Predicting antimicrobial peptides from eukaryotic genomes: in silico strategies to develop antibiotics.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 22884922)

Published in Peptides on August 03, 2012

Authors

André C Amaral1, Osmar N Silva, Nathália C C R Mundim, Maria J A de Carvalho, Ludovico Migliolo, Jose R S A Leite, Maura V Prates, Anamélia L Bocca, Octávio L Franco, Maria S S Felipe

Author Affiliations

1: Biological Sciences Institute, Universidade de Brasília, Brasília - DF 70910-900, Brazil.

Articles by these authors

Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae. J Bacteriol (2005) 2.15

Phylogenetic analysis reveals a high level of speciation in the Paracoccidioides genus. Mol Phylogenet Evol (2009) 1.99

Plant gamma-thionins: novel insights on the mechanism of action of a multi-functional class of defense proteins. Int J Biochem Cell Biol (2005) 1.12

Comparative proteome analysis of Xanthomonas campestris pv. campestris in the interaction with the susceptible and the resistant cultivars of Brassica oleracea. FEMS Microbiol Lett (2009) 1.09

Early transcriptional response of Paracoccidioides brasiliensis upon internalization by murine macrophages. Microbes Infect (2007) 1.07

Identification of a cowpea gamma-thionin with bactericidal activity. FEBS J (2006) 1.03

Transcriptome profiling of Paracoccidioides brasiliensis yeast-phase cells recovered from infected mice brings new insights into fungal response upon host interaction. Microbiology (2007) 0.99

Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Front Microbiol (2013) 0.98

A Review of Computational Tools in microRNA Discovery. Front Genet (2013) 0.98

Dermaseptins from Phyllomedusa oreades and Phyllomedusa distincta. Anti-Trypanosoma cruzi activity without cytotoxicity to mammalian cells. J Biol Chem (2002) 0.96

Phylloseptins: a novel class of anti-bacterial and anti-protozoan peptides from the Phyllomedusa genus. Peptides (2004) 0.96

Inhibition of trypsin by cowpea thionin: characterization, molecular modeling, and docking. Proteins (2002) 0.95

Identification of an antifungal peptide from Trapa natans fruits with inhibitory effects on Candida tropicalis biofilm formation. Peptides (2011) 0.93

The transcriptome analysis of early morphogenesis in Paracoccidioides brasiliensis mycelium reveals novel and induced genes potentially associated to the dimorphic process. BMC Microbiol (2007) 0.93

Plant-pathogen interactions: what is proteomics telling us? FEBS J (2008) 0.92

Poly(lactic acid-glycolic acid) nanoparticles markedly improve immunological protection provided by peptide P10 against murine paracoccidioidomycosis. Br J Pharmacol (2010) 0.91

Novel dermaseptins from Phyllomedusa hypochondrialis (Amphibia). Biochem Biophys Res Commun (2006) 0.91

Differences in cell morphometry, cell wall topography and gp70 expression correlate with the virulence of Sporothrix brasiliensis clinical isolates. PLoS One (2013) 0.90

Biotechnological potential of antimicrobial peptides from flowers. Peptides (2008) 0.90

Biochemical and biological properties of phospholipases A(2) from Bothrops atrox snake venom. Biochem Pharmacol (2002) 0.88

The divergent eukaryote Trichomonas vaginalis has an m7G cap methyltransferase capable of a single N2 methylation. Nucleic Acids Res (2008) 0.88

Antitumor effect and toxicity of free rhodium (II) citrate and rhodium (II) citrate-loaded maghemite nanoparticles in mice bearing breast cancer. J Nanobiotechnology (2013) 0.87

Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom. PLoS One (2012) 0.87

N, N'-Olefin functionalized bis-imidazolium gold(I) salt is an efficient candidate to control keratitis-associated eye infection. PLoS One (2013) 0.87

Circulating miR-1, miR-133a, and miR-206 levels are increased after a half-marathon run. Biomarkers (2014) 0.87

Amphotericin B in poly(lactic-co-glycolic acid) (PLGA) and dimercaptosuccinic acid (DMSA) nanoparticles against paracoccidioidomycosis. J Antimicrob Chemother (2009) 0.86

Cn-AMP1: a new promiscuous peptide with potential for microbial infections treatment. Biopolymers (2012) 0.86

Transcriptional response of murine macrophages upon infection with opsonized Paracoccidioides brasiliensis yeast cells. Microbes Infect (2007) 0.86

