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1
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A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants.
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Clin Pharmacol Ther
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2006
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3.09
|
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2
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4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and Tanzanians.
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Pharmacogenet Genomics
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2008
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1.52
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3
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A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.
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Br J Clin Pharmacol
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2009
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1.33
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4
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Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations.
|
PLoS One
|
2013
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1.17
|
|
5
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Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients.
|
PLoS One
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2011
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1.17
|
|
6
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Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans.
|
Eur J Clin Pharmacol
|
2007
|
1.13
|
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7
|
CYP3A5 genotype has significant effect on quinine 3-hydroxylation in Tanzanians, who have lower total CYP3A activity than a Swedish population.
|
Pharmacogenet Genomics
|
2006
|
1.06
|
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8
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Long-term effect of efavirenz autoinduction on plasma/peripheral blood mononuclear cell drug exposure and CD4 count is influenced by UGT2B7 and CYP2B6 genotypes among HIV patients.
|
J Antimicrob Chemother
|
2011
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1.04
|
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9
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Anti-tuberculosis therapy-induced hepatotoxicity among Ethiopian HIV-positive and negative patients.
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PLoS One
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2008
|
1.03
|
|
10
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β-defensin genomic copy number is associated with HIV load and immune reconstitution in sub-saharan Africans.
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J Infect Dis
|
2012
|
1.03
|
|
11
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Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype.
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Pharmacogenet Genomics
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2006
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1.02
|
|
12
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Keratin-18 and microRNA-122 complement alanine aminotransferase as novel safety biomarkers for drug-induced liver injury in two human cohorts.
|
Liver Int
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2013
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1.00
|
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13
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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.
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Pharmacogenomics J
|
2009
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1.00
|
|
14
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VKORC1 Asp36Tyr warfarin resistance marker is common in Ethiopian individuals.
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Blood
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2008
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1.00
|
|
15
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Influence of efavirenz pharmacokinetics and pharmacogenetics on neuropsychological disorders in Ugandan HIV-positive patients with or without tuberculosis: a prospective cohort study.
|
BMC Infect Dis
|
2013
|
1.00
|
|
16
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Mutations in CYP1B1 cause primary congenital glaucoma by reduction of either activity or abundance of the enzyme.
|
Hum Mutat
|
2008
|
1.00
|
|
17
|
Liver enzyme abnormalities and associated risk factors in HIV patients on efavirenz-based HAART with or without tuberculosis co-infection in Tanzania.
|
PLoS One
|
2012
|
0.97
|
|
18
|
PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2.
|
Pharmacogenet Genomics
|
2014
|
0.97
|
|
19
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Risk factors for mortality among HIV-positive patients with and without active tuberculosis in Dar es Salaam, Tanzania.
|
Antivir Ther
|
2011
|
0.94
|
|
20
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MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs.
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Eur Neuropsychopharmacol
|
2009
|
0.93
|
|
21
|
Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients.
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Eur J Clin Pharmacol
|
2010
|
0.91
|
|
22
|
Induction of CYP1A2 by heavy coffee consumption in Serbs and Swedes.
|
Eur J Clin Pharmacol
|
2007
|
0.90
|
|
23
|
Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.
|
Eur J Clin Pharmacol
|
2010
|
0.88
|
|
24
|
PharmGKB summary: caffeine pathway.
|
Pharmacogenet Genomics
|
2012
|
0.86
|
|
25
|
In vivo evaluation of CYP2A6 and xanthine oxidase enzyme activities in the Serbian population.
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Eur J Clin Pharmacol
|
2010
|
0.86
|
|
26
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CYP2C19 activity comparison between Swedes and Koreans: effect of genotype, sex, oral contraceptive use, and smoking.
|
Eur J Clin Pharmacol
|
2010
|
0.86
|
|
27
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Analysis of CYP2C9*5 in Caucasian, Oriental and black-African populations.
|
Eur J Clin Pharmacol
|
2002
|
0.84
|
|
28
|
Comparison of N-acetyltransferase-2 enzyme genotype-phenotype and xanthine oxidase enzyme activity between Swedes and Koreans.
|
J Clin Pharmacol
|
2011
|
0.84
|
|
29
|
CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.
|
BMC Infect Dis
|
2013
|
0.83
|
|
30
|
Copy number variation of Fc gamma receptor genes in HIV-infected and HIV-tuberculosis co-infected individuals in sub-Saharan Africa.
|
PLoS One
|
2013
|
0.82
|
|
31
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HIV/AIDS patients display lower relative bioavailability of efavirenz than healthy subjects.
|
Clin Pharmacokinet
|
2011
|
0.80
|
|
32
|
Haplotypes in the 5'-untranslated region of the CYP1A2 gene are inversely associated with lung cancer risk but do not correlate with caffeine metabolism.
|
Environ Mol Mutagen
|
2012
|
0.80
|
|
33
|
PharmGKB summary: very important pharmacogene information for CYP1A2.
|
Pharmacogenet Genomics
|
2012
|
0.80
|
|
34
|
Monoamine metabolites level in CSF is related to the 5-HTT gene polymorphism in treatment-resistant depression.
|
Neuropsychopharmacology
|
2007
|
0.80
|
|
35
|
Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans.
|
Ther Drug Monit
|
2010
|
0.79
|
|
36
|
Pharmacogenetics for off-patent antipsychotics: reframing the risk for tardive dyskinesia and access to essential medicines.
|
Expert Opin Pharmacother
|
2006
|
0.79
|
|
37
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CYP2B6 genotype, but not rifampicin-based anti-TB cotreatments, explains variability in long-term efavirenz plasma exposure.
|
Pharmacogenomics
|
2014
|
0.79
|
|
38
|
Search for the molecular basis of ultra-rapid CYP2C9-catalysed metabolism: relationship between SNP IVS8-109A>T and the losartan metabolism phenotype in Swedes.
|
Eur J Clin Pharmacol
|
2012
|
0.79
|
|
39
|
Comparisons of CYP2A6 genotype and enzyme activity between Swedes and Koreans.
|
Drug Metab Pharmacokinet
|
2012
|
0.78
|
|
40
|
The Psychostimulant Khat (Catha edulis) Inhibits CYP2D6 Enzyme Activity in Humans.
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J Clin Psychopharmacol
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2015
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0.78
|
|
41
|
N-Acetyltransferase-2 (NAT2) gene polymorphisms and enzyme activity in Serbs: unprecedented high prevalence of rapid acetylators in a White population.
|
J Clin Pharmacol
|
2010
|
0.77
|
|
42
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The VKORC1 Asp36Tyr variant and VKORC1 haplotype diversity in Ashkenazi and Ethiopian populations.
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J Appl Genet
|
2014
|
0.77
|
|
43
|
Prevalence and risk factors for efavirenz-based antiretroviral treatment-associated severe vitamin D deficiency: A prospective cohort study.
|
Medicine (Baltimore)
|
2016
|
0.75
|