexas.edu

Articles citing this

A novel computational biostatistics approach implies impaired dephosphorylation of growth factor receptors as associated with severity of autism. Transl Psychiatry (2014) 0.96

Characterization, neurosteroid binding and brain distribution of human membrane progesterone receptors δ and {epsilon} (mPRδ and mPR{epsilon}) and mPRδ involvement in neurosteroid inhibition of apoptosis. Endocrinology (2012) 0.94

Enhancement of cell surface expression and receptor functions of membrane progestin receptor α (mPRα) by progesterone receptor membrane component 1 (PGRMC1): evidence for a role of PGRMC1 as an adaptor protein for steroid receptors. Endocrinology (2014) 0.93

Novel progesterone receptors: neural localization and possible functions. Front Neurosci (2013) 0.89

G-protein-coupled receptor kinase 2-mediated desensitization of adiponectin receptor 1 in failing heart. Circulation (2015) 0.88

PGRMC1 and PGRMC2 in uterine physiology and disease. Front Neurosci (2013) 0.80

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms. Front Neurosci (2013) 0.79

Estradiol Membrane-Initiated Signaling and Female Reproduction. Compr Physiol (2015) 0.78

Classical and membrane-initiated estrogen signaling in an in vitro model of anterior hypothalamic kisspeptin neurons. Endocrinology (2015) 0.78

Allopregnanolone's attenuation of the lordosis-inhibiting effects of restraint is blocked by the antiprogestin, CDB-4124. Pharmacol Biochem Behav (2014) 0.77

Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction. J Neuroendocrinol (2016) 0.76

Dose-dependent effects of the antiprogestin, RU486, on sexual behavior of naturally cycling Fischer rats. Behav Brain Res (2015) 0.76

Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts. Endocrinology (2016) 0.76

Rethinking progesterone regulation of female reproductive cyclicity. Proc Natl Acad Sci U S A (2016) 0.76

Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma Spheroids In Vitro. Biomed Res Int (2016) 0.75

Modulatory Effects of Sex Steroids Progesterone and Estradiol on Odorant Evoked Responses in Olfactory Receptor Neurons. PLoS One (2016) 0.75

Acute Simian Varicella Virus Infection Causes Robust and Sustained Changes in Gene Expression in the Sensory Ganglia. J Virol (2016) 0.75

Rodent Models of Non-classical Progesterone Action Regulating Ovulation. Front Endocrinol (Lausanne) (2017) 0.75

The ESC/E(Z) complex, an effector of response to ovarian steroids, manifests an intrinsic difference in cells from women with premenstrual dysphoric disorder. Mol Psychiatry (2017) 0.75

Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling. Sci Rep (2017) 0.75

Articles cited by this

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell (1997) 21.42

The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med (2005) 5.95

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells. Cancer Cell (2005) 4.48

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc Natl Acad Sci U S A (2003) 2.82

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor. Proc Natl Acad Sci U S A (2003) 2.48

Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol Cell (2001) 2.44

Progesterone receptor membrane component 1: an integrative review. J Steroid Biochem Mol Biol (2007) 2.06

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model. Nat Rev Drug Discov (2004) 2.05

PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J Mol Evol (2005) 1.88

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun (2011) 1.86

Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Endocrinology (2006) 1.75

Progesterone receptor membrane component-1 (PGRMC1) is the mediator of progesterone's antiapoptotic action in spontaneously immortalized granulosa cells as revealed by PGRMC1 small interfering ribonucleic acid treatment and functional analysis of PGRMC1 mutations. Endocrinology (2007) 1.74

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J (2008) 1.73

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J Biol Chem (1998) 1.68

Membrane-initiated steroid actions and the proteins that mediate them. Proc Soc Exp Biol Med (1999) 1.68

Characteristics of membrane progestin receptor alpha (mPRalpha) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions. Front Neuroendocrinol (2008) 1.60

Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev (1998) 1.57

Steroid and G protein binding characteristics of the seatrout and human progestin membrane receptor alpha subtypes and their evolutionary origins. Endocrinology (2006) 1.54

PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding. Pharmacol Ther (2008) 1.41

Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Mol Endocrinol (2006) 1.39

Reproductive tissue selective actions of progesterone receptors. Reproduction (2004) 1.33

Identification of XPR-1, a progesterone receptor required for Xenopus oocyte activation. Proc Natl Acad Sci U S A (2000) 1.33

Progesterone receptor A (PRA) and PRB-independent effects of progesterone on gonadotropin-releasing hormone release. Endocrinology (2009) 1.31

Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med (2010) 1.30

Sphingolipids function as downstream effectors of a fungal PAQR. Mol Pharmacol (2008) 1.30

Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology (1999) 1.28

Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression. Mol Cell Endocrinol (2010) 1.26

Neurosteroids as modulators of neurogenesis and neuronal survival. Trends Endocrinol Metab (2008) 1.25

The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism. Proc Natl Acad Sci U S A (2000) 1.23

Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants. J Neurosci Res (2007) 1.22

Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J Mol Neurosci (2000) 1.22

Progesterone receptor membrane component 1--many tasks for a versatile protein. Steroids (2007) 1.19

Cloning and characterization of an ovine intracellular seven transmembrane receptor for progesterone that mediates calcium mobilization. Endocrinology (2006) 1.18

Progesterone receptor-mediated effects of neuroactive steroids. Neuron (1993) 1.18

CREST--a large and diverse superfamily of putative transmembrane hydrolases. Biol Direct (2011) 1.12

Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice. Mol Endocrinol (1996) 1.12

Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone. J Endocrinol (2008) 1.10

The role of Xenopus membrane progesterone receptor beta in mediating the effect of progesterone on oocyte maturation. Mol Endocrinol (2006) 1.10

GABAergic integration of progesterone and androgen feedback to gonadotropin-releasing hormone neurons. Biol Reprod (2004) 1.10

Neuroactive steroid effects on cognitive functions with a focus on the serotonin and GABA systems. Brain Res Rev (2005) 1.09

Candidates for membrane progestin receptors--past approaches and future challenges. Comp Biochem Physiol C Toxicol Pharmacol (2008) 1.09

Cloning and identification of a membrane progestin receptor in goldfish ovaries and evidence it is an intermediary in oocyte meiotic maturation. Gen Comp Endocrinol (2005) 1.09

Distribution of mRNAs encoding classical progestin receptor, progesterone membrane components 1 and 2, serpine mRNA binding protein 1, and progestin and ADIPOQ receptor family members 7 and 8 in rat forebrain. Neuroscience (2010) 1.08

Progestin signaling through an olfactory G protein and membrane progestin receptor-alpha in Atlantic croaker sperm: potential role in induction of sperm hypermotility. Endocrinology (2008) 1.08

Expression and function of PAIRBP1 within gonadotropin-primed immature rat ovaries: PAIRBP1 regulation of granulosa and luteal cell viability. Biol Reprod (2005) 1.05

Progesterone reverses the mesenchymal phenotypes of basal phenotype breast cancer cells via a membrane progesterone receptor mediated pathway. Breast Cancer Res (2010) 1.03

Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids (2010) 1.02

Progesterone regulates granulosa cell viability through a protein kinase G-dependent mechanism that may involve 14-3-3sigma. Biol Reprod (2004) 1.02

Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells. J Endocrinol (2006) 1.01

Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3alpha,5alpha-THP-facilitated lordosis. Psychopharmacology (Berl) (2006) 1.01

Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines. J Neurosci Res (2003) 0.99

Interactions between neural membrane glycerophospholipid and sphingolipid mediators: a recipe for neural cell survival or suicide. J Neurosci Res (2007) 0.98

Membrane progesterone receptors localization in the mouse spinal cord. Neuroscience (2009) 0.98

