PubRank

Justin Legleiter

Author PubWeight™ 28.31‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J Biol Chem 2007 3.13
2 Structure of gel phase DMPC determined by X-ray diffraction. Biophys J 2002 2.65
3 Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nat Chem Biol 2011 2.24
4 ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J Biol Chem 2004 2.19
5 Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet 2006 1.77
6 Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease. Hum Mol Genet 2010 1.71
7 Collagen VI protects neurons against Abeta toxicity. Nat Neurosci 2009 1.19
8 Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. J Biol Chem 2012 1.07
9 Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle. J Biol Chem 2010 1.01
10 Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration. Front Neurol 2013 0.96
11 The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin. J Biol Chem 2013 0.94
12 Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy. Methods 2010 0.88
13 Amyloid-forming proteins alter the local mechanical properties of lipid membranes. Biochemistry 2013 0.88
14 The role of amyloidogenic protein oligomerization in neurodegenerative disease. J Mol Med (Berl) 2013 0.85
15 Huntingtin disrupts lipid bilayers in a polyQ-length dependent manner. Biochim Biophys Acta 2013 0.84
16 Point mutations in Aβ result in the formation of distinct polymorphic aggregates in the presence of lipid bilayers. PLoS One 2011 0.84
17 Specific domains of Aβ facilitate aggregation on and association with lipid bilayers. J Mol Biol 2013 0.81
18 Curvature enhances binding and aggregation of huntingtin at lipid membranes. Biochemistry 2014 0.80
19 Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation. J Mass Spectrom 2015 0.80
20 Mapping the mechanical properties of cholesterol-containing supported lipid bilayers with nanoscale spatial resolution. Langmuir 2012 0.78
21 Preparation protocols of aβ(1-40) promote the formation of polymorphic aggregates and altered interactions with lipid bilayers. Biochemistry 2014 0.76
22 The emerging role of the first 17 amino acids of huntingtin in Huntington's disease. Biomol Concepts 2015 0.76
23 Point mutations in Aβ induce polymorphic aggregates at liquid/solid interfaces. ACS Chem Neurosci 2011 0.76
24 Investigation of temperature induced mechanical changes in supported bilayers by variants of tapping mode atomic force microscopy. Scanning 2014 0.76
25 Atomic force microscopy assays for evaluating polyglutamine aggregation in solution and on surfaces. Methods Mol Biol 2013 0.75