PubRank

A Shafferman

Author PubWeight™ 76.32‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Essential virulence determinants of different Yersinia species are carried on a common plasmid. Plasmid 1981 4.07
2 Search for correlates of protective immunity conferred by anthrax vaccine. Infect Immun 2001 2.67
3 Plasmid R6K DNA replication. III. Regulatory properties of the pi initiation protein. J Mol Biol 1982 2.12
4 Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax. Infect Immun 2000 1.93
5 Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. J Biol Chem 1993 1.72
6 Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level. Biochemistry 1999 1.55
7 Conditional expression of the vesicular stomatitis virus glycoprotein gene in Escherichia coli. Proc Natl Acad Sci U S A 1981 1.53
8 Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II. Acta Crystallogr D Biol Crystallogr 2000 1.47
9 Passively transferred antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. Vaccine 1993 1.32
10 Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening. Infect Immun 2002 1.26
11 Structural properties of the beta origin of replication of plasmid R6K. J Biol Chem 1983 1.22
12 Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase. Biochemistry 2000 1.21
13 N-glycosylation of human acetylcholinesterase: effects on activity, stability and biosynthesis. Biochem J 1993 1.20
14 Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core. J Biol Chem 1994 1.14
15 Genome-based bioinformatic selection of chromosomal Bacillus anthracis putative vaccine candidates coupled with proteomic identification of surface-associated antigens. Infect Immun 2003 1.11
16 The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem 1991 1.10
17 ColE1 DNA sequences interacting in cis, essential for mitomycin-C induced lethality. Mol Gen Genet 1979 1.08
18 Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers. Biochemistry 1999 1.05
19 Semliki Forest virus E2 envelope epitopes induce a nonneutralizing humoral response which protects mice against lethal challenge. J Virol 1989 1.04
20 Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center. FEBS Lett 1993 1.04
21 Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase. J Biol Chem 1995 1.03
22 Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase. J Biol Chem 2000 1.03
23 Modulation of circulatory residence of recombinant acetylcholinesterase through biochemical or genetic manipulation of sialylation levels. Biochem J 1998 1.00
24 Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite. Biochemistry 1995 1.00
25 The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors. J Biol Chem 1996 1.00
26 Use of a promoter trap system in Bacillus anthracis and Bacillus subtilis for the development of recombinant protective antigen-based vaccines. Infect Immun 2003 1.00
27 Interrelations between assembly and secretion of recombinant human acetylcholinesterase. J Biol Chem 1993 1.00
28 Involvement of oligomerization, N-glycosylation and sialylation in the clearance of cholinesterases from the circulation. Biochem J 1995 0.99
29 The "back door" hypothesis for product clearance in acetylcholinesterase challenged by site-directed mutagenesis. J Biol Chem 1994 0.99
30 Evaluation of anchorage-dependent cell propagation systems for production of human acetylcholinesterase by recombinant 293 cells. Cytotechnology 1993 0.95
31 Resolving pathways of interaction of covalent inhibitors with the active site of acetylcholinesterases: MALDI-TOF/MS analysis of various nerve agent phosphyl adducts. Chem Res Toxicol 2001 0.94
32 Cleavage maps of a tetracycline plasmid from Staphylococcus aureus. J Bacteriol 1978 0.94
33 Identification and characterization of the functional alpha origin of DNA replication of the R6K plasmid and its relatedness to the R6K beta and gamma origins. Mol Gen Genet 1987 0.94
34 Functional characteristics of the oxyanion hole in human acetylcholinesterase. J Biol Chem 1998 0.93
35 Oral spore vaccine based on live attenuated nontoxinogenic Bacillus anthracis expressing recombinant mutant protective antigen. Infect Immun 2005 0.93
36 Effect of human acetylcholinesterase subunit assembly on its circulatory residence. Biochem J 2001 0.90
37 The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors. Biochem J 1998 0.89
38 Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity. Biochem J 2001 0.89
39 A DNA segment within the colicin E1 structural gene on ColE1 affecting immunity to colicin. Mol Gen Genet 1978 0.88
40 Efficacious, nontoxigenic Bacillus anthracis spore vaccines based on strains expressing mutant variants of lethal toxin components. Vaccine 2005 0.87
41 Transcription signals in a region essential for replication of plasmid R6K. Plasmid 1985 0.87
42 Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? Biochemistry 2001 0.87
43 Role of tyrosine 337 in the binding of huperzine A to the active site of human acetylcholinesterase. Mol Pharmacol 1994 0.86
44 Reversal of signal-mediated cellular retention by subunit assembly of human acetylcholinesterase. J Biol Chem 1994 0.86
45 Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives. Mol Pharmacol 1996 0.86
46 A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase. Chem Biol Interact 1999 0.86
47 Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects. J Biol Chem 1987 0.86
