PubRank

Erkang Fan

Author PubWeight™ 40.52‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation. J Infect Dis 2013 1.71
2 Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem 2012 1.56
3 Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother 2011 1.37
4 Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem 2012 1.35
5 Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem 2012 1.35
6 Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. Genes Dev 2012 1.33
7 Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands. J Biomol Screen 2009 1.25
8 A novel calcium-dependent protein kinase inhibitor as a lead compound for treating cryptosporidiosis. J Infect Dis 2013 1.23
9 Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection. Structure 2012 1.18
10 Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorg Med Chem Lett 2012 1.12
11 Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. J Am Chem Soc 2002 1.08
12 Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target. FEMS Microbiol Rev 2004 1.02
13 Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem 2006 1.00
14 Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. J Am Chem Soc 2002 1.00
15 Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J Mol Biol 2008 0.98
16 Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs. J Mol Biol 2010 0.97
17 Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer. Chem Biol 2004 0.95
18 Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie 2010 0.93
19 Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Curr Top Med Chem 2009 0.90
20 3,5-Substituted phenyl galactosides as leads in designing effective cholera toxin antagonists; synthesis and crystallographic studies. Bioorg Med Chem 2004 0.90
21 The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol 2010 0.88
22 Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets. J Am Chem Soc 2005 0.87
23 Multivalent drug design and inhibition of cholera toxin by specific and transient protein-ligand interactions. Chem Biol Drug Des 2008 0.85
24 The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. J Mol Biol 2011 0.85
25 Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target. Antimicrob Agents Chemother 2013 0.84
26 Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin. J Org Chem 2004 0.84
27 Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase. Mol Biochem Parasitol 2011 0.84
28 Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei. Biochemistry 2003 0.84
29 Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chem Biol 2002 0.82
30 Prediction of protein crystallization outcome using a hybrid method. J Struct Biol 2010 0.82
31 Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design. Mol Biochem Parasitol 2013 0.81
32 The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J Struct Biol 2010 0.80
33 TFA-sensitive arylsulfonylthiourea-assisted synthesis of N,N'-substituted guanidines. J Org Chem 2003 0.79
34 Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr 2012 0.79
35 Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica. Mol Biochem Parasitol 2009 0.78
36 Synthesis and biological evaluation of 6-substituted 5-alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs. ChemMedChem 2011 0.77
37 The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody. Mol Biochem Parasitol 2013 0.77
38 Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design. Org Lett 2004 0.77
39 Solid-phase and solution-phase syntheses of oligomeric guanidines bearing peptide side chains. J Org Chem 2005 0.77
40 Recent advances in the DABOs family as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. Curr Med Chem 2011 0.76
41 Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem 2011 0.75
42 Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. PLoS One 2016 0.75
43 Automated affinity chromatography measurements of compound mixtures using a lab-on-valve apparatus coupled to electrospray ionization mass spectrometry. Anal Biochem 2004 0.75
44 Improving carbene-copper-catalyzed asymmetric synthesis of α-aminoboronic esters using benzimidazole-based precursors. J Org Chem 2013 0.75
45 Metal free catalytic hydroboration of multiple bonds in methanol using N-heterocyclic carbenes under open atmosphere. Org Biomol Chem 2013 0.75
46 Solvent-free or low-solvent large-scale preparation of chloropyrimidine and analogues. J Org Chem 2011 0.75
47 Modular synthesis and study of multivalent carbohydrate ligands with long and flexible linkers. Methods Enzymol 2003 0.75