Humanizing murine IgG3 anti-GD2 antibody m3F8 substantially improves antibody-dependent cell-mediated cytotoxicity while retaining targeting in vivo.

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Published in Oncoimmunology on July 01, 2012

Authors

Nai-Kong V Cheung1, Hongfen Guo, Jian Hu, Dimiter V Tassev, Irene Y Cheung

Author Affiliations

1: Department of Pediatrics; Memorial Sloan-Kettering Cancer Center; New York, NY USA.

Associated clinical trials:

Humanized 3F8 Monoclonal Antibody (Hu3F8) in Patients With High-Risk Neuroblastoma and GD2-Positive Tumors | NCT01419834

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