Published in Photochem Photobiol on September 01, 1990
High density synthetic oligonucleotide arrays. Nat Genet (1999) 29.99
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science (2001) 15.54
Accessing genetic information with high-density DNA arrays. Science (1996) 13.89
Using oligonucleotide probe arrays to access genetic diversity. Biotechniques (1995) 12.18
Light-generated oligonucleotide arrays for rapid DNA sequence analysis. Proc Natl Acad Sci U S A (1994) 9.59
Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79
Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis. Nat Genet (1996) 4.19
Fluorescence energy transfer dye-labeled primers for DNA sequencing and analysis. Proc Natl Acad Sci U S A (1995) 3.45
Stable fluorescent complexes of double-stranded DNA with bis-intercalating asymmetric cyanine dyes: properties and applications. Nucleic Acids Res (1992) 3.28
The first step in vision: femtosecond isomerization of rhodopsin. Science (1991) 3.06
Vibrationally coherent photochemistry in the femtosecond primary event of vision. Science (1994) 2.96
Evolutionarily conserved sequences on human chromosome 21. Genome Res (2001) 2.95
Chromophore structure in bacteriorhodopsin's N intermediate: implications for the proton-pumping mechanism. Biochemistry (1988) 2.69
Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem (1994) 2.56
Single-molecule fluorescence detection: autocorrelation criterion and experimental realization with phycoerythrin. Proc Natl Acad Sci U S A (1989) 2.55
Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays. Genome Res (1998) 2.17
The role of back-reactions and proton uptake during the N----O transition in bacteriorhodopsin's photocycle: a kinetic resonance Raman study. Biochemistry (1990) 2.12
Solid-state 13C NMR detection of a perturbed 6-s-trans chromophore in bacteriorhodopsin. Biochemistry (1985) 2.09
Functional integration of PCR amplification and capillary electrophoresis in a microfabricated DNA analysis device. Anal Chem (1996) 2.09
Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions. J Med Chem (1994) 2.04
Ultra-high-speed DNA fragment separations using microfabricated capillary array electrophoresis chips. Proc Natl Acad Sci U S A (1994) 2.02
Evolutionary sequence comparisons using high-density oligonucleotide arrays. Nat Genet (1998) 1.90
Integrated portable genetic analysis microsystem for pathogen/infectious disease detection. Anal Chem (2004) 1.87
Discrimination of DNA hybridization using chemical force microscopy. Biophys J (1999) 1.86
Determination of retinal chromophore structure in bacteriorhodopsin with resonance Raman spectroscopy. J Membr Biol (1985) 1.83
How color visual pigments are tuned. Trends Biochem Sci (1999) 1.82
Assignment of fingerprint vibrations in the resonance Raman spectra of rhodopsin, isorhodopsin, and bathorhodopsin: implications for chromophore structure and environment. Biochemistry (1987) 1.81
Resonance Raman Structural Evidence that the Cis-to-Trans Isomerization in Rhodopsin Occurs in Femtoseconds. J Phys Chem B (2001) 1.80
Ultra-high-speed DNA sequencing using capillary electrophoresis chips. Anal Chem (1995) 1.68
Heterodimeric DNA-binding dyes designed for energy transfer: stability and applications of the DNA complexes. Nucleic Acids Res (1993) 1.62
Wavelength dependent cis-trans isomerization in vision. Biochemistry (2001) 1.57
A stable double-stranded DNA-ethidium homodimer complex: application to picogram fluorescence detection of DNA in agarose gels. Proc Natl Acad Sci U S A (1990) 1.54
The first step in vision occurs in femtoseconds: complete blue and red spectral studies. Proc Natl Acad Sci U S A (1993) 1.50
Capillary electrophoresis chips with integrated electrochemical detection. Anal Chem (1998) 1.50
Single-molecule DNA amplification and analysis in an integrated microfluidic device. Anal Chem (2001) 1.48
