PubRank

John F Hunt

Author PubWeight™ 98.49‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer. Mol Cell 2002 4.79
2 Protein production and purification. Nat Methods 2008 3.97
3 Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator. EMBO J 2003 3.35
4 Impact of the deltaF508 mutation in first nucleotide-binding domain of human cystic fibrosis transmembrane conductance regulator on domain folding and structure. J Biol Chem 2004 2.66
5 Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters. J Biol Chem 2002 2.64
6 Robotic cloning and Protein Production Platform of the Northeast Structural Genomics Consortium. Methods Enzymol 2005 2.54
7 The structural basis of cyclic diguanylate signal transduction by PilZ domains. EMBO J 2007 2.39
8 Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature 2006 2.24
9 Asthma outcomes: biomarkers. J Allergy Clin Immunol 2012 1.88
10 A protein sequence that can encode native structure by disfavoring alternate conformations. Nat Struct Biol 2002 1.85
11 Understanding the physical properties that control protein crystallization by analysis of large-scale experimental data. Nat Biotechnol 2009 1.78
12 Effects of a peer-led asthma self-management program for adolescents. Arch Pediatr Adolesc Med 2011 1.65
13 Exhaled-breath condensate pH can be safely and continuously monitored in mechanically ventilated patients. Respir Care 2006 1.59
14 Acute effects of aerosolized S-nitrosoglutathione in cystic fibrosis. Am J Respir Crit Care Med 2002 1.51
15 Phospholipid-induced monomerization and signal-peptide-induced oligomerization of SecA. J Biol Chem 2002 1.50
16 Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. J Biol Chem 2010 1.47
17 Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study. Proteins 2009 1.44
18 Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma. Respiration 2009 1.38
19 High titers of IgE antibody to dust mite allergen and risk for wheezing among asthmatic children infected with rhinovirus. J Allergy Clin Immunol 2012 1.38
20 Integrated biophysical studies implicate partial unfolding of NBD1 of CFTR in the molecular pathogenesis of F508del cystic fibrosis. Protein Sci 2010 1.28
21 Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant. Protein Eng Des Sel 2010 1.26
22 Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1. Protein Sci 2010 1.25
23 Crystal structures of the BtuF periplasmic-binding protein for vitamin B12 suggest a functionally important reduction in protein mobility upon ligand binding. J Biol Chem 2002 1.22
24 Normative data for pH of exhaled breath condensate. Chest 2006 1.17
25 Structural genomics target selection for the New York consortium on membrane protein structure. J Struct Funct Genomics 2009 1.14
26 Bacillus subtilis SecA ATPase exists as an antiparallel dimer in solution. Biochemistry 2003 1.14
27 ATS workshop proceedings: exhaled nitric oxide and nitric oxide oxidative metabolism in exhaled breath condensate. Proc Am Thorac Soc 2006 1.11
28 The SufE sulfur-acceptor protein contains a conserved core structure that mediates interdomain interactions in a variety of redox protein complexes. J Mol Biol 2004 1.10
29 Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapy. Am J Respir Crit Care Med 2002 1.09
30 Post-translational modification of ribosomal proteins: structural and functional characterization of RimO from Thermotoga maritima, a radical S-adenosylmethionine methylthiotransferase. J Biol Chem 2009 1.09
31 Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. J Am Chem Soc 2012 1.08
32 Dynamics of ATP-binding cassette contribute to allosteric control, nucleotide binding and energy transduction in ABC transporters. J Mol Biol 2004 1.08
33 Solution structure of the NaV1.2 C-terminal EF-hand domain. J Biol Chem 2009 1.08
34 Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases. Nat Chem Biol 2013 1.08
35 The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. J Struct Funct Genomics 2010 1.07
36 How acidopneic is my patient? A new question in the pulmonary laboratory. Am J Respir Crit Care Med 2002 1.06
37 Enzymological and structural studies of the mechanism of promiscuous substrate recognition by the oxidative DNA repair enzyme AlkB. Proc Natl Acad Sci U S A 2009 1.05
38 The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase. Structure 2002 1.04
39 Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1. Biochem J 2004 1.03
40 S-Adenosylmethionine-dependent radical-based modification of biological macromolecules. Curr Opin Struct Biol 2010 1.02