Progestin functions in vertebrate gametes mediated by membrane progestin receptors (mPRs): Identification of mPRalpha on human sperm and its association with sperm motility. Steroids (2008) 0.97

Antagonism of human adiponectin receptors and their membrane progesterone receptor paralogs by TNFalpha and a ceramidase inhibitor. Biochemistry (2009) 0.97

DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis. PLoS One (2010) 0.96

The negative feedback actions of progesterone on gonadotropin-releasing hormone secretion are transduced by the classical progesterone receptor. Proc Natl Acad Sci U S A (1998) 0.96

Multiple rapid progestin actions and progestin membrane receptor subtypes in fish. Steroids (2004) 0.96

Genomic and non-genomic actions of progesterone in the control of female hamster sexual behavior. Horm Behav (1994) 0.95

Induction of apoptotic cell death in hen granulosa cells by ceramide. Endocrinology (1996) 0.94

Ceramide triggers meiotic cell cycle progression in Xenopus oocytes. A potential mediator of progesterone-induced maturation. J Biol Chem (1995) 0.94

Nonclassical mechanisms of progesterone action in the brain: I. Protein kinase C activation in the hypothalamus of female rats. Endocrinology (2008) 0.93

Membrane mechanism mediates progesterone stimulatory effect on LHRH release from superfused rat hypothalami in vitro. Neuroendocrinology (1987) 0.93

Activation of the MEK/MAPK pathway is involved in bryostatin1-induced monocytic differenciation and up-regulation of X-linked inhibitor of apoptosis protein. Exp Cell Res (2002) 0.93

Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models. Gen Comp Endocrinol (2011) 0.92

Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis. Neuroscience (2011) 0.92

Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors. Horm Cancer (2012) 0.91

Progesterone potentiates calcium release through IP3 receptors by an Akt-mediated mechanism in hippocampal neurons. Cell Calcium (2008) 0.89

Hypothalamic progesterone receptor-A mediates gonadotropin surges, self priming and receptivity in estrogen-primed female mice. J Mol Endocrinol (2007) 0.89

Role of gonadotrophins and progesterone in the regulation of morphological remodelling and atresia in the monkey peri-ovulatory follicle. Hum Reprod (2000) 0.88

Progesterone induces meiotic division in the amphibian oocyte by releasing lipid second messengers from the plasma membrane. Steroids (1999) 0.87

Progestin receptor subtypes in the brain: the known and the unknown. Endocrinology (2008) 0.87

Involvement of estradiol-17beta and its membrane receptor, G protein coupled receptor 30 (GPR30) in regulation of oocyte maturation in zebrafish, Danio rario. Gen Comp Endocrinol (2008) 0.87

Progestin signaling through mPRα in Atlantic croaker granulosa/theca cell cocultures and its involvement in progestin inhibition of apoptosis. Endocrinology (2010) 0.86

Occupation of either site for the neurosteroid allopregnanolone potentiates the opening of the GABAA receptor induced from either transmitter binding site. Mol Pharmacol (2011) 0.86

Soluble Fas ligand activates the sphingomyelin pathway and induces apoptosis in luteal steroidogenic cells independently of stress-activated p38(MAPK). Endocrinology (2002) 0.85

Progesterone receptor is not required for progesterone action in the rat corpus luteum of pregnancy. Steroids (1999) 0.85

The neuroactive steroid allopregnanolone suppresses hypothalamic gonadotropin-releasing hormone release through a mechanism mediated by the gamma-aminobutyric acidA receptor. J Endocrinol (1998) 0.84

Bovine ovarian non-genomic progesterone binding sites: presence in follicular and luteal cell membranes. J Endocrinol (1998) 0.83

Luteinizing hormone secretion from wild-type and progesterone receptor knockout mouse anterior pituitary cells. Endocrinology (2001) 0.82

Progesterone release of lipid second messengers at the amphibian oocyte plasma membrane: role of ceramide in initiating the G2/M transition. Biochem Biophys Res Commun (1998) 0.82

