Published in Insights Imaging on October 16, 2011
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PACAP27 prevents Parkinson-like neuronal loss and motor deficits but not microglia activation induced by prostaglandin J2. Biochim Biophys Acta (2014) 0.79
Comparative Evaluation of Three TSPO PET Radiotracers in a LPS-Induced Model of Mild Neuroinflammation in Rats. Mol Imaging Biol (2017) 0.78
Preventing vascular effects on brain injury and cognition late in life: knowns and unknowns. Neuropsychol Rev (2014) 0.77
Translocator protein (TSPO) role in aging and Alzheimer's disease. Curr Aging Sci (2014) 0.76
Synthesis and Evaluation of Tricarbonyl (99m)Tc-Labeled 2-(4-Chloro)phenyl-imidazo[1,2-a]pyridine Analogs as Novel SPECT Imaging Radiotracer for TSPO-Rich Cancer. Int J Mol Sci (2016) 0.75
Imaging neuroinflammation in multiple sclerosis using TSPO-PET. Clin Transl Imaging (2015) 0.75
Identification of brain regions predicting epileptogenesis by serial [(18)F]GE-180 positron emission tomography imaging of neuroinflammation in a rat model of temporal lobe epilepsy. Neuroimage Clin (2017) 0.75
The impact of high and low dose ionising radiation on the central nervous system. Redox Biol (2016) 0.75
Insight into the Molecular Imaging of Alzheimer's Disease. Int J Biomed Imaging (2016) 0.75
The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory 'M1' human macrophages. PLoS One (2017) 0.75
Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with [(125)I]iodoDPA SPECT-CT. J Nucl Med (2017) 0.75
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Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation (2004) 2.91
Evidence of axonal damage in the early stages of multiple sclerosis and its relevance to disability. Arch Neurol (2001) 2.75
Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nat Rev Drug Discov (2010) 2.68
Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers. Eur J Nucl Med Mol Imaging (2008) 2.41
PET radiotracers: crossing the blood-brain barrier and surviving metabolism. Trends Pharmacol Sci (2009) 2.32
Microglia activation in recent-onset schizophrenia: a quantitative (R)-[11C]PK11195 positron emission tomography study. Biol Psychiatry (2008) 2.28
Neuroinflammation in schizophrenia-related psychosis: a PET study. J Nucl Med (2009) 2.17
Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106. Biol Psychiatry (2008) 2.06
Mixed-affinity binding in humans with 18-kDa translocator protein ligands. J Nucl Med (2010) 2.00
Microglial activation in presymptomatic Huntington's disease gene carriers. Brain (2007) 1.93
Two binding sites for [3H]PBR28 in human brain: implications for TSPO PET imaging of neuroinflammation. J Cereb Blood Flow Metab (2010) 1.85
Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation. J Nucl Med (2007) 1.81
Molecular imaging: current status and emerging strategies. Clin Radiol (2010) 1.79
The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci (2006) 1.68
Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. Mol Cell Endocrinol (2010) 1.60
PET visualization of microglia in multiple sclerosis patients using [11C]PK11195. Eur J Neurol (2003) 1.59
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med (2009) 1.58
11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med (2007) 1.53
DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med (2008) 1.49
Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans. J Nucl Med (2009) 1.44
Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06. J Nucl Med (2009) 1.36
Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain. J Nucl Med (2006) 1.36
Microglial activation in regions related to cognitive function predicts disease onset in Huntington's disease: a multimodal imaging study. Hum Brain Mapp (2011) 1.32
Radiopharmaceutical chemistry for positron emission tomography. Adv Drug Deliv Rev (2010) 1.24
The translocator protein. J Nucl Med (2011) 1.22
Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study. Mult Scler (2005) 1.17
Radiolabelled molecules for imaging the translocator protein (18 kDa) using positron emission tomography. Curr Med Chem (2009) 1.14
Molecular tracers for the PET and SPECT imaging of disease. Chem Soc Rev (2010) 1.13
The positron emission tomography ligand DAA1106 binds with high affinity to activated microglia in human neurological disorders. J Neuropathol Exp Neurol (2008) 1.12
Imaging microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol (2008) 1.11