41 Nucleotide exchange from the high-affinity ATP-binding site in SecA is the rate-limiting step in the ATPase cycle of the soluble enzyme and occurs through a specialized conformational state. Biochemistry 2004 1.02
42 Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex. Proc Natl Acad Sci U S A 2011 1.01
43 Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure 2010 0.99
44 Structure and dynamics of the P7 protein from the bacteriophage phi 12. J Mol Biol 2008 0.98
45 Computational design of a protein-based enzyme inhibitor. J Mol Biol 2013 0.98
46 Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. J Biol Chem 2011 0.95
47 Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. J Biol Chem 2005 0.95
48 Role of a conserved glutamate residue in the Escherichia coli SecA ATPase mechanism. J Biol Chem 2005 0.92
49 Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon. Biochemistry 2009 0.92
50 Structural genomics reveals EVE as a new ASCH/PUA-related domain. Proteins 2009 0.92
51 Mutations that change the position of the putative gamma-phosphate linker in the nucleotide binding domains of CFTR alter channel gating. J Biol Chem 2002 0.91
52 Membrane protein stability can be compromised by detergent interactions with the extramembranous soluble domains. Protein Sci 2014 0.91
53 Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins 2011 0.89
54 Buffering airway acid decreases exhaled nitric oxide in asthma. J Allergy Clin Immunol 2006 0.89
55 Large-scale experimental studies show unexpected amino acid effects on protein expression and solubility in vivo in E. coli. Microb Inform Exp 2011 0.88
56 Crystal structure of human 3-hydroxy-3-methylglutaryl-CoA Lyase: insights into catalysis and the molecular basis for hydroxymethylglutaric aciduria. J Biol Chem 2005 0.88
57 The crystal structure of the olfactory marker protein at 2.3 A resolution. J Mol Biol 2002 0.87
58 The structure of vimentin linker 1 and rod 1B domains characterized by site-directed spin-labeling electron paramagnetic resonance (SDSL-EPR) and X-ray crystallography. J Biol Chem 2012 0.86
59 NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway. J Struct Funct Genomics 2008 0.85
60 Physiological response to membrane protein overexpression in E. coli. Mol Cell Proteomics 2011 0.85
61 The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase. J Biol Chem 2003 0.85
62 The 2.35 A structure of the TenA homolog from Pyrococcus furiosus supports an enzymatic function in thiamine metabolism. Acta Crystallogr D Biol Crystallogr 2005 0.83
63 The methylthiolation reaction mediated by the Radical-SAM enzymes. Biochim Biophys Acta 2011 0.83
64 Structural characterization of an MJ1267 ATP-binding cassette crystal with a complex pattern of twinning caused by promiscuous fiber packing. Acta Crystallogr D Biol Crystallogr 2003 0.83
65 Evaluation of exhaled breath condensate pH as a biomarker for COPD. Respir Med 2011 0.82
66 Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage. Biol Direct 2012 0.82
67 Plant, animal, and fungal micronutrient queuosine is salvaged by members of the DUF2419 protein family. ACS Chem Biol 2014 0.82
68 Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells. Am J Respir Cell Mol Biol 2006 0.81
69 S-nitrosothiols regulate cell-surface pH buffering by airway epithelial cells during the human immune response to rhinovirus. Am J Physiol Lung Cell Mol Physiol 2006 0.80
70 Disorder breathes life into a DEAD motor. Nat Struct Mol Biol 2006 0.80
71 Assessment of protein folding/solubility in live cells. Methods Mol Biol 2003 0.80
72 Cell biology: shape-shifting protein channel. Nature 2004 0.79
73 ATPase active-site electrostatic interactions control the global conformation of the 100 kDa SecA translocase. J Am Chem Soc 2013 0.79
74 Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatus. Biochemistry 2013 0.78
75 Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product. J Struct Funct Genomics 2012 0.78
76 Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations. Biochemistry 2012 0.77
77 1H, 15N and 13C backbone assignment of MJ1267, an ATP-binding cassette. J Biomol NMR 2002 0.76
78 The structure and enzymatic properties of a novel RNase II family enzyme from Deinococcus radiodurans. J Mol Biol 2011 0.75
79 Safety of an alkalinizing buffer designed for inhaled medications in humans. Respir Care 2012 0.75
80 The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res 2015 0.75