PubRank

Matthew R Redinbo

Author PubWeight™ 85.42‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Crystal structure of an ancient protein: evolution by conformational epistasis. Science 2007 3.56
2 Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science 2010 2.99
3 Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chem Biol 2003 2.05
4 Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nat Struct Mol Biol 2005 2.03
5 Regulation of cyp3a gene transcription by the pregnane x receptor. Annu Rev Pharmacol Toxicol 2002 1.87
6 Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Mol Cell 2008 1.82
7 Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol 2003 1.57
8 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry 2003 1.55
9 Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Mol Endocrinol 2005 1.55
10 Mechanisms of camptothecin resistance by human topoisomerase I mutations. J Mol Biol 2004 1.46
11 Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nat Struct Biol 2003 1.46
12 Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. J Mol Biol 2006 1.42
13 Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Mamm Genome 2010 1.40
14 Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J Mol Biol 2005 1.40
15 Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. J Mol Biol 2007 1.35
16 Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proc Natl Acad Sci U S A 2007 1.32
17 Orphan nuclear receptors adopted by crystallography. Curr Opin Struct Biol 2005 1.28
18 Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Mol Endocrinol 2007 1.25
19 Structural insights into CPT-11 activation by mammalian carboxylesterases. Nat Struct Biol 2002 1.25
20 Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry 2007 1.20
21 Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proc Natl Acad Sci U S A 2013 1.20
22 Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry 2010 1.20
23 Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorg Med Chem 2006 1.19
24 A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities. Biochemistry 2002 1.19
25 Structure and function of the human nuclear xenobiotic receptor PXR. Curr Drug Metab 2005 1.14
26 Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clin Cancer Res 2007 1.12
27 Active nuclear receptors exhibit highly correlated AF-2 domain motions. PLoS Comput Biol 2008 1.12
28 Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proc Natl Acad Sci U S A 2009 1.09
29 Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Pharm Res 2009 1.09
30 Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry 2006 1.07
31 Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Mol Pharmacol 2010 1.06
32 The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Mol Endocrinol 2005 1.04
33 Structural insights into the promiscuity and function of the human pregnane X receptor. Curr Opin Drug Discov Devel 2002 1.03
34 PXR antagonists and implication in drug metabolism. Drug Metab Rev 2013 1.03
35 Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. PLoS Comput Biol 2009 1.01
36 8-Oxoguanine rearranges the active site of human topoisomerase I. Proc Natl Acad Sci U S A 2002 1.00
37 Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Mol Pharmacol 2008 0.99
38 Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Mol Pharmacol 2006 0.99
39 Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proc Natl Acad Sci U S A 2013 0.98
40 Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. J Mol Biol 2005 0.98
41 An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 2013 0.97
42 Multiple NSAID-induced hits injure the small intestine: underlying mechanisms and novel strategies. Toxicol Sci 2012 0.96
43 Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. J Pharmacol Exp Ther 2012 0.96
44 The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1. Nucleic Acids Res 2010 0.96
45 Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner. PLoS One 2011 0.95
46 Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica 2013 0.94
47 Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR. J Biol Chem 2013 0.93
48 Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol 2013 0.93
49 Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Mol Pharmacol 2013 0.91
50 Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin. J Mol Biol 2009 0.91
51 Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chem Res Toxicol 2005 0.90
52 Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. J Biol Chem 2003 0.89
53 Understanding and modulating mammalian-microbial communication for improved human health. Annu Rev Pharmacol Toxicol 2013 0.89
54 Crystal structure of the plant epigenetic protein arginine methyltransferase 10. J Mol Biol 2011 0.88
55 The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families. Drug Metab Rev 2010 0.88
56 Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Sci 2011 0.87
57 Electrostatic contribution of serine phosphorylation to the Drosophila SLBP--histone mRNA complex. Biochemistry 2004 0.87
58 The human microbiome is a source of therapeutic drug targets. Curr Opin Chem Biol 2013 0.86
59 Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins. Biochemistry 2011 0.86
60 Retracted Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. FASEB J 2012 0.85
61 Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation. Infect Immun 2013 0.84
62 Promiscuity: what protects us, perplexes us. Drug Discov Today 2004 0.83
63 A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer. J Mol Biol 2008 0.82
64 Functional characterization of the multidomain F plasmid TraI relaxase-helicase. J Biol Chem 2011 0.82
65 Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. J Mol Biol 2013 0.82
66 Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metab Rev 2012 0.81
67 Winning the asymmetric war: new strategies for combating antibacterial resistance. Future Microbiol 2008 0.80
68 Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme. FEBS Lett 2011 0.80
69 Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility. J Bacteriol 2012 0.80
70 Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model. Biochemistry 2004 0.80
71 A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors. Curr Chem Genomics 2011 0.80
72 Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids. Biochem Biophys Res Commun 2012 0.80
73 Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization. J Bacteriol 2011 0.79
74 Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. PLoS One 2011 0.78
75 Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry 2012 0.78
76 Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles. Biotechnol Prog 2011 0.75
77 NSAID-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells. ACS Infect Dis 2017 0.75