Published in PLoS One on June 29, 2012
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A small interfering RNA screen of genes involved in DNA repair identifies tumor-specific radiosensitization by POLQ knockdown. Cancer Res (2010) 1.65
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Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2. Cancer Res (2008) 1.55
Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine inhibitor PI-103 enhances tumor radiosensitivity. Cancer Res (2008) 1.53
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Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev (2003) 1.33
A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene (2005) 1.32
Activation of nuclear factor kappaB In vivo selectively protects the murine small intestine against ionizing radiation-induced damage. Cancer Res (2004) 1.30
Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy. Clin Cancer Res (2008) 1.30
Involvement of p54(nrb), a PSF partner protein, in DNA double-strand break repair and radioresistance. Nucleic Acids Res (2009) 1.27
Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients. Clin Cancer Res (2005) 1.26
Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity. J Biol Chem (2001) 1.26
Gene expression following ionising radiation: identification of biomarkers for dose estimation and prediction of individual response. Int J Radiat Biol (2010) 1.26
Genetic variation in normal tissue toxicity induced by ionizing radiation. Mutat Res (2008) 1.25
Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer. Clin Cancer Res (2006) 1.24
Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A (2009) 1.23
Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Cancer Res (2002) 1.23
Silencing expression of the catalytic subunit of DNA-dependent protein kinase by small interfering RNA sensitizes human cells for radiation-induced chromosome damage, cell killing, and mutation. Cancer Res (2002) 1.22
Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes. Int J Radiat Oncol Biol Phys (2009) 1.22
The late radiotherapy normal tissue injury phenotypes of telangiectasia, fibrosis and atrophy in breast cancer patients have distinct genotype-dependent causes. Br J Cancer (2007) 1.20
Enhanced radiosensitivity and radiation-induced apoptosis in glioma CD133-positive cells by knockdown of SirT1 expression. Biochem Biophys Res Commun (2009) 1.20
A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer. Int J Cancer (2002) 1.20
ATM mutations in female breast cancer patients predict for an increase in radiation-induced late effects. Int J Radiat Oncol Biol Phys (2002) 1.18
A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J Sci Am (1999) 1.17
Radiation and stress-induced apoptosis: a role for Fas/Fas ligand interactions. Proc Natl Acad Sci U S A (1997) 1.16
Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer. Radiat Res (2008) 1.16
Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells. Oncogene (2010) 1.14
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras. Cancer Res (2005) 1.13
Differentially expressed genes in radioresistant nasopharyngeal cancer cells: gp96 and GDF15. Mol Cancer Ther (2007) 1.11
Radiation-induced micro-RNA expression changes in peripheral blood cells of radiotherapy patients. Int J Radiat Oncol Biol Phys (2011) 1.11
Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes. Radiat Res (2010) 1.11
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Down-regulation of survivin expression by small interfering RNA induces pancreatic cancer cell apoptosis and enhances its radiosensitivity. World J Gastroenterol (2006) 1.10
Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: implications for evaluation of clinical radiosensitivity. Int J Radiat Oncol Biol Phys (2006) 1.10
IL-17 receptor knockout mice have enhanced myelotoxicity and impaired hemopoietic recovery following gamma irradiation. J Immunol (2006) 1.09
Influence of tumor cell and stroma sensitivity on tumor response to radiation. Cancer Res (2007) 1.09
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. J Orthop Res (2007) 1.09
Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity. Radiother Oncol (2010) 1.08
Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples. Int J Radiat Biol (2006) 1.08
Enhanced radiosensitivity of cultured fibroblasts from ataxia telangiectasia heterozygotes manifested by defective colony-forming ability and reduced DNA repair replication after hypoxic gamma-irradiation. Cancer Res (1979) 1.07
Inhibition of the tumor necrosis factor-alpha pathway is radioprotective for the lung. Clin Cancer Res (2008) 1.07
Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice. Oncogene (2006) 1.06
Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1/2 mutations. J Clin Oncol (2000) 1.06
Antibodies to CD40 induce a lethal cytokine cascade after syngeneic bone marrow transplantation. Biol Blood Marrow Transplant (2001) 1.06