Identification and characterization of Tc1/mariner-like DNA transposons in genomes of the pathogenic fungi of the Paracoccidioides species complex. BMC Genomics (2010) 0.85

Plant cyclotides: an unusual class of defense compounds. Peptides (2007) 0.85

Solution NMR structures of the antimicrobial peptides phylloseptin-1, -2, and -3 and biological activity: the role of charges and hydrogen bonding interactions in stabilizing helix conformations. Peptides (2008) 0.85

Proteomic analysis of Metarhizium anisopliae secretion in the presence of the insect pest Callosobruchus maculatus. Microbiology (2008) 0.84

Exploring the pharmacological potential of promiscuous host-defense peptides: from natural screenings to biotechnological applications. Front Microbiol (2011) 0.84

Functional characterization of a synthetic hydrophilic antifungal peptide derived from the marine snail Cenchritis muricatus. Biochimie (2011) 0.84

Identification and characterization of a bactericidal and proapoptotic peptide from Cycas revoluta seeds with DNA binding properties. J Cell Biochem (2012) 0.84

A lactose specific lectin from the sponge Cinachyrella apion: purification, characterization, N-terminal sequences alignment and agglutinating activity on Leishmania promastigotes. Comp Biochem Physiol B Biochem Mol Biol (2009) 0.83

In silico identification of novel hevein-like peptide precursors. Peptides (2012) 0.83

Identification of a Passiflora alata Curtis dimeric peptide showing identity with 2S albumins. Peptides (2010) 0.82

Characterization and pharmacological properties of a novel multifunctional Kunitz inhibitor from Erythrina velutina seeds. PLoS One (2013) 0.82

A novel antimicrobial peptide from Crotalaria pallida seeds with activity against human and phytopathogens. Curr Microbiol (2009) 0.82

Structure and enzyme properties of Zabrotes subfasciatus alpha-amylase. Arch Insect Biochem Physiol (2006) 0.81

Conformational and functional effects induced by D- and L-amino acid epimerization on a single gene encoded peptide from the skin secretion of Hypsiboas punctatus. PLoS One (2013) 0.81

Proteomics applied to exercise physiology: a cutting-edge technology. J Cell Physiol (2012) 0.81

Proteomic identification, nucleotide sequence, heterologous expression and immunological reactivity of the triosephosphate isomerase of Paracoccidioides brasiliensis. Microbes Infect (2004) 0.81

Use of phage display to select novel cystatins specific for Acanthoscelides obtectus cysteine proteinases. Biochim Biophys Acta (2003) 0.81

Screening of entomopathogenic Metarhizium anisopliae isolates and proteomic analysis of secretion synthesized in response to cowpea weevil (Callosobruchus maculatus) exoskeleton. Comp Biochem Physiol C Toxicol Pharmacol (2006) 0.81

Murine dendritic cells transcriptional modulation upon Paracoccidioides brasiliensis infection. PLoS Negl Trop Dis (2012) 0.81

Beta-helical catalytic domains in glycoside hydrolase families 49, 55 and 87: domain architecture, modelling and assignment of catalytic residues. FEBS Lett (2002) 0.81

Purification and characterization of a trypsin-papain inhibitor from Pithecelobium dumosum seeds and its in vitro effects towards digestive enzymes from insect pests. Plant Physiol Biochem (2007) 0.81

In vitro antifungal activity and toxicity of itraconazole in DMSA-PLGA nanoparticles. J Nanosci Nanotechnol (2011) 0.80

In vivo proteome analysis of Xanthomonas campestris pv. campestris in the interaction with the host plant Brassica oleracea. FEMS Microbiol Lett (2008) 0.80

In vivo antimicrobial evaluation of an alanine-rich peptide derived from Pleuronectes americanus. Peptides (2013) 0.80

Screening and secretomic analysis of enthomopatogenic Beauveria bassiana isolates in response to cowpea weevil (Callosobruchus maculatus) exoskeleton. Comp Biochem Physiol C Toxicol Pharmacol (2007) 0.79

A 2S albumin-homologous protein from passion fruit seeds inhibits the fungal growth and acidification of the medium by Fusarium oxysporum. Arch Biochem Biophys (2003) 0.79

Dentistry proteomics: from laboratory development to clinical practice. J Cell Physiol (2013) 0.79

Molecular identification of four different alpha-amylase inhibitors from baru (Dipteryx alata) seeds with activity toward insect enzymes. J Biochem Mol Biol (2007) 0.79

