PubRank

Ethan A Merritt

Author PubWeight™ 57.13‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Optimal description of a protein structure in terms of multiple groups undergoing TLS motion. Acta Crystallogr D Biol Crystallogr 2006 14.21
2 Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. Nat Struct Mol Biol 2010 2.34
3 A molecular viewer for the analysis of TLS rigid-body motion in macromolecules. Acta Crystallogr D Biol Crystallogr 2005 1.82
4 Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii. ACS Med Chem Lett 2010 1.82
5 Sequence determinants of a specific inactive protein kinase conformation. Chem Biol 2013 1.78
6 Cooperative hydrogen bond interactions in the streptavidin-biotin system. Protein Sci 2006 1.67
7 Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity. J Med Chem 2012 1.56
8 High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design. J Mol Biol 2006 1.49
9 Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice. Antimicrob Agents Chemother 2011 1.37
10 Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem 2012 1.35
11 Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies. Mol Microbiol 2008 1.22
12 Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors. J Clin Invest 2012 1.22
13 Structural genomics of pathogenic protozoa: an overview. Methods Mol Biol 2008 1.20
14 Validation of crystallographic models containing TLS or other descriptions of anisotropy. Acta Crystallogr D Biol Crystallogr 2010 1.17
15 HingeMaster: normal mode hinge prediction approach and integration of complementary predictors. Proteins 2008 1.13
16 Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1. Bioorg Med Chem Lett 2012 1.12
17 Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. J Am Chem Soc 2002 1.08
18 Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl. J Biol Chem 2009 1.02
19 Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem 2006 1.00
20 Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. J Mol Biol 2008 0.98
21 Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate. Biochimie 2010 0.93
22 Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.93
23 Active site profiling reveals coupling between domains in SRC-family kinases. Nat Chem Biol 2012 0.91
24 Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium. Curr Top Med Chem 2009 0.90
25 Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3. Mol Biochem Parasitol 2010 0.90
26 The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase. J Mol Biol 2010 0.88
27 Atomic resolution studies of carbonic anhydrase II. Acta Crystallogr D Biol Crystallogr 2010 0.85
28 The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer. J Mol Biol 2011 0.85
29 Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily. Protein Sci 2005 0.85
30 Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.84
31 Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site. Proteins 2006 0.83
32 Structure of ribose 5-phosphate isomerase from Plasmodium falciparum. Acta Crystallogr Sect F Struct Biol Cryst Commun 2006 0.83
33 Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chem Biol 2002 0.82
34 Prediction of protein crystallization outcome using a hybrid method. J Struct Biol 2010 0.82
35 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc 2012 0.82
36 The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs. J Struct Biol 2010 0.80
37 Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia. Acta Crystallogr D Biol Crystallogr 2012 0.79
38 Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin. Int J Med Microbiol 2004 0.78
39 The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 0.76
40 PROSPERO: online prediction of crystallographic success from experimental results and sequence. J Appl Crystallogr 2012 0.75
41 Screening a fragment cocktail library using ultrafiltration. Anal Bioanal Chem 2011 0.75
42 Combating infectious diseases through multivalent design. Curr Drug Targets Infect Disord 2002 0.75