Inhibition of STAT-3 results in radiosensitization of human squamous cell carcinoma. Radiother Oncol (2009) 1.05
Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. Int J Radiat Oncol Biol Phys (2001) 1.05
Crosstalk between Bak/Bax and mTOR signaling regulates radiation-induced autophagy. Autophagy (2007) 1.05
Protein phosphatase-1alpha regulates centrosome splitting through Nek2. Cancer Res (2007) 1.05
Overexpression of c-Myc alters G(1)/S arrest following ionizing radiation. Mol Cell Biol (2002) 1.04
The sequential treatment with ionizing radiation followed by TRAIL/Apo-2L reduces tumor growth and induces apoptosis of breast tumor xenografts in nude mice. Int J Oncol (2004) 1.03
APE1 and XRCC1 protein expression levels predict cancer-specific survival following radical radiotherapy in bladder cancer. Clin Cancer Res (2005) 1.03
Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2. Oncogene (2003) 1.03
Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients. Int J Radiat Oncol Biol Phys (2000) 1.03
Gene expression profiles distinguish the carcinogenic effects of aristolochic acid in target (kidney) and non-target (liver) tissues in rats. BMC Bioinformatics (2006) 1.02
Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. Nucleic Acids Res (2008) 1.01
Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study. Breast Cancer Res (2006) 1.01
Identification of differentially expressed genes contributing to radioresistance in lung cancer cells using microarray analysis. Radiat Res (2005) 1.00
Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells. Radiother Oncol (2009) 1.00
Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc Natl Acad Sci U S A (2002) 1.00
Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes. Int J Radiat Oncol Biol Phys (2005) 1.00
Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia. Mol Cancer (2010) 1.00
IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. Clin Cancer Res (2008) 0.99
Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. Neuro Oncol (2008) 0.99
Sustained expression of NADPH oxidase 4 by p38 MAPK-Akt signaling potentiates radiation-induced differentiation of lung fibroblasts. J Mol Med (Berl) (2010) 0.99
Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients. Clin Cancer Res (2009) 0.99
The radiosensitizing effect of Ku70/80 knockdown in MCF10A cells irradiated with X-rays and p(66)+Be(40) neutrons. Radiat Oncol (2010) 0.99
Heat shock protein 27 as a new therapeutic target for radiation sensitization of head and neck squamous cell carcinoma. Mol Ther (2009) 0.98
Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells. Int J Cancer (2009) 0.98
The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res (2007) 9.32
PrimerBank: a resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res (2009) 5.03
Use of normal tissue complication probability models in the clinic. Int J Radiat Oncol Biol Phys (2010) 4.33
Radiation dose-volume effects in radiation-induced rectal injury. Int J Radiat Oncol Biol Phys (2010) 3.83
Radiation dose-volume effects in the lung. Int J Radiat Oncol Biol Phys (2010) 3.73
A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol (2006) 3.68
High-performance flat-panel solar thermoelectric generators with high thermal concentration. Nat Mater (2011) 2.96
The genome of the pear (Pyrus bretschneideri Rehd.). Genome Res (2012) 2.55
LNCipedia: a database for annotated human lncRNA transcript sequences and structures. Nucleic Acids Res (2012) 2.40
Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC): an introduction to the scientific issues. Int J Radiat Oncol Biol Phys (2010) 2.32
A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer. Gynecol Oncol (2009) 2.26
Survival among men with clinically localized prostate cancer treated with radical prostatectomy or radiation therapy in the prostate specific antigen era. J Urol (2012) 2.24
A microRNA expression signature for cervical cancer prognosis. Cancer Res (2010) 2.14
A comprehensive collection of experimentally validated primers for Polymerase Chain Reaction quantitation of murine transcript abundance. BMC Genomics (2008) 2.07
Enhanced thermoelectric figure-of-merit in nanostructured p-type silicon germanium bulk alloys. Nano Lett (2008) 1.97
A nomogram to predict radiation pneumonitis, derived from a combined analysis of RTOG 9311 and institutional data. Int J Radiat Oncol Biol Phys (2007) 1.90
Multivariable modeling of radiotherapy outcomes, including dose-volume and clinical factors. Int J Radiat Oncol Biol Phys (2006) 1.85
Progress toward a microradiation therapy small animal conformal irradiator. Med Phys (2006) 1.84
Combination of plasma microRNAs with serum CA19-9 for early detection of pancreatic cancer. Int J Cancer (2011) 1.68
Modeling radiation pneumonitis risk with clinical, dosimetric, and spatial parameters. Int J Radiat Oncol Biol Phys (2006) 1.67
Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy. Int J Radiat Oncol Biol Phys (2005) 1.65
The lessons of QUANTEC: recommendations for reporting and gathering data on dose-volume dependencies of treatment outcome. Int J Radiat Oncol Biol Phys (2010) 1.65
Intensity-modulated radiation therapy for oropharyngeal carcinoma: impact of tumor volume. Int J Radiat Oncol Biol Phys (2004) 1.64
A functional MicroRNA-155 ortholog encoded by the oncogenic Marek's disease virus. J Virol (2008) 1.59
Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding? Blood (2013) 1.54
Broadband ZnO single-nanowire light-emitting diode. Nano Lett (2006) 1.54
4D-CT motion estimation using deformable image registration and 5D respiratory motion modeling. Med Phys (2008) 1.49
The use and QA of biologically related models for treatment planning: short report of the TG-166 of the therapy physics committee of the AAPM. Med Phys (2012) 1.46
IMRT treatment planning based on prioritizing prescription goals. Phys Med Biol (2007) 1.32
Radiation dose-volume effects and the penile bulb. Int J Radiat Oncol Biol Phys (2010) 1.30
Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation (2007) 1.29
A fast inverse consistent deformable image registration method based on symmetric optical flow computation. Phys Med Biol (2008) 1.29
Dosimetric correlates for acute esophagitis in patients treated with radiotherapy for lung carcinoma. Int J Radiat Oncol Biol Phys (2004) 1.29
Accurate accumulation of dose for improved understanding of radiation effects in normal tissue. Int J Radiat Oncol Biol Phys (2010) 1.28
Concurrent multimodality image segmentation by active contours for radiotherapy treatment planning. Med Phys (2007) 1.26
Partial p16 staining in oropharyngeal squamous cell carcinoma: extent and pattern correlate with human papillomavirus RNA status. Mod Pathol (2012) 1.23
Generation of recombinant vaccinia viruses via green fluorescent protein selection. DNA Cell Biol (2009) 1.23
Heart irradiation as a risk factor for radiation pneumonitis. Acta Oncol (2010) 1.20
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations. Nat Genet (2013) 1.19
Photoinduced oxygen release and persistent photoconductivity in ZnO nanowires. Nanoscale Res Lett (2011) 1.17
IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 1.16
Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects. Int J Radiat Oncol Biol Phys (2010) 1.14
Fusobacterium nucleatum adhesin FadA binds vascular endothelial cadherin and alters endothelial integrity. Mol Microbiol (2011) 1.12
A novel RT-PCR method for quantification of human papillomavirus transcripts in archived tissues and its application in oropharyngeal cancer prognosis. Int J Cancer (2012) 1.11
Treatment planning constraints to avoid xerostomia in head-and-neck radiotherapy: an independent test of QUANTEC criteria using a prospectively collected dataset. Int J Radiat Oncol Biol Phys (2011) 1.10
FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. G3 (Bethesda) (2013) 1.09
Flexible asymmetric supercapacitors based upon Co9S8 nanorod//Co3O4@RuO2 nanosheet arrays on carbon cloth. ACS Nano (2013) 1.08
SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur J Immunol (2010) 1.08
Specific sequence determinants of miR-15/107 microRNA gene group targets. Nucleic Acids Res (2011) 1.08
Zero thermal expansion in PbTiO3-based perovskites. J Am Chem Soc (2008) 1.07
Feasibility of small animal cranial irradiation with the microRT system. Med Phys (2008) 1.06
Intravoxel incoherent motion diffusion-weighted MRI at 3.0 T differentiates malignant breast lesions from benign lesions and breast parenchyma. J Magn Reson Imaging (2013) 1.05
Deformable registration of abdominal kilovoltage treatment planning CT and tomotherapy daily megavoltage CT for treatment adaptation. Med Phys (2009) 1.03
The hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E(-/-) mice. Br J Pharmacol (2013) 1.02
Plasma concentrations of pro- and anti-inflammatory cytokines and outcome prediction in elderly hip fracture patients. Injury (2011) 1.02
Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3D conformal radiotherapy without daily image guidance. Radiat Oncol (2014) 1.02
Power factor enhancement by modulation doping in bulk nanocomposites. Nano Lett (2011) 1.02
KiSS-1 overexpression as an independent prognostic marker in hepatocellular carcinoma: an immunohistochemical study. Virchows Arch (2007) 1.01
Detection and significance of human papillomavirus, CDKN2A(p16) and CDKN1A(p21) expression in squamous cell carcinoma of the larynx. Mod Pathol (2012) 0.98
Geometric interpretation of the gamma dose distribution comparison technique: interpolation-free calculation. Med Phys (2008) 0.98
A Bayesian network approach for modeling local failure in lung cancer. Phys Med Biol (2011) 0.98
