| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer.
|
Cancer Res
|
2005
|
2.42
|
|
2
|
Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity.
|
J Biol Chem
|
2005
|
2.05
|
|
3
|
Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression.
|
Sci Transl Med
|
2012
|
1.67
|
|
4
|
A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells.
|
Cancer Res
|
2006
|
1.67
|
|
5
|
Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι.
|
Metabolism
|
2012
|
1.63
|
|
6
|
Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo.
|
J Cell Biol
|
2004
|
1.63
|
|
7
|
Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.
|
J Biol Chem
|
2004
|
1.56
|
|
8
|
Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota.
|
J Biol Chem
|
2006
|
1.55
|
|
9
|
Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
|
Cancer Res
|
2008
|
1.43
|
|
10
|
Splice variants of SmgGDS control small GTPase prenylation and membrane localization.
|
J Biol Chem
|
2010
|
1.25
|
|
11
|
Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis.
|
Cancer Res
|
2010
|
1.20
|
|
12
|
Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.
|
Cancer Res
|
2009
|
1.17
|
|
13
|
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.
|
PLoS One
|
2012
|
1.10
|
|
14
|
PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.
|
Mol Cancer Res
|
2013
|
1.10
|
|
15
|
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
|
Int J Cancer
|
2008
|
1.09
|
|
16
|
Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon.
|
Physiol Genomics
|
2007
|
1.09
|
|
17
|
Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis.
|
J Cell Biol
|
2002
|
1.08
|
|
18
|
Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.
|
J Cell Physiol
|
2011
|
1.08
|
|
19
|
Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2.
|
J Biol Chem
|
2006
|
1.08
|
|
20
|
Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.
|
J Biol Chem
|
2010
|
1.08
|
|
21
|
Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.
|
Anticancer Drugs
|
2013
|
1.04
|
|
22
|
Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study.
|
Biomarkers
|
2003
|
1.03
|
|
23
|
Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.
|
Cancer Res
|
2009
|
1.02
|
|
24
|
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
|
PLoS One
|
2011
|
0.97
|
|
25
|
Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure.
|
J Biol Chem
|
2012
|
0.97
|
|
26
|
Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis.
|
J Biol Chem
|
2004
|
0.96
|
|
27
|
Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations.
|
Front Oncol
|
2012
|
0.96
|
|
28
|
RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells.
|
Mol Cell Endocrinol
|
2006
|
0.96
|
|
29
|
Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1).
|
J Biol Chem
|
2011
|
0.95
|
|
30
|
Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo.
|
J Biol Chem
|
2004
|
0.91
|
|
31
|
Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.
|
Clin Cancer Res
|
2009
|
0.90
|
|
32
|
Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis.
|
J Biol Chem
|
2002
|
0.90
|
|
33
|
Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter.
|
J Biol Chem
|
2003
|
0.88
|
|
34
|
Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis.
|
Inflamm Bowel Dis
|
2010
|
0.88
|
|
35
|
A mixed-methods feasibility trial of protein kinase C iota inhibition with auranofin in asymptomatic ovarian cancer patients.
|
Oncology
|
2014
|
0.87
|
|
36
|
Genomic analysis of glucocorticoid-regulated promoters in murine T-lymphoma cells.
|
Recent Prog Horm Res
|
2003
|
0.87
|
|
37
|
Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism.
|
PLoS One
|
2013
|
0.86
|
|
38
|
Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.
|
PLoS One
|
2012
|
0.85
|
|
39
|
Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction.
|
Biochim Biophys Acta
|
2007
|
0.84
|
|
40
|
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.
|
Int J Cancer
|
2008
|
0.81
|
|
41
|
Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics.
|
Curr Protoc Pharmacol
|
2013
|
0.81
|
|
42
|
Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2.
|
J Biol Chem
|
2013
|
0.79
|
|
43
|
Rapid backbone 1H, 13C, and 15N assignment of the V1 domain of human PKC iota using the new program IBIS.
|
J Biomol NMR
|
2003
|
0.75
|
|
44
|
Letter to the Editor: Rapid backbone (1)H, (13)C, and (15)N assignment of the V1 domain of human PKC iota using the new program IBIS.
|
J Biomol NMR
|
2003
|
0.75
|