DNA methylation, histone modifications, and signal transduction pathways: a close relationship in malignant gliomas pathophysiology.

PubWeight™: 0.76‹?›

🔗 View Article (PMC 3407642)

Published in J Signal Transduct on July 17, 2012

Authors

Raúl Alelú-Paz1, Nadia Ashour, Ana González-Corpas, Santiago Ropero

Author Affiliations

1: Department of Biochemistry and Molecular Biology, School of Medicine, University of Alcalá, Carretera Madrid-Barcelona Km. 33.6, 28871 Madrid, Spain.

Articles cited by this

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res (2006) 17.42

Epigenetic reprogramming in mammalian development. Science (2001) 13.42

Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N Engl J Med (2000) 12.34

Principles and challenges of genomewide DNA methylation analysis. Nat Rev Genet (2010) 10.71

Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81

The epigenetic progenitor origin of human cancer. Nat Rev Genet (2006) 9.65

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29

Tissue distribution of 5-hydroxymethylcytosine and search for active demethylation intermediates. PLoS One (2010) 6.38

Cancer stem cells: mirage or reality? Nat Med (2009) 5.20

5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci (2011) 4.15

Timing of CNS cell generation: a programmed sequence of neuron and glial cell production from isolated murine cortical stem cells. Neuron (2000) 3.99

Homeotic genes and the homeobox. Annu Rev Genet (1986) 3.60

Epigenetic signatures of stem-cell identity. Nat Rev Genet (2007) 3.56

DNA methylation signatures within the human brain. Am J Hum Genet (2007) 3.50

Epigenetic gene silencing in cancer: the DNA hypermethylome. Hum Mol Genet (2007) 3.12

Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies. Lancet Neurol (2009) 3.05

The RASSF1A tumor suppressor. J Cell Sci (2007) 2.89

Dosage compensation: the beginning and end of generalization. Nat Rev Genet (2007) 2.84

A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat Genet (2006) 2.33

Physical and functional interactions between the human DNMT3L protein and members of the de novo methyltransferase family. J Cell Biochem (2005) 2.27

A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics (2009) 2.21

Integrative genome analysis reveals an oncomir/oncogene cluster regulating glioblastoma survivorship. Proc Natl Acad Sci U S A (2010) 2.07

Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer (2010) 1.93

A tale of histone modifications. Genome Biol (2001) 1.85

Epigenetic mechanisms in glioblastoma multiforme. Semin Cancer Biol (2009) 1.69

Rassf family of tumor suppressor polypeptides. J Biol Chem (2008) 1.63

Promoter hypermethylation of the RB1 gene in glioblastomas. Lab Invest (2001) 1.54

Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma. Proc Natl Acad Sci U S A (2007) 1.54

Homeobox genes in normal and malignant cells. J Cell Physiol (2001) 1.54

Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res (2006) 1.50

Frequent epigenetic inactivation of RASSF1A and BLU genes located within the critical 3p21.3 region in gliomas. Oncogene (2004) 1.48

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res (2004) 1.44

HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer. Int J Cancer (2008) 1.44

Downregulation of RUNX3 and TES by hypermethylation in glioblastoma. Oncogene (2006) 1.41

The necessity of a human epigenome project. Carcinogenesis (2006) 1.40

Gene expression profile analysis of primary glioblastomas and non-neoplastic brain tissue: identification of potential target genes by oligonucleotide microarray and real-time quantitative PCR. J Neurooncol (2008) 1.40

Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res (1996) 1.38

EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res (2005) 1.37

Identification of interactive networks of gene expression associated with osteosarcoma oncogenesis by integrated molecular profiling. Hum Mol Genet (2009) 1.33

PTEN methylation and expression in glioblastomas. Acta Neuropathol (2003) 1.31

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression. Neuro Oncol (2011) 1.29

Frequent hypermethylation of the DNA repair gene MGMT in long-term survivors of glioblastoma multiforme. J Neurooncol (2006) 1.26

CpG island promoter hypermethylation of the pro-apoptotic gene caspase-8 is a common hallmark of relapsed glioblastoma multiforme. Carcinogenesis (2007) 1.25

Copy number alterations of the polycomb gene BMI1 in gliomas. Acta Neuropathol (2008) 1.09

Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin Cancer Res (2007) 1.09

Hypermethylation of the proapoptotic gene TMS1/ASC: prognostic importance in glioblastoma multiforme. J Neurooncol (2006) 1.08

RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs. Brain Pathol (2008) 1.05

PI3Kinase signaling in glioblastoma. J Neurooncol (2010) 1.01

The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma. Cell Mol Neurobiol (2011) 1.00

Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma. Clinics (Sao Paulo) (2011) 0.99

Identification of new members of the Gas2 and Ras families in the 22q12 chromosome region. Genomics (1996) 0.98