The temporal dynamics of poststroke neuroinflammation: a longitudinal diffusion tensor imaging-guided PET study with 11C-PK11195 in acute subcortical stroke. J Nucl Med (2010) 1.11
PET tracers for the peripheral benzodiazepine receptor and uses thereof. Drug Discov Today (2010) 1.10
PET imaging of the peripheral benzodiazepine receptor: monitoring disease progression and therapy response in neurodegenerative disorders. Curr Pharm Des (2008) 1.04
The future of hybrid imaging-part 2: PET/CT. Insights Imaging (2011) 0.95
In vivo evidence for microglial activation in neurodegenerative dementia. Acta Neurol Scand Suppl (2006) 0.94
Drug distribution in man: a positron emission tomography study after oral administration of the labelled neuroprotective drug vinpocetine. Eur J Nucl Med Mol Imaging (2002) 0.91
Radioisotopic imaging of neuroinflammation. J Nucl Med (2009) 0.91
In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa). Eur J Nucl Med Mol Imaging (2010) 0.87
Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216. J Nucl Med (2009) 0.80
PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects. Acta Neurol Scand (2002) 0.79
[Cerebral uptake and regional distribution of [11C]-vinpocetin after intravenous administration to healthy men: a PET study]. Orv Hetil (2002) 0.78
Retracted Neutralizing aptamers from whole-cell SELEX inhibit the RET receptor tyrosine kinase. PLoS Biol (2005) 2.77
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[18F]Galacto-RGD: synthesis, radiolabeling, metabolic stability, and radiation dose estimates. Bioconjug Chem (2004) 2.20
In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution. Blood (2009) 1.99
Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation. J Nucl Med (2009) 1.58
Dopaminergic function and dopamine transporter binding assessed with positron emission tomography in Parkinson disease. Arch Neurol (2002) 1.54
11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med (2007) 1.53
PET imaging of medullary thyroid carcinoma in MEN2A transgenic mice using 6-[(18)F]F-L-DOPA. Eur J Nucl Med Mol Imaging (2010) 1.46
Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab (2009) 1.43
Darwinian molecular imaging. Eur J Nucl Med Mol Imaging (2009) 1.40
Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging. J Neurosci (2012) 1.37
Characterization of hyperinsulinism in infancy assessed with PET and 18F-fluoro-L-DOPA. J Nucl Med (2005) 1.26
Nucleic acid aptamers in cancer medicine. FEBS Lett (2002) 1.22
1-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: design, synthesis, and radiosynthesis of a new [18F]fluoropyridine-based maleimide reagent for the labeling of peptides and proteins. Bioconjug Chem (2005) 1.21
Noninvasive molecular imaging of neuroinflammation. J Cereb Blood Flow Metab (2012) 1.19
In vivo imaging of human cerebral nicotinic acetylcholine receptors with 2-18F-fluoro-A-85380 and PET. J Nucl Med (2005) 1.18
Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-¹¹C]-2-(4'-methylaminophenyl)- 6-hydroxybenzothiazole. Ann Neurol (2011) 1.18
Functional recovery in a primate model of Parkinson's disease following motor cortex stimulation. Neuron (2004) 1.15
Proteomic analysis of beta-catenin activation in mouse liver by DIGE analysis identifies glucose metabolism as a new target of the Wnt pathway. Proteomics (2009) 1.14
Differential SELEX in human glioma cell lines. PLoS One (2009) 1.13
Biodistribution and radiation dosimetry of 18F-fluoro-A-85380 in healthy volunteers. J Nucl Med (2003) 1.11
Fluorine-18-labeled phospholipid quantum dot micelles for in vivo multimodal imaging from whole body to cellular scales. Bioconjug Chem (2008) 1.11
New device for real-time bioluminescence imaging in moving rodents. J Biomed Opt (2008) 1.05
Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]befloxatone. J Clin Psychopharmacol (2009) 1.04
Segmentation of rodent whole-body dynamic PET images: an unsupervised method based on voxel dynamics. IEEE Trans Med Imaging (2008) 0.97
In vivo imaging of neuroinflammation: a comparative study between [(18)F]PBR111, [ (11)C]CLINME and [ (11)C]PK11195 in an acute rodent model. Eur J Nucl Med Mol Imaging (2010) 0.96
Molecular imaging study on in vivo distribution and pharmacokinetics of modified small interfering RNAs (siRNAs). Oligonucleotides (2008) 0.95
The translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo. Eur J Nucl Med Mol Imaging (2012) 0.94
Long-lasting occupancy of central nicotinic acetylcholine receptors after smoking: a PET study in monkeys. J Neurochem (2003) 0.93
