Published in Eur J Med Chem on July 04, 2012
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Tryptophan-based fluorophores for studying protein conformational changes. Bioorg Med Chem (2014) 0.75
Regioselective one-pot protection of carbohydrates. Nature (2007) 1.87
Impaired phagocytosis of capsular serotypes K1 or K2 Klebsiella pneumoniae in type 2 diabetes mellitus patients with poor glycemic control. J Clin Endocrinol Metab (2006) 1.71
Association between antidepressant resistance in unipolar depression and subsequent bipolar disorder: cohort study. Br J Psychiatry (2011) 1.63
Persistent tissue kinetics and redistribution of nanoparticles, quantum dot 705, in mice: ICP-MS quantitative assessment. Environ Health Perspect (2007) 1.61
Diverse cellular transformation capability of overexpressed genes in human hepatocellular carcinoma. Biochem Biophys Res Commun (2004) 1.50
Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan. Arthritis Res Ther (2010) 1.45
Epidemiological features and costs of herpes zoster in Taiwan: a national study 2000 to 2006. Acta Derm Venereol (2009) 1.38
Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice. Obesity (Silver Spring) (2009) 1.36
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer Res (2004) 1.36
Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice. Environ Sci Technol (2008) 1.30
A nanostructure-initiator mass spectrometry-based enzyme activity assay. Proc Natl Acad Sci U S A (2008) 1.27
Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents. J Med Chem (2003) 1.18
A randomised placebo-controlled trial of a traditional Chinese herbal formula in the treatment of primary dysmenorrhoea. PLoS One (2007) 1.17
Effects of carrier on disposition and antitumor activity of intraperitoneal Paclitaxel. Pharm Res (2007) 1.09
Novel dengue virus-specific NS2B/NS3 protease inhibitor, BP2109, discovered by a high-throughput screening assay. Antimicrob Agents Chemother (2010) 1.09
Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery. Biomacromolecules (2007) 1.08
IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer. J Cell Physiol (2015) 1.04
Paclitaxel-loaded gelatin nanoparticles for intravesical bladder cancer therapy. Clin Cancer Res (2004) 1.04
Do neutrophils play a role in establishing liver abscesses and distant metastases caused by Klebsiella pneumoniae? PLoS One (2010) 1.03
Structure-based drug design of a novel family of PPARgamma partial agonists: virtual screening, X-ray crystallography, and in vitro/in vivo biological activities. J Med Chem (2006) 0.98
Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system for the treatment of liver cancer. Biomaterials (2005) 0.98
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery. Biomaterials (2009) 0.96
Immune response and pathophysiological features of Klebsiella pneumoniae liver abscesses in an animal model. Lab Invest (2011) 0.96
HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clin Cancer Res (2012) 0.95
Efficacy of Sanfujiu to treat allergies: patient outcomes at 1 year after treatment. Evid Based Complement Alternat Med (2006) 0.95
Major depressive disorder and stroke risks: a 9-year follow-up population-based, matched cohort study. PLoS One (2012) 0.94
A natural compound (ginsenoside Re) isolated from Panax ginseng as a novel angiogenic agent for tissue regeneration. Pharm Res (2005) 0.93
Conserved extracellular cysteines differentially regulate the inhibitory effect of ethanol in rat P2X4 receptors. Biochem Biophys Res Commun (2009) 0.92
Angiogenesis inhibitor bevacizumab increases the risk of ischemic heart disease associated with chemotherapy: a meta-analysis. PLoS One (2013) 0.91
Disseminated cryptococcosis initially presenting as cellulitis in a rheumatoid arthritis patient. J Chin Med Assoc (2007) 0.91
The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes. Life Sci (2006) 0.91
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem Pharmacol (2009) 0.90
Regioselective one-pot protection of glucose. Nat Protoc (2008) 0.90
Synthesis of biologically potent alpha1-->2-linked disaccharide derivatives via regioselective one-pot protection-glycosylation. Angew Chem Int Ed Engl (2002) 0.89
Effects of chitosan-nanoparticle-mediated tight junction opening on the oral absorption of endotoxins. Biomaterials (2011) 0.88
Epidemiological study of psoriasis in the national health insurance database in Taiwan. Acta Derm Venereol (2009) 0.87
Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression. Int J Cancer (2014) 0.87
Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification. J Med Chem (2010) 0.87
Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer. Clin Cancer Res (2003) 0.87
Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo. J Med Chem (2012) 0.87
Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus. Antiviral Res (2013) 0.86
H2O2 accumulation mediates differentiation capacity alteration, but not proliferative decline, in senescent human fetal mesenchymal stem cells. Antioxid Redox Signal (2012) 0.86
Novel indole-based peroxisome proliferator-activated receptor agonists: design, SAR, structural biology, and biological activities. J Med Chem (2005) 0.85
Preparation of nanoparticles composed of chitosan/poly-gamma-glutamic acid and evaluation of their permeability through Caco-2 cells. Biomacromolecules (2005) 0.85
Quercetin and rutin reduced the bioavailability of cyclosporine from Neoral, an immunosuppressant, through activating P-glycoprotein and CYP 3A4. J Agric Food Chem (2011) 0.85
Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet. J Ethnopharmacol (2007) 0.85
Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity. J Med Chem (2012) 0.84
Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents. J Med Chem (2010) 0.84
Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study. Toxicol Sci (2008) 0.84
Transgenic zebrafish model to study translational control mediated by upstream open reading frame of human chop gene. Nucleic Acids Res (2011) 0.84
Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach. J Med Chem (2009) 0.84
Exclusive breastfeeding is associated with reduced cow's milk sensitization in early childhood. Pediatr Allergy Immunol (2014) 0.84
Central pressor effects of CART peptides in anesthetized rats. Neuropeptides (2004) 0.83
Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J Med Chem (2010) 0.83
Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3). Bioorg Med Chem (2011) 0.83
Effects of paclitaxel and doxorubicin in histocultures of hepatocelular carcinomas. J Biomed Sci (2007) 0.83
Minocycline, a microglial inhibitor, blocks spinal CCL2-induced heat hyperalgesia and augmentation of glutamatergic transmission in substantia gelatinosa neurons. J Neuroinflammation (2014) 0.83
Cloning and characterization of spermidine synthase and its implication in polyamine biosynthesis in Helicobacter pylori strain 26695. Protein Expr Purif (2005) 0.83
Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice. Int J Pharm (2008) 0.83
Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075. Anticancer Res (2010) 0.82
Oral delivery of peptide drugs using nanoparticles self-assembled by poly(gamma-glutamic acid) and a chitosan derivative functionalized by trimethylation. Bioconjug Chem (2008) 0.82
Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91. Pharmacol Res (2009) 0.82
Synthesis of heparin oligosaccharides and their interaction with eosinophil-derived neurotoxin. Org Biomol Chem (2011) 0.82
Intravenous paclitaxel against metastasis of human gastric tumors of diffuse type. Cancer Chemother Pharmacol (2010) 0.82
The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes. Food Chem Toxicol (2007) 0.81
Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes. J Med Chem (2010) 0.81
Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. J Med Chem (2014) 0.81
Activation of synaptic group II metabotropic glutamate receptors induces long-term depression at GABAergic synapses in CNS neurons. J Neurosci (2013) 0.81
A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors. Anticancer Res (2012) 0.81
Paclitaxel-loaded poly(gamma-glutamic acid)-poly(lactide) nanoparticles as a targeted drug delivery system against cultured HepG2 cells. Bioconjug Chem (2006) 0.81
Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents. J Med Chem (2011) 0.80
BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells. PLoS One (2011) 0.80