Transforming pathways unleashed by a HDAC2 mutation in human cancer. Oncogene (2008) 0.93

The p53/Mdm2/p14ARF cell cycle control pathway genes may be inactivated by genetic and epigenetic mechanisms in gliomas. Cancer Genet Cytogenet (2006) 0.93

Pharmacology of cyclophosphamide and metabolites. Cancer Treat Rep (1981) 0.92

Epigenetic changes in gliomas. Cancer Biol Ther (2008) 0.91

Quantitative methylation analysis of HOXA3, 7, 9, and 10 genes in glioma: association with tumor WHO grade and clinical outcome. J Cancer Res Clin Oncol (2011) 0.88

MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA. Childs Nerv Syst (2011) 0.88

Increased repair of O6-alkylguanine DNA adducts in glioma-derived human cells resistant to the cytotoxic and cytogenetic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea. Carcinogenesis (1986) 0.83

Tumour and serum MGMT promoter methylation and protein expression in glioblastoma patients. Clin Transl Oncol (2011) 0.83

Lack of death receptor 4 (DR4) expression through gene promoter methylation in gastric carcinoma. Langenbecks Arch Surg (2009) 0.82

DNA hypermethylation and histone modifications downregulate the candidate tumor suppressor gene RRP22 on 22q12 in human gliomas. Brain Pathol (2011) 0.79

Articles by these authors

Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A (2005) 15.46

Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet (2005) 8.45

A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14

Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res (2007) 5.62

Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88

A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell (2010) 2.78

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21

A microarray-based DNA methylation study of glioblastoma multiforme. Epigenetics (2009) 2.21

BRCA1 CpG island hypermethylation predicts sensitivity to poly(adenosine diphosphate)-ribose polymerase inhibitors. J Clin Oncol (2010) 2.18

A DNA methylation fingerprint of 1628 human samples. Genome Res (2011) 2.16

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res (2009) 1.87

Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells. Proc Natl Acad Sci U S A (2004) 1.77

Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells. Cancer Res (2007) 1.71

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer. Proc Natl Acad Sci U S A (2006) 1.70

A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer Res (2004) 1.44

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells. Nucleic Acids Res (2007) 1.42

EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res (2005) 1.37

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci U S A (2009) 1.27

Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis (2006) 1.24

Epigenetic inactivation of the Groucho homologue gene TLE1 in hematologic malignancies. Cancer Res (2008) 1.23

The impact of MECP2 mutations in the expression patterns of Rett syndrome patients. Hum Genet (2004) 1.21

Combinatorial effects of splice variants modulate function of Aiolos. J Cell Sci (2007) 1.04

Hypermethylation of the thrombospondin-1 gene is associated with poor prognosis in penile squamous cell carcinoma. BJU Int (2008) 1.04

Epigenetic inactivation of the circadian clock gene BMAL1 in hematologic malignancies. Cancer Res (2009) 1.03

Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer. Am J Clin Pathol (2008) 1.00

Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis. Int J Oncol (2004) 0.99

Initially metastatic breast carcinoma has a distinct disease pattern but an equivalent outcome compared with recurrent metastatic breast carcinoma. Cancer (2004) 0.94

Inhibition of Fatty Acid Synthase (FASN) synergistically enhances the efficacy of 5-fluorouracil in breast carcinoma cells. Oncol Rep (2007) 0.94

Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. Breast Cancer Res Treat (2002) 0.92

HER2 (erbB-2)-targeted effects of the omega-3 polyunsaturated fatty acid, alpha-linolenic acid (ALA; 18:3n-3), in breast cancer cells: the "fat features" of the "Mediterranean diet" as an "anti-HER2 cocktail". Clin Transl Oncol (2006) 0.91

A DNA hypermethylation profile reveals new potential biomarkers for prostate cancer diagnosis and prognosis. Prostate (2014) 0.91

Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells. Cell Signal (2013) 0.90

EGF prevents the neuroendocrine differentiation of LNCaP cells induced by serum deprivation: the modulator role of PI3K/Akt. Neoplasia (2007) 0.84

Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. Oncol Rep (2004) 0.82

Histone H3 and H4 modification profiles in a Rett syndrome mouse model. Epigenetics (2006) 0.80

DNA methylation pattern of gene promoters of major neurotransmitter systems in older patients with schizophrenia with severe and mild cognitive impairment. Int J Geriatr Psychiatry (2014) 0.77

A DNA Hypermethylation Profile Independently Predicts Biochemical Recurrence Following Radical Prostatectomy. Urol Int (2016) 0.77

Growth and molecular interactions between tamoxifen and trastuzumab. Clin Cancer Res (2005) 0.75

DNA methylation alterations in grade II- and anaplastic pleomorphic xanthoastrocytoma. BMC Cancer (2014) 0.75

Retraction: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2016) 0.75