Optogenetic manipulation of neural circuits and behavior in Drosophila larvae.

PubWeight™: 0.91‹?›

🔗 View Article (PMC 3751580)

Published in Nat Protoc on July 12, 2012

Authors

Ken Honjo1, Richard Y Hwang, William Daniel Tracey

Author Affiliations

1: Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA.

Articles citing this

Independent optical excitation of distinct neural populations. Nat Methods (2014) 3.53

Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol (2012) 1.12

High-throughput analysis of stimulus-evoked behaviors in Drosophila larva reveals multiple modality-specific escape strategies. PLoS One (2013) 1.01

Dendrite architecture organized by transcriptional control of the F-actin nucleator Spire. Development (2014) 0.85

Algal photoreceptors: in vivo functions and potential applications. Planta (2013) 0.85

Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory. Development (2015) 0.83

Neuron class-specific requirements for Fragile X Mental Retardation Protein in critical period development of calcium signaling in learning and memory circuitry. Neurobiol Dis (2016) 0.80

Induction of associative olfactory memory by targeted activation of single olfactory neurons in Drosophila larvae. Sci Rep (2014) 0.77

Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae. Front Behav Neurosci (2016) 0.75

Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila. Neuron (2017) 0.75

Sensory integration and neuromodulatory feedback facilitate Drosophila mechanonociceptive behavior. Nat Neurosci (2017) 0.75

Articles cited by this

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26

Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08

Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci U S A (2003) 15.17

Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Curr Biol (2005) 8.01

The development and application of optogenetics. Annu Rev Neurosci (2011) 6.84

The effect of chromosomal position on the expression of the Drosophila xanthine dehydrogenase gene. Cell (1983) 6.67

An internal thermal sensor controlling temperature preference in Drosophila. Nature (2008) 6.52

Light-induced activation of distinct modulatory neurons triggers appetitive or aversive learning in Drosophila larvae. Curr Biol (2006) 6.40

Conditional modification of behavior in Drosophila by targeted expression of a temperature-sensitive shibire allele in defined neurons. J Neurobiol (2001) 6.07

Remote control of behavior through genetically targeted photostimulation of neurons. Cell (2005) 5.46

Channelrhodopsin-2 and optical control of excitable cells. Nat Methods (2006) 5.46

Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron (1995) 5.42

painless, a Drosophila gene essential for nociception. Cell (2003) 4.93

Ultrafast optogenetic control. Nat Neurosci (2010) 4.73

Refinement of tools for targeted gene expression in Drosophila. Genetics (2010) 4.53

Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Curr Biol (2007) 4.07

Genetic mosaic with dual binary transcriptional systems in Drosophila. Nat Neurosci (2006) 3.95

The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis. Cell (2010) 3.75

Writing memories with light-addressable reinforcement circuitry. Cell (2009) 3.66

Electrical silencing of Drosophila pacemaker neurons stops the free-running circadian clock. Cell (2002) 3.53

Motor control in a Drosophila taste circuit. Neuron (2009) 3.48

Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature (2010) 3.13

Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila. Nature (2011) 3.06

Sex-specific control and tuning of the pattern generator for courtship song in Drosophila. Cell (2008) 2.89

Spectral characteristics of the photocycle of channelrhodopsin-2 and its implication for channel function. J Mol Biol (2007) 2.88

Electrical hyperexcitation of lateral ventral pacemaker neurons desynchronizes downstream circadian oscillators in the fly circadian circuit and induces multiple behavioral periods. J Neurosci (2006) 2.65

Temporal dynamics of neuronal activation by Channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae. J Neurophysiol (2009) 2.30

Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr Biol (2003) 2.25

Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr Biol (2010) 2.20

Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila. Neuron (2011) 2.14

Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila. J Neurosci (2006) 1.93

A user's guide to channelrhodopsin variants: features, limitations and future developments. Exp Physiol (2010) 1.84

Light activation of an innate olfactory avoidance response in Drosophila. Curr Biol (2007) 1.81

Electrical coupling between olfactory glomeruli. Neuron (2010) 1.80

Homeostatic control of presynaptic release is triggered by postsynaptic membrane depolarization. Neuron (2001) 1.80

Channelrhodopsin engineering and exploration of new optogenetic tools. Nat Methods (2010) 1.70

Functional connectivity and selective odor responses of excitatory local interneurons in Drosophila antennal lobe. Neuron (2010) 1.59

Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster. PLoS One (2010) 1.49

Optogenetic control of cells and circuits. Annu Rev Cell Dev Biol (2011) 1.40

Characterization of the decision network for wing expansion in Drosophila using targeted expression of the TRPM8 channel. J Neurosci (2009) 1.39

Excitatory and inhibitory switches for courtship in the brain of Drosophila melanogaster. Curr Biol (2004) 1.36

Refining GAL4-driven transgene expression in Drosophila with a GAL80 enhancer-trap. Genesis (2004) 1.34

A genetic mosaic approach for neural circuit mapping in Drosophila. Proc Natl Acad Sci U S A (2010) 1.31

Refined LexA transactivators and their use in combination with the Drosophila Gal4 system. Proc Natl Acad Sci U S A (2010) 1.31

Turning males on: activation of male courtship behavior in Drosophila melanogaster. PLoS One (2011) 1.26

A Gateway MultiSite recombination cloning toolkit. PLoS One (2011) 1.17

Optogenetics in the teaching laboratory: using channelrhodopsin-2 to study the neural basis of behavior and synaptic physiology in Drosophila. Adv Physiol Educ (2011) 1.11

Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci (2010) 1.09

Optogenetically Induced Olfactory Stimulation in Drosophila Larvae Reveals the Neuronal Basis of Odor-Aversion behavior. Front Behav Neurosci (2010) 1.04

Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway. Proc Natl Acad Sci U S A (2010) 1.02

Behavioral responses to hypoxia in Drosophila larvae are mediated by atypical soluble guanylyl cyclases. Genetics (2010) 0.96

Focusing transgene expression in Drosophila by coupling Gal4 with a novel split-LexA expression system. Genetics (2011) 0.94

Molecular genetic approaches to the targeted suppression of neuronal activity. Curr Biol (2001) 0.91

Using the Q system in Drosophila melanogaster. Nat Protoc (2011) 0.89

Manipulation of an innate escape response in Drosophila: photoexcitation of acj6 neurons induces the escape response. PLoS One (2009) 0.86