48 Partitioning of electrostatic and conformational contributions in the redox reactions of modified cytochromes c. Biochim Biophys Acta 1979 0.86
49 Bovine acetylcholinesterase: cloning, expression and characterization. Biochem J 1998 0.85
50 Variation in the CD4+ and CD8+ populations in lymph nodes does not reflect that in the blood during SIVMNE/E11S infection of macaques. J Med Primatol 1992 0.85
51 Overexpressed monomeric human acetylcholinesterase induces subtle ultrastructural modifications in developing neuromuscular junctions of Xenopus laevis embryos. J Neurochem 1994 0.84
52 The study of 1-electron equivalent oxidation-reduction reactions by fast pulse generation of reagents. Cytochrome c/ferri-ferrocyanide system. J Biol Chem 1976 0.84
53 Identification of the P1 compatibility and plasmid maintenance locus by a mini P1/ac+-plasmid. Virology 1979 0.84
54 Alpha and beta replication origins of plasmid R6K show similar distortions of the DNA helix in vivo. Proc Natl Acad Sci U S A 1990 0.84
55 Structural modifications of the omega loop in human acetylcholinesterase. FEBS Lett 1996 0.83
56 Delineation of protective epitopes on the E2-envelope glycoprotein of Semliki Forest virus. Vaccine 1991 0.82
57 Intramolecular electron transfer and binding constants in iron hexacyanide-cytochrome c complexes as studied by pulse radiolysis. Biochim Biophys Acta 1979 0.82
58 Reduction of ferricytochrome c by hydrogen atoms: evidence for intramolecular transfer of reducing equivalent. Biochim Biophys Acta 1974 0.82
59 Novel adjuvant strategies for experimental malaria and AIDS vaccines. Ann N Y Acad Sci 1993 0.82
60 Bovine interferon alpha genes. Structure and expression. J Biol Chem 1985 0.81
61 Reaction of cytochrome c with one-electron redox reagents. I. Reduction of ferricytochrome c by the hydrated electron produced by pulse radiolysis. Biochim Biophys Acta 1973 0.80
62 Reaction of hydrated electrons with ferricytochrome C. Science 1973 0.80
63 Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry. FEBS Lett 1997 0.80
64 Theoretical and experimental investigations of electrostatic effects on acetylcholinesterase catalysis and inhibition. Chem Biol Interact 1999 0.80
65 Altered (copy-up) forms of initiator protein pi suppress the point mutations inactivating the gamma origin of plasmid R6K. J Bacteriol 1995 0.79
66 Molecular aspects of genetic instability of an artificial 68 bp perfect palindrome in Escherichia coli. Mol Gen Genet 1987 0.79
67 Three novel plasmid R6K proteins act in concert to distort DNA within the alpha and beta origins of DNA replication. Mol Microbiol 1996 0.79
68 Effects of alcohol/water mixtures on the structure and reactivity of cytochrome c. Biochim Biophys Acta 1978 0.79
69 Aging of somanyl-acetylcholinesterase adducts: facts and models. Biochem J 1997 0.79
70 Conformation-dependent participation of the protein in electron equivalent transfer to cytochrome c. Biochim Biophys Acta 1977 0.78
71 Study of biochemical redox processes by the technique of pulse radiolysis. Biochim Biophys Acta 1975 0.77
72 Genetic and physical characterization of P1dlw prophage and its derivatives. Virology 1978 0.76
73 Divergent envelope E2 alphavirus sequences spanning amino acids 297 to 352 induce in mice virus-specific protective immunity and antibodies with complement-mediated cytolytic activity. J Virol 1992 0.76
74 Cloning of a bovine interferon-alpha gene subfamily and comparisons between genetically engineered and leukocyte bovine interferons. Dev Biol Stand 1985 0.75
75 Cloning, expression and biological activity of a new variant of human interferon alpha identified in virus induced lymphoblastoid cells. Dev Biol Stand 1985 0.75
76 DNA repair in the in vivo site specific excision of palindromic sequences. Prog Clin Biol Res 1985 0.75
77 Production of monoclonal antibodies toward bovine interferons-alpha suitable for immunopurification. J Interferon Res 1989 0.75
78 Mutations not altering the symmetrical sequences in the trp operator yield a constitutive phenotype. Mol Gen Genet 1984 0.75
79 Reactions of phenylalanine derivatives, methionine derivatives, and their mixtures in aqueous solution with pulse-radiolytically generated H atoms. Radiat Res 1974 0.75
80 Segregation patterns of an oversized P1 plasmid. Contrib Microbiol Immunol 1979 0.75
81 Induction and characterization of bovine leukocyte interferon. Methods Enzymol 1986 0.75
82 Genetic engineering of human interferons from lymphoblastoid cells: III. Purification, physicochemical and biological properties of bacterial IFN-alpha J1. Adv Biotechnol Processes 1985 0.75
83 Reduction of ferricytochrome c by some free radical agents. Science 1974 0.75
84 Genetic engineering of human interferons from lymphoblastoid cells: I. Cloning of interferon species expressed in Sendai-induced Namalva cells. Adv Biotechnol Processes 1985 0.75
85 Isolation of bovine IFN-alpha genes and their expression in bacteria. Methods Enzymol 1986 0.75
86 Genetic engineering of human interferons from lymphoblastoid cells: II. Construction of trp expression plasmids and their use for efficient expression of IFN-alpha J1. Adv Biotechnol Processes 1985 0.75
87 Protection of cattle from infection with vaccinia virus by bovine interferon alpha C. Vet Rec 1989 0.75
88 Tetracycline resistance expressed by pSC101 hybrids. Contrib Microbiol Immunol 1979 0.75