Non-genomic progesterone signalling and its non-canonical receptor. Biochem Soc Trans (2012) 0.82

Genomic and membrane actions of progesterone: implications for reproductive physiology and behavior. Behav Brain Res (1999) 0.82

Neuroprotective actions of neurosteroids. Front Endocrinol (Lausanne) (2011) 0.82

Expression of membrane progesterone receptors (mPR/PAQR) in ovarian cancer cells: implications for progesterone-induced signaling events. Horm Cancer (2010) 0.80

Changing dose of progesterone results in sudden changes in frequency of luteinizing hormone pulses and secretion of 17 beta-estradiol in bovine females. Biol Reprod (1996) 0.80

Inhibition of recombinant L-type voltage-gated calcium channels by positive allosteric modulators of GABAA receptors. J Pharmacol Exp Ther (2011) 0.80

Internalisation of membrane progesterone receptor-α after treatment with progesterone: Potential involvement of a clathrin-dependent pathway. Mol Med Rep (2011) 0.78

Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cells. J Cell Biochem (2006) 0.78

Role of proestrous progesterone secretion in suppressing basal pulsatile LH secretion during estrus of the estrous cycle. Neuroendocrinology (1989) 0.77

Nongenomic steroid- and ceramide-induced maturation in amphibian oocytes involves functional caveolae-like microdomains associated with a cytoskeletal environment. Biol Reprod (2011) 0.77

Articles by these authors

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes. Proc Natl Acad Sci U S A (2003) 2.82

Identification and characterization of membrane androgen receptors in the ZIP9 zinc transporter subfamily: II. Role of human ZIP9 in testosterone-induced prostate and breast cancer cell apoptosis. Endocrinology (2014) 1.87

Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Mol Endocrinol (2006) 1.39

Progesterone receptor A (PRA) and PRB-independent effects of progesterone on gonadotropin-releasing hormone release. Endocrinology (2009) 1.31

Progestin, estrogen and androgen G-protein coupled receptors in fish gonads. Steroids (2005) 1.19

Comparison between steroid binding to membrane progesterone receptor alpha (mPRalpha) and to nuclear progesterone receptor: correlation with physicochemical properties assessed by comparative molecular field analysis and identification of mPRalpha-specific agonists. Steroids (2010) 1.02

Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors alpha and beta in transfected cells. J Endocrinol (2006) 1.01

Multiple rapid progestin actions and progestin membrane receptor subtypes in fish. Steroids (2004) 0.96

Enhancement of cell surface expression and receptor functions of membrane progestin receptor α (mPRα) by progesterone receptor membrane component 1 (PGRMC1): evidence for a role of PGRMC1 as an adaptor protein for steroid receptors. Endocrinology (2014) 0.93

Membrane progesterone receptors (mPRs) mediate progestin induced antimorbidity in breast cancer cells and are expressed in human breast tumors. Horm Cancer (2012) 0.91

Characterization and expression of the nuclear progestin receptor in zebrafish gonads and brain. Biol Reprod (2009) 0.90

Distribution and estrogen regulation of membrane progesterone receptor-β in the female rat brain. Endocrinology (2012) 0.88

Membrane progesterone receptor gamma: tissue distribution and expression in ciliated cells in the fallopian tube. Mol Reprod Dev (2007) 0.87

Progestin signaling through mPRα in Atlantic croaker granulosa/theca cell cocultures and its involvement in progestin inhibition of apoptosis. Endocrinology (2010) 0.86

Characterization of multiple membrane progestin receptor (mPR) subtypes from the goldfish ovary and their roles in the induction of oocyte maturation. Gen Comp Endocrinol (2012) 0.84

Protective actions of progesterone in the cardiovascular system: potential role of membrane progesterone receptors (mPRs) in mediating rapid effects. Steroids (2013) 0.80

Role of ERβ and GPR30 in the endocrine pancreas: A matter of estrogen dose. Steroids (2012) 0.78