Comparison of different strategies to select aptamers against a transmembrane protein target. Oligonucleotides (2006) 0.93
Metastasis-focused cell-based SELEX generates aptamers inhibiting cell migration and invasion. Int J Cancer (2011) 0.93
Reduced PBR/TSPO expression after minocycline treatment in a rat model of focal cerebral ischemia: a PET study using [(18)F]DPA-714. Mol Imaging Biol (2011) 0.92
Differential expression of the 18 kDa translocator protein (TSPO) by neoplastic and inflammatory cells in mouse tumors of breast cancer. Mol Pharm (2011) 0.92
In vivo imaging of brain lesions with [(11)C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors. Glia (2007) 0.92
Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening. J Nucl Med (2011) 0.91
Quantification of cerebral nicotinic acetylcholine receptors by PET using 2-[18F]fluoro-A-85380 and the multiinjection approach. J Cereb Blood Flow Metab (2007) 0.91
Radioisotopic imaging of neuroinflammation. J Nucl Med (2009) 0.91
[18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106-selective radioligands for imaging TSPO 18 kDa with PET: automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls. Appl Radiat Isot (2011) 0.90
Non-invasive in vivo imaging of calcium signaling in mice. PLoS One (2007) 0.89
Acute effects of physostigmine and galantamine on the binding of [18F]fluoro-A-85380: a PET study in monkeys. Synapse (2005) 0.88
Encapsulated GDNF-producing C2C12 cells for Parkinson's disease: a pre-clinical study in chronic MPTP-treated baboons. Neurobiol Dis (2004) 0.88
Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy. J Neurosci (2009) 0.88
In vivo validation of free-space fluorescence tomography using nuclear imaging. Opt Lett (2010) 0.88
The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model. J Nucl Med (2013) 0.88
In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa). Eur J Nucl Med Mol Imaging (2010) 0.87
Internal radiotherapy of liver cancer with rat hepatocarcinoma-intestine-pancreas gene as a liver tumor-specific promoter. Hum Gene Ther (2008) 0.87
18F-ZW-104: a new radioligand for imaging neuronal nicotinic acetylcholine receptors--in vitro binding properties and PET studies in baboons. J Nucl Med (2009) 0.87
An autocrine loop involving ret and glial cell-derived neurotrophic factor mediates retinoic acid-induced neuroblastoma cell differentiation. Mol Cancer Res (2006) 0.87
In vivo quantification of monoamine oxidase A in baboon brain: a PET study using [(11)C]befloxatone and the multi-injection approach. J Cereb Blood Flow Metab (2009) 0.86
Analysis of the growth dynamics of angiogenesis-dependent and -independent experimental glioblastomas by multimodal small-animal PET and MRI. J Nucl Med (2012) 0.86
Striatal and extrastriatal dopamine transporter in cannabis and tobacco addiction: a high-resolution PET study. Addict Biol (2011) 0.86
The potential of carbon-11 and fluorine-18 chemistry: illustration through the development of positron emission tomography radioligands targeting the translocator protein 18 kDa. J Labelled Comp Radiopharm (2013) 0.85
Sodium iodide symporter is expressed at the preneoplastic stages of liver carcinogenesis and in human cholangiocarcinoma. Gastroenterology (2007) 0.85
Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture. J Cell Mol Med (2009) 0.85
Effects of selected OATP and/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide. AAPS J (2013) 0.85
Synthesis of a [2-pyridinyl-18F]-labelled fluoro derivative of (-)-cytisine as a candidate radioligand for brain nicotinic alpha4beta2 receptor imaging with PET. Bioorg Med Chem (2003) 0.85
Labelled oligonucleotides as radiopharmaceuticals: pitfalls, problems and perspectives. Curr Pharm Des (2002) 0.85
Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding. RNA (2010) 0.85
Early detection and longitudinal monitoring of experimental primary and disseminated melanoma using [¹⁰F]ICF01006, a highly promising melanoma PET tracer. Eur J Nucl Med Mol Imaging (2012) 0.85
Tumor-targeted polydiacetylene micelles for in vivo imaging and drug delivery. Small (2011) 0.84
Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in the aortic wall of experimental abdominal aneurysms. J Vasc Surg (2012) 0.84
In vivo imaging of oligonucleotidic aptamers. Methods Mol Biol (2009) 0.84
Metabolism and quantification of [(18)F]DPA-714, a new TSPO positron emission tomography radioligand. Drug Metab Dispos (2012) 0.83