DNA sequencing using capillary array electrophoresis. Anal Chem (1992) 1.46
Radial capillary array electrophoresis microplate and scanner for high-performance nucleic acid analysis. Anal Chem (1999) 1.38
High-throughput genetic analysis using microfabricated 96-sample capillary array electrophoresis microplates. Proc Natl Acad Sci U S A (1998) 1.37
Excited-state structure and isomerization dynamics of the retinal chromophore in rhodopsin from resonance Raman intensities. Biophys J (1988) 1.35
Design and synthesis of fluorescence energy transfer dye-labeled primers and their application for DNA sequencing and analysis. Anal Biochem (1995) 1.33
Resonance Raman spectra of the acidified and deionized forms of bacteriorhodopsin. Biophys J (1985) 1.32
Mechanisms of spectral tuning in blue cone visual pigments. Visible and raman spectroscopy of blue-shifted rhodopsin mutants. J Biol Chem (1998) 1.32
Vibrational analysis of the all-trans retinal protonated Schiff base. Biophys J (1985) 1.28
High-sensitivity DNA detection with a laser-excited confocal fluorescence gel scanner. Biotechniques (1991) 1.26
High-sensitivity two-color detection of double-stranded DNA with a confocal fluorescence gel scanner using ethidium homodimer and thiazole orange. Nucleic Acids Res (1991) 1.25
Fully integrated PCR-capillary electrophoresis microsystem for DNA analysis. Lab Chip (2001) 1.24
Resonance raman analysis of chromophore structure in the lumi-R photoproduct of phytochrome. Biochemistry (1996) 1.24
Resonance Raman analysis of the Pr and Pfr forms of phytochrome. Biochemistry (1990) 1.23
An unnatural biopolymer. Science (1993) 1.23
Cassette labeling for facile construction of energy transfer fluorescent primers. Nucleic Acids Res (1996) 1.21
High-speed DNA genotyping using microfabricated capillary array electrophoresis chips. Anal Chem (1997) 1.21
Bacteriorhodopsin's M412 intermediate contains a 13-cis, 14-s-trans, 15-anti-retinal Schiff base chromophore. Biochemistry (1989) 1.17
Picogram detection of stable dye-DNA intercalation complexes with two-color laser-excited confocal fluorescence gel scanner. Methods Enzymol (1993) 1.15
Fluorometric assay using dimeric dyes for double- and single-stranded DNA and RNA with picogram sensitivity. Anal Biochem (1993) 1.13
Probing the photoreaction mechanism of phytochrome through analysis of resonance Raman vibrational spectra of recombinant analogues. Biochemistry (2000) 1.13
Resonance Raman evidence that the thioester-linked 4-hydroxycinnamyl chromophore of photoactive yellow protein is deprotonated. Biochemistry (1995) 1.12
DNA sequencing using a four-color confocal fluorescence capillary array scanner. Electrophoresis (1996) 1.11
Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates. Nucleic Acids Res (1998) 1.11
Bacteriorhodopsin's L550 intermediate contains a C14-C15 s-trans-retinal chromophore. Proc Natl Acad Sci U S A (1988) 1.10
Resonance Raman microprobe spectroscopy of rhodopsin mutants: effect of substitutions in the third transmembrane helix. Biochemistry (1992) 1.09
Why are blue visual pigments blue? A resonance Raman microprobe study. Proc Natl Acad Sci U S A (1989) 1.09
Complete assignment of the hydrogen out-of-plane wagging vibrations of bathorhodopsin: chromophore structure and energy storage in the primary photoproduct of vision. Biochemistry (1989) 1.08
Orientation of the protonated retinal Schiff base group in bacteriorhodopsin from absorption linear dichroism. Biophys J (1989) 1.07
Retinal analog study of the role of steric interactions in the excited state isomerization dynamics of rhodopsin. Biochemistry (1996) 1.07
Low-temperature solid-state 13C NMR studies of the retinal chromophore in rhodopsin. Biochemistry (1987) 1.05
Two color hybridization analysis using high density oligonucleotide arrays and energy transfer dyes. Nucleic Acids Res (1998) 1.05
Optimization of high-speed DNA sequencing on microfabricated capillary electrophoresis channels. Anal Chem (1999) 1.05