Normal Tissue Complication Probability (NTCP) modeling of late rectal bleeding following external beam radiotherapy for prostate cancer: A Test of the QUANTEC-recommended NTCP model. Acta Oncol (2010) 0.98
Tailoring a 67 attosecond pulse through advantageous phase-mismatch. Opt Lett (2012) 0.97
Osteopontin expression predicts overall survival after liver transplantation for hepatocellular carcinoma in patients beyond the Milan criteria. J Hepatol (2010) 0.95
TACE combined with PEI versus TACE alone in the treatment of HCC: a meta-analysis. Med Oncol (2010) 0.94
A treatment planning study comparing HDR and AGIMRT for cervical cancer. Med Phys (2004) 0.94
A microRNA expression signature for the prognosis of oropharyngeal squamous cell carcinoma. Cancer (2012) 0.94
Transcriptome analysis of the differences in gene expression between testis and ovary in green mud crab (Scylla paramamosain). BMC Genomics (2014) 0.94
Modeling the risk of radiation-induced acute esophagitis for combined Washington University and RTOG trial 93-11 lung cancer patients. Int J Radiat Oncol Biol Phys (2011) 0.93
Multi-parameter systematic strategies for predictive, preventive and personalised medicine in cancer. EPMA J (2013) 0.93
Absence of multiple local minima effects in intensity modulated optimization with dose-volume constraints. Phys Med Biol (2003) 0.93
Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis. J Mol Cell Cardiol (2011) 0.90
Verrucous carcinomas of the head and neck, including those with associated squamous cell carcinoma, lack transcriptionally active high-risk human papillomavirus. Hum Pathol (2013) 0.90
Comparing primary tumors and metastatic nodes in head and neck cancer using intravoxel incoherent motion imaging: a preliminary experience. J Comput Assist Tomogr (2013) 0.90
Combining multiple models to generate consensus: application to radiation-induced pneumonitis prediction. Med Phys (2008) 0.90
Structural analysis of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions. PLoS One (2011) 0.89
Identification of the proteomic variations of invasive relative to non-invasive non-functional pituitary adenomas. Electrophoresis (2014) 0.89
Genetic changes at specific stages of breast cancer progression detected by comparative genomic hybridization. J Mol Med (Berl) (2008) 0.89
Deblurring of breathing motion artifacts in thoracic PET images by deconvolution methods. Med Phys (2006) 0.88
Technical note: DIRART--A software suite for deformable image registration and adaptive radiotherapy research. Med Phys (2011) 0.88
A bioinformatics approach for biomarker identification in radiation-induced lung inflammation from limited proteomics data. J Proteome Res (2011) 0.87
The critical time of avian leukosis virus subgroup J-mediated immunosuppression during early stage infection in specific pathogen-free chickens. J Vet Sci (2011) 0.87
The generalized equivalent uniform dose function as a basis for intensity-modulated treatment planning. Phys Med Biol (2002) 0.87
Technical note: deformable image registration on partially matched images for radiotherapy applications. Med Phys (2010) 0.87
Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study. Breast Cancer Res Treat (2008) 0.86
Can lymph node evaluation be performed well by video-assisted thoracic surgery? J Cancer Res Clin Oncol (2014) 0.86
Amyloid plaques dissociate pentameric to monomeric C-reactive protein: a novel pathomechanism driving cortical inflammation in Alzheimer's disease? Brain Pathol (2011) 0.86
Motion correction of multi-b-value diffusion-weighted imaging in the liver. Acad Radiol (2012) 0.85
Dose/volume-response relations for rectal morbidity using planned and simulated motion-inclusive dose distributions. Radiother Oncol (2013) 0.85
Beyond bixels: generalizing the optimization parameters for intensity modulated radiation therapy. Med Phys (2002) 0.84
The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection. Infect Immun (2014) 0.84
A research agenda for radiation oncology: results of the radiation oncology institute's comprehensive research needs assessment. Int J Radiat Oncol Biol Phys (2012) 0.84
Retrospective monte carlo dose calculations with limited beam weight information. Med Phys (2007) 0.83
Dimethylsilyl ketene acetal as a nucleophile in asymmetric Michael reaction: enhanced enantioselectivity in oxazaborolidinone-catalyzed reaction. Org Lett (2004) 0.83
Influence of growth medium on cometabolic degradation of polycyclic aromatic hydrocarbons by Sphingomonas sp. strain PheB4. Appl Microbiol Biotechnol (2007) 0.83
Dysregulation of the mitogen granulin in human cancer through the miR-15/107 microRNA gene group. Cancer Res (2010) 0.82
Statistical simulations to estimate motion-inclusive dose-volume histograms for prediction of rectal morbidity following radiotherapy. Acta Oncol (2012) 0.82
Effects of (12)C(6+) ion radiation and ferulic acid on the zebrafish (Danio rerio) embryonic oxidative stress response and gene expression. Mutat Res (2013) 0.81