Cloning, molecular characterization and heterologous expression of AMY1, an alpha-amylase gene from Cryptococcus flavus. FEMS Microbiol Lett (2008) 0.79

Structural and functional characterization of a multifunctional alanine-rich peptide analogue from Pleuronectes americanus. PLoS One (2012) 0.79

The antigenic and catalytically active formamidase of Paracoccidioides brasiliensis: protein characterization, cDNA and gene cloning, heterologous expression and functional analysis of the recombinant protein. Microbes Infect (2004) 0.79

Identification and structural characterization of novel cyclotide with activity against an insect pest of sugar cane. J Biol Chem (2011) 0.79

Molecular modeling and inhibitory activity of cowpea cystatin against bean bruchid pests. Proteins (2006) 0.79

Expression of metalloproteinases and interleukins on anastomoses in septic rats. J Surg Res (2013) 0.78

Pharmacological potential of exercise and RAS vasoactive peptides for prevention of diseases. Curr Protein Pept Sci (2013) 0.78

Bioinsecticidal activity of a novel Kunitz trypsin inhibitor from Catanduva (Piptadenia moniliformis) seeds. Plant Physiol Biochem (2013) 0.78

Rooteomics: the challenge of discovering plant defense-related proteins in roots. Curr Protein Pept Sci (2008) 0.77

High molecular mass proteomics analyses of left ventricle from rats subjected to differential swimming training. BMC Physiol (2012) 0.77

Effects of acute exercise over heart proteome from monogenic obese (ob/ob) mice. J Cell Physiol (2013) 0.77

Cm-p5: an antifungal hydrophilic peptide derived from the coastal mollusk Cenchritis muricatus (Gastropoda: Littorinidae). FASEB J (2015) 0.77

The use of MALDI-TOF-MS and in silico studies for determination of antimicrobial peptides' affinity to bacterial cells. J Am Soc Mass Spectrom (2012) 0.77

Inhibitory effects of a Kunitz-type inhibitor from Pithecellobium dumosum (Benth) seeds against insect-pests' digestive proteinases. Plant Physiol Biochem (2012) 0.77

The fractal based analysis of human face and DNA variations during aging. Biosci Trends (2016) 0.77

A Kunitz proteinase inhibitor from corms of Xanthosoma blandum with bactericidal activity. J Nat Prod (2011) 0.77

Toxicity to cotton boll weevil Anthonomus grandis of a trypsin inhibitor from chickpea seeds. Comp Biochem Physiol B Biochem Mol Biol (2005) 0.77

Practical and theoretical characterization of Inga laurina Kunitz inhibitor on the control of Homalinotus coriaceus. Comp Biochem Physiol B Biochem Mol Biol (2010) 0.77

Molecular cloning of alpha-amylases from cotton boll weevil, Anthonomus grandis and structural relations to plant inhibitors: an approach to insect resistance. J Protein Chem (2003) 0.76

Identification of a novel antimicrobial peptide from Brazilian coast coral Phyllogorgia dilatata. Protein Pept Lett (2013) 0.76

Evaluation of Magainin I interactions with lipid membranes: an optical and electrochemical study. Chem Phys Lipids (2012) 0.76

Comparative proteomical analysis of zygotic embryo and endosperm from Coffea arabica seeds. J Agric Food Chem (2008) 0.76

Post-secretory events alter the peptide content of the skin secretion of Hypsiboas raniceps. Biochem Biophys Res Commun (2008) 0.76

Molecular cloning and expression of an alpha-amylase inhibitor from rye with potential for controlling insect pests. Protein J (2005) 0.76

Antifungal nanofibers made by controlled release of sea animal derived peptide. Nanoscale (2015) 0.76

Identification of a napin-like peptide from Eugenia malaccensis L. seeds with inhibitory activity toward Staphylococcus aureus and Salmonella Enteritidis. Protein J (2014) 0.75

Bactericidal activity identified in 2S Albumin from sesame seeds and in silico studies of structure-function relations. Protein J (2011) 0.75

Comparative proteomics between natural Microcystis isolates with a focus on microcystin synthesis. Proteome Sci (2012) 0.75

Exercise Impacts The Global Profile Of MiRNA In Plasma And Skeletal Muscle In Hypertensive Rats: 2627 Board #150 June 3, 9: 30 AM - 11: 00 AM. Med Sci Sports Exerc (2016) 0.75

Partial characterization of a novel amphibian hemoglobin as a model for graduate student investigation on peptide chemistry, mass spectrometry, and atomic force microscopy. Biochem Mol Biol Educ (2011) 0.75