Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

PubWeight™: 1.47‹?› | Rank: Top 5%

🔗 View Article (PMC 3583181)

Published in BMC Biol on July 31, 2012

Authors

Bhupinder Virk1, Gonçalo Correia, David P Dixon, Inna Feyst, Jie Jia, Nikolin Oberleitner, Zoe Briggs, Emily Hodge, Robert Edwards, John Ward, David Gems, David Weinkove

Author Affiliations

1: School of Biological and Biomedical Sciences, Durham University, UK.

Articles citing this

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell (2013) 3.10

Interspecies systems biology uncovers metabolites affecting C. elegans gene expression and life history traits. Cell (2014) 1.73

Microbial Genetic Composition Tunes Host Longevity. Cell (2017) 1.39

You are what you host: microbiome modulation of the aging process. Cell (2014) 1.18

Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans. EMBO Mol Med (2013) 1.00

Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli. BMC Microbiol (2012) 0.94

Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Aging (Albany NY) (2014) 0.89

Worms, bacteria, and micronutrients: an elegant model of our diet. Trends Genet (2014) 0.86

Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy. Trends Endocrinol Metab (2014) 0.85

Effects of nutritional components on aging. Aging Cell (2014) 0.84

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins. Mech Ageing Dev (2016) 0.81

Folate status of gut microbiome affects Caenorhabditis elegans lifespan. BMC Biol (2012) 0.80

Microbiomes. Microb Ecol (2013) 0.80

Food, pathogen, signal: The multifaceted nature of a bacterial diet. Worm (2013) 0.79

Folate Acts in E. coli to Accelerate C. elegans Aging Independently of Bacterial Biosynthesis. Cell Rep (2016) 0.78

Changes in intestinal microflora of Caenorhabditis elegans following Bacillus nematocida B16 infection. Sci Rep (2016) 0.77

The Natural Biotic Environment of Caenorhabditis elegans. Genetics (2017) 0.77

Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans. Age (Dordr) (2015) 0.76

Cell biology: The stressful influence of microbes. Nature (2014) 0.75

Dietary and microbiome factors determine longevity in Caenorhabditis elegans. Aging (Albany NY) (2016) 0.75

Gene-diet interactions and aging in C. elegans. Exp Gerontol (2016) 0.75

Membrane ion transport in non-excitable tissues. WormBook (2014) 0.75

A genome-wide screen of bacterial mutants that enhance dauer formation in C. elegans. Sci Rep (2016) 0.75

From aging worms to the influence of the microbiota: an interview with David Weinkove. BMC Biol (2013) 0.75

Association with pathogenic bacteria affects life-history traits and population growth in Caenorhabditis elegans. Ecol Evol (2015) 0.75

Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation. Dev Cell (2016) 0.75

Phenotypes, antioxidant responses, and gene expression changes accompanying a sugar-only diet in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). BMC Evol Biol (2017) 0.75

Combination of Metabolomic and Proteomic Analysis Revealed Different Features among Lactobacillus delbrueckii Subspecies bulgaricus and lactis Strains While In Vivo Testing in the Model Organism Caenorhabditis elegans Highlighted Probiotic Properties. Front Microbiol (2017) 0.75

C. elegans and its bacterial diet as a model for systems-level understanding of host-microbiota interactions. Curr Opin Biotechnol (2017) 0.75

Articles cited by this

The genetics of Caenorhabditis elegans. Genetics (1974) 102.14

A core gut microbiome in obese and lean twins. Nature (2008) 52.30

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol (2006) 40.15

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi. Nature (2003) 26.58

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J (1991) 23.69

Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector. Gene (1986) 13.92

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature (2011) 13.53

The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature (1997) 13.09

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene (2001) 11.09

Distribution and function of genes concerned with aromatic biosynthesis in Escherichia coli. J Bacteriol (1966) 7.80

Gut microbiota in health and disease. Physiol Rev (2010) 7.76

EcoCyc: a comprehensive view of Escherichia coli biology. Nucleic Acids Res (2008) 7.05

MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucleic Acids Res (2009) 5.70

Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi. Curr Biol (2002) 5.66

Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics (2002) 5.52

Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol (2006) 5.20

Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans. Aging Cell (2009) 4.01

Characterization of a germ-line proliferation mutation in C. elegans. Development (1992) 3.70

Highly sensitive feature detection for high resolution LC/MS. BMC Bioinformatics (2008) 3.70

Experimental and computational assessment of conditionally essential genes in Escherichia coli. J Bacteriol (2006) 2.93

Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics (2000) 2.41

Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q. Science (2002) 2.20

Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol (2007) 2.19

Update on the Keio collection of Escherichia coli single-gene deletion mutants. Mol Syst Biol (2009) 2.11

Axenic growth up-regulates mass-specific metabolic rate, stress resistance, and extends life span in Caenorhabditis elegans. Exp Gerontol (2002) 1.94

Involvement of mitochondrial ferredoxin and para-aminobenzoic acid in yeast coenzyme Q biosynthesis. Chem Biol (2010) 1.93

Mutations affecting the cytochrome d-containing oxidase complex of Escherichia coli K12: identification and mapping of a fourth locus, cydD. J Gen Microbiol (1989) 1.80

Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech Ageing Dev (2005) 1.75

Heteroduplex analysis of P-plasmid evolution: the role of insertion and deletion of transposable elements. Mol Gen Genet (1983) 1.68

Chemically defined medium and Caenorhabditis elegans. BMC Biotechnol (2003) 1.37

The microbiome and obesity: is obesity linked to our gut flora? Curr Gastroenterol Rep (2009) 1.24

Isotope ratio-based profiling of microbial folates. J Am Soc Mass Spectrom (2007) 1.23

A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol (2010) 1.19

A molecular analysis of transductional marker rescue involving P-group plasmids in Pseudomonas aeruginosa. Mol Gen Genet (1976) 1.18

para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae. J Biol Chem (2010) 1.18

Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q. Aging Cell (2008) 1.06

Comprehensive metabolic profiling of mono- and polyglutamated folates and their precursors in plant and animal tissue using liquid chromatography/negative ion electrospray ionisation tandem mass spectrometry. Rapid Commun Mass Spectrom (2005) 1.04

Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms. Biogerontology (2011) 1.02

[Observations on influenceability of age phenomena in experimental animals by peroral administration of combinations of 2-(p-aminobenzolsulfonamide)-pyrimidin]. Munch Med Wochenschr (1958) 0.99

Occurrence of Crithidia factors and folic acid in various bacteria. J Bacteriol (1970) 0.96

Dietary restriction of Caenorhabditis elegans by axenic culture reflects nutritional requirement for constituents provided by metabolically active microbes. J Gerontol A Biol Sci Med Sci (2008) 0.94

Escherichia coli abg genes enable uptake and cleavage of the folate catabolite p-aminobenzoyl-glutamate. J Bacteriol (2007) 0.93

The cloning and analysis of the aroD gene of E. coli K-12. Gene (1981) 0.90

Folate derived from cecal bacterial fermentation does not increase liver folate stores in 28-d folate-depleted male Sprague-Dawley rats. J Nutr (2003) 0.83

Articles by these authors

The minimum information about a genome sequence (MIGS) specification. Nat Biotechnol (2008) 31.04

The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes. Nucleic Acids Res (2005) 29.61

Quality control and preprocessing of metagenomic datasets. Bioinformatics (2011) 13.84

Community genomics among stratified microbial assemblages in the ocean's interior. Science (2006) 13.31

Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4. Science (2011) 4.96

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet (2013) 4.35

TagCleaner: Identification and removal of tag sequences from genomic and metagenomic datasets. BMC Bioinformatics (2010) 4.32

Metagenomic analysis of the microbial community associated with the coral Porites astreoides. Environ Microbiol (2007) 4.21

Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol (2003) 4.05

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J (2007) 3.83

Fast identification and removal of sequence contamination from genomic and metagenomic datasets. PLoS One (2011) 3.74

Dietary restriction in long-lived dwarf flies. Science (2002) 3.71

Sex and death: what is the connection? Cell (2005) 3.70

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. J Biol Chem (2004) 3.52

Mechanisms of ageing: public or private? Nat Rev Genet (2002) 3.49

GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Nat Genet (2013) 3.42

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell (2013) 3.10

Viral and microbial community dynamics in four aquatic environments. ISME J (2010) 2.95

Experimental and computational assessment of conditionally essential genes in Escherichia coli. J Bacteriol (2006) 2.93

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev (2007) 2.75

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans. Genes Dev (2008) 2.71

Whole proteome analysis of post-translational modifications: applications of mass-spectrometry for proteogenomic annotation. Genome Res (2007) 2.67

A stress-responsive RNA switch regulates VEGFA expression. Nature (2008) 2.58

Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol (2007) 2.19

Essential genes on metabolic maps. Curr Opin Biotechnol (2006) 2.18

Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions. Cell Rep (2011) 2.17

Robot-assisted versus open radical prostatectomy: a comparison of one surgeon's outcomes. Urology (2004) 2.12

Plant glutathione transferases. Genome Biol (2002) 2.07

The GAIT system: a gatekeeper of inflammatory gene expression. Trends Biochem Sci (2009) 1.88

Probing the diversity of the Arabidopsis glutathione S-transferase gene family. Plant Mol Biol (2002) 1.87

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet (2007) 1.82

Phlegmonous gastritis: case report and review. Gastrointest Endosc (2005) 1.82

Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily. J Exp Bot (2009) 1.80

Metagenomic and stable isotopic analyses of modern freshwater microbialites in Cuatro Ciénegas, Mexico. Environ Microbiol (2008) 1.77

The mystery of C. elegans aging: an emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome? Bioessays (2012) 1.75

Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways. Mech Ageing Dev (2005) 1.75

Laminar and columnar development of barrel cortex relies on thalamocortical neurotransmission. Neuron (2013) 1.74

Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nat Commun (2013) 1.73

Abrolhos bank reef health evaluated by means of water quality, microbial diversity, benthic cover, and fish biomass data. PLoS One (2012) 1.72

Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice. Dev Biol (2009) 1.68

Insights into antibiotic resistance through metagenomic approaches. Future Microbiol (2012) 1.65

Functional divergence in the glutathione transferase superfamily in plants. Identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana. J Biol Chem (2002) 1.60

Characterization and engineering of the bifunctional N- and O-glucosyltransferase involved in xenobiotic metabolism in plants. Proc Natl Acad Sci U S A (2007) 1.55

A prospective study evaluating the clinical relevance of a chemoresponse assay for treatment of patients with persistent or recurrent ovarian cancer. Gynecol Oncol (2013) 1.54

Efficacy of vaccination with recombinant vaccinia and fowlpox vectors expressing NY-ESO-1 antigen in ovarian cancer and melanoma patients. Proc Natl Acad Sci U S A (2012) 1.51

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO. Mol Syst Biol (2010) 1.48

Missed opportunities for appropriate anticoagulation among emergency department patients with uncomplicated atrial fibrillation or flutter. Ann Emerg Med (2013) 1.48

Roles for glutathione transferases in plant secondary metabolism. Phytochemistry (2010) 1.48

A multi-center phase II evaluation of the small molecule survivin suppressor YM155 in patients with unresectable stage III or IV melanoma. Invest New Drugs (2009) 1.47

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol Genomics (2006) 1.47

Long-term efficacy and safety of canagliflozin monotherapy in patients with type 2 diabetes inadequately controlled with diet and exercise: findings from the 52-week CANTATA-M study. Curr Med Res Opin (2013) 1.46

Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma. Clin Immunol (2011) 1.45

Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: a phase II study of the Gynecologic Oncology Group. Gynecol Oncol (2010) 1.43

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes. Nat Struct Mol Biol (2005) 1.42

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. Mech Ageing Dev (2006) 1.41

Impact of obesity on clinical outcomes in robotic prostatectomy. Urology (2005) 1.39

Increasing attendance at colorectal cancer screening: testing the efficacy of a mailed, psychoeducational intervention in a community sample of older adults. Health Psychol (2003) 1.39

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol (2004) 1.39

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor. Genetics (2008) 1.38

Stress-induced protein S-glutathionylation in Arabidopsis. Plant Physiol (2005) 1.37

Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31. Nat Commun (2013) 1.36

Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J Immunol (2012) 1.35

The C-glycosylation of flavonoids in cereals. J Biol Chem (2009) 1.34

Benchmarks for ageing studies. Nature (2007) 1.34

Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans. Free Radic Biol Med (2004) 1.32

Beyond the evolutionary theory of ageing, from functional genomics to evo-gero. Trends Ecol Evol (2006) 1.27

Two-site phosphorylation of EPRS coordinates multimodal regulation of noncanonical translational control activity. Mol Cell (2009) 1.27

Identification and removal of ribosomal RNA sequences from metatranscriptomes. Bioinformatics (2011) 1.25

Plant glutathione transferases. Methods Enzymol (2005) 1.24

Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans. Exp Gerontol (2003) 1.23

Multiple roles for plant glutathione transferases in xenobiotic detoxification. Drug Metab Rev (2011) 1.23

Biomarker-based ovarian carcinoma typing: a histologic investigation in the ovarian tumor tissue analysis consortium. Cancer Epidemiol Biomarkers Prev (2013) 1.22

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage. Free Radic Biol Med (2011) 1.21

Clinical model for distinguishing nonalcoholic steatohepatitis from simple steatosis in patients with nonalcoholic fatty liver disease. Liver Int (2006) 1.21

Surrogate endpoints for cancer screening trials: general principles and an illustration using the UK Flexible Sigmoidoscopy Screening Trial. J Med Screen (2007) 1.21

Long-term starvation and ageing induce AGE-1/PI 3-kinase-dependent translocation of DAF-16/FOXO to the cytoplasm. BMC Biol (2006) 1.19

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans. PLoS Biol (2013) 1.18

Interactions between co-expressed Arabidopsis sucrose transporters in the split-ubiquitin system. BMC Biochem (2003) 1.17

Curcumin-induced histone hypoacetylation: the role of reactive oxygen species. Biochem Pharmacol (2005) 1.16

Glutathione transferases. Arabidopsis Book (2010) 1.16

The G-protein gamma subunit gpc-1 of the nematode C.elegans is involved in taste adaptation. EMBO J (2002) 1.16

O-Glucosyltransferase activities toward phenolic natural products and xenobiotics in wheat and herbicide-resistant and herbicide-susceptible black-grass (Alopecurus myosuroides). Phytochemistry (2002) 1.15

Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds. Proc Natl Acad Sci U S A (2013) 1.14

A casein kinase 1 and PAR proteins regulate asymmetry of a PIP(2) synthesis enzyme for asymmetric spindle positioning. Dev Cell (2008) 1.13

Transcriptional profiling of Mycoplasma hyopneumoniae during heat shock using microarrays. Infect Immun (2006) 1.12

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation. Aging Cell (2011) 1.12

No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free Radic Biol Med (2003) 1.12

Stimulus-dependent phosphorylation of profilin-1 in angiogenesis. Nat Cell Biol (2012) 1.12

Differential roles of miR-199a-5p in radiation-induced autophagy in breast cancer cells. FEBS Lett (2013) 1.10

Clinical insights from metagenomic analysis of sputum samples from patients with cystic fibrosis. J Clin Microbiol (2013) 1.10

Evolution of male longevity bias in nematodes. Aging Cell (2003) 1.10

Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity. J Biol Chem (2003) 1.10