Published in J Gerontol A Biol Sci Med Sci on July 25, 2012
Cells of renin lineage take on a podocyte phenotype in aging nephropathy. Am J Physiol Renal Physiol (2014) 2.25
Structural and Functional Changes With the Aging Kidney. Adv Chronic Kidney Dis (2016) 0.90
Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age. Am J Physiol Renal Physiol (2015) 0.83
The Expression Changes of Inflammasomes in the Aging Rat Kidneys. J Gerontol A Biol Sci Med Sci (2015) 0.80
The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney. PLoS Genet (2015) 0.80
Specific renal parenchymal-derived urinary extracellular vesicles identify age-associated structural changes in living donor kidneys. J Extracell Vesicles (2016) 0.79
The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age. Kidney Int (2017) 0.77
A roadmap for the genetic analysis of renal aging. Aging Cell (2015) 0.76
Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr) (2016) 0.76
Dietary fat composition influences glomerular and proximal convoluted tubule cell structure and autophagic processes in kidneys from calorie-restricted mice. Aging Cell (2016) 0.75
High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy. PLoS One (2017) 0.75
A C. elegans mutant that lives twice as long as wild type. Nature (1993) 20.42
Positionally cloned gene for a novel glomerular protein--nephrin--is mutated in congenital nephrotic syndrome. Mol Cell (1998) 9.85
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet (2000) 7.98
Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet (2000) 7.39
Longitudinal studies on the rate of decline in renal function with age. J Am Geriatr Soc (1985) 7.02
Cell biology of the glomerular podocyte. Physiol Rev (2003) 6.85
Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol (2005) 4.79
Progression of glomerular diseases: is the podocyte the culprit? Kidney Int (1998) 3.47
The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol (1999) 3.46
Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice. J Clin Invest (2010) 3.44
Apoptosis in podocytes induced by TGF-beta and Smad7. J Clin Invest (2001) 3.40
Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev (2007) 3.16
Urinary excretion of viable podocytes in health and renal disease. Am J Physiol Renal Physiol (2003) 2.55
Podocyte hypertrophy, "adaptation," and "decompensation" associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction. J Am Soc Nephrol (2005) 2.49
Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int (2001) 2.33
Nutritional influences on aging of Fischer 344 rats: I. Physical, metabolic, and longevity characteristics. J Gerontol (1985) 2.20
Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol (1975) 2.20
Nephrin--a unique structural and signaling protein of the kidney filter. Trends Mol Med (2007) 1.74
Cell renewal of glomerular cell types in normal rats. An autoradiographic analysis. Kidney Int (1983) 1.71
The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli. Kidney Int (2012) 1.68
Urinary sediment podocalyxin in children with glomerular diseases. Nephron Clin Pract (2003) 1.64
Inflammation and cardiovascular events in individuals with and without chronic kidney disease. Kidney Int (2008) 1.64
The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family. J Am Soc Nephrol (2004) 1.64
The role of podocytes in glomerular pathobiology. Clin Exp Nephrol (2003) 1.57
GLEPP1, a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and characterization in rabbit. J Biol Chem (1994) 1.56
Oral glycotoxins determine the effects of calorie restriction on oxidant stress, age-related diseases, and lifespan. Am J Pathol (2008) 1.56
Podocyte is the major culprit accounting for the progression of chronic renal disease. Microsc Res Tech (2002) 1.55
Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J (1996) 1.54
Pathological changes during aging in barrier-reared Fischer 344 male rats. J Gerontol (1977) 1.52
Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci (2002) 1.52
NFkappaB promotes inflammation, coagulation, and fibrosis in the aging glomerulus. J Am Soc Nephrol (2010) 1.49
Prevalence of WT1 mutations in a large cohort of patients with steroid-resistant and steroid-sensitive nephrotic syndrome. Kidney Int (2004) 1.46
Urinary podocytes in primary focal segmental glomerulosclerosis. Nephron (2001) 1.41
Biomarkers of frailty in older persons. J Endocrinol Invest (2002) 1.25
Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomised-desoxycorticosterone hypertensive rat. Virchows Arch (1994) 1.24
Anatomic and physiologic age changes in the kidney. Exp Gerontol (1986) 1.19
Reproduction and longevity: secrets revealed by C. elegans. Trends Cell Biol (2006) 1.19
Transcriptional regulation of podocyte specification and differentiation. Microsc Res Tech (2002) 1.08
Drosophila aging 2006/2007. Exp Gerontol (2007) 1.05
Changes with age in the human kidney. Exp Gerontol (1982) 1.05
Iron and oxygen radicals in brain. Ann Neurol (1992) 1.05
Podocyte proliferation and differentiation in glomerular disease: role of cell-cycle regulatory proteins. Nephrol Dial Transplant (2003) 1.03
Classification of chronic kidney disease in the elderly: pitfalls and errors. Nephron Clin Pract (2011) 1.01
Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain. Lab Invest (1986) 1.00
Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS. A dedifferentiation hypothesis for the nephrotic syndrome. Exp Nephrol (1998) 0.95
Elevated plasma ceruloplasmin in insulin-dependent diabetes mellitus: evidence for increased oxidative stress as a variable complication. Metabolism (1995) 0.94
Food restriction retards body growth and prevents end-stage renal pathology in remnant kidneys of rats regardless of protein intake. Lab Invest (1989) 0.91
Antioxidant ceruloplasmin is expressed by glomerular parietal epithelial cells and secreted into urine in association with glomerular aging and high-calorie diet. J Am Soc Nephrol (2006) 0.90
Ceruloplasmin: an acute phase reactant that scavenges oxygen-derived free radicals. Ann N Y Acad Sci (1982) 0.89
Activation of the immune response is a key feature of aging in mice. Biogerontology (2009) 0.89
The aging kidney: structure, function, mechanisms, and therapeutic implications. J Am Geriatr Soc (1987) 0.86
A new single nephron model of focal and segmental glomerulosclerosis in the Munich-Wistar rat. Kidney Int (1994) 0.85
Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol Pathol (2000) 0.85
Role of amount and nature of carbohydrates in the course of experimental renal failure. Kidney Int (1986) 0.82
Localization of PDGF alpha-receptor in the developing and mature human kidney. Kidney Int (1997) 0.81
New findings in transgenic, gene knockout and mutant mice. Exp Gerontol (2006) 0.80
Progeria kidney has abnormal mesangial collagen distribution. Pediatr Nephrol (2000) 0.77