Published in Exp Eye Res on June 08, 2012
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Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model. Proc Natl Acad Sci U S A (2012) 1.94
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ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy. Mol Ther (2011) 1.32
Identification of a lycopene beta-cyclase required for bacteriorhodopsin biogenesis in the archaeon Halobacterium salinarum. J Bacteriol (2002) 1.28
Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease. Invest Ophthalmol Vis Sci (2007) 1.27
In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Mol Ther (2010) 1.26
The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse. Invest Ophthalmol Vis Sci (2007) 1.26
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Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice. Hum Gene Ther (2012) 1.24
Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease. Mol Ther (2012) 1.24
AAV delivery of wild-type rhodopsin preserves retinal function in a mouse model of autosomal dominant retinitis pigmentosa. Hum Gene Ther (2011) 1.20
Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system. Invest Ophthalmol Vis Sci (2009) 1.14
Identification of Candida albicans genes induced during thrush offers insight into pathogenesis. Mol Microbiol (2003) 1.13
The importance of mitochondria in age-related and inherited eye disorders. Ophthalmic Res (2010) 1.13
Optic neuropathy induced by reductions in mitochondrial superoxide dismutase. Invest Ophthalmol Vis Sci (2003) 1.13
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Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Mol Ther (2009) 1.07
rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Exp Neurol (2007) 1.05
Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy. Invest Ophthalmol Vis Sci (2007) 1.05
A high-throughput screening method for small-molecule pharmacologic chaperones of misfolded rhodopsin. Invest Ophthalmol Vis Sci (2008) 1.03
Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency. Hum Gene Ther (2011) 1.03
Gene therapy in animal models of autosomal dominant retinitis pigmentosa. Mol Vis (2012) 0.99
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Knockdown of wild-type mouse rhodopsin using an AAV vectored ribozyme as part of an RNA replacement approach. Mol Vis (2005) 0.96
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Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration. PLoS One (2013) 0.96
Suppression of complex I gene expression induces optic neuropathy. Ann Neurol (2003) 0.96
Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation. Arch Ophthalmol (2007) 0.95
Downregulation of p22phox in retinal pigment epithelial cells inhibits choroidal neovascularization in mice. Mol Ther (2008) 0.93
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Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice. Mol Vis (2012) 0.88
Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature. Invest Ophthalmol Vis Sci (2009) 0.88
Proteolytic processing of connective tissue growth factor in normal ocular tissues and during corneal wound healing. Invest Ophthalmol Vis Sci (2012) 0.86
Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci (2014) 0.86
Down-regulation of expression of rat pyruvate dehydrogenase E1alpha gene by self-complementary adeno-associated virus-mediated small interfering RNA delivery. Mitochondrion (2007) 0.85
Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice. Exp Eye Res (2011) 0.85
Range of retinal diseases potentially treatable by AAV-vectored gene therapy. Novartis Found Symp (2004) 0.85
Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts. Invest Ophthalmol Vis Sci (2013) 0.85
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Gene therapy for mouse models of ADRP. Adv Exp Med Biol (2008) 0.83
Functional rescue of P23H rhodopsin photoreceptors by gene delivery. Adv Exp Med Biol (2012) 0.83
An allele of microtubule-associated protein 1A (Mtap1a) reduces photoreceptor degeneration in Tulp1 and Tub Mutant Mice. Invest Ophthalmol Vis Sci (2012) 0.82
NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS. Mol Ther (2013) 0.82
Ribozyme knockdown of the gamma-subunit of rod cGMP phosphodiesterase alters the ERG and retinal morphology in wild-type mice. Invest Ophthalmol Vis Sci (2005) 0.82
Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA. J Virol (2008) 0.81
Hammerhead ribozyme-mediated knockdown of mRNA for fibrotic growth factors: transforming growth factor-beta 1 and connective tissue growth factor. Methods Mol Biol (2012) 0.81
Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector. Adv Exp Med Biol (2012) 0.81
Bacteriorhodopsin chimeras containing the third cytoplasmic loop of bovine rhodopsin activate transducin for GTP/GDP exchange. Protein Sci (2006) 0.81
Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response. Adv Exp Med Biol (2014) 0.81
The AraC/XylS family activator RhaS negatively autoregulates rhaSR expression by preventing cyclic AMP receptor protein activation. J Bacteriol (2010) 0.80
Design and validation of therapeutic hammerhead ribozymes for autosomal dominant diseases. Methods Mol Biol (2004) 0.79
Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation. Hum Gene Ther (2015) 0.79
Decreased expression of the insulin-like growth factor 1 receptor by ribozyme cleavage. Invest Ophthalmol Vis Sci (2003) 0.79
Designing and characterizing hammerhead ribozymes for use in AAV vector-mediated retinal gene therapies. Methods Enzymol (2002) 0.78
Geographic atrophy in age-related macular degeneration and TLR3. N Engl J Med (2009) 0.78
Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin. Methods Mol Biol (2015) 0.78
In vitro and in vivo characterization of a tunable dual-reactivity probe of the Nrf2-ARE pathway. ACS Chem Biol (2013) 0.78
Down-regulation of rhodopsin gene expression by AAV-vectored short interfering RNA. Adv Exp Med Biol (2006) 0.76
In vitro analysis of ribozyme-mediated knockdown of an ADRP associated rhodopsin mutation. Adv Exp Med Biol (2008) 0.76
Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome. J Inherit Metab Dis (2015) 0.76
Gene delivery of wild-type rhodopsin rescues retinal function in an autosomal dominant retinitis pigmentosa mouse model. Adv Exp Med Biol (2012) 0.76
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