Structure of the retinal chromophore in sensory rhodopsin I from resonance Raman spectroscopy. J Biol Chem (1989) 1.05
High-sensitivity capillary electrophoresis of double-stranded DNA fragments using monomeric and dimeric fluorescent intercalating dyes. Anal Chem (1994) 1.03
Single molecule fluorescence burst detection of DNA fragments separated by capillary electrophoresis. Anal Chem (1995) 1.03
Cyanine dyes with high absorption cross section as donor chromophores in energy transfer primers. Anal Biochem (1996) 1.03
Structure of the retinal chromophore in the hR578 form of halorhodopsin. J Biol Chem (1984) 1.02
Chromophore structure in lumirhodopsin and metarhodopsin I by time-resolved resonance Raman microchip spectroscopy. Biochemistry (2001) 1.02
Rapid sizing of short tandem repeat alleles using capillary array electrophoresis and energy-transfer fluorescent primers. Anal Chem (1995) 1.01
Are C14-C15 single bond isomerizations of the retinal chromophore involved in the proton-pumping mechanism of bacteriorhodopsin? Proc Natl Acad Sci U S A (1986) 1.00
Turn geometry for minimizing band broadening in microfabricated capillary electrophoresis channels. Anal Chem (2000) 1.00
Imaging biomolecule arrays by atomic force microscopy. Biophys J (1995) 1.00
Combinatorial chemistry--applications of light-directed chemical synthesis. Trends Biotechnol (1994) 1.00
Resonance Raman examination of the wavelength regulation mechanism in human visual pigments. Biochemistry (1997) 0.98
High-resolution capillary array electrophoretic sizing of multiplexed short tandem repeat loci using energy-transfer fluorescent primers. Electrophoresis (1996) 0.98
Analysis of femtosecond dynamic absorption spectra of nonstationary states. Annu Rev Phys Chem (1992) 0.97
Solid-state NMR studies of the mechanism of the opsin shift in the visual pigment rhodopsin. Biochemistry (1990) 0.97
Rapid-flow resonance Raman spectroscopy of bacterial photosynthetic reaction centers. Proc Natl Acad Sci U S A (1991) 0.96
Microfluidic genetic analysis with an integrated a-Si:H detector. Biomed Microdevices (2005) 0.96
Microfabricated capillary electrophoresis amino acid chirality analyzer for extraterrestrial exploration. Anal Chem (1999) 0.95
Resonance Raman study of halorhodopsin photocycle kinetics, chromophore structure, and chloride-pumping mechanism. Biochemistry (1992) 0.94
Single-molecule detection of DNA separations in microfabricated capillary electrophoresis chips employing focused molecular streams. Anal Chem (1999) 0.94
Structure of the retinal chromophore in the hRL intermediate of halorhodopsin from resonance raman spectroscopy. Biochemistry (1987) 0.94
High-speed parallel separation of DNA restriction fragments using capillary array electrophoresis. Anal Biochem (1993) 0.93
Halorhodopsin and sensory rhodopsin contain a C6-C7 s-trans retinal chromophore. Biophys J (1989) 0.93
Time-resolved ultraviolet resonance Raman studies of protein structure: application to bacteriorhodopsin. Biochemistry (1992) 0.93
Effects of modified chromophores on the spectral sensitivity of salamander, squirrel and macaque cones. J Physiol (1990) 0.93
Temperature dependence of the Qy resonance Raman spectra of bacteriochlorophylls, the primary electron donor, and bacteriopheophytins in the bacterial photosynthetic reaction center. Biochemistry (1997) 0.93
Ultraviolet resonance Raman examination of the light-induced protein structural changes in rhodopsin activation. Biochemistry (1997) 0.92
Raman spectroscopic study of left-handed Z-RNA. Biochemistry (1987) 0.92
High-performance genetic analysis using microfabricated capillary array electrophoresis microplates. Electrophoresis (2001) 0.91
Energy-transfer fluorescent reagents for DNA analyses. Curr Opin Biotechnol (1997) 0.91
Capillary array electrophoresis DNA sequencing. Anal Chem (1999) 0.90